Characterization of G2/M checkpoint classifier for personalized treatment in uterine corpus endometrial carcinoma by Yiming Liu, Yusi Wang, Shu Tan, Xiaochen Shi, Jinglin Wen, Dejia Chen, Yue Zhao, Wenjing Pan, Zhaoyang Jia, Chunru Lu, Ge Lou

“…Results We constructed a classifier based on the overall activity of the G2/M checkpoint signaling pathway to identify patients with different risks and treatment responses, and attempted to explore potential therapeutic targets. The results showed that two G2MC subtypes have completely different G2/M checkpoint-related gene expression profiles. …”
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Diagnostic pathways for breast cancer in 10 International Cancer Benchmarking Partnership (ICBP) jurisdictions: an international comparative cohort study based on questionnaire and... by David Weller, Usha Menon, Alina Zalounina Falborg, Henry Jensen, Andriana Barisic, Anne Kari Knudsen, David H Brewster, Victoria Cairnduff, Eva Grunfeld, Elizabeth Harland, Mats Lambe, Rebecca-Jane Law, Yulan Lin, Martin Malmberg, Donna Turner, Richard D Neal, Victoria White, Samantha Harrison, Peter Vedsted, Una MacLeod, Conan Donnelly, Anna Gavin, Jon Emery, Oliver Bucher, Jatinderpal Kalsi, Chantelle Anandan, Evangelia Ourania Fourkala, Therese Kearney, Marie-Louise Essink-Bot, Sigrun Saur Almberg, Breann Hawryluk, Jacqueline Kelly, Jackie Boylan, Jan Willem Coebergh, David Brewster, Stefan Bergström, Victoria Hammersley, Rebecca Bergin, Alina Zalounina Falborg, Andriana Barisi, Kerry Moore, Maria Rejmyr Davis

“…Objectives A growing body of evidence suggests longer time between symptom onset and start of treatment affects breast cancer prognosis. To explore this association, the International Cancer Benchmarking Partnership Module 4 examined differences in breast cancer diagnostic pathways in 10 jurisdictions across Australia, Canada, Denmark, Norway, Sweden and the UK.Setting Primary care in 10 jurisdictions.Participant Data were collated from 3471 women aged >40 diagnosed for the first time with breast cancer and surveyed between 2013 and 2015. …”
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Differentiating the cognitive development of early-term births in infants and toddlers: a cross-sectional study in China by Jing Hua, Jie Sun, Zhijuan Cao, Xiaotian Dai, Senran Lin, Jialin Guo, Guixiong Gu, Wenchong Du

“…Objectives This study aimed to explore the cognitive development of low-risk children during early childhood for early-term births at 37 and 38 weeks of gestation compared with full term births at 39–41 weeks of gestation.Setting and participants We conducted a cross-sectional study in Shanghai, one of the largest cities in China. …”
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Evaluation of spinal deformity and its progression in pyogenic spondylodiscitis: A retrospective MRI study of 59 cases by Andreas Kramer, Jonathan Neuhoff, Santhosh G. Thavarajasingam, Rebecca Sutherland, Hugh McCaughan, Benjamin Davies, Ehab Shiban, Florian Ringel, Andreas K. Demetriades

“…Research question: This study explores spinal deformity progression in conservatively treated patients and identifies predictive factors for deformity advancement. …”
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Adherence to four healthy lifestyles and their influencing factors among residents aged 35 to 75 years in Fujian province: a longitudinal study by Ze YANG, Xin FANG, Yefa ZHANG, Wenling ZHONG, Tiehui CHEN, Jingyu CHEN, Yanrong YIN, Xiaoqing LI

“…The correlation between these lifestyle habits and socio-demographic characteristics such as sex, age, and education level was also explored. ResultsAfter age and sex standardization, the adherence rates to the four individual healthy lifestyle habits among the 31 610 residents in Fujian province, from the highest to the lowest, were non-drinking or moderate drinking (95.7%), non-smoking (76.2%), adequate physical activity during leisure time (26.1%), and a healthy diet (11.4%). …”
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Machine learning assisted radiomics in predicting postoperative occurrence of deep venous thrombosis in patients with gastric cancer by Yuan Zeng, Yuhao Chen, Dandan Zhu, Jun Xu, Xiangting Zhang, Huiya Ying, Xian Song, Ruoru Zhou, Yixiao Wang, Fujun Yu

“…Therefore, it is particularly important to find a suitable way to predict the risk of postoperative occurrence of DVT in GC patients. This study aims to explore the effectiveness of using machine learning (ML) assisted radiomics to build imaging models for prediction of lower extremity DVT occurrence in GC patients after surgery. …”
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Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease by Nour Rahnama, MD, Arthur Colson, MD, PhD, Pamela Baldin, MD, PhD, Agnès Pasquet, MD, PhD, Damien Gruson, MD, PhD, David Vancraeynest, MD, PhD, Christophe Beauloye, MD, PhD, Frédéric Debiève, MD, PhD, Sophie Pierard, MD, PhD

“…Objectives: This study aimed to compare the prevalence of MVM in pregnant women with CHD to those without CHD, assess its association with obstetric and neonatal outcomes, and explore potential risk factors for MVM. Methods: In this prospective single-center study, we enrolled pregnant women with CHD who were followed from March 2021 to June 2023, along with a control group matched for age, parity, and body mass index. …”
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Insights into quinoa endophytes: core bacterial communities reveal high stability to water stress and genotypic variation by Isaac Maestro-Gaitán, Miguel Redondo-Nieto, Sara González-Bodí, Laura Rodríguez-Casillas, Javier Matías, Luis Bolaños, María Reguera

“…Results We aimed to characterize the core endophytic communities in quinoa seeds and roots from two distinct genotypes under well-watered (WW) and water-deficit (WD) conditions, utilizing various soil infusions as inoculants to explore potential changes in these endophytes. Our findings reveal distinct changes with quinoa seeds exhibiting a high degree of conservation in their endophytic microbiome, even between maternal and offspring seeds, with specific bacterial taxa showing only minor differences. …”
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Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“… Objective: The third gender community, commonly referred to as the ‘hijra’ community and including transgender, intersex, and eunuch individuals, faces widespread societal discrimination, leading to marginalization and reduced opportunities for social and economic participation. This study aims to explore the educational and healthcare challenges faced by this community, as perceived by its members, to gain deeper insight into the complexities of their lived experiences. …”
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A medical insurance fund operation performance evaluation system under the DRG payment mode reform by Zijian Wang, Zijian Wang, Zijian Wang, Weifu Chang, Weifu Chang, Aijing Luo, Aijing Luo, Aijing Luo

“…It develops an innovative performance evaluation system for medical insurance funds utilizing the AHP-EWM-FCE evaluation method. Finally, it explores the key influencing factors by applying the Tobit regression model.ResultsAs the reform of DRG payment methods has advanced, the operational performance scores related to the management, fundraising, utilization, and satisfaction of DRG medical insurance funds have consistently improved. …”
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Parents’ use of coercive and indulgent feeding practices for children with avid eating behaviour: an Ecological Momentary Assessment study by Abigail Pickard, Katie L. Edwards, Claire Farrow, Emma Haycraft, Moritz Herle, Clare Llewellyn, Helen Croker, Alice Kininmonth, Jacqueline Blissett

“…Abstract Background Children with avid eating behaviour display high food responsiveness, high emotional overeating and low sensitivity to fullness; behaviours which may increase the risk of obesity and are challenging for parents to manage. This study explores the situational predictors of coercive or indulgent feeding practices among parents of children with avid eating behaviours using Ecological Momentary Assessment (EMA). …”
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Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study by Qingzheng Wu, Bing Li, Yuepeng Wang, Yuepeng Wang, Yue Zhang, Qian Wang, Binqi Li, Binqi Li, Wei Jing, Jing Yang, Yiming Mu

“…Pearson correlation analysis and binary logistic regression analysis were conducted to explore the association of WWI with T2DM risk factors and with T2DM risk.ResultsThe prevalence of obesity, central obesity and T2DM was 14.2%, 46.8% and 11.0% respectively, with a median age of 57 years. …”
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Enhancing feature selection for multi-pose facial expression recognition using a hybrid of quantum inspired firefly algorithm and artificial bee colony algorithm by Mu Panliang, Sanjay Madaan, Siddiq Ahmed Babikir Ali, Gowrishankar J., Ali Khatibi, Anas Ratib Alsoud, Vikas Mittal, Lalit Kumar, A. Johnson Santhosh

“…The proposed algorithm uses the attributes of both the QIFA and ABC algorithms to enhance search space exploration, thereby improving the robustness of features in FER. …”
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Duckweed: a starch-hyperaccumulating plant under cultivation with a combination of nutrient limitation and elevated CO2 by Ling Guo, Ling Guo, Yang Fang, Songhu Wang, Yao Xiao, Yanqiang Ding, Yanling Jin, Xueping Tian, Anping Du, Zhihua Liao, Kaize He, Shuang Chen, Yonggui Zhao, Li Tan, Zhuolin Yi, Yuqing Che, Lanchai Chen, Jinmeng Li, Leyi Zhao, Peng Zhang, Zhengbiao Gu, Fangyuan Zhang, Yan Hong, Qing Zhang, Hai Zhao

“…Therefore, there is a pressing need to explore and develop new sources of starch.MethodsWe develop a novel duckweed cultivation technology that combines nutrients limitation and CO2 supplementation to achieve very high starch content. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…The clinical relevance was further explored in a cohort with metabolic disease by ranking patients according to PTPRD expression and analysing its association with metabolic disease markers.Results The analysis of individuals ranked according to PTPRD expression and Ptprd-deficient mice, showed that PTPRD levels were associated with hepatic glucose/lipid signalling and peroxisome function. …”
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Effects of community family doctors-led intervention for self-management and medication adherence in type 2 diabetes mellitus patients: study protocol of a cluster randomised contr... by Yue Chen, Biqi Ren, Ningsheng Wang, Shuang Lei, Shuzhi Lin, Lianye Liu, Yufang Xiang, Bianling Feng

“…The development of community-based type 2 diabetes management in China has not yet reached an ideal state, and the most suitable management methods for diabetic patients are still being explored. Few studies have used community-based family doctors to perform interventions of appropriate intensity. …”
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From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…Besides, therapeutic applications of CRISPR/Cas have been extensively explored in preclinical in vitro and in vivo studies, targeting various ocular conditions, such as retinitis pigmentosa, Leber congenital amaurosis, Usher syndrome, fundus neovascular diseases, glaucoma, and corneal diseases. …”
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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Quantified IgM and IgG using ELISA and FC. Explored public databases for potential correlation molecules. …”
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Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) by Liguo Qiu, Peng Yu, Qiang Li, Cuiping Wen, Haiyang Wang, Dongying Zhao, Tianyu Zhang, Chenghui Wang, Lixia Liu, Dongxue Li, Shiyong Wen, Yinghui Sun

“…Bisphenol A (BPA) and its substitute bisphenol S (BPS) have been widely used worldwide, while the evaluation of their safety, especially the newly discovered visual toxicity mechanism caused by them in recent years, has not been clearly explored. In the present study, we investigated the effects of BPA treatment (1, 10, and 100 μg/L) on cone cell development and function to evaluate visual toxicity. …”
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Morpho-meristic variations of the native and Vietnam-originated climbing perch (Anabas testudineus), collected from hatchery sources in Bangladesh by Md. Arif Shahariar, Md. Mahamudul Hassan, Swagata Aditya, Tanjina Saulin, Atika Khondokar, Mohammad Shafiqul Alam

“…Therefore, the present study sought to explore morphological variation between native and Vietnam-originated populations of climbing perch collected from eight divisions of Bangladesh. …”
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