Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…The HslVU enzyme complex, a proteasomal analog found in bacteria, consists of two components, i.e., the HslV protease and the HslU ATPase. …”
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Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway by Weiwei Tang, Xiaomin Huang, Yun-Di Yi, Fan Cao, Manli Deng, Jiawei Fan, Zheng-Xuan Jiang, Li-Ming Tao, Xianwen Wang, Lei Shi

“…In summary, this study revealed that HA-CUR NPs, which are composed of a natural product and biomacromolecules with outstanding artificial antioxidant enzyme activities, may be novel agents for effectively and safely treating uveitis and other ROS-related diseases.…”
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The effect of silymarin on ischemia-reperfusion injury in skeletal muscles of rats by Abdullah Ozer, Basak Kocak, Mustafa Arslan, Baris Mardin, Aysegul Kucuk, Saban Cem Sezen, Mustafa Hakan Zor, Mustafa Kavutcu

“…The activity of the CAT enzyme was much higher in Group I/R compared to Group C. …”
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The first experience of two-stage treatment of transsphincteric fistulas of rectum by means of fibrin sealant by S. A. Frolov, A. M. Kuzminov, V. Yu. Korolik, I. S. Bogormistrov, M. O. Chernozhukova, Sh. T. Minbayev

“…To improve the short­term and long­term results of transsphincteric rectal fistulas treatment by patented two­stage method that includes elimination of fistulous tract with the subsequent enzyme treatment of the wound channel and delayed sealing by two­component biological glue. …”
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Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition by Jin Zhengyu, Chen Yuning

“…Peptidase M20 domain containing 1 (PM20D1) is a secretory enzyme associated with glucose and lipid metabolism. …”
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Chronic pancreatitis: issues remain unresolved by V. T. Ivashkin, K. V. Ivashkin, A. V. Okhlobystin

“…Treatment should include high dose microgranulated enzymes in the form of capsules (the starting dose should be no less than 40 U of lipolytic activity per meal) as well as proton pump inhibitors. …”
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Carbohydrate intolerance by V. O. Kaybysheva, Ye. K. Baranskaya

“…If food intolerance was confirmed, high performance treatment methods should be applied including dietary modification with elimination of intolerable food products, addition of specific enzyme preparations to the treatment mode. Conclusion. …”
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Cyclical Changes in Prolactin Levels among Infertile Women Attending University of Port Harcourt Teaching Hospital by Braide A Solomon, Adego O Adebayo, Bamigbowu E Olugbenga

“…Prolactin samples of the subjects were determined at follicular (day3), Midcycle (day14) and luteal phase (day21) using enzyme immune assay method (EIA). Prolactin was significantly increased in infertile subjects compared with the controls (Apparently fertile) suggesting an increase in prolactin concentration in infertile subjects. …”
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Chronic cholecystitis at patients with the various trophological status: mechanisms and feature of clinical course by Ye. V. Anisimova, I. V. Kozlova, S. V. Volkov

“…Food behavior analysis was carried out, clinical features, anthopometry were determined, bile lipid spectrum, serum content of leptin and insulin were studied by enzyme-linked immunoassay.Results. Investigation of gallbladder diseases has objectively demonstrated, that trophological status affects development and course of chronic cholecystitis, but is not the only determining factor.Conclusions. …”
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Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells by Dingbo Zhang, Fiona Parth, Laura Matos da Silva, Teng-Cheong Ha, Axel Schambach, Jens Boch

“…Truncations result in an extraordinarily small enzyme. The SsdA-base editor efficiently converts C-to-T in rice and barley protoplasts and induces mutations in rice plants and mammalian cells. …”
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Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice by Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu

“…Besides, the level of liver apoptosis and apoptosis-related genes such as BAX and Bcl-2 were significantly reduced especially in the high concentration SEN pretreatment group, and antioxidant enzyme activities such as CAT and GSH-Px also showed similar changes. …”
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…Inhibiting Aldose Reductase (AR), an enzyme that converts glucose to sorbitol, has been studied to prevent long-term diabetic consequences. …”
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Size, shape, and dose — three crucial determinants for applying nanoparticles in sustainable plant biology by Anindita Dey, Papiya Nandy

“…The positive impact on plants is shown in better plant growth, increased biomass production, enhanced enzyme actions, and improved crop productivity. In contrast, negative effects include germination retardation, growth inhibition, cell impairment, deterioration, and eventually death. …”
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Pear Fruits Ripening Response to Ethylene and Temperature Treatments by Ikbal MuhammedGharib Tahir

“…Results indicate that compote variety was differing significantly in decreasing weight loss and fruits firmness and increasing fruits peel pigments content and peroxidase enzyme activity compared to spadona variety. Slower ripening process was gained from cold storage treatment where the fruits remain non-ripened compared to other treatments, whereas ripening fruits at 20C° for 12 days fastened the ripening process by giving highest TSS, and lowest fruits firmness, in addition to percent of weight loss. …”
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COVID-19 Pandemic and Irritable Bowel Syndrome — is there a Relationship? by V. A. Akhmedov

“…It has been noted that the COVID-19 may contribute to the formation of post-infectious functional gastrointestinal diseases, given that angiotensin-converting enzyme-2 (ACE-2) receptors, the site of binding of the SARS-CoV-2 virus to human cells, are also present in epithelial intestinal cells; virus was found in feces in about half of patients, gastrointestinal symptoms, including diarrhea occur in about one fifth of patients, fecal calprotectin, a marker of GI inflammation is elevated in patients with COVID-19, macroscopically as well as histologically, patients show signs of damage mucous membrane of the gastrointestinal tract, and also, as noted above, they have a dysbiosis of the intestinal microbiota.Conclusion. …”
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Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine sett... by Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano

“…A focus on carbonic anhydrase IX showed that ischemic stress altered subcellular distributions of this enzyme in rodent neuronal populations. Given the enzyme's canonical membrane localization, we implemented pharmacological inhibition using a membrane-impermeant sulfonamide inhibitor in neuronal models of brain ischemia. …”
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Effect of seed priming and foliar application of organic liquid manure on germination, growth, yield and quality of late-sown wheat by Okram Ricky Devi, Omvati Verma, Bibek Laishram, S. Anbarasan, Abhijit Debnath, Narinder Panotra, Priyanka Elumle, Sunita T. Pandey, R. Ajaykumar, Samreen

“…From the information presented above, it can be inferred that seed priming with 10% HK along with 100% of the recommended dose of nutrients, followed by foliar applications of 10% HK at various growth stages, increased the growth, productivity and enzyme activity of late sown wheat that priming with 10% HK and its foliar application under 100% RDN increased the growth, productivity, grain quality indices, enzyme activities, and economic profitability of late-sown wheat. …”
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IMPACT OF FISH WASTE PROTEIN ENZYMETIC HYDROLYSATE ON GROWTH OF SOME OF Lactobacillus sp. AND Bifidobacterium sp. by A. S. Mohammed

“…They were hydrolysed by pepsin enzyme lyophilized powder ≥ 2500 units/mg conc.1.5gm/100gm protein concentrates for (30, 60, 90, and 120) minutes. …”
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Evolution of copro-tests in active detection of colorectal cancer by V. I. Chissov, N. S. Sergeyeva, Ye. V. Zenkina, N. V. Marshrutina

“…Searches of the laboratory methods, that allow to overcome this restriction, resulted in development several qualitative (rapid) and quantitative enzyme-linked immunoassays for detection of hemoglobin in feces (FIT). …”
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