Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

“…We conducted a multi-omic characterization of established VTX-resistant isogenic human myeloma cell lines (HMCL) and primary MM patient samples pre- and post-VTX treatment. …”
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Use of linear features by red-legged partridges in an intensive agricultural landscape: implications for landscape management in farmland by Perrot, Charlotte, Seranne, Léo, Berceaux, Antoine, Noël, Mathias, Arroyo, Beatriz, Bacon, Léo

“…Through GPS-monitoring of adult birds, we first assess home range size throughout the year and during the breeding season, in relation to breeding status and to linear features (seminatural linear vegetation and tracks-roads for human traffic) density. Then, we focus on habitat selection during the breeding period in relation to linear features. …”
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Decade-Long Analysis: Unravelling the Spatio-Temporal Dynamics of PM10 Concentrations in Malaysian Borneo by Salwa Naidin, Justin Sentian, Farrah Anis Fazliatul Adnan, Franky Herman, Siti Rahayu Mohd Hashim

“…For many years, Malaysia has experienced a hazy atmosphere due to high levels of particulate matter (PM10) from regional biomass burning and other human activities. This study aims to analyse the changes in PM10 levels over time in Malaysian Borneo. …”
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Enhanced genome editing with a Streptococcus equinus Cas9 by Jingtong Liu, Yao Wang, Jingjing Wei, Shengzhou Wang, Miaomiao Li, Zheyong Huang, Sufang Zhang, Huihui Liu, Jinhai Huang, Yongming Wang

“…In this study, a GFP-activation assay was used to screen a panel of 18 SpCas9 orthologs, ten of which demonstrated activity in human cells. Notably, these orthologs had a preference for purine-rich PAM sequences. …”
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Quinoid to benzenoid transition-driven glutathione sensing: Dual-emission carbon dots and smartphone-based ratiometric fluorescence analysis by Al-Montaser Bellah H. Ali, Ashraf M. Mahmoud, Yousef A. Bin Jardan, Aya M. Mostafa, James Barker, Mohamed M. El-Wekil

“…Practical validation using human serum samples demonstrated the method's robustness in complex biological matrices, achieving high recovery rates between 98.5 % and 101.0 %, confirming its suitability for real-world clinical applications. …”
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Effect of sleep quality on the severity of perimenstrual symptoms in Japanese female students: a cross-sectional, online survey by Yukio Urabe, Makoto Komiya, Noriaki Maeda, Satoshi Arima, Tsubasa Tashiro, Rami Mizuta, Sakura Oda, Takaaki Nagasawa, Koichi Naito

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Investigating the production and synergistic antibacterial activity of bacteriocin-like substance from Brevibacillus laterosporus SA-14 (TISTR 2453) for enhanced wound healing by Husna Madoromae, Apichart Atipairin, Malatee Tayeh, Monthon Lertcanawanichakul

“…This study aimed to enhance the production of bacteriocin-like substances (BLS) from Brevibacillus laterosporus SA-14 (TISTR 2453) by optimizing nutrients, evaluating antibacterial activity, assessing synergy with vancomycin, and testing the cytotoxicity and wound healing effects on human keratinocytes. The results showed that when the SA-14 strain was cultured in half-formula Luria-Bertani broth (LB/2) with added carbon sources (glucose, sucrose, and lactose), all cultures reached the late log phase at 24 h, and antibacterial activity was exhibited against various MRSA strains after 48 h, except for the LB/2 supplemented with glucose, likely due to carbon catabolite repression. …”
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Pengaruh Ciri Temporal, Spasial, dan Frekuensi pada Klasifikasi Motor Imagery by Afin Muhammad Nurtsani, Muhammad Adib Syamlan, Agung Wahyu Setiawan

“…Selain itu, pengklasifikasi RF memberikan kinerja yang paling baik dibandingkan dengan SVM; k-NN; serta NB.    Abstract  Human-computer interaction is a necessity and will be deployed in the near future, especially in rehabilitation engineering. …”
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Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 by Yanqing Liu, Jie Chen, Xiang Li, Yu Fan, Cheng Peng, Xiaochun Ye, Yingshuang Wang, Xin Xie

“…RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, and metastasis. …”
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Immunogenicity of Two Fractional Inactivated Poliovirus Vaccine Doses vs Single Intramuscular Inactivated Poliovirus Vaccine Dose in Infants of Low- and Middle-income Countries: A... by Kunal Kumar, Sangita Yadav, Raghvendra Singh, Archana Thakur

“…The study measured the levels of antibodies using human poliovirus (PV) antibody immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) kits and identified seroprotection as the presence of antibody >1:8 dilution. …”
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Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

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Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank by Ji He, Yanmin He, Qigang Zhan, Zhipan Wu, Qi Sheng, Wei Zhang, Faming Zhu

“…Methods To study the feasibility of constructing an HLA (human leukocyte antigen)-matched induced pluripotent stem cell haplobank in China, 5421 umbilical cord blood samples were randomly collected from the Umbilical Cord Blood Bank of Zhejiang Province, China. …”
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Host-symbiont-gene phylogenetic reconciliation by Menet, Hugo, Trung, Alexia Nguyen, Daubin, Vincent, Tannier, Eric

“…We finally evaluate different hypotheses on human population histories in the light of their coevolving Helicobacter pylori symbionts, reconciled together with their genes. …”
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Riesgo de contagio por COVID-19 en un entorno urbano (Málaga, noviembre del 2020) by Ángel Miramontes Carballada, Rubén Lois González, María Jesús Perles Roselló, Jesús Miranda Páez

“…The search for correlation between the distribution of contagion and various factors of the natural environment and the human environment have been treated both at the urban micro-scale and on a planetary scale. …”
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Smartphone overuse and distraction: which relationship with general well-being across different generations? by Diego Bellini, Maria Lidia Mascia, Rachele Conti, Maria Pietronilla Penna

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Role of microRNA in the risk stratification of ischemic strokes by Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, May Adel Alhamid, Fawaz Al-Mufti

“…Selection criteria included human research, a certain date, or categories of studies. …”
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Comparison of chemical constituents in Lysimachia species and their antimicrobial activity for extending the shelf life of foods by Li-Li Chen, Shuang Long Yang, Ji-Cun Bao, Wei-You Xie, Zhao-Chan Wang, Nian Shi, Zhao-Jie Wang

“…Food spoilage causes significant economic losses and endangers human health. Developing novel antimicrobial agents and preservatives is urgently needed for anti-foodborne diseases and improving food storage. …”
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Oncogenic processes: a neglected parameter in the evolutionary ecology of animals by Thomas, Frédéric, Asselin, Klara, MacDonald, Nick, Brazier, Lionel, Meliani, Jordan, Ujvari, Beata, Dujon, Antoine Marie

“…Traditionally, cancer has been viewed primarily as a disease relevant to human and domesticated animal health, attracting attention mainly from oncologists. …”
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Complex and severe infection in a 67-year-old liver transplant recipient due to Cunninghamella elegans, Bordetella bronchiseptica, and Pneumocystis jirovecii by Muyun Wei, Kangyi Gu, Juanxiu Qin, Xinhua Lu, Junqi Feng, Shaowei Mao, Min Li, Zhilan Li, Changsheng Wang

“…B. bronchiseptica, P. jirovecii, Aspergillus fumigatus, and human alphaherpesvirus 1 (HSV1) were detected by clinical metagenomic next-generation sequencing (mNGS) of his bronchoalveolar lavage fluid (BLAF). …”
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Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 by Yining He, Jing Zhao, Lanhui Wang, Chao Han, Ruxue Yan, Peiqi Zhu, Tianyang Qian, Siyao Yu, Xiaolin Zhu, Weiming He

“…The estimated annual percentage change was used to depict temporal trends, whereas Pearson correlation analysis explore its correlation with the human development index (HDI), the SDI, and age-standardised rates (ASRs). …”
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