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221
Glycogen Storage Disease Type Ia: A Retrospective Claims Analysis of Complications, Resource Utilization, and Cost of Care
Published 2025-01-01“…The most frequent complications in patients with GSDIa vs comparators included anemia due to enzyme disorders (odds ratio, 4.0 × 103; 95% confidence interval, 555.9–2.8 × 104), hepatocellular adenoma (305.9; 41.6–2.2 × 104), liver transplantation (164.6; 21.8-1.2 × 103), and gastrostomy (152.2; 61.1-379.2), as well as acidosis (45.5; 29.4-70.3), hepatomegaly (43.6; 29.1-65.3), hyperuricemia (23.6; 11.9-46.9), and hypoglycemia (20.2; 14.3-28.7). …”
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222
Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion
Published 2023-07-01“…Furthermore, the concentration of interferon-gamma (IFN-γ), transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10) was measured quantitatively using the enzyme-linked immunosorbent assay technique. Statistical Analysis Used: Normality and comparisons between study groups were performed by non-parametric unpaired Mann–Whitney, Kruskal–Wallis rank sum test, and one-way ANOVA. …”
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223
Spatial and seasonal distribution of selected nitrogen cycle genes in deep waters of the Baltic Proper
Published 2025-02-01“…Anammox-related genes were not present within sites, thus denitrification pathway enzymes, namely, NOR and N2O reductase (NOS) were responsible for nitrogen loss. …”
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224
Continuously relapsing (for two years) course of diarrheal variant of IBS (<i>Clinical case</i>)
Published 2013-10-01“…Antispasmodics of various groups, enzyme and antisecretory agents in this relation were prescribed to him without any noteworthy effect for two years prior to admission to Vasilenko Clinic of internal diseases propedeutics, gastroenterology and hepatology. …”
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225
Role and mechanism of dexmedetomidine in regulating bone metabolism in tail-suspended osteoporotic rats
Published 2025-02-01“…Secondly, after primary osteoblasts were isolated from the tibiae of tail-suspended rats and then treated with 1 nmol/L Dex, the proportion of alkaline phosphatase (ALP)-positive osteoblasts and the activity of the enzyme were detected by ALP staining and activity test. qRT-PCR was applied to measure the expression of osteogenic activity-related factors, including osteocalcin (Ocn), Runt related transcription factor 2 (Runx2), Osterix protein (Osx), and type 1 collagen (Col1). …”
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226
Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine
Published 2025-02-01“…Additionally, this combined treatment increased the activity of antioxidant enzymes and up-regulated the expression of antioxidant genes in the Nrf2 signaling pathway in stress mice. …”
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227
A Case of Exacerbation of Chronic Pancreatitis Against the Background of COVID-19 Complicated by Pancreaticopleural Fistula with Enzymatic Pleurisy
Published 2024-01-01“…The causative agent of COVID-19 has a high affinity for angiotensin-converting enzyme 2 receptors, which are present in large numbers on acinar, ductal, and secretory cells of the pancreas. …”
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228
Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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229
Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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230
The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind,...
Published 2025-02-01“…Oxidative stress parameters were assessed using the standard calorimetric method, and inflammatory parameters were measured via the enzyme-linked immunosorbent assay method (ELISA). …”
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231
Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association
Published 2018-08-01“…PEI in the state it which secretion of pancreatic enzymes into duodenum is insufficient for normal digestion of nutrients. …”
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232
Lead toxicity in Nicotiana tabacum L.: Damage antioxidant system and disturb plant metabolism
Published 2025-02-01“…Meanwhile, Pb treatment increased the activity of tobacco SOD and POD enzymes. Metabolomics results showed that Pb stress enhanced tryptophan metabolism, glutathione metabolism, alanine, aspartate, and glutamate metabolism, as well as cysteine and methionine metabolism pathways. …”
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233
LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress
Published 2025-02-01“…We found that the gene and protein expression levels of glycolytic-related enzyme LDHA significantly decreased at early phase after oxidative stress injury both in vitro and in vivo, and exhibited anti-inflammatory effects on macrophages (Mφ). …”
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234
<i>Clostridium difficile</i>-associated disease
Published 2015-12-01“…Nowadays there are several laboratory diagnostic tests for Clostridial infection: testing for C. difficile glutamate dehydrogenase, enzyme-linked immunoassay, polymerase chain reaction for toxigenic strain of C. difficile. …”
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235
Ficus deltoidea standardized methanolic extract improves kidney structure and function against streptozotocin-induced diabetic nephropathy in rats
Published 2025-02-01“…Serum creatinine, urea, uric acid, total bilirubin, and urinary creatinine were measured to estimate kidney function. Enzyme-linked immunosorbent assays (ELISA) assessed the levels of oxidative stress, antioxidants, and apoptosis-related proteins in the kidney tissue. …”
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236
Dose-dependent effects of hydroquinone on liver injury and lipid dysregulation based on SCD1/AMPK signaling pathway in C57BL/6 mice
Published 2025-01-01“…In contrast, the highest dose (50.0 mg/kg) resulted in elevated liver enzyme levels, indicative of liver damage, while lipid levels decreased. …”
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237
Genetically edited human placental organoids cast new light on the role of ACE2
Published 2025-02-01“…Despite increased expression of ACE2 protein, ACE2 enzyme activity was significantly decreased in ACE2 rs2074192 TT placental organoids. …”
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238
Effect of icatibant on sweating-induced dermal pain
Published 2025-02-01“…Icatibant did not affect the changes in whole blood and plasma histamine, and serum angiotensin-converting enzyme levels after the induction of the dermal pain. …”
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239
The relationship between oxLDL, sLOX-1, PCSK9 and carotid intima-media thickness in patients with prediabetes and type 2 diabetes
Published 2025-02-01“…Measurement of serum oxLDL, sLOX-1 and PCSK9 levels were assessed by using a commercially available human enzyme-linked immunosorbent assay (ELISA) method. …”
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240
Physiological and transcriptome analysis reveals the mechanism of Gymnocarpos przewalskii response to drought stress
Published 2025-02-01“…There were 2,134 and 1,739 DEGs enriched in 47 GO secondary categories and 129 KEGG pathways, respectively. 2 up-regulated DEGs were annotated to P5CS, a key enzyme in the biosynthesis of proline. 32 DEGs were annotated to various antioxidases and antioxidants. 81 DEGs were annotated to 8 plant hormone signaling pathways, in which the auxin and ABA signaling pathways exhibited dominant enrichment. 150 DEGs were annotated to 35 transcription factor families with the abundant enrichment of TF families containing WRKY, bZIP, ERF, bHLH, MYB, and NAC. …”
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