Stapled peptides: targeting protein-protein interactions in drug development by Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

“…Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. …”
Get full text

Zika, a Mosquito-Transmitted Virus by L. Phil Lounibos, Barry W. Alto, Nathan D. Burkett-Cadena, Cynthia C. Lord, Chelsea T. Smartt, C. Roxanne Rutledge Connelly, Jorge R. Rey

“…In its native range in West Africa and Uganda, the Zika virus stays in the forest for the most part, and human infections are considered incidental and medically inconsequential. …”
Get full text

RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome by Raghib Ashraf, Hana Polasek-Sedlackova, Victoria Marini, Jana Prochazkova, Zdenka Hasanova, Magdalena Zacpalova, Michala Boudova, Lumir Krejci

“…This underscores the importance of RECQ4-MUS81 in safeguarding genome integrity and suggests potential implications for human disease. Our findings demonstrate the RECQ4-MUS81 interaction as a key mechanism in alleviating replication stress at hard-to-replicate regions and highlight its relevance in pathological conditions such as RTS.…”
Get full text

AN ASSESSMENT OF PERCEPTION OF THE PEOPLE ON MALARIA PREVENTION AND CONTROL IN DONGA LOCAL GOVERNMENT AREA OF TARABA STATE by SILAS JOSHUA, SUNDAY EMMANUEL BAMISE

“…Generally, (78.33%) believed that mosquitoes can transmit malaria to human while (67.5%) of the respondents’ household have mosquitoe nets, also (56.67%) opined that mosquitoes net are often used by the respondents. …”
Get full text

The Impact of Adequate Selenium Intake on Severity Symptoms and Quality of Life among People with Allergic Rhinitis by Thanyapron Tiyawisutsri, Napassorn Suwanpanyakul, Weeraya Kongkasri, Kamonwan Thongsri, Roger Timothy Callaghan, Alongkote Singhato

“…Background: Selenium (Se) deficiency leads to impairment of human immune function. Allergic Rhinitis (AR) is one of the most common immune-related diseases that affects the quality of life among patients. …”
Get full text

The Effect of Transobturator Tape Surgery on Female Sexual Functions: A Systematic Review by Engin Yildirim, Nuriye Buyukkayaci Duman, Umit Gorkem, Ozgur Kan

“…study desıgn: Data were taken from those cohort, case-control and cross-sectional studies that were done with human subjects in full texts, were written in the English language. …”
Get full text

ENVIRONMENTAL IMPACT OF WATER TREATMENT PROCESS. A SYSTEMATIC REVIEW OF EVALUATION METHOD by FLORINA FABIAN, VALENTIN NEDEFF, MIRELA PANAINTE -LEHADUS, OANA IRIMIA, SILVIA RACOVITA

“…The results in short show that Carbon Footprint only assesses the global warming potential of a water treatment plant, whereas Life Cycle Analysis and assess multiple environmental impact categories, which may include global warming, but also impacts on human health, ecosystems quality, etc. There are different standards and organizations around each assessment. …”
Get full text

Does management support drive sustained agile usage? a serial mediation model and cIPMA perspective. by Uthpala Wijesinghe, Vidara Mapitiyage, Chathurya Wickramarathne, Chamoda Wickramage, Krishantha Wisenthige, Chathuni Aluthwala

“…Agile software development is immensely popular in the industry, but most teams struggle to sustain its use. Human factors like management support, agile training, agile mindset, and team resilience are often neglected, hindering long-term success. …”
Get full text

Micro-Characterization of Indoor Deposited Particles Using FTIR, SEM-EDS, and XRD Techniques: A Case Study of a University Campus, Bangladesh by Mamun Mahmud, Kazi ABM Mohiuddin

“…Abstract Micro-characterization of indoor atmospheric particles is essential for understanding atmospheric particle consequences on human health. In this study, the atmospheric particles were collected from inside the different buildings of KUET campus. …”
Get full text

Relationships between multivitamins, blood biochemistry markers, and BMC and BMD based on RF: A cross-sectional and population-based study of NHANES, 2017-2018. by Lijuan Xu, Mengqi Wu, Ying Zhang, Hongsheng Kun, Jiangbao Xu

“…<h4>Conclusion</h4>The effect of vitamin serum concentrations and blood calcium serum concentrations on human bone density was not significant. ALP, CPK and creatinine serum concentrations body development indicators were identified as the most important factors related to bone status. …”
Get full text

Microplastics in agricultural soils: sources and microbial remediation approaches by Nataliia Tkachuk, Liubov Zelena, Yaroslav Novikov

“…The sources of microplastics in agricultural soils are plastics used to cover fertilizers, pesticides and seeds, film for mulching, use of wastewater for irrigation, sludge from wastewater treatment as fertilizers that can lead to the occurrence of environmental risks for the functioning of agroecosystems and human health. Microbial remediation is a promising direction for the removal of microplastics from agricultural soils. …”
Get full text

Isolation, Identification, and Antimicrobial Study of Yersinia spp. Isolated from Traditional and Industrial Olivier Salad Specimens in Tehran by Farnaz Eskandarzadeh, Mohammad Reza Mohammadi, Abbas Rahimi Foroushani, Mohammad Mehdi Soltan Dallal

“…The biotype of Yersinia enterocolitica was investigated, and three strains of biotype 1A and one strain of biotype 1B were identified. The human pathogenic serotype was not found in the serotype analysis. …”
Get full text

Which curriculum components do medical students find most helpful for evaluating AI outputs? by William J. Waldock, George Lam, Ana Baptista, Risheka Walls, Amir H. Sam

“…Abstract Introduction The risk and opportunity of Large Language Models (LLMs) in medical education both rest in their imitation of human communication. Future doctors working with generative artificial intelligence (AI) need to judge the value of any outputs from LLMs to safely direct the management of patients. …”
Get full text

Geometric morphometric analysis of projectile points from the Southwest United States by Bischoff, Robert J.

Get full text

Sex ratio at birth in Kogi state, North-Central Nigeria by Adekunle Bakare, Deborah Peter, Motunrayo Mojoyin Coker, Silas Fagbenro, Okunola A. Alabi

“… The human secondary sex ratio is the male-to-female ratio at birth. …”
Get full text

3D convolutional deep learning for nonlinear estimation of body composition from whole body morphology by Isaac Y. Tian, Jason Liu, Michael C. Wong, Nisa N. Kelly, Yong E. Liu, Andrea K. Garber, Steven B. Heymsfield, Brian Curless, John A. Shepherd

“…In this study, we present a novel application of deep 3D convolutional graph networks and nonlinear Gaussian process regression for human body shape parameterization and body composition estimation. …”
Get full text

Comparison of Dentinal Defects Induced by Rotary, Reciprocating, and Hand Files in Oval Shaped Root Canal - An In-Vitro Study by Harakh Chand Branawal, Neelam Mittal, Prachi Rani, Aiyman Ayubi, Silviya Samad

“…Materials and Methods: One hundred and five extracted human mandibular premolars with single root and oval canals were selected for the study. …”
Get full text

La filière d’assainissement, quel rôle dans la lutte contre l’antibiorésistance ? by Arnal, Charlotte, Belhadj-Kaabi, Faten, Ingrand, Valérie

“…The sources of bacteria or antimicrobial resistance genes are linked to human activities: urban, hospital and industrial discharges, livestock farms). …”
Get full text

Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Antimicrobial drugs that target human pathogenic bacteria and fungi include derivatives of thiosemicarbazone and semicarbazone. …”
Get full text

STUDYING HOW DIESEL ENGINE ADDITIVES USING SILVER OXIDE (Ag2O) NANOPARTICLES AFFECT THE ENVIRONMENT by CIHAN BAYINDIRLI, MEHMET CELIK

“…In case of complete combustion reaction in engines, the products released do not directly threaten human health. Compared to diesel fuel, biodiesel has worse combustion performance due to some fuel properties. …”
Get full text