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261
Multi-omics reveals that ST6GAL1 promotes colorectal cancer progression through LGALS3BP sialylation
Published 2025-02-01“… ST6 β-galactoside α2,6-sialyltransferase 1 (ST6GAL1), a crucial enzyme for tumor-associated sialic acid modification, has been reported to positively correlate with colorectal cancer (CRC) tumorigenesis; however, the underlying mechanism remains unclear. …”
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262
Micro-/nanobubble oxygenation irrigation enhances soil phosphorus availability and yield by altering soil bacterial community abundance and core microbial populations
Published 2025-02-01“…Therefore, we established two irrigation methods, conventional irrigation (CF) and micro-/nanobubble oxygenation irrigation (MB), to investigate the combined effects on enzyme activity, microbial communities, and soil phosphorus availability in the rhizosphere soil of maize.The results showed that compared to the CF treatment, the MB treatment significantly increased available phosphorus content and alkaline phosphatase activity in maize rhizosphere soil by 21.3% and 15.4%, respectively. …”
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263
Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy
Published 2025-02-01“…RNA sequencing illuminated a potential relationship between HVEM and GPT2, an enzyme tied to amino acid metabolism and cellular energetics. …”
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264
Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells
Published 2025-02-01“…Two aptamers (AP4-2 and AP17-4) were selected for enzyme-linked aptamer sorbent assay (ELASA) and further analysis. …”
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265
Pengaruh Paparan Medan Magnet Extremely Low Frequency (ELF) terhadap Perubahan pH Pada Proses Fermentasi Biji Kopi Lanang (Peaberry) Kering
Published 2021-09-01“…The study aims to examine the effect of exposure to the ELF (Extremely Low Frequency) magnetic field on changes of pH in the fermentation process of robusta peaberry dray coffee beans with the addition of -amylase enzyme. The type of research that use in the experimental reseacrh with a randomized subject post test only control grup design, it aiming to examine the effect of treatment by repeating the experiment. …”
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266
Seroprevalence of brucellosis in camels and humans in the Al-Qassim region of Saudi Arabia and its implications for public health
Published 2025-02-01“…The Rose Bengal Test (RBT), Antigen Rapid Brucella Antibody Test (ARBT), indirect enzyme-linked immunosorbent assay (I-ELISA), and complement fixation test (CFT) were used to detect brucellosis in both camels and humans. …”
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267
Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives
Published 2025-02-01“…These interactions encompassed diverse molecular bonding types, suggesting these compounds’ potential to hinder enzyme activity and demonstrate notable antifungal properties. …”
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268
Diagnostics and treatment of exocrine pancreatic insufficiency: clinical guidelines of the Russian gastroenterological Association
Published 2018-08-01“…Exocrine pancreatic insufficiency (EPI) develops if activity of the enzymes in duodenal lumen in response to meal stimulation is insufficient to maintain normal nutrient digestion. …”
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269
Coronil effectively inhibits the interaction of clinically relevant Omicron mutants of SARS-CoV-2 spike proteins with human ACE2 receptor
Published 2025-02-01“…Background: Accumulating evidence suggests that the receptor binding domain (RBD) of the SARS-CoV-2 Omicron variant has several times more binding affinity to the human angiotensin-converting enzyme 2 (ACE2) receptor compared to the RBD of the original Covid-19 strain. …”
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270
Association between adult body shape index and serum levels of the anti-aging protein Klotho in adults: a population-based cross-sectional study of the NHANES from 2007 to 2016
Published 2025-02-01“…Visceral adiposity was determined using the ABSI score, and Klotho protein concentration was measured using an enzyme-linked immunosorbent assay kit. Multiple regression models were used to estimate the association between ABSI and Klotho protein after adjusting for several potential confounding variables. …”
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271
Genome-wide association study of the antibody response to <i>Corynebacterium pseudotuberculosis</i> in sheep
Published 2025-02-01“…The sheep were classified into healthy and diseased groups based on two different commercial enzyme-linked immunosorbent assay (ELISA) serological antigen tests. …”
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272
Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc−/GSH/GPX4 axis
Published 2025-01-01“…The Se-Met alleviated lipid peroxidation, oxidative stress, and damaged mitochondrial in T-2 toxin-infected chondrocytes, enhanced antioxidant enzyme activity, and activated the system Xc−/GSH/GPX4 axis, thereby antagonizing ferroptosis of chondrocytes and alleviating articular cartilage damage. …”
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273
O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway
Published 2025-02-01“…As an important rate-limiting enzyme in the pentose phosphate pathway (PPP), elevated G6PDH provided a mass of nicotinamide adenine dinucleotide phosphate (NADPH) to improve the redox state of glutathione (GSH) and eventually led to ferroptosis resistance. …”
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274
Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis
Published 2025-02-01“…Metabolomics and RNA-seq assays revealed enhanced activity of the arachidonic acid (AA)/eicosanoid metabolism pathway in lung tissues from mice exposed to Cr(VI). COX-2, the key enzyme of the AA/eicosanoid pathway, was significantly upregulated in Cr(VI)-exposed lung tissues, as well as in the Cr(VI)-induced transformed (Cr-T) cells compared to parental BEAS-2B (B2B) cells. …”
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275
Metabolomics and transcriptomics analyses revealed overexpression of TaMGD enhances wheat plant heat stress resistance through multiple responses
Published 2025-01-01“…Under high-temperature stress, the overexpressed wheat lines exhibited higher grain weight, increased antioxidant enzyme activity, and lower H2O2 and malondialdehyde contents in leaves. …”
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276
RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2
Published 2025-02-01“…Importantly, the induced antibodies effectively inhibited the binding of RBD to human angiotensin-converting enzyme 2 (hACE2) and neutralized SARS-CoV-2 pseudoviruses. …”
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277
Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA
Published 2025-02-01“…Abstract Background Pompe disease (PD) is an autosomal recessive lysosomal storage disorder caused by the deficient activity of acid alpha glucosidase (GAA) enzyme due to mutations in the GAA gene. As a result, undigested glycogen accumulates within lysosomes causing their dysfunction. …”
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278
Principles of Medical Biochemistry /
Published 2017Table of Contents: “…Introduction to biomolecules -- Introduction to protein structure -- Oxygen-binding proteins : hemoglobin and myoglobin -- Enzymatic reactions -- Coenzymes -- DNA, RNA, and protein synthesis -- The human genome -- Protein targeting and proteostasis -- Introduction to genetic diseases -- Viruses -- DNA technology -- Biological membranes -- The cytoskeleton -- The extracellular matrix -- Extracellular messengers -- Intracellular messengers -- Plasma proteins -- Defense mechanisms -- Cellular growth control and cancer -- Digestive enzymes -- Introduction to metabolic pathways -- Glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation -- Oxygen deficiency and oxygen toxicity -- Carbohydrate metabolism -- The metabolism of fatty acids and triglycerides -- The metabolism of membrane lipids -- Lipid transport -- Amino acid metabolism -- Metabolism of iron and heme -- The metabolism of purines and pyrimidines -- Micronutrients -- Integration of metabolism.…”
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279
Herb5GluCon: A novel polyherbal formulation with dual-action inhibiting properties against oxidative stress and glycoside hydrolases – an in silico and in vitro approach
Published 2025-02-01“…Introduction: Oxidative stress contributes to hyperglycaemia by inducing the hyperactivity of alpha-amylase (AA) and alpha-glucosidase (AG) enzymes. The study aimed to evaluate the antioxidant and anti-glycoside hydrolase potential of a novel polyherbal formulation (Herb5GluCon) and identify its phytoconstituents. …”
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280
Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents
Published 2025-02-01“…Purpose: The current study focuses on the evaluation of isolated juglone derivatives from Reynoutria japonica as anti-biofilm agents and enzyme inhibitors against Methicillin Resistant Staphylococcus aureus (MRSA). …”
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