Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care by Drew M Pardoll, Suzanne L Topalian

“…Neoadjuvant (presurgical) anti-programmed cell death protein-1 (PD-1)-based immunotherapy as a new approach to cancer treatment has been developing on an accelerated trajectory since the seminal clinical trial results from studies in lung cancer and melanoma were published in 2018. Groundbreaking regulatory approvals in triple-negative breast cancer, non-small cell lung cancer and melanoma will certainly be followed by additional approvals in other disease indications, as clinical and basic research are burgeoning globally in hundreds of clinical trials across dozens of cancer types. …”
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Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review by Jun Wang, Jun Wang, Xiaojing Li, Shuang Dong, Sheng Hu, Fengming Ran, Yu Qian

“…Lastly, the third acquired mechanism pertains to histological transformation, such as the emergence of small cell lung cancer (SCLC) clones. The transformation of pathological types has brought great confusion to the clinical diagnosis and treatment process. …”
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No Apparent Workup for most new Indeterminate Pulmonary Nodules in US Commercially-Insured Patients by Bruce S. Pyenson, Carol M. Bazell, Michael J. Bellanich, Melissa A. Caplen, Javier J. Zulueta

“…**Background:** A recent study estimated that more than 1.5 million Americans have an indeterminate pulmonary nodule (IPN) identified on a chest computed tomography (CT) scan each year outside of lung cancer screening programs. However, the cost and pattern of subsequent IPN workup have not been described for real-world settings. …”
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Adaptive genetic algorithm based deep feature selector for cancer detection in lung histopathological images by Avigyan Roy, Priyam Saha, Nandita Gautam, Friedhelm Schwenker, Ram Sarkar

“…The source code for this work can be found https://github.com/priyam-03/GA-Feature-Selector-Lung-Cancer .…”
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Hospice Care by Suzanna Smith

“…“Recently a friend’s mother, Alice, was diagnosed with lung cancer, and even though she received all the possible treatments, the cancer was incurable. …”
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Squeeze-and-Excitation Vision Transformer for Lung Nodule Classification by Xiaozhong Xue, Yanhe Ma, Weiwei Du, Yahui Peng

“…Lung cancer is one of the deadliest cancers. Early diagnosis of lung cancer can increase the 5-year survival rate to 70%, and the lung nodule classification is the basis for early diagnosis. …”
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Characterization, Distribution, and Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in the Workplaces of an Electric Arc Furnace (EAF) Steelmaking Factory by Ying-Fang Wang, Riza P. Gumaling, Mei-Ru Chen, Yu-Chieh Kuo, Lin-Chi Wang

“…Abstract This study measured workplace polycyclic aromatic hydrocarbons (PAHs) in an electric arc furnace (EAF) factory during regular and maintenance periods and estimated workers’ lung cancer risk from 40 years of exposure using Monte Carlo Simulation. …”
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Risk factors for emergency presentation with lung and colorectal cancers: a systematic review by Una MacLeod, Elizabeth D Mitchell, Benjamin Pickwell-Smith

“…Higher deprivation increased the likelihood of lung cancer EP, but evidence for colorectal was less conclusive. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

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Colorectal cancer: state-of-the-art by Ya. S. Tsimmerman

“…CRC is the 2nd most common cause of morbidity after the lung cancer. It includes hereditary non-polyposis CRC (Lynch syndrome), hereditary CRC at familial adenomatosis and sporadic (non-hereditary) CRC. …”
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Indications, contributing factors, and short-term outcomes of pneumonectomy: an 8-year retrospective study in a resource-limited setting by Mekonnen Feyissa Senbu, Dereje Gulilat, Hiwot Tadesse Habtamu

“…Today, pneumonectomy is primarily indicated for non-small cell lung cancer (NSCLC) worldwide. However, it carries a higher risk of morbidity and mortality compared to less extensive lung resections. …”
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CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

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Assessing Lung and Skin Cancer Risks for Steel and Iron Manufacturing Industry Workers Exposed to Polycyclic Aromatic Hydrocarbons by Ying-Fang Wang, Yu-Chieh Kuo, Ming-Yeng Lin, Perng-Jy Tsai

“…The estimated lifetime excessive lung cancer risks for the latter (2.09 × 10−3) were lower than that of the former (3.43 × 10-3–8.84 × 10−3), they were all higher than the significant risk (10−3) defined by the US Supreme Court. …”
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A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review by Zhihua Li, Jian Chu, Wennan Shen, Junnan Chen, Yuemei Dong, Manze Zhang, Nan Zhao, Wei Zhao, Haoran Zha, Ning Wang, Yalin Han, Zhaoxia Li

“…Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. …”
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A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights by Junxi Hu, Junxi Hu, Shuyu Tian, Shuyu Tian, Qingwen Liu, Qingwen Liu, Jiaqi Hou, Jiaqi Hou, Jun wu, Jun wu, Xiaolin Wang, Xiaolin Wang, Yusheng Shu, Yusheng Shu

“…Additionally, variations were noted in the IC50 values for key lung cancer medications such as Cisplatin, Docetaxel, and Paclitaxel. …”
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Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform by Alexia Exarchos, Ariel B. Bourla, Maneet Kaur, Katja Schulze, Sophia Maund, Yi Cao, Yihua Zhao, Elizabeth H. Williams, Sarah C. Gaffey, Richard Zuniga, Shaily Lakhanpal, Vladan Antic, Michelle Doral, Johanna Sy, Neal J. Meropol, Anne C. Chiang

“…Methods: Adults with stage IV or recurrent metastatic non-small cell lung cancer or extensive-stage small-cell lung cancer were enrolled at 23 US sites upon initiating a standard line of therapy. …”
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Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…Therefore, a better understanding of the molecular mechanism responsible for T cell senescence in the TME and development of novel strategies to prevent effector T cell senescence are urgently needed for cancer immunotherapy.Methods Senescent T cell populations in the TMEs in mouse lung cancer, breast cancer, and melanoma tumor models were evaluated. …”
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Role of aspirin in cancer prevention by Meng Sun, Jun Yu, Jie Wan, Xiaoyun Dou, Xiaoying Chen, Fang Ye

“…The available evidence shows that aspirin can effectively prevent and treat diseases such as rectal, gastric, ovarian, prostate, and lung cancer. Aspirin has been extensively studied for the prevention and treatment of colorectal cancer. …”
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Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis by Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter S. Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu

“…Long-term exposure to hexavalent chromium [Cr(VI)] has been linked to lung cancer, and cyclooxygenase-2 (COX-2) is a well-known inflammatory factor. …”
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