4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…Biodistribution studies of muFAP-4-1BBL indicated enriched tumor targeting to irradiated tumors. Human colorectal cancer samples pre and post irradiation showed enhanced FAP expression after radiotherapy.Conclusion Increased FAP expression in the TME as a result of radiotherapy can be exploited to target agonist 4-1BB immunotherapy to malignant tumor lesions using an FAP-4-1BBL antibody fusion protein.…”
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Psychosocial risks and mental health of health and social care workers in the context of the COVID-19 pandemic by Nadia Vilahur Chiaraviglio

“…Public bodies such as the European Agency for Safety and Health at Work (EU-OSHA) are currently focusing their research efforts on further understanding and documenting the evidence on the multiple risks- including chemical, physical and psychosocial hazards -experienced by workers in the human health and social care activities sector, and their complex interplay. …”
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Phenomenology of Organizational Silence (Case Study Farhangian University) by Iraj Mehdizadeh, Saeed Rajaipour, Seyed Ali Siadat

“…In the internal organizational category, the main themes include structural, communicative, managerial, human resources, supervisory, economic factors, and organizational climate. …”
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Protocol of the TransformUs SecondaryTeachers’ perceptions of the program reach, effectiveness,adoption, implementation and maintenance schools program: a type II hybrid implementa... by Harriet Koorts, Anna Timperio, Jo Salmon, David Revalds Lubans, Gavin Abbott, Nicola D Ridgers, Natalie Lander, Ana María Contardo Ayala, Emiliano Mazzoli

“…Additionally, qualitative data will be thematically analysed using deductive and inductive coding in NVivo.Ethics and dissemination These trials were approved by the Deakin University Human Research Ethics Committee (2021–269) and by the following education authorities: Australian Capital Territory Education Directorate (RES 2317), New South Wales Department of Education (2022253), Northern Territory Department of Education (20865), Victoria Department of Education (2023_004712), Queensland Department of Education (550/27/2585), South Australian Department of Education (2022–0019), Tasmanian Department of Education (2022–25), Western Australian Department of Education (D23/1152724), and Melbourne Archdiocese Catholic Schools (1232). …”
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Evolution, Characteristics and Inspirations of Management Zoning for National Parks in the United States by Zhenwei ZHANG, Hanyue XIAO, Yankang MAO

“…ObjectiveThe zoning system for national parks is a comprehensive technical measure that reflects the interaction among resource characteristics and values, human activities, management objectives, and control measures. …”
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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…Additionally, leveraging human-machine collaboration through intelligent workflows can further enhance decision-making by combining real-time data analysis with human expertise. …”
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Mechanism analysis of mechanical extraction of Pleioblastus amarus fibers by saturated steam pretreatment by Xiaofeng Xu, Weipeng Yu, Xingduo Fan, Zhenhong Gong, Wei Zhang

“…This process is also complex and requires significant human and material resources. In contrast, the saturated steam softening pretreatment method studied in this study is environmentally friendly and significantly simplifies the post-processing of bamboo fiber preparation. …”
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Sm-Nd Isotope Data Compilation from Geoscientific Literature Using an Automated Tabular Extraction Method by Zhixin Guo, Tao Wang, Chaoyang Wang, Jianping Zhou, Guanjie Zheng, Xinbing Wang, Chenghu Zhou

“…However, the scattering of critical geoscience data across multiple publications poses significant challenges regarding human capital and time. In response, we present an automated tabular extraction method for harvesting tabular geoscience data. …”
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Microdissection and Single-Cell Suspension of Neocortical Layers From Ferret Brain for Single-Cell Assays by Lucia Del-Valle-Anton, Salma Amin, Víctor Borrell

“…It also facilitates the study of laboratory animal models that recapitulate human cortical development better than mice, like ferrets.…”
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Induced protein expression in Leptospira spp. and its application to CRISPR/Cas9 mutant generation by L. G. V. Fernandes, A. L. T. O. Nascimento, J. E. Nally

“…Pathogenic Leptospira are responsible for over 1 million human leptospirosis cases annually and significantly impact domestic animals. …”
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AI-based medical ethics education: examining the potential of large language models as a tool for virtue cultivation by Shimpei Okamoto, Masanori Kataoka, Makoto Itano, Tsutomu Sawai

“…Positing LLMs as central to mimicking nuanced human communication, it examines their use in medical education and the ethicality of embedding AI in such contexts. …”
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Theoretical considerations on the pedagogical competencies of Imaging and Medical Radiophysics teachers by Fernando Machado Acuña, Geovanis Olivares Paizan, Marhyam Solano Pérez, Susel Moll Varela

“…Discussion: medical education faces theoretical and practical challenges that lead to the development of professional and pedagogical skills and the training of human resources in quality health. Conclusions: the development of the pedagogical skills of Imaging and Medical Radiophysics teachers is a necessary and urgent process. …”
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Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore by Wai Sze Agnes Chan, Yisheng Wong, Hazel Hwee Boon Oon, Colin Thiam Seng Theng, Wei-Sheng Chong

“…Introduction: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of both interleukin (IL)-12 and IL-23, and it is approved for the treatment of moderate to severe plaque psoriasis. …”
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Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab t... by Huanhuan Li, Chao Ren, Donghai Cui, Tao Wu, Zhiyong Nie

“…BackgroundHuman epidermal growth factor receptor 2(HER-2) is the most prominent therapeutic target for gastric (G)/gastroesophageal junction (GEJ) cancer. …”
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Copper deposit development potential on the Qinghai-Xizang Plateau in China based on the pressure-state-response framework by Chonghao Liu, Jinshan Xu, Jianan Zhao, Jian Dong, Xiangying Jia, Jing Liu, Xiu Wang

“…In this study, we take into account the intricate interplay between human activities, environmental conditions, and economic strategies. …”
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A review of research progress on disease burden of foodborne aflatoxins by Mei QIN, Jinyao CHEN, Lishi ZHANG, Jiao HUO, Yang SONG, Li CHENG

“…The International Agency for Research on Cancer (IARC) has classified AFB1, AFB2, AFG1 and AFG2 as Group 1 carcinogens, primarily causing hepatocellular carcinoma (HCC) in humans, but also affecting growth and development in children and damaging the human immune system, resulting in varying degrees of health burden to populations. …”
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Pregnancy Outcomes of Infertile Patients Presenting to Our Assisted Reproductive Technology Center by Hasan Ali Inal, Zeynep Ozturk Inal

“…RESULTS: Female age, infertility period, baseline follicle-stimulating hormone, luteinizing hormone, estradiol levels, duration of stimulation, total gonadotropin dose required, peak E2 level, and endometrial thickness on human chorionic gonadotropin administration day were statistically significant between the groups (p<0.05). …”
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Glocalization of Yoruba Omoluwabi Ideology by Ademola O. Dasylva

“…The paper argues that Omoluwabi remains one great ideology in the Yoruba Ifa knowledge systems practice that possesses a capacity for gauging socially approved human rela­tions of global magnitude; there is a plurality of poetics, not just one. …”
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Brain CT image classification based on mask RCNN and attention mechanism by Shoulin Yin, Hang Li, Lin Teng, Asif Ali Laghari, Ahmad Almadhor, Michal Gregus, Gabriel Avelino Sampedro

“…Brain tumor is one of the major diseases threatening human life. The number of deaths caused by these diseases is increasing dramatically every year in the world. …”
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Real-time Monitoring of Suspended Particulate Matter in Indoor Air: Validation and Application of a Light-scattering Sensor by Anna Susz, Pascal Pratte, Catherine Goujon-Ginglinger

“…Abstract Since the 1950s, awareness of the impact of air pollution on human health has been growing. Of the many recognized air pollutants, suspended particulate matter has received the most attention, as both PM2.5 and PM10 can affect humans upon inhalation. …”
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