Exploring the Effects of Sub-Dissociative Doses of Ketamine on Sedation Quality in Bronchoscopy: A Double-Blind Clinical Study by Hamidreza Shetabi, Samira Rostami

“…Methods: This research utilized randomized clinical trial design involving three cohorts, each consisting of 30 participants. …”
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Annual Zoledronic Acid for the Treatment of Osteoporosis: A Randomized Controlled Trial by Asif Hussain, Sushil Kumar Saini, Jaydeep Patel, Chandra Prakash Pal, Hemant Singh Chahar, Rohit Yadav

“…Methods: This is a blinded randomized clinical trial conducted at a government hospital. Patients aged 50–89 years with bone mineral density (BMD) T score < −2.5 or < −1.5 with 2 mild vertebral fractures or 1 moderate vertebral fractures were randomized to receive placebo versus zoledronic acid. …”
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A systematic review of Aspilia africana (Pers.) C.D. adams traditional medicinal uses, phytoconstituents, bioactivities, and toxicities by Gang, Roggers, Okello, Denis, Yeongjun, Ban, Kang, Youngmin

“…Additionally, toxicity and clinical trial data for A. africana are limited with most toxicological assessments being acute in nature. …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…These data provide the rationale for the 2 ongoing studies evaluating CPX-351 vs 7+3 in non–MRC-AML and non–t-AML using MRD as the primary end point for ALFA-2101 phase 2 clinical trial and event-free survival for AMLSG 30-18 phase 3 clinical trial.…”
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Experiences of working as a clinical nurse while pregnant during the coronavirus disease-2019 pandemic: a qualitative study by Lin Ye Wu, Wing Fai Yeung, Yao Lin Pei, Ling Xi Chen, Meng Qi Li, Jia Yin Ruan

“…Moreover, research on moral stigma and bullying in nursing during pregnancy deserves further exploration. Clinical trial number Not applicable.…”
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Oral health status, behavior and impact profile among naval personnel in the Malaysian naval armed forces by Nik Madihah Nik Azis, Raja Noreihan Raja Abdullah, Mohamad Nur Adzmi Mohamad Ayub, Badiah Baharin

“…These findings highlight the need for tailored oral health interventions within the naval setting to enhance deployment readiness, improve oral health outcomes, and elevate the quality of life for naval personnel. Clinical trial number Not applicable.…”
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Bupivacaine–fentanyl isobaric spinal anesthesia reduces the risk of ICU admission in elderly patients undergoing lower limb orthopedic surgery by Wenxun Liu, Shuzhen Bao, Jiaxin Chen, Yan Li, Yinghua Gu, Qingshan Ye, Kerong Hai

“…Trial registration: This study has been registered in the Chinese Clinical Trial Registry (ChiCTR2000033411).…”
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Assessing the relationship between nursing process competency and work environment among clinical nurses: a cross-sectional correlational study by Reza Nemati-Vakilabad, Ehsan Kamalifar, Mobina Jamshidinia, Alireza Mirzaei

“…Additionally, targeted training programs should be provided to focus on the nursing process and skills enhancement, thereby boosting both confidence and competency. Clinical trial number Not applicable.…”
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Persistence with Early-Line Abatacept versus Tumor Necrosis Factor-Inhibitors for Rheumatoid Arthritis Complicated by Poor Prognostic Factors by Xue Han, Francis Lobo, Michael S. Broder, Eunice Chang, Sarah N. Gibbs, David J. Ridley, Irina Yermilov

“…Gathering data on treatment patterns outside of a clinical trial setting can provide useful context for clinicians. …”
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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…It can be further developed in clinical studies for the unmet medical needs in management of CVDs and overcome the pharmacogenomic limitations of Clopidogrel.Trial registration number Clinical Trial Registry-India URL: http://ctri.nic.in. …”
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Effect of Dynamic Neuromuscular Stabilization Exercises on Activity of External Oblique Muscle in Low Back Pain by Hediyeh Hosseini, Abbas Rahimi, Khodabakhsh Javanshir, Mohammad Taghipour, Aliyeh Daryabor, Sedigheh Sadat Naimi

“…Materials and Methods: In a randomized clinical trial, 44 people with chronic NSLBP were randomly assigned to the experimental and the control groups, with 22 participants in each group. …”
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Did selective kinase inhibitors change the management of patients with radioiodine-refractory thyroid cancer? by Tommaso Porcelli, Cristina Luongo, Anna Cerbone, Carmine Di Luccio, Mariantonia Nacchio, Maria Angela De Stefano, Martin Schlumberger, Domenico Salvatore

“…Patients and methods: We extracted data from 69 consecutive patients referred to Federico II University Hospital from September 2016 to September 2024, among whom 44 patients were treated with TKIs as first-line treatment and outside any clinical trial, and form the basis of this report. Results: Thirty-one (71%) patients were treated with the antiangiogenesis inhibitor lenvatinib and 13 (29%) were treated with selective tyrosine kinase inhibitors (s-TKIs). …”
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Effectiveness of Single-Tablet Combination Therapy in Improving Adherence and Persistence and the Relation to Clinical and Economic Outcomes by Carly J. Paoli, Jörg Linder, Khushboo Gurjar, Deepika Thakur, Julie Wyckmans, Stacy Grieve

“…This may be due to clinical trial procedures aimed at maximizing adherence and HRQoL measures that are not designed to evaluate drug administration. …”
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Effects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial by Xiang Yan, Chen Liang, Jia Jiang, Ying Ji, An-Shi Wu, Chang-Wei Wei

“…This anesthetic regimen has shown good feasibility without significantly increasing the patient’s pain score and complications. Clinical trial registration number Clinicaltrials.gov, Identifier: NCT05411159. …”
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Efficacy of continuous intravenous infusion of lidocaine on postoperative sore throat after laryngeal mask insertion: a randomized controlled trial by Jianxin Jiang, Jimin Wu, Shuqi Shi, Xiaoli Dong, Jiaxiang Yin, Yini Wu

“…Trial Registration Chinese Clinical Trial Registry (ChiCTR2300070339,04/10/2023).…”
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Network Meta-Analysis of Once Weekly Selinexor-Bortezomib-Dexamethasone in Previously Treated Multiple Myeloma by Michael Dolph, Gabriel Tremblay, Adrienne M Gilligan, Hoyee Leong

“…**Methods**: Ovid was systematically searched for phase 2-3 randomized clinical trials (RCTs) in MM that assessed progression-free survival (PFS), overall survival (OS) and overall response rates (ORR). …”
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Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review by Ming Cheng, Yuan Ding, Dongmei Wang, Chunxiu Gong

“…Elevated levels of IAAs and an inappropriate insulin to C-peptide molar ratio during an extended OGTT are critical indicators. Clinical Trial Number Not applicable.…”
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Hymecromone Efficacy in the Treatment of Biliary Pancreatitis by A. V. Okhlobystin, M. A. Tatarkina, O. Z. Okhlobystina, S. A. Budzinskiy, P. V. Pavlov, L. A. Labut

“…An open single-centre clinical trial included 30 patients with chronic pancreatitis (CP), which was diagnosed according to the Cambridge criteria. …”
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Home-based transcranial direct current stimulation paired with cognitive training to reduce fatigue in multiple sclerosis by Leigh Charvet, Judith D. Goldberg, Xiaochun Li, Pamela Best, Matthew Lustberg, Michael Shaw, Lana Zhovtis, Josef Gutman, Abhishek Datta, Marom Bikson, Giuseppina Pilloni, Lauren Krupp

“…We conducted a double-blind, sham-controlled, randomized clinical trial to compare active vs. low-dose (sham) tDCS paired with computer-based cognitive training, delivered as a home-based intervention, to reduce MS-related fatigue. …”
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Impact of parathyroidectomy on inflammatory and cardiovascular risk parameters in primary hyperparathyroidism: a retrospective analysis by Nese Bulbul, Suat Sen, Fettah Acibucu

“…The study also suggests that these risk factors may be modifiable with timely surgical intervention. Clinical trial number Not applicable.…”
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