Applying Machine Learning Techniques to Identify Undiagnosed Patients with Exocrine Pancreatic Insufficiency by Bruce Pyenson, Maggie Alston, Jeffrey Gomberg, Feng Han, Nikhil Khandelwal, Motoharu Dei, Monica Son, Jaime Vora

“…EPI can be caused by a variety of disorders, including chronic pancreatitis, pancreatic cancer, and celiac disease. EPI remains underdiagnosed because of the nonspecific nature of clinical symptoms, lack of an ideal diagnostic test, and the inability to easily identify affected patients using administrative claims data. …”
Get full text

Screening of multi deep learning-based de novo molecular generation models and their application for specific target molecular generation by Yishu Wang, Mengyao Guo, Xiaomin Chen, Dongmei Ai

“…Moreover, we evaluated the performance of these NLP-based generation models and another new model architecture based on a selective state space and selected the best approach jointing a transfer learning strategy for de novo drug discovery to target L858R/T790M/C797S-mutant EGFR in non-small cell lung cancer.…”
Get full text

Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…This disorder affects approximately 6–20% of individuals, primarily emerging during early adolescence, and considerably increases the risk of conditions such as impaired glucose tolerance, type 2 diabetes, endometrial cancer, cardiovascular diseases, dyslipidemia, and postpartum complications. …”
Get full text

Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature by Weiming Wang, Baogang Zhang, Zhangli Wu, Chuanling Hou, Mengyao Li, Tianyi Zhang

“…There have been similar cases reported before, involving a 57-year-old male-patient (Sahetia et al. in Ind J Cancer 60:575–577, 2023).…”
Get full text

Clinical benefits of the 5th intercostal incision in uniportal VATS for female patients by Dalin Wang, Zhilin Luo, Jia Ming

“…A retrospective analysis of 150 female lung cancer patients was conducted, divided into 4 and 5th intercostal incision groups (n = 75 each). …”
Get full text

Medullary breast carcinoma: a pathogenic review and immunohistochemical study using tissue microarray by Ming Lee, Ana Richelia Jara-Lazaro, Poh Yian Cheok, Aye Aye Thike

“…Presence of lymphovascular invasion and nodal stage were significantly correlated with recurrence and breast cancer-related deaths, respectively. ER negativity was significantly correlated with triple positivity for basal markers CK14, EGFR and 34BE12, which comprised patients who showed a significantly decreased disease-free survival rate within a 10–15-year follow-up period. …”
Get full text

Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia by M. Carmen Jiménez-López, Ana Carolina Moreno-Maldonado, Natividad Martín-Morales, Francisco O’Valle, M. Ricardo Ibarra, Gerardo F. Goya, Ignacio J. Molina

“…Abstract There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41 °C. …”
Get full text

EMFF-Net: Edge-Enhancement Multi-Scale Feature Fusion Network by Xuhui Guan, Jiwang Zhou, Jian Chen, Xiaodan Xu, Yizhang Jiang, Kaijian Xia

“…According to medical research, colorectal polyps are considered typical precancerous lesions, making colonoscopic polyp images crucial for the early diagnosis of rectal cancer. However, variations in polyp size and shape, texture inconsistencies, and boundary ambiguities often pose significant challenges for polyp segmentation. …”
Get full text

Pathways and processes to adopting or switching to a single-dose HPV vaccination schedule in low- and middle-income countries: a qualitative study. by Sunny Roy, Megan D Wysong, Erica N Rosser, Ishani Sheth, Casey Geddes, Rupali J Limaye, Joseph G Rosen

“…The World Health Organization (WHO) recently endorsed a single-dose human papillomavirus vaccination (HPVV) schedule, but adoption of the revised immunization schedule has not been uniform, notably in low- and middle-income countries (LMICs) with outsized cervical cancer burdens. We sought to characterize the sequence of events, as well as actors/institutions involved, that facilitate or impede country-level decision-making related to the HPVV schedule. …”
Get full text

Unraveling multimodality of digital health records by comparing mortality trajectories of diagnoses of diseases from over 12 million patients. by Hyojung Paik

“…For example, viral hepatitis, a known predisposing feature of liver cancer in Asia, was observed to initiate in younger Koreans. …”
Get full text

The quantitative characteristic of morphological and structural changes in the diverted regions of the large intestine by A. S. Akopyan, E. V. Manukyan, T. G. Bagdasaryan, A. F. Abramyan, A. A. Akopyan

“…Radical surgery at complicated forms of colorectal cancer frequently results in colostoma formation. …”
Get full text

A cross-sectional survey on the effects of ambient temperature and humidity on health outcomes in individuals with chronic respiratory disease by Samantha Mekhuri, Shirley Quach, Caroline Barakat, Winnie Sun, Mika L Nonoyama

“…., asthma, sleep apnea, interstitial lung disease, lung cancer) and residing in Canada for ≥ 1 year. Negative responders to weather extremes were *a priori* defined as having a change of ≥ 2 points in the CAT…”
Get full text

Unraveling relationship between the genetic polymorphism CYP2A13 and nicotine metabolism of male smokers in Medan, Indonesia by Noni Novisari Soeroso, Rozaimah Zain-Hamid, Syamsul Bihar, Chaliza Soliha, Fannie Rizki Ananda, Aida

“…CYP2A13, a key enzyme in nicotine and xenobiotic metabolism, is implicated in tobacco smoke-related lung cancer. Aim This study investigated the association between CYP2A13 genetic polymorphism and nicotine metabolism in male smokers in Medan, Indonesia. …”
Get full text

Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, and DNA methylation profiling, to investigate the response of a representative panel of GBM patient-derived cancer stem cells (CSCs) to astrocytic differentiation and RT and TMZ treatments. …”
Get full text

Effects of group music sessions on cognitive and psychological functions in healthy older adults by Takamitsu Shinada, Michio Takahashi, Akari Uno, Keishi Soga, Yasuyuki Taki, Yasuyuki Taki

Get full text

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length by Fan Zhang, De Cheng, Kenneth I. Porter, Emily A. Heck, Shuwen Wang, Hui Zhang, Christopher J. Davis, Gavin P. Robertson, Jiyue Zhu

“…These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.…”
Get full text

Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The model of bacterial involvement in colorectal cancer progression is under study. Besides, the increasing attention of doctors and scientists is attracted to the issue intestinal microflora changes at antibiotic treatment. …”
Get full text

ARE QUALITY INDICATORS IMPORTANT IN COLONOSCOPIES? ANALYSIS OF 3,076 EXAMS IN A PRIVATE TERTIARY SERVICE IN SOUTHEASTERN BRAZIL by Adriana Borgonovi CHRISTIANO, Danielle Rossana Queiroz Martins BONILHA, Mauro Augusto MARCHIORI JUNIOR, Priscilla de Sene Portel OLIVEIRA, Maria de Lourdes Setsuko AYRIZONO

“…ABSTRACT BACKGROUND: The carcinogenesis of colorectal cancer is well understood. Adenomas are the precursor lesions in about 70% of cases, highlighting the importance of screening programs. …”
Get full text

Increase in assisted suicide in Switzerland: did the socioeconomic predictors change? Results from the Swiss National Cohort by Marcel Zwahlen, Nicole Steck, Christoph Junker

“…Crude rates of assisted suicide more than tripled during the study period from 3.60 to 11.21 per 100 000 person-years; the increase was more pronounced in the older age group. Cancer was the most common underlying diagnosis (41.8%), but the percentage dying assisted was highest among patients with diseases of the nervous system (5.25% in the younger and 1.23% in the older age group). …”
Get full text

Annotation-free deep learning for predicting gene mutations from whole slide images of acute myeloid leukemia by Bo-Han Wei, Xavier Cheng-Hong Tsai, Kuo-Jui Sun, Min-Yen Lo, Sheng-Yu Hung, Wen-Chien Chou, Hwei-Fang Tien, Hsin-An Hou, Chien-Yu Chen

“…Despite the demonstrated potential for characterizing gene mutations directly from WSIs in certain cancers, challenges remain due to image resolution and reliance on manual annotations for acute myeloid leukemia (AML). …”
Get full text