Dynamics of agonist-evoked opioid receptor activation revealed by FRET- and BRET-based opioid receptor conformation sensors by Sina B. Kirchhofer, Claudia Kurz, Lorenz Geier, Anna-Lena Krett, Cornelius Krasel, Moritz Bünemann

“…Abstract The opioid receptor family, particularly the µ opioid receptor, are the main drug targets in the management of severe pain. …”
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Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study by Anne Bouthillier, Gabriel Bastien, Christina McAnulty, Hamzah Bakouni, Bernard Le Foll, M. Eugenia Socias, Didier Jutras-Aswad

Subjects: “…Opioid use disorder…”
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Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial by Hanane Barakat, Linda Gholmieh, Jessy Abou Nader, Vanda Yazbeck Karam, Obey Albaini, Mohamad El Helou, Rony Al Nawwar

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The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research by Jafal Nader-Mugurel, Stoleru Smaranda, Zugravu Aurelian, Orban Carmen, Popescu Mihai, Marin Ruxandra Cristina, Fulga Ion-Gigel

“…Opioids represent one of the key pillars in postoperative pain management, but their use has been associated with a variety of serious side effects. …”
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Opioid Prescribing Trends by Croatian Dentists - Is there a Reason for Concern? by Lara Vranić, Krešimir Bašić, Ivana Šutej

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Disparities in Opioid Use Disorder Treatment Admissions in the United States by Peter J. Mallow, Michael Mercado, Michael Topmiller

“…**Objectives:** The Cincinnati region has been at the epicenter of the nation’s unfolding opioid epidemic. The objectives of this study were twofold: (1) to compare the Cincinnati region to the United States in length of time to obtain treatment and planned medication-assisted therapy for the treatment for opioid use disorder (OUD); and (2) to assess racial disparities within the Cincinnati region in wait time and type of treatment. …”
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Pain catastrophizing is associated with high-dose opioids in patients with cancer pain by Simon van Rysewyk, Melanie Lovell, Paul Glare

“…At referral, most patients were on strong opioids, with many on high doses (>100 mg oral morphine equivalents (OME) per day). …”
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Is It Still Prohibited to Perform Spinal Anesthesia in Patients with Advanced Heart Disease? by Maryam Vosoughian, Shide Dabir, Faramarz Mosaffa

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Perceptions and attitudes of medical students toward opioid education: A qualitative study by Angelina Luciano, Mara Schenker, Dawn L. Comeau, Courtney R. Yarbrough, Nicholas A. Giordano

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Treatment of irritable bowel syndrome: the past, present and future by V. T. Ivashkin, Ye. A. Poluektova, O. S. Lyashenko, D. V. Reykhart

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Perspectives of substance use disorder counselors on the benefits and drawbacks of medications for opioid use disorder by Nicholas C. Cardamone, Rebecca E. Stewart, Kyle M. Kampman, Steven C. Marcus

Subjects: “…Medications for opioid use disorder…”
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Patients' perspectives on buprenorphine subcutaneous implant: a case series by Claudio Pierlorenzi, Marco Nunzi, Sabino Cirulli, Giovanni Francesco Maria Direnzo, Lucia Curatella, Sandra Liberatori, Annalisa Pascucci, Edoardo Petrone, Generoso Ventre, Concettina Varango, Maria Luisa Pulito, Antonella Varango, Cosimo Dandolo, Brunella Occupati, Roberta Marenzi, Claudio Leonardi

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Assessing medical students’ beliefs about the opioid crisis and their post-graduation plans: a cross-sectional study by Samuel Borgemenke, Nicholas Durstock, Elizabeth A. Beverly

Subjects: “…Opioids…”
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Risk Factors Associated with Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients with Osteoarthritis by Stuart Silverman, Patricia Schepman, J. Bradford Rice, Craig G. Beck, William Pajerowski, Alan G. White, Sheena Thakkar, Rebecca L. Robinson, Birol Emir

“…**Objective:** Opioids are associated with negative clinical outcomes, including increased risk of falls and fractures. …”
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Estimating the Prevalence of Opioid use Disorder in the Cincinnati Region using Probabilistic Multiplier Methods and Model Averaging by Peter J. Mallow, Nila Sathe, Michael Topmiller, Jennifer Chubinski, Dillon Carr, Roni Christopher

“…**Background:** Opioid use disorder (OUD) and its consequences have strained the resources of health, social, and criminal justice services in the Cincinnati region. …”
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Identifying Priority Areas for Increasing the Supply of Medication-Assisted Treatments for Opioid Use Disorder: A Geospatial Approach by Michael Topmiller, Peter J. Mallow, Aaron T. Vissman, Jene Grandmont

“…**Background:** The opioid epidemic has disproportionately affected several areas across the United States (US), with research indicating that these areas may be underserved and lack access to sufficient medication-assisted treatment (MAT) options. …”
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Peripheral Nerve Blocks Are Associated With Decreased Early Medical Complications, Dislocations, and Opioid Consumption Following Total Hip Arthroplasty by Brian P. McCormick, MD, Sean B. Sequeira, MD, Mark D. Hasenauer, MD, Robert P. McKinstry, MD, Frank R. Ebert, MD, Henry R. Boucher, MD

“…The purpose of this study was to evaluate the association between PNBs and postoperative complication rates, healthcare utilization, and opioid consumption following elective THA. Methods: Opioid-naive patients who received PNBs on the same day as undergoing THA for degenerative etiologies were identified from a large national database and matched 1:5 to a control cohort using propensity scoring. …”
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Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity by Ryan P.D. Alexander, Kevin J. Bender

“…Summary: Opioids regulate circuits associated with motivation and reward across the brain. …”
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Association Between Vaso-Occlusive Crises and Opioid Prescriptions Among Patients with Sickle Cell Disease: A Retrospective Claims-Based Study by Hyeun Ah Kang, Jamie C. Barner, Kristin M. Richards, Menaka Bhor, Jincy Paulose, Abdullah Kutlar

“…The aim of this study was to examine the association between VOC events and opioid use and assess the association between opioid prescriptions and health care resource utilization among SCD patients. …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Introduction More than 2 million individuals in the USA have an opioid use disorder (OUD). Methadone maintenance treatment is the gold standard of medication-based treatment for OUD, but high-dose methadone is associated with cardiotoxicity and respiratory complications, among other side effects. …”
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