Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight by Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser

“…Abstract Returning to the moon and traveling to Mars represent the main targets of human space exploration missions within the upcoming decades. …”
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The physiological responses to volume-matched high-intensity functional training protocols with varied time domains by Jessica S. Smith, Jessica S. Smith, Gabriella F. Bellissimo, Gabriella F. Bellissimo, Fabiano T. Amorim

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Fabrication of Nano-Silver Composite Using Amomum longiligulare Fruit Polysaccharides and Their Biological Activities by Lian Y, Ma N, Cheng Q, Luo M, Xu Z, He F, Zhou X, Zhang Y, Jin D, Kong Y, Wang Y, Wei N

“…Yong Lian,1,* Ning Ma,2,* Qianying Cheng,1,* Mingquan Luo,1 Zhen Xu,1 Fei He,1 Xiaomei Zhou,1 Ying Zhang,1 Dejun Jin,1 Yidan Kong,1 Yong Wang,1 Na Wei1 1Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human-Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China; 2Reproductive Medical Center, Hainan Women and Children’s Medical Center, Haikou, Hainan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Na Wei; Yong Wang, Hainan Provincial Key Laboratory of R&D on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China, Email [email protected]; [email protected]: Study aims to optimize the synthesis conditions for silver nanoparticle composites [ALP(D)-AgNPs] using a rapid and environmentally friendly method and investigate the antioxidant, antibacterial, and anticancer activities of the fabricated composite.Methods: The polysaccharide component ALP-D was extracted and purified from the fruits of Amomum longiligulare and subsequently used for further experiments. …”
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Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation by Ting Shen, Jing Yu, Bin Xie, Cuiping Huang, Jingjie Cui, Kefu Liu, Chunyu Liu, Chao Chen

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Identifikasi Tanaman Obat Indonesia Melalui Citra Daun Menggunakan Metode Convolutional Neural Network (CNN) by Budi Setiyono, Muhammad Riv’an Arif, Qonita Qurratu Aini, Theophil Henry Soegianto, Jasti Ohanna, Ricky Andrean Fernanda Gunawan, Ayu Putri Rizkia

“…Indonesian people have used plants as traditional medicine since ancient times. At this time, human knowledge in recognizing the types of medicinal plants is decreasing due to humans' limited memory. …”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…In vitro experiments, human aortic smooth muscle cells were extracted, and an in vitro dissection model was constructed with angiotensin II. siRNA silencing studies were performed to investigate the effects of MR-1 and ROCK1 on the development of AD and their interconnections.Results: Analysis of aortic tissues revealed significantly elevated levels of MR-1 and ROCK1 in AD patients, and meanwhile the inflammatory indexes showed the same trend. …”
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Genetic characteristics of influenza A and B viruses circulating in Russia in 2019–2023 by Svetlana B. Yatsyshina, Anna A. Artamonova, Maria A. Elkina, Anna V. Valdokhina, Victoria P. Bulanenko, Aleksandra A. Berseneva, Vasily G. Akimkin

“…All influenza A(H1N1)pdm09 viruses in the 2022–2023 season had a previously unknown mutation E224A in HA, which increases its affinity for α-2,3 sialic acids — receptors localized in the human lungs, to which the virus binds via HA. 2 and 3% of influenza A(H1N1)pdm09 viruses in 2019–2020 and 2022–2023, respectively, had the D222N mutation in the receptor-binding site of HA, which is associated with more severe disease. …”
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Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells by Caitlin M. Tressler, Kanchan Sonkar, Menglin Cheng, Vinay Ayyappan, Ruoqing Cai, Kristine Glunde

“…We sought to further investigate these clinical observations at the molecular level by combining metabolic and transcriptomic studies in two human TNBC cell lines treated with six different chemotherapeutic agents. …”
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Defining Nocturnal Polyuria in Adolescents by Tasmia Promi, Anthony Brooks, Gulzhan Tologonova, Marie-Claire Roberts, Sarita Dhuper, Meseret Tena, Oluwatoyin Bamgbola, Monique Hanono, Jeffrey P. Weiss, Karel Everaert, Tine DeBacker, Thomas F. Monaghan, Louis Salciccioli, Stephen Wadowski, Elka Jacobson-Dickman, Jason M. Lazar

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Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression by Fang T, Hu L, Chen T, Li F, Yang L, Liang B, Wang W, Zeng F

“…We aimed to explore the roles of LDHA and LDH5 isoenzyme activity in BC, which provides a new insight into LDHA for the treatment of BC.Methods: The expression of LDHA in BC and its relationship with clinicopathological features were obtained from various databases including The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), Breast Cancer-Gene Expression Miner (bc-GenExMiner), TNMplot, UALCAN. …”
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Mechanism of the blood-brain barrier modulation by cadherin peptides by Elinaz Farokhi, Ahmed L. Alaofi, Vivitri D. Prasasty, Filia Stephanie, Marlyn D. Laksitorini, Krzysztof Kuczera, Teruna J. Siahaan

“…Aim: This study was aimed at finding the binding site on the human E-cadherin for Ala-Asp-Thr Cyclic 5 (ADTC5), ADTC7, and ADTC9 peptides as blood-brain barrier modulator (BBBM) for determining their mechanism of action in modulating the blood-brain barrier (BBB). …”
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An initial benchmark of the quality of the diagnosis and surgical treatment of breast cancer in South Africa by S Nietz, H Cubasch, I Buccimazza, S Čačala, B Phakathi, M Joffe, W C C Chen, S Norris, P Ruff

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Unpacking the benefits of black soldier fly frass fertilizer towards nematode suppression and potato production by Emmanuel O. Anedo, Emmanuel O. Anedo, Emmanuel O. Anedo, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Solveig Haukeland, Solveig Haukeland, Xavier Cheseto, Moses Nyongesa, Patrick Pwaipwai, Sevgan Subramanian, Abdou Tenkouano, Betty Kibaara, Chrysantus M. Tanga

“…Mineral fertilizers and synthetic nematicides are costly and cause negative impacts on humans and the environment, while organic fertilizers are less effective for soil health and nematode management. …”
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Development of antibacterial magnetic clay-based nanocomposites for water treatment by Horue, Manuel, Barraqué, Facundo, Montes, María Luciana, Zelaya-Soulé, María Emilia, Morantes, César Fernández, Urruchua, Florencia Camila, Correa, Hilda Edith, Castro, Guillermo Raul, Fernandez, Mariela Alejandra

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Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Abstract Haptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. …”
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Clinical and molecular analysis of JCPyV and BKPyV infection and associated risk of urothelial carcinoma development in the upper tract by Chun-Nun Chao, Chi-Feng Hung, Wei‑Hong Lai, Chun-Liang Tung, Wan-Yun Yeh, Kai-Wu Yang, Meilin Wang, Ya-Yan Lai, Pei-Lain Chen, Cheng-Huang Shen

“…Abstract Background Human polyomaviruses (HPyVs), JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV), have been found in upper tract urothelial carcinoma UTUC; however, the association of the viral oncogenic factors and clinical characteristics of UTUC remains unclear. …”
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Systematic collection, annotation, and pattern analysis of viral vaccines in the VIOLIN vaccine knowledgebase by Anthony Huffman, Mehul Gautam, Arya Gandhi, Priscilla Du, Lauren Austin, Kallan Roan, Jie Zheng, Yongqun He, Yongqun He

“…., viral entry, assembly, exit, and immune evasion) as identified in top ranked human, animal vaccines, and HPV vaccines. The vaccine antigen proteins also show up in different virion locations in viruses such as HRSV vaccines. …”
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Analisis Perubahan Luas Lahan Hijau Di Kota Bogor Dengan Citra Landsat 8 Menggunakan Normalized Difference Vegetation Index by Asep Denih, Irma Anggraeni, Runanto

“…The growing population certainly affects the increasing human need for land use for infrastructure such as settlements, socio-economic and services. …”
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Spatial-temporal differentiation and influencing factors of ecosystem health in Three-River-Source national Park by Yanqin Wang, Huaju Xue, Aiqing Li, Xiaofan Ma, Ailing Sun, Jinhe Zhang

“…It also showed significant “high-high” and “low-low” clustering effects in the eastern and northwestern regions. (3) Among all the indicators assessed, ecosystem vigor was the indicator that contributed the most to the growth of the ecosystem health index. (4) Variations in ecosystem health of TNP were mainly shaped by land use intensity and precipitation, and interactions between natural environmental factors and human activity factors enhanced the explanation of these changes. …”
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INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…A direct dependence of the economic development and rule of law indices has been revealed, since under the condition of ensuring the latter, there is a guarantee of the harmonious existence of all sectors of society, and conditions are created to prevent the emergence of existential threats to the national interests of the state, including the provision of human rights and freedoms. The mechanism for bringing judges to disciplinary responsibility has been established in accordance with international standards, including 1) a special procedure for bringing judges to disciplinary responsibility, which is defined by law; 2) the formation of an independent body that should consider such cases; 3) ensuring the right of a judge to participate in such procedure directly or through a representative, to exercise his right of defence and to express his opinion; 4) the right to appeal against the decision taken on the basis of the results of this procedure; 5) the exhaustiveness of the sanctions that can be applied and their proportionality. …”
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