The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research by Jafal Nader-Mugurel, Stoleru Smaranda, Zugravu Aurelian, Orban Carmen, Popescu Mihai, Marin Ruxandra Cristina, Fulga Ion-Gigel

Subjects: “…morphine…”
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Protocol to study the role of medial entorhinal cortex-basolateral amygdala circuit in context-induced retrieval of morphine withdrawal memory in mice by Yali Fu, Ting Ye, Ming Chen, Bin Lai, Ping Zheng

“…Summary: The medial entorhinal cortex (MEC) is crucial for context memory, yet its role in context-induced retrieval of morphine withdrawal memory remains to be investigated. …”
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Jack London and White Fang: a lost struggle by Zilberstein, Gleb, Zilberstein, Svetlana, Rocco, Richard M., Righetti, Pier Giorgio

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Clinical Benefits of Parasternal Block with Multihole Catheters when Inserted before Sternotomy by Vedat Eljezi, Crispin Jallas, Bruno Pereira, Melanie Chasteloux, Christian Dualé, Lionel Camilleri

“…In 23/26 patients (88%), the mean pain score at cough was ≤≤3.5/10 and the treatment was considered successful. Morphine consumption over 48 h was significantly lower in the intervention group compared to the control group 7 mg [6; 21] versus 142 mg [116; 176] (P < 0.001). …”
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Evaluation of postoperative pain on Transversus Abdominis Plane block and Erector Spinae Plane block in patients undergoing gynecological surgery: a prospective, comparative study by D. Tavianto, O. M. Pison, Azka Putra Rakhmatullah

“…CONCLUSION: ESP block results in a lower postoperative pain score NRS value and reduces the need for morphine in post-gynecological surgery patients with a median incision compared to the TAP block. …”
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The perioperative analgesic effects of thoracolumbar interfacial block and erector spinae plane block for open lumbar fusion: a randomized controlled trial by V. H. Phuong, Tran Viet Duc, N. T. Duyen, N. H. Tu

“…The intraoperative fentanyl and morphine consumption at 12 and 24 hour postoperatively were recorded. …”
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Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial by Hanane Barakat, Linda Gholmieh, Jessy Abou Nader, Vanda Yazbeck Karam, Obey Albaini, Mohamad El Helou, Rony Al Nawwar

“…Independent samples t-test or Mann–Whitney U test was used to assess for differences across the two groups. Results PACU morphine consumption, total postoperative morphine consumption, anti-emetic requirements up to 48 h after surgery, and pain levels after surgery were not statistically significantly different between OFA and OBA groups. …”
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Global cervical cancer elimination: quantifying the status, progress, and gaps by Liangru Zhou, Yi Li, Hongyun Wang, Ruixi Qin, Zhen Han, Ruifeng Li

“…The 10 countries with the highest annual opioid consumption (excluding methadone) for CC, in oral morphine equivalence per capita (2017), were all HICs. …”
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Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model. by Zubair Khalid Labu, Samira Karim, Md Tarekur Rahman, Md Imran Hossain, Sarder Arifuzzaman, Md Shakil

“…<h4>Results</h4>In hot plate method, the highest pain inhibitory activity was found at a dose of 500 mg/kg of crude extract (3.37 ± 0.31 sec) which differed significantly (P < 0.01 and P < 0.001) with that of the standard drug morphine (6.47 ± 0.23 sec). The extract significantly prolonged reaction latency to thermal-induced pain in hotplate model. …”
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Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-expl... by Yanhua Zhao, Zhisheng Lu, Xuesong Song, Haihui Xie, Xungang Xiao, Guonian Wang, Qi Zhou, Qingmei Zhang, Liang Liu, Zhijian Lan, Ning Bai, Haiyan Wang, Zhihao Pan, Liang Dong, Xianzhong Lin, Gang Chen, Qinghui Wang, Jiangtao Dong, Jia Deng, Yongshan Nan, Jiaqiang Zhang, Xiaohua Zhou, Yanjuan Huang, Yongquan Chen, Huanzhong He, Ye Yang, Dengpan Yao, Jintai Jia, Shuan Jin, Yafeng Zhang, Zhonghui Luo, Jiangang Li, Linzhong Zhang, Fang Wang, Juehua Jing, Jiang Zhu, Lin Li, Guangda Wang, Huajing Guo, Qiang Wang, Diansan Su, Weifeng Yu, Xiyao Gu

“…In Phase II, 121 patients were divided into four groups to receive varying patient-controlled analgesia (PCA) doses of SHR8554 or morphine. Phase III involved 320 patients with similar groupings, including a placebo group. …”
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Pain catastrophizing is associated with high-dose opioids in patients with cancer pain by Simon van Rysewyk, Melanie Lovell, Paul Glare

“…At referral, most patients were on strong opioids, with many on high doses (>100 mg oral morphine equivalents (OME) per day). Despite higher doses of opioids, pain interference, depression, anxiety, self-efficacy, and catastrophizing scores were worse in patients with severe pain. …”
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Cost of Intravenous Analgesia for the Management of Acute Pain in the Emergency Department is Substantial in the United States by Pamela P. Palmer, Judith A. Walker, Asad E. Patanwala, Carin A. Hagberg, John A. House

“…The mean cost per encounter of IV administration of an initial dose of the three most frequently prescribed opioids were: morphine $145, hydromorphone $146, and fentanyl $147. …”
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Use of a Non-Pharmacological Pain Relief Kit to Reduce Opioid Use Following Orthopedic Surgery: A Prospective Randomized Study by Denis J O'Hara, Timothy F Tyler, Malachy P McHugh, Susan Y Kwiecien, Tyler Bergeron

“… # Results There was no significant difference in total opioid use between the treatment (108±252 milligram morphine equivalents) and control groups (132±158 MME; p=0.696). …”
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Effects of local infiltration of analgesia and tranexamic acid in total knee replacements: safety and efficacy in reducing blood loss and comparability to intra-articular tranexami... by Harish Sivasubramanian, Cheryl Marise Peilin Tan, Lushun Wang

“…They also received pericapsular infiltration consisting of 0.5 mL of adrenaline, 0.4 mL of morphine, 1 g of vancomycin, 1 mL of ketorolac and 15 mL of ropivacaine. …”
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Psychiatric Symptoms in Acute Intermittent Porphyria - Case Report and Course of Treatment Using Placebo by Waldemar Kosiba, Dominika Prystacka-Szar, Jakub Siemko, Wojciech Kupczak

“…In the treatment, glucose infusions, morphine, psychiatric and psychological therapy were used - saline solution was administered as a placebo. …”
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Illicit drug use derived from wastewater-based epidemiology in Iran, their removal during wastewater treatment, and occurrence in receiving waters by Anvar Asadi, Shabnam Zarei, Nebile Daglioglu, Evsen Yavuz Guzel, Neda Ravankhah

“…Among the analytes measured, morphine and codeine exhibited the most prevalent occurrence and highest concentration levels in all the samples. …”
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Peripheral Nerve Blocks Are Associated With Decreased Early Medical Complications, Dislocations, and Opioid Consumption Following Total Hip Arthroplasty by Brian P. McCormick, MD, Sean B. Sequeira, MD, Mark D. Hasenauer, MD, Robert P. McKinstry, MD, Frank R. Ebert, MD, Henry R. Boucher, MD

“…Total cost and perioperative opioid consumption in morphine milligram equivalents (MMEs) per day were also evaluated and compared between groups. …”
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The use of strong analgesics for prehospital pain management in children in the region of Southern Denmark: a register-based study by Josefine Tvede Colding-Jørgensen, Gina Maj Graven Brandstrup, Vibe Maria Laden Nielsen, Josefine Gradman, Line Anker Bang Thybo, Peter Martin Hansen, Daniel Wittrock, Stig Nikolaj Fasmer Blomberg, Helle Collatz Christensen, Søren Mikkelsen

“…In one in seventeen of all prehospital contacts with children, fentanyl, alfentanil, morphine and/or s-ketamine was administered. Three-quarters of the doses of strong analgesics were administered to patients older than 10 years. …”
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Clinical and Economic Outcomes Associated With Use of Liposomal Bupivacaine Versus Standard of Care for Management of Postsurgical Pain in Pediatric Patients Undergoing Spine Surge... by Robert Tracy Ballock, John Seif, Ryan Goodwin, Jennifer H. Lin, Jessica Cirillo

“…Outcomes included in-hospital postsurgical opioid consumption (morphine milligram equivalents [MMEs]), opioid-related adverse events (ORAEs), LOS (days), and total hospital costs. …”
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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…Importantly, ARIP exerted an opioid-sparing effect in vivo, as intrathecal injection of ARIP potentiated morphine’s analgesic effect in the tail-flick test, consistent with previous findings of genetic inhibition of β-arrestins. …”
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