Germ cell quantification in human fetal and prepubertal testis tissues: a comparison of current methodologies by Emma Kearney, David Greenald, Gabriele Matilionyte, Sheila Lane, Melissa D Tharmalingam, Jill Davies, Jan-Bernd Stukenborg, Grace Forsyth, Rod T Mitchell

Get full text

Airborne Levels of Lung Carcinogens at an Ascon Manufacturing Site by Kyeongmin Lee, Sungwon Choi, Miyeon Kim, Dongwoo Song, Ki-Youn Kim

“…This study presents the first environmental evaluation at an ascon production facility in terms of substances that cause lung cancer.…”
Get full text

Synthetic CT generation from CBCT and MRI using StarGAN in the Pelvic Region by Paritt Wongtrakool, Chanon Puttanawarut, Pimolpun Changkaew, Supakiet Piasanthia, Pareena Earwong, Nauljun Stansook, Suphalak Khachonkham

“…The dataset comprised 53 cases of pelvic cancer. Evaluation involved qualitative and quantitative analyses, focusing on synthetic image quality and dose distribution calculation. …”
Get full text

Phytochemicals of Vitis vinifera L. var. King Ruby protect mice from benzo(a)pyrene-induced lung injury by Gehad S. Ahmedy, Hend M. Selim, Mona El-Aasr, Souzan M. Ibrahim, Suzy A. El-Sherbeni

“…Abstract The world’s concern about smoking hazards, chronic obstructive pulmonary disease (COPD) and lung cancer was the motivation to investigate plants as a source of new drugs with lung protective effect. …”
Get full text

Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

Get full text

LncRNA GAS5 inhibits glioma progression through miR-135b-5p/APC axis by ZHANG Jidong, WANG Yutao, JI Jianwen

“…Western blotting and qRT-PCR indicated that GAS5 was down-regulated in the glioma cell lines and tissues than human normal astrocytes and para-cancer tissues (P<0.01). The results of CCK-8, Transwell and wound healing assays revealed that overexpression of GAS5 significantly inhibited the viability, invasion and migration abilities in T98 cells when compared with the cells of the vector group (P<0.01). …”
Get full text

Clinical Practice Guidelines of the Russian Scientific Liver Society, Russian Gastroenterological Association, Russian Association of Endocrinologists, Russian Association of Geron... by V. T. Ivashkin, M. V. Maevskaya, M. S. Zharkova, Yu. V. Kotovskaya, O. N. Tkacheva, E. A. Troshina, M. V. Shestakova, I. V. Maev, V. V. Breder, N. I. Gheivandova, V. L. Doshchitsin, E. N. Dudinskaya, E. V. Ershova, Kh. B. Kodzoeva, K. A. Komshilova, N. V. Korochanskaya, A. Yu. Mayorov, E. E. Mishina, M. Yu. Nadinskaya, I. G. Nikitin, N. V. Pogosova, A. I. Tarzimanova, M. Sh. Shamkhalova

“…Complications of nonalcoholic fatty liver disease include aggravation of cardiometabolic risks, development of hepatocellular cancer, progression of liver fibrosis to cirrhotic stage.Conclusion. …”
Get full text

Determination of Total Levels of Secondary Metabolites and Oral Acute Toxicity Testing of Purple Leaf Ethanol Extract (PLEE) in Wistar Rats by Niluh Puspita Dewi, Miranti Miranti, Magfirah Magfirah, Athia Kurnia Kasim, I Made Dipayana

“…These leaves are traditionally used to treat rheumatism, menstruation, hemorrhoids, urinary tract infections, scabies, swelling, wounds, dermatitis, ear diseases, laxatives, and cancer. The aim of this study was to determine the total levels of secondary metabolites from purple leaf extract ethanol (PLEE) and evaluate the effect of administering PLEE on acute toxicity (LD50) in Wistar rats. …”
Get full text

Self-reported knowledge and difficulties towards palliative care among healthcare professionals in rural China: a cross-sectional study by Junwei Niu, Min Feng, Changhui Song, Hui Xie

“…Data were collected on participants’ demographic characteristics, information on recently deceased cancer patients they had cared for, and PC-related information. …”
Get full text

Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein by Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

“…Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and functions of phase-separated condensates, as a potential therapeutic modality. …”
Get full text

Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

“…It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition of the cystine-glutamate antiporter, system Xc–, induces ferroptosis. …”
Get full text

Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes by Chloe Wong, Jun Yan Ng, Yang Yie Sio, Fook Tim Chew

“…Various phenotypes such as wrinkling, pigmentation changes, and skin cancers have been linked to specific genetic loci. …”
Get full text

Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

Get full text

Quality of life and overall well-being between healthy individuals and patients with varied clinical diagnoses by Mohamad Adam Bujang, Wei Hong Lai, Xun Ting Tiong, Selvasingam Ratnasingam, Alex Ren Jye Kim, Masliyana Husin, Yvonne Yih Huan Jee, Nurul Fatma Diyana Ahmad, Clare Hui Hong Tan, Khoo Sing Yee, Yoon Khee Hon, Eileen Pin Pin Yap, Fazalena Johari, Alan Yean Yip Fong

“…Among the non-healthy participants, 41 (9.1%) had end-stage renal diseases (ESRD), 48 (10.6%) were diagnosed with cancer, 40 (8.8%) had depressive disorder, and the remaining had heart disease (8.6%). …”
Get full text

The association between tobacco and alcohol use and health outcomes in individuals living with diabetes and prediabetes in South Africa: A cross-sectional study by S J Mulder, T Chivese, C O Egbe

“…Problem/risky alcohol use was significantly associated with 40% increased odds of COPD/asthma (aOR 1.40; 95% CI 1.1 - 1.7; p=0.001) and 92% increased odds of having cancer (aOR 1.92; 95% CI 1.5 - 2.5; p<0.001). Conclusion. …”
Get full text

Prevalence of communicable, non-communicable diseases, disabilities and related risk factors in Khyber Pakhtunkhwa Pakistan: Findings from the Khyber Pakhtunkhwa Integrated Populat... by Ziaul Haq, Saima Afaq, Muhammad Ibrahim, Zala, Muhammad Asim

“…<h4>Objectives</h4>The objective of this study was to present the demographic characteristics and the burden of locally-specific CDs (hepatitis B and C, TB, AIDS), NCDs (diabetes, renal diseases, asthma, epilepsy, coronary heart diseases, cancer, hypertension, cholesterol, thalassemia), and disabilities (congenital, post-disease, post-injury, paralysis) stratified by sex, age and setting in the Khyber Pakhtunkhwa province of Pakistan.…”
Get full text

Acceptability of and experiences with menstrual hygiene cups among adolescent girls and young women aged 15–24 in two communities in Lusaka, Zambia: an exploratory study nested in... by Melleh Gondwe, Melvin Simuyaba, Mwelwa Phiri, Chisanga Mwansa, Albertus Schaap, Lucheka Sigande, Kwame Shanaube, Sian Floyd, Sarah Fidler, Helen Ayles, Musonda Simwinga, Bernadette Hensen

“…Misconceptions that cups cause cancer and fears that they could get stuck in the vagina, cause sore, vagina enlargement, and loss of virginity were raised by AGYW. …”
Get full text

Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study by Qingzheng Wu, Bing Li, Yuepeng Wang, Yuepeng Wang, Yue Zhang, Qian Wang, Binqi Li, Binqi Li, Wei Jing, Jing Yang, Yiming Mu

“…This study aimed to examine the association between WWI and T2DM in Chinese urban adults.MethodA total of 5,0978 eligible participants drawn from the prospective REACTION study (Cancer Risk Assessment in Chinese People with Diabetes) were included in this study. …”
Get full text

Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant... by Maryam Alaei, Mohamad Ghazanfari Hashemi, Seyedeh Nooshin Miratashi Yazdi, Mohammad Ali Kaviani, Ali Asadifar, Sahand Adib Moradi, Khazar Adibmoradi Langaroudi, Helia Helali, Mina Mahboudi, Aynaz Gerami

Get full text

Helicobacter pylori infection at long-term treatment by proton pump inhibitors for acid-related diseases (Literature review and resolution of Advisory council, March 22, 2018) by V. T. Ivashkin, I. V. Mayev, R. A. Abdulkhakov, O. P. Alekseyeva, S. A. Alekseyenko, A. Yu. Baranovsky, Ye. K. Baranskaya, I. L. Klyaritskaya, N. V. Korochanskaya, Yu. A. Kucheryavy, T. L. Lapina, M. F. Osipenko, V. I. Simanenkov, G. N. Tarasova, A. S. Trukhmanov, I. B. Khlynov, A. A. Sheptulin

“…Monotherapy by proton pump inhibitors (PPI) in H. pylori-positive patients with GERD may lead to progression of gastric corpus atrophy that can be regarded as risk factor for stomach cancer development. H. pylori infection eradication promotes reduction of gastritis-like changes severity irrespective of maintaining of acid-suppressive treatment. …”
Get full text