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141
How endocrine disruptors affect fish reproduction on multiple levels: A review
Published 2024-09-01“…These substances, including bisphenols, heavy metals, pesticides, phthalates, and polychlorinated biphenyls (PCBs), act as hormone mimics, receptor blockers, or enzyme inhibitors that affect hormonal regulation in the hypothalamic-pituitary-gonadal (HPG) axis. …”
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142
Mediators of intercellular interactions and histological signs of chronic viral liver disease
Published 2014-11-01“…Scores of ICAM-1, VCAM-1, Е-selectin, L-selectin and the Р-selectin were determined by enzyme-linked immunoassay method and were compared to values of Knodell histological activity index and Desmet fibrosis score as well as to E.M. …”
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143
Effect of Ozone Combined with 1-MCP on the Color and Quality of Nectarines during Postharvest Storage
Published 2025-02-01“…Compared with 1-MCP group alone, 1-MCP group combined with ozone treatment had higher anthocyanin content, centaurin-3-O-glucoside content, centaurin-3-O-rutin content and enzyme activity related to anthocyanin metabolism at the later stage of storage. …”
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144
Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study
Published 2018-08-01“…Statistically significant difference in serum aminotransferases levels in non-cirrhotic PVT vs Child-Pugh class A HCV-LC was observed: enzyme levels were 1,5-2 fold higher in LC (р…”
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145
Oxidative Stress and Its Association with COVID-19: A Narrative Review
Published 2020-06-01“…Especially the virus’s route to cell entry via angiotensin-converting enzyme 2 (ACE2) receptor is well known that leads to pathogenesis in angiotensin II (AT II) which are critical in NADH/NADPH oxidase inducing ROS generation. …”
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146
Unraveling relationship between the genetic polymorphism CYP2A13 and nicotine metabolism of male smokers in Medan, Indonesia
Published 2025-02-01“…Abstract Background Nicotine metabolism significantly influences the levels of harmful nicotine metabolites in smokers. CYP2A13, a key enzyme in nicotine and xenobiotic metabolism, is implicated in tobacco smoke-related lung cancer. …”
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147
Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum
Published 2025-02-01“…Then, a combined approach of qRT-PCR, enzyme assay, and ultrastructure observation was applied to investigate its regulatory effects on the related genes, cellular parameters, and histological structures, respectively. …”
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148
Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment.
Published 2025-01-01“…We observed that activation of NF-κB was positively correlated with the levels of O-6-methylguanine-DNA methyltransferase (MGMT) protein, a direct DNA repair enzyme leading to TMZ resistance, regardless of MGMT promoter methylation status, further supporting the clinical potential for inhibition of NF-kB signaling in GBM treatment. …”
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149
Immunosuppressants in modern approaches to treatment of inflammatory bowel diseases
Published 2013-05-01“…In all other cases (20 patients) allelic variant TPMT*1 with normal enzyme production have been found.Conclusions. There is no need of study for genetic mutations before prescription of thiopurines, however application of effective methods of evaluation of prognosis of bone marrow toxicity development remains an actual issue. …”
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150
A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients
Published 2020-06-01“…The aim is to evaluate the efficacy of pomegranate peel extract on the clinical and biochemical measures of (IL-1β) and the enzyme (AST) in saliva of (T2DM) patients suffering from gingivitis in comparison with chlorhexidine. …”
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151
Effects of Endurance Training and Chlorogenic Acid on Oxidative and Nitrosative Stress Markers in Prediabetic Male Mice
Published 2025-01-01“…Next, 24 hours after the last intervention, tissue samples were taken from the quadriceps femoris muscles and analyzed using the enzyme-linked immunosorbent assay (ELISA) method. …”
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152
Clinical and Morphological Manifestations of Gastritis and Serum Cytokine Levels in Schoolchildren with Familial History of Gastric Cancer
Published 2021-10-01“…Serum cytokine levels (IL-2, IL-4, IL-8, IL-18, IL-1β, IFN-α, TNM-α) were obtained in enzyme immunoassays (ELISA).Results. Schoolchildren with gastritis and familial history of gastric cancer revealed a higher 59.8% rate of dyspeptic complaints vs. 40.8% in negative history (p = 0.001), as well as complaints of weekly heartburn in 14.2 and 8.3% cas-es (p = 0.019), respectively. …”
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153
Mini meta-analysis of anticholinesterase actions of atorvastatin, simvastatin and rosuvastatin, and in silico identification of their protein targets in Mus musculus
Published 2025-06-01“…Dyslipidemic statins reduce blood and brain cholinesterase (ChE) activities in mice, with scarce information on other protein/enzyme targets. The study aims at conducting a mini meta-analysis on in vivo and in vitro adverse anti-ChE effects of atorvastatin, simvastatin and rosuvastatin in mice, and using the SwissPrediction to identify in silico body target proteins. …”
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154
Correlation between serum neurofilament light chain and short-term outcomes in patients with hypertensive intracerebral hemorrhage
Published 2025-02-01“…The serum values of light chain protein of the experimental group and control group were measured by enzyme-linked immunosorbent assay. The Glasgow Outcome Scale of enrolled patients at 30 days of onset was recorded, and the collected data were statistically analyzed. …”
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155
Vascular endothelial growth factor A: friend or foe in the pathogenesis of HIV and SARS-CoV-2 infections?
Published 2025-02-01“…We then focus on SARS-CoV-2 infection and show how the binding of the viral pathogen to the angiotensin-converting enzyme 2 receptor, as well as to NRP-1, leads to elevated levels of VEGF-A and consequences such as coagulation, vascular dysfunction, and inflammation. …”
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156
Construction of a multienzyme cascade reaction system and its application in D-tagatose biosynthesis
Published 2025-02-01“…This multienzyme approach improved the conversion of the intermediate product D-glucose to D-tagatose by 3.84% compared with the dual-enzyme system. Thus, our study provides a theoretical basis and technical support for the industrial production of D-tagatose.…”
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157
Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals
Published 2023“…While alloxan substantially (p < 0.05) increased the levels of some biological molecules and enzyme activity, it lowered those of others. The extract however significantly (p < 0.05) reversed all the alloxan-induced alterations, with the extract at 100 mg/kg b.w producing figures that compared (p > 0.05) well with those of the d.w treated non-diabetic animals and metformin-treated diabetic animals. …”
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158
Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations
Published 2025-03-01“…Insufficient enzyme levels can lead to the progression of motor symptoms, undermining treatment goals. …”
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159
Biochemistry /
Published 2011Table of Contents: “…Carbohydrates, lipids, and amino acids : metabolic fuels and biosynthetic precursors -- Proteins and enzymes -- Membrane biochemistry and signal transduction -- Nutrition -- Generation of energy from dietary fuels -- Carbohydrate metabolism -- Lipid metabolism -- Nitrogen metabolism -- Integration of metabolism -- Nucleotide synthesis and metabolism -- Organization, synthesis, and repair of DNA -- Gene expression -- DNA technology -- Common laboratory values.…”
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160
Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes
Published 2024-03-01“…Missense mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic disorders with developmental defects. Despite the enzyme’s biological significance, the molecular architecture of the FAM111A serine protease domain (SPD) is unknown. …”
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