Therapeutic efficacy of LysGH15 against necrotising pneumonia caused by Staphylococcus aureus in a rabbit model by Bowei Zhang, Liran Song, Yongran Wang, Meimei Zhang, Chong Chen, Hui Ning, Li Wang, Cao Qiu, Xinwu Wang, Changjiang Sun, Xin Feng, Wenyu Han, Wenyu Han, Bin Wang, Yalu Ji, Jingmin Gu, Jingmin Gu

“…IntroductionStaphylococcus aureus (S. aureus) is one of the most important zoonotic pathogens and can be transmitted to humans through the meat diet routes, causing necrotising pneumonia.MethodsThis study investigated the therapeutic effect of bacteriophage lysin LysGH15 on necrotising pneumonia in rabbit model caused by S. aureus.ResultsIn the in vitro experiments, 50 μg/mL LysGH15 not only significantly reduced the viable count (approximately 3.24 × 106 CFU/g) of chicken meat stored at 4°C for 48 h but also effectively reduced the viable count of chicken meat thawed at 4°C and 30°C, with reductions of approximately 1.42 × 106 CFU/g and 2.78 × 106 CFU/g, respectively. …”
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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecie... by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

“…It is the causative pathogen of the granulomatous inflammatory enteritis in ruminants, Johne’s Disease. …”
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Protective potential of structural proteins of the SARS-CoV-2 virus in protecting against COVID-19 by Inna V. Dolzhikova, Daria M. Grousova, Ilya D. Zorkov, Anna A. Ilyukhina, Anna V. Kovyrshina, Olga V. Zubkova, Olga D. Popova, Tatiana A. Ozharovskaya, Denis I. Zrelkin, Daria M. Savina, Ekaterina G. Samokhvalova, Amir I. Tukhvatulin, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…Due to the high rate of variability of the pathogen, in this study we analyzed the variability of the structural proteins of the SARS-CoV-2 virus and compared their protective potential in protecting animals from COVID-19. …”
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Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Using a preclinical murine sepsis model, we found that both PKCα knockout and the use of a PKCα-inhibitor midostaurin successfully restored liver function without hindering the host’s response or ability to clear the pathogen, highlighting PKCα’s vital role in excretory liver failure. …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…We also carried out additional validations including colocalization, linkage disequilibrium check and host–pathogen interactome predictions. We integrated MR findings with clinical trial evidence from several drug gene related databases to identify drugs with repurposing potential. …”
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Chromosome-level genome sequencing and assembly of the parasitoid wasp Leptopilina myrica by Zhi Dong, Zixuan Xu, Junwei Zhang, Yulong Guo, Qichao Zhang, Lan Pang, Ting Feng, Wenqi Shi, Yifeng Sheng, Jianhua Huang, Jiani Chen

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Comparative functional analysis of a new CDR1-like ABC transporter gene in multidrug resistance and virulence between Magnaporthe oryzae and Trichophyton mentagrophytes by Jing Wang, Chenwen Xiao, Shuang Liang, Muhammad Noman, Yingying Cai, Zhen Zhang, Xueming Zhu, Rongyao Chai, Haiping Qiu, Zhongna Hao, Yanli Wang, Jiaoyu Wang, Guolian Bao, Guochang Sun, Fucheng Lin

“…ABC transporters play pivotal roles in multidrug resistance in fungi, with some ABC proteins indispensable for the pathogenicity of plant fungal pathogens. However, the roles of ABC proteins in animal pathogenic fungi, and the functional connections between ABC homologues in plant and animal pathogenic fungi are largely obscure. …”
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The antimicrobial susceptibility patterns of diabetic foot ulcers in the South African public healthcare sector by M J Turner, S Leigh-de Rapper, T P Mokoena, S van Vuuren

“…Each sample swab was spread onto blood agar plates, and thereafter individual pathogens were isolated. The antimicrobial susceptibility patterns of all isolated pathogens were determined using zone of inhibition measurements. …”
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A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence by Hennart, Mélanie, Crestani, Chiara, Bridel, Sébastien, Armatys, Nathalie, Brémont, Sylvie, Carmi-Leroy, Annick, Landier, Annie, Passet, Virginie, Fonteneau, Laure, Vaux, Sophie, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain

“…Phylogenetic lineages Gravis and Mitis contrasted strikingly in their pathogenicity-associated genes. Conclusions: This work provides a bioinformatics tool and global population framework to analyze C. diphtheriae genomes, revealing important heterogeneities in virulence and resistance features. …”
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Citrus Diseases Exotic to Florida: Huanglongbing (Citrus Greening) by Kuang-Ren Chung, R. H. Briansky

“… Citrus is susceptible to a large number of diseases caused by plant pathogens. Economic losses due to plant diseases can be severe, but fortunately, not all pathogens attacking citrus are present in Florida. …”
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Citrus Diseases Exotic to Florida: Huanglongbing (Citrus Greening) by Kuang-Ren Chung, R. H. Briansky

“… Citrus is susceptible to a large number of diseases caused by plant pathogens. Economic losses due to plant diseases can be severe, but fortunately, not all pathogens attacking citrus are present in Florida. …”
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Guide to Identifying and Controlling Postharvest Tomato Diseases in Florida by Jerry A. Bartz, Gary E. Vallad, Steven A. Sargent

“… Pathogens are present in all tomato production areas and are most numerous when the weather becomes warm and wet. …”
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Guide to Identifying and Controlling Postharvest Tomato Diseases in Florida by Jerry A. Bartz, Gary E. Vallad, Steven A. Sargent

“… Pathogens are present in all tomato production areas and are most numerous when the weather becomes warm and wet. …”
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Case report: identification of novel variant in SLC26A2 gene and preimplantation genetic testing for monogenic disorders in preventing diastrophic dysplasia by Ziravard N. Tonyan, Yulia A. Nasykhova, Maria M. Danilova, Elena S. Shabanova, Olesya N. Bespalova, Igor Y. Kogan, Andrey S. Glotov

“…This allowed us to identify linkage groups associated with the analyzed pathogenic variants during the in vitro fertilization cycle with PGT-M, enabling the selection of an embryo that did not inherit pathogenic variants from either parent. …”
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Impact of Tomato Varieties and Maturity State on Susceptibility of Tomatoes to Salmonella by Massimiliano Marvasi, George Hochmuth, Max Teplitski

“… Non-typhoidal Salmonella has emerged as one of the problematic human pathogens associated with fresh produce, nuts, and complex foods containing them. …”
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Impact of Tomato Varieties and Maturity State on Susceptibility of Tomatoes to Salmonella by Massimiliano Marvasi, George Hochmuth, Max Teplitski

“… Non-typhoidal Salmonella has emerged as one of the problematic human pathogens associated with fresh produce, nuts, and complex foods containing them. …”
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A new atypical splice mutation in PKD2 leading to autosomal dominant polycystic kidney disease in a Chinese family by Junlin Zhang, Yiting Wang, Yingwang Zhao, Fang Liu

“…These findings suggested that the atypical splice site alteration, IVS6+5G>C, in the PKD2 gene was the potential pathogenic mutation leading to ADPKD in this Chinese family. …”
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Limited transmission of avian influenza viruses, avulaviruses, coronaviruses and Chlamydia sp. at the interface between wild birds and a free-range duck farm by Chloé Le Gall-Ladevèze, Benjamin Vollot, Julien Hirschinger, Laëtitia Lèbre, Rachid Aaziz, Karine Laroucau, Jean-Luc Guérin, Mathilde Paul, Julien Cappelle, Guillaume Le Loc’h

“…Abstract Recent outbreaks of highly pathogenic avian influenza in Europe have raised questions regarding the epidemiological role of commensal wild birds on free-range poultry farms. …”
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Optimized production and antiviral activity evaluation of recombinant chicken interferon-alpha using an improved Baculovirus expression system by Yuxia Zhang, Wenwen Dong, Feng Li, Kai Meng, Guiming Li, Xiaoyuan Yuan

“…Despite extensive vaccination efforts, certain pathogens continue to pose significant challenges to the poultry industry. …”
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Malaria exposure remodels the plasma proteome of Ghanaian children by Aisha M. Mohammed, Charles Ochieng’ Olwal, Andrea Fossati, Nancy K. Nyakoe, Jacqueline M. Fabius, Martin Gordon, Benjamin J. Polacco, Danielle L. Swaney, Gordon A. Awandare, Nevan J. Krogan, Mehdi Bouhaddou, Yaw Bediako

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