Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities by Pei Pei Lau, Chun-Yu Wei, Min-Rou Lin, Wan-Hsuan Chou, Yu-Jui Yvonne Wan, Wei-Chiao Chang

“…Pathway analysis of GWAS significant genes revealed that lipid metabolism and the peroxisome proliferator-activated receptor (PPAR) signaling pathway are causes of hepatic fat accumulation. Conclusion This study identified six independent NAFLD-associated variants in GCKR, LPL, TRIB1AL, and FTO and emphasized ZPR1 and FTO as shared risk genes for FLI-defined FLD in both Taiwanese and European populations. …”
Get full text

Improvement of surgical treatment of an acute biliary pancreatitis at elderly and senile patients by V. I. Midlenko, A. L. Charyshkin, O. V. Midlenko, I. I. Midlenko, V. Yu. Shchegolev

“…To estimate various variants of surgical treatment of acute biliary pancreatitis at patients of over 60 years old, to develop a method of cholecystectomy at the large Hartmann pouch adherent to biliary tracts, to decrease such complications, as bleeding, bile leakage, damage (intersection) of common bile or common hepatic duct.Material and methods. Patients separated into 3 groups in relation to operative access. …”
Get full text

Supplemental technologies of liver ultrasound investigation at the 1-st type tyrosinemia in pediatrics by G. M. Dvoryakovskaya, S. A. Ivleva, I. V. Dvoryakovsky, S. I. Polyakova

“…To carry out objective estimation of liver parenchyma state in children with the 1-st type hereditary tyrosinemia (НТ-1) by ultrasound method with quantitative estimation of hepatic parenchyma pattern.Material and methods. Overall 14 children with the 1-st type tyrosinemia aged 3 months to 14 years (6 — with acute and subacute forms and 8 — with chronic form) were studied. …”
Get full text

Evaluation of antidiabetic potential, cardio, pancreatic, nephroprotective effect, and herb-herb-drug interaction of Madhukiran formulations in T2 diabetic rats by Vrushabh S. Kondalkar, Pranali P. Polshettiwar, Ganesh B. Choudhari, Anil T. Pawar, Vishnu P. Choudhari

“…Herb-herb interactions (HHI), and herb-drug interactions (HDI) along with antidiabetic, cardio, hepatic, pancreatic, and nephroprotective effects of Madhukiran Formulations (MFs) were studied on STZ-NA-induced T2D rats. …”
Get full text

Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Because isolation of the donor lung on the ex vivo lung perfusion (EVLP) circuit removes it from the influence of renal and hepatic clearance mechanisms, a much-prolonged half-life of IL-10 is anticipated. …”
Get full text

Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. …”
Get full text

Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…In this study, we challenged rats with sucrose-sweetened water and investigated the potential effects of JNK inhibition by employing network analysis based on the transcriptome profiling obtained from hepatic and extrahepatic tissues, including visceral white adipose tissue, skeletal muscle, and brain. …”
Get full text

The Cytotoxicity Assessment of Grapefruit Peel Essential Oil and Its Effect on Frying Stability of Sunflower Oil by Ghania Kaanin-Boudraa, Fatiha Brahmi, Linda Grimaud, Mohamed Lamine Freidja, Ourdia-Nouara Kernou, Daniel Henrion, Samir Hadjal, Khodir Madani, Lila Boulekbache-Makhlouf

“…Various EO concentrations (0.01-0.5 mg/ml) were added to cultured cells Human Umbilical Vein Endothelial Cells (HUVECs) and Human Stellar Hepatic Cell lines LX-2 (SCC064) and incubated for 24 and 48 h. …”
Get full text

Impact of long-term cyanotoxin exposure on cattle: Biochemical, histological, and oxidative stress assessment by Mounira Bensalem, Amina Amrani, Hadjer Zaidi, Fateh Sedrati, Omar Laouar, Zhi Wang, Hichem Nasri

“…Results: Exposed cattle exhibited significant elevations in liver enzymes and oxidative stress markers, indicating hepatic inflammation and redox imbalance. Histological analysis revealed macrovacuolar steatosis, fibrosis, and bile duct dilatation. …”
Get full text

Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice by Weimin Guo, Nicholas Crossland, Jimmy W. Crott

“…At the end of the study hepatic Cyp2E1, an enzyme that metabolize AOM, was lower in males than females. …”
Get full text

Ultrasound radiomics-based logistic regression model for fibrotic NASH by Fei Xia, Wei Wei, Junli Wang, Yuhe Wang, Kun Wang, Chaoxue Zhang, Qiwei Zhu

“…Methods The study used SD rats to create a model of hepatic steatosis and fibrosis by feeding them a high-fat diet and injecting Ccl4 subcutaneously. …”
Get full text

High-grade liver injury: outcomes with a trauma surgery–liver surgery collaborative approach by J Wallis Marsh, Abhinav Humar, Jason L Sperry, David A Geller, Deepika Mohan, Timothy R Billiar, Juan Carlos Puyana, Brian Zuckerbraun, Joshua B Brown, Matthew D Neal, Matthew R Rosengart, David Newhouse, Christine Leeper, Andrew B Peitzman, Raquel Forsythe, Rafael G Ramos-Jimenez, Andrew-Paul Deeb, Evelyn I Truong, Sowmya Narayanan, Louis Alarcon, Graciela M Bauza, Vaishali Dixit Schuchert, Gregory Watson, Amit D Tevar

“…Procedures at the initial operation included hepatorrhaphy±packing (66.4%), nonanatomic resection (5.6%), segmentectomy (9.3%), and hepatic lobectomy (7.5%). Thirty-day mortality in the OM group was substantially lower than prior reports (23.4%). …”
Get full text

Ameliorated Impact of Fenugreek Seed Extract on Some Blood Cellular and Biochemical Parameters in Female Albino Rats Exposed to Lead Acetate by Rozhya Abduljalil Naser, Rabar Yousif Mameik, Nazar M. Shareef Mahmood, Kurdo Bapir Chato

“…It has a several diverse-organ toxicant effect in various healthy issues included diseases of the hepatic, renal, and other body systems. Fenugreek seeds (Trigonella foenum graecum L.) were used in curing medicine and as food supplement since ancient times. …”
Get full text

Anti-Obesity Effects of Arum maculatum, Nasturtium officinale Plant Extracts and Exercise in High Fat Diet-Induced Obese Rats by Zana Hassan Ibrahim

“…Conclusions: Consumption of HFD for 8 weeks caused HFD-C rats obese, hyperglycemic and hyperlipidemic with hepatic cellular injury when compared to the NC rats. …”
Get full text

Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…The pathogenesis of NAFLD closely correlates to both hepatic and cardiovascular involvement that significantly influences both treatment choice and life prognosis. …”
Get full text

Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease by Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan

“…Mechanistically, during hepatic steatosis, altered lipid profiles exhibited lipotoxicity, inducing hepatocyte apoptosis and necroptosis, whereas endoplasmic reticulum (ER) stress triggered lipid remodeling processes similar to those observed in MASLD. …”
Get full text

Discordance between 90Y-PET/CT(MR)-estimated activity and dose calibrator measured administered activity: an international study in SIRT patients treated with resin and glass micro... by Thomas Carlier, Silvano Gnesin, Justin K. Mikell, Maurizio Conti, John O. Prior, Niklaus Schaefer, Maria del Sol Pérez Lago, Clément Bailly, Yuni K. Dewaraja, Thiago V. M. Lima

“…Conclusions We observed in patients similar activity discrepancies as reported for vials, with a relative difference of 44 ± 16% between glass and resin 90Y-loaded microspheres. In 90Y hepatic radioembolization, the 10% accuracy prerequisite on knowing the administered therapeutic activity is then unlikely to be met.…”
Get full text

Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease by Aracely Janneth Naranjo-Viteri, Matías Jávega Cometto, Matías Caverzan, Leandro Gabriel Champarini, María Paula Zunino, Rogelio E. Abburra, Claudia B. Hereñú, Rosana Crespo

“…We evaluated tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression in the brain caudate-putamen unit; inflammatory cytokine (TNF-α, IL-6) expression in the hippocampus; liver, kidney, and gut histology; serum parameters; and hepatic lipid content. Results: Our findings indicate that EuEO is mainly composed of 1,8-cineole (81.8 %) and that, in the parkinsonian rats, it improved impairments in spatial memory, motor performance, and strength; increased TH and DAT protein content; decreased TNF-α expression; diminished liver lipid content and body weight gain without changes in the rats’ food/water consumption or their serum lipid levels; diminished transaminase and alkaline phosphatase activity, and the albumin/globulin ratio. …”
Get full text

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

Get full text

Epidemiologic features of non-alcoholic fatty liver disease in Russia by O. M. Drapkina, V. T. Ivashkin

“…The prevalence of NAFLD among adult population of the Russian Federation was 27%, including 80,3% of hepatic steatosis cases, 16,8% — nonalcoholic steatohepatitis and 2,9% — liver cirrhosis. …”
Get full text