Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Supervised machine learning is commonly used to score drug candidates but is hindered by the lack of reliable negative data—drugs that fail due to inefficacy or toxicity— which is difficult to access, lowering their prediction accuracy and generalization. Positive-Unlabeled (PU) learning has been used to overcome this issue by either randomly sampling unlabeled drugs or identifying probable negatives but still suffers from misclassification or oversimplified decision boundaries. …”
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Implementing a rapid geographic range expansion - the role of behavior changes by Logan, Corina, McCune, Kelsey, LeGrande-Rolls, Christa, Marfori, Zara, Hubbard, Josephine, Lukas, Dieter

“…It is generally thought that behavioral flexibility, the ability to change behavior when circumstances change, plays an important role in the ability of species to rapidly expand their geographic range. …”
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Impact of the Timing of Enzyme Replacement Therapy Initiation and Cognitive Impairment Status on Outcomes for Patients with Mucopolysaccharidosis II (MPS II) in the United States:... by Karen S. Yee, David Alexanderian, Yidie Feng, Xiaowei Ren, Bernd Schweikert, Olulade Ayodele

“…Evaluation of developmental and behavioral signs and symptoms in the full study population showed that communication delay (70.0% of patients), cognitive delay (62.1%), behavioral problems (52.9%), and toileting delay (50.0%) were particularly common; earliest documented signs and symptoms were motor delay (median [range] age at first documentation: 4.2 [0.9-18.7] years) and behavioral problems (4.4 [0.6-13.7] years). Patients with CI generally experienced greater symptom burden and higher HRU than those without CI, with the most notable differences documented for communication and toileting delays. …”
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An automated adaptive trading system for enhanced performance of emerging market portfolios by Cristiana Tudor, Robert Sova

“…The system incorporates an Autoregressive Moving Average-Generalized AutoRegressive Conditional Heteroskedasticity model that offers an interpretability advantage over machine-learning methods. …”
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The effect of R&D capitalization on revenue-expense matching: Focusing on the bio-pharmaceutical industries in South Korea by Dongjoon Choi, Inkyung Yoon, Hansol Lee

“…The results indicate that R&D capitalization generally weakens revenue-expense matching in these industries. …”
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Oral health status, behavior and impact profile among naval personnel in the Malaysian naval armed forces by Nik Madihah Nik Azis, Raja Noreihan Raja Abdullah, Mohamad Nur Adzmi Mohamad Ayub, Badiah Baharin

“…Additionally, oral health behaviours were generally inadequate, with 12% of participants reporting infrequent brushing and 68.2% indicating limited use of interdental aids. …”
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The Impact of Baseline Risk Factors on the Incidence of Febrile Neutropenia in Breast Cancer Patients Receiving Chemotherapy with Pegfilgrastim Prophylaxis: A Real-World Data Analy... by Edward Li, Bridgette Kanz Schroader, David Campbell, Kim Campbell, Weijia Wang

“…Logistic regression and generalized estimating equations models were used to compare outcomes among patients with and without patient-specific risk factors and among those receiving regimens categorized as high-, intermediate-, or other-risk for FN (low-risk or undefinable by clinical practice guidelines). …”
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Progress in the Management of Retinal Detachment Associated With Morning Glory Syndrome by Wu S, Wang W, Liu L, Wang W, Jiang K, Peng C, Sun H, Zhang J

“…Surgical interventions are generally employed to manage complications, especially retinal detachments, with procedures such as vitrectomy, paraoptic disc laser photocoagulation, and the use of silicone oil or gas tamponade, though success rates can vary widely. …”
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Conceptos sobre infraestructura tecnológica de un canal de televisión y su aplicación al diseño by Leonardo Andrés Carvajal Álvarez

“…El presente artículo establece los conceptos generales acerca de la infraestructura tecnológica de un canal de televisión de emisión abierta radio propagada o virtual a través de red de datos, tomando como referencia configuraciones estándar y normas aceptadas en la industria para implementación de sistemas de audio y video que hacen posible definir, diseñar, implementar, operar y mantener dicha infraestructura. …”
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Prevalence of Nonalcoholic Steatohepatitis and Associated Fibrosis Stages Among US Adults Using Imaging-Based vs Biomarker-Based Noninvasive Tests by Jesse Fishman, Tom O'Connell, Christina M. Parrinello, Jonathan J. Woolley, Eric Bercaw, Michael R. Charlton

“…**Conclusion:** Prevalence of NASH among US adults was estimated to range from 1.3% to 4.8% when predicted using imaging-based noninvasive test values for participants with presumed NAFLD, generally aligning with estimates in the literature of prevalence of biopsy-confirmed NASH. …”
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Overview of styles, content, learning effects and attitudes of students towards digitally enhanced physiotherapy education – a scoping review by Larissa Pagels, Oskar Schindler, Kerstin Luedtke

“…Conclusion Digitally enhanced learning formats in physiotherapy education can enhance learning experiences and is generally welcomed by students, especially when blended with traditional methods. …”
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Advances and trends of modern and contemporary research on the geology of coal-measure minerals in China by Yong QIN

“…Advances Based on textual research and the analysis of logical relations, this study generalized the advances in research on the geology of CMMs in China into four aspects. (1) Increasingly improved geological theory system of CMMs: China’s classic theoretical system of coal field geology was formed in the second half of the 20th century, and the geological theory system focusing on coals, coal-measure gas, and coal-measure critical metals has been gradually developed since the 21st century. (2) Research on the origin and genesis of coals, advancing the international coal geology: The advancements include the development of the new coal metamorphism theory, the discovery of the world's youngest soft lignite, the reveal of late-stage coalification jumps, the establishment of the ordinary organic petrology, and the comprehensive ascertainment of the formation and evolutionary mechanisms of coals. (3) The unique CMM accumulation, distribution, and metallogenic theory: The specific outcomes include the establishment of multiple sedimentary and structural coal-controlling patterns, the reveal of the fundamental framework of coal accumulation in sea areas, the identification of deposits of various coal-measure critical metals, and the determination of the division schemes for coal-controlling geotectonic units and the metallogenic zones of coal-measure critical metals, and the development of a geological theory system for coalbed methane. (4) Significant achievements in the geological surveys and assessment of special coal resources: Specifically, the methodological system for the geological prediction and assessment of special coal types and high-quality, eco-friendly, and clean coal resources has been developed, the methodological system for the resource potential assessment of tar-rich coals and underground coal gasification has been formed, and the coal resources for related purposes have been preliminarily investigated. …”
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Blood pressure, gallstones, and age at first cholecystectomy in U.S. adults: a cross-sectional study by Yue Zhang, Ruifeng Duan, Xin Chen, Lijuan Wei

“…Additionally, this study employed generalized additive models (GAM) and smooth-fitting curves to delineate the relationships. …”
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Anxiety, Depression, and Stress Reaction/Adjustment Disorders and Their Associations with Healthcare Resource Utilization and Costs Among Newly Diagnosed Patients With Breast Cance... by Dingwei Dai, Henriette Coetzer, Sean R. Zion, Michael J. Malecki

“…HCRU and costs were assessed using data collected 12 months after the index date. Generalized linear regressions were performed to examine the association between healthcare costs and anxiety, depression, and stress reaction/adjustment disorder. …”
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EVALUACIÓN Y DIAGNÓSTICO CLÍNICO-FUNCIONAL DE LOS TRASTORNOS DE CONDUCTA EN LA POBLACIÓN INFANTIL: CONSIDERACIONES CONCEPTUALES Y METODOLÓGICAS by José Alonso Aguilar-Valera

“…El descarte de estas alteraciones es de vital importancia para el cumplimiento y la viabilidad de los objetivos generales y específicos de los especialistas involucrados en esta esfera de la clínica infantil y la pedagogía. …”
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Novel Intuitionistic Fuzzy Fault Tree Analysis for Effective Infectious Medical Waste Management by Rocky Khajuria, Komal, Morteza Yazdani

“…To prevent the spread of such diseases in a healthy civil society, an effective medical waste management system is required to be developed. Generally, to develop an effective medical waste management system, identification of the most critical incidents is needed, which requires a large quantity of data that may not be available. …”
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Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D by Vasundhara Megha, Jeevendra Nath Shukla, Rajat Kumar Singh, Chitrita Gupta Mukherjee, Siddharth Anand, Aparna Singh

“…Clinical Significance: This study sets a benchmark for the dental fraternity and other health specialists to analyze serum iron, serum ferritin, serum albumin, and Vitamin D levels, while generally treating pediatric patients with or without dental caries. …”
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Implementasi Teknologi Blockchain dengan Sistem Smart Contract pada Klaim Asuransi by Baihaqsani, Ari Kusyanti, Primantara Hari Trisnawan

“…Abstract The development of the insurance claim system in Indonesia generally still applies the submission of claims using a manual system with cashless and reimbursement methods. …”
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Efficacy and safety of repetitive transcranial magnetic stimulation in the treatment of male smokers with tobacco use disorder: a randomized controlled trial by Salma W. Mousa, Adel A. Badawy, Gehan F. Attia, Wesam A. Ghareeb

“…Urinary cotinine levels, a biomarker of nicotine intake, were also significantly lower in the active r-TMS group during the follow-up period (p = 0.011). The treatment was generally well-tolerated, with only minor side effects, such as headaches (22.5%). …”
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Geospatial digital mapping of soil organic carbon using machine learning and geostatistical methods in different land uses by Yahya Parvizi, Shahrokh Fatehi

“…The SOC changes were simulated using multivariate analysis and machine learning methods including generalized linear model (GLM), linear additive model (LAM), cubist, random forest (RF), and support vector machine (SVM) models. …”
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