Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by E. D. Fedorov, V. V. Veselov, S. V. Kashin, E. V. Tikhomirova, A. V. Veselov, D. V. Zavyalov, A. Kornowski, T. E. Gorskaya, M. Volteau, T. Ponchon

“…This study is registered with the ClinicalTrials.gov Registry of Clinical Trials, No. NCT02321462.Conflict of interest: this study was sponsored by Ipsen Pharma.Acknowledgements: the authors express their sincere gratitude to all the patients who participated in the study, as well as to specialists having provided medical care for the patients, researchers and employees of the participant research centres. …”
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Role of nutritional factors at the irritable bowel syndrome by Yu. O. Shulpekova, A. V. Sedova

“…Efficacy of functional food products containing bacteria of probiotic strain Bifidobacterium animalis sp. lactis DN-173 010 for treatment of IBS symptoms is demonstrated in clinical trials. At detection of symptoms link to intake of specific products it is necessary to exclude food allergy and enzymopathies (e.g. lactase deficiency), which should be defined as independent diseases under the «mask» of irritable bowel syndrome.Conclusion. …”
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Exploring the associations between the biomechanical and psychological mechanistic pathways of lower back pain development amongst persons with lower-limb amputation: A study proto... by Alexandra Withey, Dario Cazzola, Abby Tabor, Elena Seminati

“…<h4>Trial reference number</h4>The study is registered at IRAS ID: 321729 and at ClinicalTrials.gov: NCT06243549.…”
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Post-chemoradiotherapy adjuvant chemotherapy of rectal cancer by E. V. Ledin, A. V. Kochatkov

“…The meta-analysis (2015) of 4 randomized third-phase clinical trials (EORTC 22921, I-CNR-RT, PROCTORSCRIPT, CHRONICLE) demonstrated the lack of significant of 5-fluorouracil-based adjuvant chemotherapy. …”
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Meta-Analysis and Systematic Review of the Role of Appendectomy in the Pathogenesis of Colorectal Cancer by M.I. A. Nezhad, N. P. Yabandeh

“…Our systematic investigation utilized sources including the Cochrane Library, Embase, PubMed, ClinicalTrials.gov, and Web of Science, covering research up to February 1, 2023. …”
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Electronic Cigarettes: Ally or an Enemy in Combating Tobacco-Use-Associated Diseases - An Integrative Review by Hunny Sharma, Manisha Ruikar

“…Methods: This integrative review includes findings from Randomized and non-randomized clinical trials, and laboratory-based Human studies; published in the English language in the last four years. …”
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Real-world pharmacovigilance analysis unveils the toxicity profile of amivantamab targeting EGFR exon 20 insertion mutations in non-small cell lung cancer by Jing Zhang, Wenjie Li

“…Abstract Background While clinical trials have demonstrated enduring responses to amivantamab among advanced non-small cell lung cancer (NSCLC) patients bearing EGFR exon 20 insertion mutations, the associated toxicity profile in real-world scenarios remains elusive. …”
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MECHANISMS AND CLINICAL PERSPECTIVES OF ALLERGEN-SPECIFIC IMMUNOTHERAPY by Leila Akhvlediani, Marina Izmailovich, Meruyert Gazaliyeva, Anna Skvortsova, Kanan Tanriverdiev

“…Vitamin D, particularly 25(OH)D, plays a pivotal immunomodulatory role, supporting Treg and Breg cell function, and mitigating allergic inflammation. Clinical trials demonstrate that vitamin D supplementation enhances ASIT outcomes, especially in pediatric patients. …”
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The Impact of Zinc Supplementation on the Course of Infections by Justyna Woźniak, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“…Materials and Methods: The study utilized a comprehensive approach, combining literature reviews, clinical trials, experimental studies, and microbiota analyses to investigate zinc's role in immune function, infection management, and antimicrobial resistance. …”
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Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon by Clement Orczyk, Teresa Marsden, Francesco Giganti, Joseph M. Norris, Santosh Waigankar, Louise Dickinson, Shonit Punwani, Alex Kirkham, Alex Freeman, Aiman Haider, Caroline M. Moore, Arnauld Villers, Clare Allen, Mark Emberton

“…Focal therapy (FT) is a promising approach with a low side-effect profile for treating magnetic resonance imaging (MRI)-visible PC within a limited framework of guideline recommendations or clinical trials. On the basis of accumulated clinical and research experience, we present a systematic approach to FT indications for ablation of visible targets that includes imaging findings, margin delineation, and energy selection. …”
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PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“…These inhibitors have been validated in multiple clinical trials, underscoring their robustness and effectiveness. …”
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Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…However, further research is needed to clarify the underlying molecular mechanisms and validate these compounds through preclinical and clinical trials.…”
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The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study by Xiangqian Huang, Xiaoming Zhang, Jiahao Song, Duo Lan, Mengqi Wang, Xunming Ji, Da Zhou, Ran Meng

“…Abstract Background and purpose Although Ginkgo biloba extract (GBE) has been shown to be effective in treating acute ischemic stroke (AIS) in several clinical trials, concerns regarding adverse events, such as bleeding, have been raised. …”
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Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Trial registration ClinicalTrials.gov NCT04117672. Registered on September 17, 2017. …”
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The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (H... by Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

“…GLP-1R agonists, including semaglutide and liraglutide, have demonstrated significant cardioprotective effects, such as improving vascular endothelial function, reducing inflammation, and preventing atherosclerosis. Clinical trials, such as the STEP-HFpEF trial, have shown positive results in reducing symptoms and physical restrictions in HFpEF patients. …”
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ErbB- and MUC1-targeted CAR-T cell immunotherapy of oral squamous cell carcinoma by Saffron E. Summers, Saffron E. Summers, Vehid Salih, Andrew D. Foey

“…Currently, there are few clinical trials investigating the use of CAR-T cells in HNSCC/OSCC; however, results from trials investigating similar solid tumours, such as breast cancer, can be adopted to help evaluate the use of CAR-T in this cancer. …”
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Metabolomic profile and its association with the diagnosis of prostate cancer: a systematic review by Angela Patricia Salinas Pita, Mildrey Mosquera Escudero, Eliecer Jiménez-Charris, Herney Andrés García-Perdomo

“…Methods We conducted a search strategy in MEDLINE (OVID), EMBASE, LILACS, and the Cochrane Central Register of Controlled Trials (CENTRAL) from 2008 to the present. We included Clinical trials and analytical and descriptive observational studies that reported metabolite results and metabolite profiles in serum, tissue, urine, and seminal fluid. …”
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The SGLT-2 Inhibitors and their Role in the Treatment of Heart Failure - A Review of Literature by Silvia Ciraolo, Agnieszka Kulczycka-Rowicka, Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec

“… • Research materials and methods: A comprehensive literature review was conducted, analyzing clinical trials, guideline documents, and mechanistic studies on SGLT2 inhibitors. …”
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Randomised feasibility study of an intestinal adsorbent in acute diarrhoea in The Gambia by Elena Markaryan, Matthew Dodd, Stephen Allen, Carol Howell, Angela Allen, Paul Rahden, Abdoulie Fatty, Momodou Lamin Jobarteh, Abdoulwahab Sallah, Ebrahim Jaiteh, Doreen Umoh, Fanta Bass, Radovan Hnatič

“…One serious event (death) occurred in the control arm.Conclusions A randomised, controlled trial is feasible. Further clinical trials are warranted to confirm the efficacy of polymethylsiloxane polyhydrate in acute diarrhoea and inform management guidelines.Trial registration number PACTR202302683128875.…”
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Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions by Syamand Ahmed Qadir, Qausar Hamed ALKaisy, Abdulbasit F. Hasan, Farhang Hameed Awlqadr, Ammar B. Altemimi, Aryan Mahmood Faraj, Angelo Maria Giuffrè, Mohammed N. Saeed, Sherzad Rasul Abdalla

“…A comprehensive search of PubMed, Web of Science, Scopus, Embase, and ClinicalTrials.gov from January 2000 to December 2023 identified 97 relevant studies on FMT's efficacy, safety, and microbiome changes after eliminating duplicates. …”
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