Evaluation of C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in colorectal carcinoma: Relation to the available cl... by Asmaa E. Bedeer, Nehal Abd El-Ghaffar Heabah

“…Background: Colorectal carcinoma (CRC) is the most common malignancy of the gastrointestinal tract, representing an incredible health problem. …”
Get full text

Potential of nutraceutical products for irritable bowel syndrome remission maintenance by A. I. Ulyanin, Ye. A. Poluektova, Ch. S. Pavlov, V. T. Ivashkin

“…Long-term inflammation may result in nociceptor hypersensitivity i.e. peripheral sensitization that in turn, lead to the central sensitization and indirectly - to gastrointestinal tract (GIT) motility disorders. Besides, change of intestinal microbiota may impact the development of emotional disorders (e.g.: impaired capacity of affected intestinal microbiota to produce neurotransmitters). …”
Get full text

Meta-Analysis and Systematic Review of the Role of Appendectomy in the Pathogenesis of Colorectal Cancer by M.I. A. Nezhad, N. P. Yabandeh

“…Given the potential for physiological alterations in the gastrointestinal tract following appendix removal, which may influence carcinogenesis, we embarked on a systematic review and meta-analysis to explore the possible association between appendectomy and the subsequent risk of colorectal cancer (CRC).Methods. …”
Get full text

In-Depth Exploration of Human Gut Microbiota: A Review by Maliha Rashid, Dwaipayaan Sinha, Muhammad Usama, Mariam Badam, Maryam Idrees, Saiqa Noureen, Reem Nadeem, Muhammad Mustajab Khan, Shakira Ghazanfar

“…Balanced diet, genetic makeup, and use of antibiotics highly influence the microbial population in the gastrointestinal tract. This review article presents a detailed background on the gut microbiota, including its composition and the various factors influencing its diversity and stability. …”
Get full text

Selective Serotonin Reuptake Inhibitors and Associated Bleeding Risks: A Narrative and Clinical Review by Amber N. Edinoff, Keerthiga Raveendran, Marc A. Colon, Bennett H. Thomas, Katie A. Trettin, Grace W. Hunt, Adam M. Kaye, Elyse M. Cornett, Alan D. Kaye

“…Sites of increased bleeding related to SSRI use have been reported to occur in the upper gastrointestinal tract, as well as intracranially. Based on the current literature, three studies have found that SSRIs are not associated with increased bleeding and/or increased perioperative risk, while others have demonstrated that SSRIs are associated with an increased risk in perioperative use. …”
Get full text

Pathogenesis of Functional Biliary Pain and Pharmacology of Trimebutin by E. L. Bueverova, O. Yu. Zolnikova, N. L. Dzhakhaya, A. V. Sedova, V. Т. Ivashkin

“…The diagnosis of functional disorder of the gallbladder and Oddi's sphincter is legitimate only after the exclusion of organic causes from both the gastrointestinal tract and other organs and systems. The initial appeal to surgeons with a complaint of pain in the epigastrium or right hypochondrium may lead to unjustified surgical intervention that does not bring relief to the patient's suffering. …”
Get full text

Chemotherapy-related side effects in childhood cancer in Hiwa Hospital Sulaimani city/Kurdistan region, Iraq by Awayi Ghazy Abdulkareem, Zhian Salah Ramzi, Jamal Ahmad Rashid, Heshu Sulaiman Rahman

“…The results demonstrated that chemotherapy commonly affects the gastrointestinal tract and musculoskeletal system. …”
Get full text

Physiological value of intestinal microflora by S. Yu. Kuchumova, Ye. A. Poluektova, A. A. Sheptulin, V. T. Ivashkin

“…Further studying of its functions, the states interfering qualitative and quantitative composition of microorganisms, colonizing human gastrointestinal tract, as well as the mechanism of action of probiotics and drugs of symptomatic action (defoamers) is necessary.…”
Get full text

What Do Gases in the Large Intestine Have to Do with Health? by Klaudia Pawełek, Patrycja Kinga Marta, Filip Maciej Huzarski, Gabriela Monika Ferfecka, Magdalena Rosa-Bończak, Agata Ossolińska, Weronika Kłosowicz, Oliver Carlton, Lucyna Stolarska, Natalia Morawiecka

“… A healthy human gastrointestinal tract contains approximately 200 ml of gas, with an average daily elimination of 600 ml. …”
Get full text

Effect of nano- and micro-polystyrene particles on small intestinal epithelial functions and enteric neuronal activity in vitro by Kristin Elfers, Pascal Benz, Marion Burmester, Silja Hein, Kathrin Hansen, Holger Sieg, Linda Böhmert, Maxi B. Paul, Gemma Mazzuoli-Weber

“…Abstract Based on their ubiquitous distribution in various ecosystems, plastic particles of different origin and sizes enter the (human) food chain, are ingested and reach the gastrointestinal tract, where they interact with the intestinal (epithelial) tissue. …”
Get full text

Pathogenic and therapeutic role of bile acids at reflux-gastritis by T. L. Lapina, I. M. Kartavenko, V. T. Ivashkin

“…To present data on pathogenic significance of bile acids for upper regions of gastrointestinal tract (GIT) and to describe medical properties ursodeoxycholic acid (UDCA) at reflux-gastritis.Summary. …”
Get full text

Biomimic models for in vitro glycemic index: Scope of sensor integration and artificial intelligence by Mohammed Salman C K, Muskan Beura, Archana Singh, Anil Dahuja, Vinayak B. Kamble, Rajendra P. Shukla, Sijo Joseph Thandapilly, Veda Krishnan

“…In vitro digestion models face challenges in replicating the dynamic conditions of the human gastrointestinal tract, such as enzyme variability and multi-time point analysis, leading to suboptimal predictive accuracy. …”
Get full text

Combination of Gilbert's syndrome and gastrointestinal diseases by G. M. Dubrovina, O. K. Botvinyev, A. I. Kolotilina

“…To detect relation between Gilbert's syndrome (GS) and other diseases of a gastrointestinal tract (GIT).Key points. Gilbert's syndrome - hereditary, unconjugated jaundice related to decrease of activity of uridinediphosphate glucuronosyltransferase 1А1 (UGT 1А1) in the liver. …”
Get full text

Validation of a Model Estimating the Budget Impact of Video Capsule Endoscopy for Surveillance of Crohn’s Disease in an Italian Center by Rhodri Saunders, Carlo Calabrese, Dania Gelli, Jason Davis, Rafael Torrejon Torres

“…**Background:** Crohn's disease is a chronic ailment affecting the gastrointestinal tract. Mucosal healing, a marker of reduced disease activity, is currently assessed in the colonic sections using ileocolonoscopy and magnetic resonance enteroscopy. …”
Get full text

Epidemiological and Clinical Aspects of Ulcerative Colitis in Mosul city, Iraq by Muhammed Babakir-Mina

“…Ulcerative Colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract with heterogeneous disease presentation. …”
Get full text

Features of Crohn's Disease Depending on the Age of Disease Onset by E. G. Ganich, O. B. Shchukina

“…At the time of diagnosis, ileocolitis (p = 0.01), inflammatory form of Crohn's disease (p < 0.05), and the upper gastrointestinal tract involvement (p < 0.05) were more frequently detected in group A1. …”
Get full text

Pathogenesis of Disorders of the Motor Function of the Large Intestine in Functional Constipation by M. M. Galagudza, Yu. P. Uspensky, Yu. A. Fominykh, D. Yu. Butko

“…Constipation occurs in 15 % of the adult population in the world and leads to a significant decrease in the quality of life, and in combination with some other symptoms may indicate the presence of an organic pathology of the gastrointestinal tract. The pathogenetic basis of functional constipation (FC) with slow intestinal transit is a decrease in colonic motor function, which is confirmed by the results of high-resolution manometry. …”
Get full text

Diagnostic accuracy of drooling, reluctance, oropharynx, others, and leukocytosis score as a predictor of mortality and complications following acute corrosive ingestion by Fawaz Poonthottathil, Soorya Suresh, Jamshed Nayer, Praveen Aggarwal

“…OBJECTIVES: Esophagogastroduodenoscopy is considered the gold standard in assessing the severity of injury to the gastrointestinal tract following corrosive ingestion. Zargar’s endoscopic grading of injury helps in prognostication as well as guiding management. …”
Get full text

Sarcopenia in IBD patients and the role of nutritional and physical activity interventions in its management – a systematic review by Michalina Jurkiewicz, Karolina Siembab, Julia Białeta, Katarzyna Rowińska, Agnieszka Napieralska, Wiktor Garbarczyk, Albert Kapla, Alicja Černohorská, Daria Bednarczyk, Wiktoria Pysiewicz

“… Inflammatory Bowel Diseases (IBD), namely Ulcerative Colitis and Crohn’s Disease, are chronic, relapsing, inflammatory conditions of the gastrointestinal tract, with multifactorial pathophysiology. …”
Get full text

Effect and Mechanism of Soluble Dietary Fiber from Corn Bran on Loperamide-induced Constipation in Mice by Xiangrui ZENG, Caixia JIANG, Xiaolan LIU, Xiqun ZHENG, Xuyao WEI

“…Compared to that of the model group, the levels of gastrointestinal tract-related neurotransmitters (motilin, 5-hydroxytryptamine, etc.) were elevated in mice that received CSDF, suggesting that CSDF could alleviate constipation in enteric nervous system disorders. …”
Get full text