Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity by Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi

“…Here, we performed radioactive tracer studies in combination with pharmacological enzyme inhibition, followed by targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, and found three androgen metabolites—androstanedione, androsterone, and epiandrosterone—in mouse and human meibomian glands. Accounting for the enzymatic conversion, we show tissue-endogenous 3α/3β-ketosteroid reductase expression. …”
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Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice by Ziyi Xiong, Qiling Kong, Juan Hua, Qi Chen, Dandan Wang

“…They can be accumulated through the food webs and enter the human body through dietary intake, posing health risks. …”
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Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging by Chen Zhu, Youfa Wang, Xiaosong Yang, Qiran Zhao, Wenyan Xu, Xiaolu Wang, Yanjun Liang, Qihui Chen, Shenggen Fan

“…Abstract Background The role of diet in aging is crucial, yet research findings on how specific diets influence human aging remain inconsistent. Understanding the relationship between dietary factors and aging could inform interventions to promote healthier aging outcomes. …”
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The global research trends and hotspots on phthalate esters (PAEs): A comprehensive visualization and bibliometric analysis (2000-2023) by Yajun Hong, Sizhe Zhang, Zhenfei Yan, Saraschandra Naraginti, Meiqing Zhu, Dayong Xu

“…PAEs present significant risks to human health and ecological systems, necessitating serious attention. …”
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ASD-YOLO: a lightweight network for coffee fruit ripening detection in complex scenarios by Baofeng Ye, Baofeng Ye, Renzheng Xue, Renzheng Xue, Haiqiang Xu, Haiqiang Xu

“…At present, how to judge the maturity of coffee fruit mainly depends on the visual inspection of human eyes, which is both time-consuming and labor-intensive. …”
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Meta-analysis examining the association between low platelet monoamine oxidase levels and Zuckerman's sensation seeking scale in a sex dependent manner by Jordan Winfield, Ian A. Mendez, Gabriel A. Frietze

“…MAO levels can be measured in humans by collecting blood platelets. Low platelet MAO levels in healthy individuals are associated with personality differences, such as increases in sensation seeking. …”
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ChatGPT for Univariate Statistics: Validation of AI-Assisted Data Analysis in Healthcare Research by Michael R Ruta, Tony Gaidici, Chase Irwin, Jonathan Lifshitz

“…However, its application requires careful prompt construction and human oversight to ensure accuracy. As a supplementary tool, ChatGPT can enhance data analysis efficiency and broaden research accessibility.…”
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ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats by Mohammed Esawie, Marwa Matboli, Mariam Sameh Bushra, Amany H. Hasanin, Eman Kamal Habib, Reham Hussein Mohamed, Hebatalla Said Ali

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Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study by Ryota Imai, Takafumi Abe, Kentaro Iwata, Seigo Yamaguchi, Takeshi Kitai, Atsuhiro Tsubaki

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Transcranial direct current stimulation combined with physical exercise in rotator cuff tendinopathy: a protocol for a blinded randomised controlled trial by César Augusto Medeiros Silva, Clécio Gabriel de Souza, Vinicius Batista Lima, Hannely Beatriz Menezes Cosme, Romário Nóbrega Santos Fonseca, Fuad Ahmad Hazime, Rodrigo Scattone da Silva, Rodrigo Pegado de Abreu Freitas

“…Followed the Declaration of Helsinki recommendations for research with human beings. The results will be published later in peer-reviewed journals and scientific events.Trial registration number The Brazilian Registry of Clinical Trials (RBR-59xmv6s); Results.…”
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RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…Mutations in RECQL4 have been associated with various human diseases, including Rothmund–Thomson syndrome. …”
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Parasitic contamination of lettuce: comparison between establishments located in areas with high and low economic values by Gustavo Trentini Barancelli, Larissa Kochenborger, Fernanda Gracieli Machado Brum, Fabiana Tonial, Cassiano Mateus Forcelini

“…Lettuce (Lactuca sativa) is a widespread vegetable for human alimentation. Some systematic reviews showed parasitic contamination of lettuce in Brazil. …”
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A growing degree day model determines the effect of temperature stress on diverse chickpea genotypes by Cara Jeffrey, Cara Jeffrey, Cara Jeffrey, Laura Ziems, Laura Ziems, Brent Kaiser, Brent Kaiser, Richard Trethowan, Richard Trethowan

“…Chickpeas are a globally crucial agricultural product, currently at risk due to human-induced climate change. There has been little research into the impact of heat stress on chickpea compared to other crops, but it is known that heat stress can cause up to 100% yield loss. …”
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Unaccountable counting: the folly of incorporating open ocean carbon sinks in Nationally Determined Contributions by Berger, Manon, Comte, Adrien, Kwiatkowski, Lester, Bopp, Laurent

“…However, it should be noted that this anthropogenic carbon uptake results from the physical and biogeochemical properties of water masses, rather than from human management practices. Additionally, the EEZ oceanic carbon sink is already considered in estimates of remaining carbon budgets to meet the goals of the Paris Agreement. …”
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Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response by Carlos P. Jara, Al-Murtadha Al-Gahmi, Audrey Lazenby, Michael A. Hollingsworth, Mark A. Carlson

“…These findings highlight the potential for site-specific activation of oncogenes in large animal models of epithelial tumors, with the ability to induce stromal alterations reminiscent of human PDAC.…”
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An optimized deep-forest algorithm using a modified differential evolution optimization algorithm: A case of host-pathogen protein-protein interaction prediction by Jerry Emmanuel, Itunuoluwa Isewon, Jelili Oyelade

“…The performance of the optimized deep forest model was evaluated on human-Plasmodium falciparum protein sequence datasets using 10-fold cross-validation. …”
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Exploring the role of spiritual leadership among nurse colleagues: an associative analysis of its impact on passion and altruism by Huda Gaber Hamzaa, Mohamed Hussein Ramadan Atta, Heba Mostafa Ali Taha, Mervat Amin Sayed, Asmaa Kamal Ahmed, Ahmed Abdellah Othman, Nadia Mohamed Ibrahim Wahba

“…Abstract Background Spiritual leadership emphasizes that nurses encounter situations that require compassion, empathy, and a deep understanding of the human experience. Passion can drive nurses' motivation, engagement, and commitment to patient care. …”
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Letter and Person Recognition in Freeform Air-Writing Using Machine Learning Algorithms by Huseyin Kunt, Zeki Yetgin, Furkan Gozukara, Turgay Celik

“…Air-writing is an emerging form of human-computer interaction that enables text entry through hand movements in the air. …”
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Spatial-temporal evolution of habitat quality in tropical monsoon climate region based on “pattern–process–quality” – a case study of Cambodia by Kang Junmei, Yang Fengshuo, Wang Jun, Liu Yang, Fang Dengmao, Jiang Chengcheng

“…The results show that (1) during 2000–2022, forest in Cambodia covered a wide range, showing a landscape pattern mainly distributed in the east and west. (2) The degree of fragmentation of impervious landscape pattern increased gradually from 2000 to 2022, indicating that it was seriously affected by human activities and natural factors, and with the increase in elevation and slope, the area of various types converted to impervious decreased. (3) During 2000–2022, high habitat quality areas were concentrated in Tonle SAP Lake in the east, southwest, and central part of Cambodia, while low habitat quality areas were concentrated in the central part. (4) Natural factors, socio-economic factors, policies, and regulations all have an impact on the change in land use pattern and habitat quality in Cambodia.…”
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Magnitude, risk factors and economic impacts of diabetic emergencies in developing countries: A systematic review. by Halefom Kahsay Haile, Teferi Gedif Fenta

“…As the prevalence of diabetes grows in developing countries, so too does the impact of these costly human and economic complications. Noticeable scarcity of data concerning the magnitude, the cost expenditures as well as well unidentified predictors of these complications made the management more difficult in the resource limited health care settings. …”
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