Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma by Ziyi Zhou, Lanlan Yang, Yuan Fang, Rongzhong Xu, Xi Wang, Yuli Wang, Zhihong Fang

“…Functional enrichment analysis was used to explore the potential pathway. LASSO and Cox regression were used to construct anoikis-related prognostic signature. …”
Get full text

High-power ultrasound pretreatment for enhanced protein extraction from lupin flour: Impact on yield, anti-technological and anti-nutritional factors, and techno-functional propert... by Paola Navarro-Vozmediano, Esperanza Dalmau, Jose Benedito, Jose V. Garcia-Perez

“…Quality of lupin protein is considerably compromised by the presence of anti-nutritional (ANF), such as polyphenols, alkaloids and saponins and anti-technological factors (ATF), like polyphenols and fat. This work explores how high-power ultrasound-assisted (HPU) pretreatment of lupin flour (LF) before protein extraction could affect ANF and ATF content, as well as protein yield and techno-functional properties. …”
Get full text

Improvement of the dissolution of the antineoplastic drug regorafenib through impregnation into pullulan polysaccharide using supercritical fluid technology: Optimization of the pr... by Ali Sheikhi, Sepideh Hamedi, Gholamhossein Sodeifian, Fariba Razmimanesh

“…However, its limited water solubility hinders its clinical efficacy. This study explores the impregnation of regorafenib monohydrate (REG MH) into pullulan (PULL) using supercritical carbon dioxide (scCO2), aiming to promote the oral bioavailability, water solubility and therapeutic efficacy of the drug. …”
Get full text

Perceived urban environment elements associated with momentary and long-term well-being: An experience sampling method approach by Yu-Ru Chen, Atsushi Nakagomi, Masamichi Hanazato, Noriyuki Abe, Kazushige Ide, Katsunori Kondo

“…While research has demonstrated a positive association between one’s environment and LWB, limited studies have explored the association between environmental characteristics and MWB. …”
Get full text

Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…Heavy alcohol consumption can lead to various gastrointestinal disorders, with gastric ulcers being the most prevalent. In this study, we explored the reparative effects of a functional drink (FD) enriched with trace elements (TEs) on ethanol-induced gastric ulcers in rats and elucidated its underlying mechanism. …”
Get full text

Exoscope-assisted spine surgery: Current applications and future directions–A short review by Tomas Ferreira, Sakshi Roy, Joecelyn Kirani Tan, Wireko Andrew Awuah, Vallabh Shet, Favour Tope Adebusoye, Adrenito Nicolas, Toufik Abdul-Rahman

“…Addressing these limitations by conducting large-scale clinical trials and exploring the integration of artificial intelligence (AI) could assist in realising the potential of exoscopes in spine surgery.…”
Get full text

The philosophical foundations of digital twinning by David J Wagg, Christopher Burr, Jason Shepherd, Zack Xuereb Conti, Mark Enzer, Steven Niederer

“…These differences are due to the philosophical world-view adopted within specific communities. In this paper, we explore the philosophical context which underpins the digital twin concept. …”
Get full text

Causal associations between socioeconomic status and prostate cancer using two-sample Mendelian randomization study by Zhenxing Wang, Chunyan Wang, Xing Gou, Liang Pei, Xiaoyuan Qiao

“…The findings highlight the necessity for further exploration into the underlying etiology of PCa.…”
Get full text

Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease by Shangpei Wang, Yajie Cai, Yibin Zhao, Yongqiang Yu, Xianwen Chen, Longsheng Wang

“…Background: The resting-state cerebral blood flow (CBF) alterations in Parkinson’s disease (PD) patients and tremor-dominant (TD) subtype have been explored. However, the underlying molecular architecture correlated with the altered CBF remains unknown. …”
Get full text

Efferocytosis and inflammation: a bibliometric and systematic analysis by Xin Cao, Xin Cao, Fen Li, Fen Li, Xi Xie, Xi Xie, Guanghui Ling, Guanghui Ling, Xiaoyu Tang, Xiaoyu Tang, Wenfang He, Jing Tian, Jing Tian, Yan Ge, Yan Ge

“…Future research will likely continue to explore these frontiers, with an emphasis on understanding efferocytosis in the context of chronic diseases and cancer, as well as developing novel therapeutic strategies.…”
Get full text

Quantifying the sources and health risks of groundwater nitrate via dual NO isotopes and Monte Carlo simulations in a developed planting-breeding area by Jianwei Liu, Shuo Qiao, Shilong Zhao, Hui Chen, Yong Wu, Donghao Li, Ping Liu, Ling Li

“…Nitrate (NO3−) pollution in groundwater is a worldwide environmental issue, particularly in developed planting-breeding areas where there is a substantial presence of nitrogen-related sources. Here, we explored the key sources and potential health risks of NO3− in a typical planting-breeding area in the North China Plain based on dual stable isotopes and Monte Carlo simulations. …”
Get full text

Comparison of Pregnancy Outcomes of Women with and Without Hypertension at the Latent Phase of Labor Who Were Under Medical Care for Preeclampsia by Resul Karakus, Cetin Kilicci, Enis Ozkaya, Ezgi Darici, Onder Tosun, Sultan Seren Karakus, Ali Aras

“… OBJECTIVE: We explored the association between hypertension (>140/90) at the latent phase of labor (resistant hypertension) and the subsequent development of major maternal complications or adverse infant outcomes in women with preeclampsia under medical care. …”
Get full text

Quantitative profiling of the vaginal microbiota improves resolution of the microbiota-immune axis by Eric Armstrong, Rachel Liu, James Pollock, Sanja Huibner, Suji Udayakumar, Erastus Irungu, Pauline Ngurukiri, Peter Muthoga, Wendy Adhiambo, Sergey Yegorov, Joshua Kimani, Tara Beattie, Bryan Coburn, Rupert Kaul

“…Conclusions Our results suggest that total vaginal bacterial load is at least as strong a predictor of the genital immune milieu as current BV clinical diagnostic tools, supporting exploration of the vaginal bacterial load as a predictor of adverse reproductive and sexual health outcomes. …”
Get full text

Medicinal plants with neuroprotective potential in East African countries: A systematic review by Ibe Michael Usman, Ekom Monday Etukudo, Elna Owembabazi, Wusa Makena, Augustine Oviosun, Makeri Danladi, Vivian Ojiakor, Patrick Maduabuchi Aja, Emeka Anyanwu, Yanurkis Duranones Rosales, Mario Edgar Fernandez Diaz, Josiah Ifie, Ismahil Adekunle Adeniyi, Ilemobayo Victor Fasogbon, Victor Bassey Archibong

“…Hence, the reported plants could be explored as options in complementary and alternative medicine following a thorough examination of their active ingredient and mechanism of action.…”
Get full text

Plasma myeloperoxidase interactions with cadmium, lead, arsenic, and selenium and their impact on chronic kidney disease by Hsi-Hsien Chen, Ya-Li Huang, Chih-Yin Wu, Mei-Chieh Chen, Horng-Sheng Shiue, Sheng-Lun Hsu, Ying-Chin Lin, Yu-Mei Hsueh

“…Therefore, we examined whether MPO plasma levels or MPO polymorphisms were linked to CKD, and explored whether these factors modified associations between CKD and metal concentrations. …”
Get full text

Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis by Zuojie Peng, Jia Song, Wenzhong Zhu, Haijun Bao, Yuan Hu, Yongping Shi, Xukai Cheng, Mi Jiang, Feifei Fang, Jinhuang Chen, Xiaogang Shu

“…Furthermore, HILPDA was screened by transcriptomics, and its potential mechanism was explored through ChIP, co-IP, ubiquitination experiments, phenotyping experiments, etc. …”
Get full text

Development of a respiratory virus risk model with environmental data based on interpretable machine learning methods by Shuting Shi, Haowen Lin, Leiming Jiang, Zhiqi Zeng, ChuiXu Lin, Pei Li, Yinghua Li, Zifeng Yang

“…Abstract In recent years, numerous studies have explored the relationship between atmospheric conditions and respiratory viral infections. …”
Get full text

Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation by Kaiyue Tan, Jingwei Deng, Yi Liu, Yudi Zhang, Yu Xiong, Su Yuan, Jun Liu, Zhiwei Chen, Yuanyuan Liu, Wenfu Cao

“…This study evaluates YQJSD’s effectiveness in ameliorating RIF and explores the underlying molecular mechanisms using the unilateral ureteral obstruction (UUO) model. …”
Get full text

Effect of Laminaria japonica Powder on Physicochemical Properties, Rheological Properties and Protein Structure of Silver Carp Surimi Gel by Fengchao ZHOU, Wenting JIANG, Han TIAN, Wei LUO, Xiaolan ZHANG, Jiazhen WANG, Jie LIANG, Leiwen XIANG, Shaoyun WANG, Xixi CAI, Qiming WU, Honglai LIN

“…Thus, the intrinsic cause of LJP improving the surimi gel quality was explored. Results showed that the addition of LJP significantly improved (P<0.05) the gel strength, hardness and WHC of the surimi gels, these three indicators were increased first and then decreased later with the increased of LJP addition (highest at 8% added). …”
Get full text

Profile of Egyptian pediatrics with COVID-19: insights from healthcare providers in Egypt by Salma ZEl Houchi, Hanaa I. Rady, Iman Iskander, Tamer Abdel Hamid, Salma Abdelrehim Seddik, Amira Aly Hegazy, Ahmed Taha Aboushady, Mohamed Eissa, Sherine Khamis Hussein, Dina Hanoura, Miriam Magdy Aziz, Remon Magdy, Heba Ahmed ElAwady, Esraa A. Elmazzahy

“…While initially thought to affect adults predominantly, it became clear that children and adolescents were also susceptible to the virus's effects. This study aims to explore the epidemiological patterns, clinical features, laboratory and radiological characteristics, and outcomes of COVID-19 infection in a group of Egyptian children (≤ 18 years). …”
Get full text