Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Abstract Background Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome characterized by a high familial incidence of various malignancies. It results from pathogenic/likely pathogenic heterozygous constitutional variants of the TP53 gene. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…The rise of multidrug-resistant (MDR) fungal pathogens poses a serious global threat to human health. …”
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Irritable bowel syndrome: pathophysiological and clinical issues by V. T. Ivashkin, Ye. A. Poluektova

“…Treatment of patients will allow to optimize further investigations of certain etiological, pathogenic factors, to carry out differential diagnostics of IBS more clearly.…”
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Mechanisms of bacterial-to-host interaction and their disorders at inflammatory bowel diseases by Ye. A. Poluektova, O. S. Lyashenko, A. V. Korolev, O. S. Shifrin, V. T. Ivashkin

“…Disorder of barrier function of intestine at IBD patients, in combination to prevalence of opportunistic and pathogenic microorganisms in intestinal biome, results in essential overload of innate and adaptive immune system.Conclusion. …”
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Nutritional support in early phases of acute pancreatitis: fashionable trend and essential reality by Ye. Ye. Achkasov, A. V. Pugayev, G. V. Dyatchina, V. I. Posudnevsky, Zh. G. Nabiyeva, P. V. Melnikov

“…It was demonstrated, that from the pathogenic point of view total parenteral nutrition is most justified in the phase of enzyme toxemia and intermediate phase of AP for 7 to 14 days and more in relation to the initial prognosis of disease severity. …”
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Unravelling the interplay of nitrogen nutrition and the Botrytis cinerea pectin lyase BcPNL1 in modulating Arabidopsis thaliana susceptibility by Antoine Davière, Aline Voxeur, Sylvie Jolivet, Luka Lelas, Samantha Vernhettes, Marie-Christine Soulié, Mathilde Fagard

“…Using mutant strains lacking BcPNL1, we observed reduced pathogenicity, a delay in germination and a lag in triggering the plant defense response. …”
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Recombinant human growth hormone treatment of Floating-Harbor syndrome: a case report and literature review by Qing He, Yi Deng, Lei Xu, Zhe Xu, Yi Ding, Menghui Wu

“…Whole exome sequencing (WES) detected a pathogenic variant (c.7303 C > T, p.R2435X) in the SRCAP gene of this patient, which is a denovo variant. …”
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Trace metals induce microbial risk and antimicrobial resistance in biofilm in drinking water by Bowei Li, Ling Feng, Rakia Chouari, Sofia Samoili, Stefanos Giannakis

“…The overall exposure risk of antibiotic resistance genes (ARGs) increased, whereas Fe(III) enhanced the co-occurrence of ARGs and pathogens, potentially leading to serious hidden microbial risks. …”
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Biological Control of Weeds: Is it Safe? by Carey Minteer, Eutychus Kariuki, James P. Cuda

“…Classical biological control of invasive plants is the use of natural enemies, imported insects and mites or pathogens, to control the target plants. This publication explains the strategies and rules in place to ensure that organisms released for the biological control of weeds are safe and effective. …”
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Disinfection of Horticultural Tools by Geoffrey C. Denny, Gary E. Vallad

“…Vallad, provides assistance to producers and home gardeners in selecting the appropriate method to sterilize or disinfect horticultural tools and implements to prevent the spread of disease-causing pathogens. Published by the UF Department of Environmental Horticulture, August 2009. …”
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Disinfection of Horticultural Tools by Geoffrey C. Denny, Gary E. Vallad

“…Vallad, provides assistance to producers and home gardeners in selecting the appropriate method to sterilize or disinfect horticultural tools and implements to prevent the spread of disease-causing pathogens. Published by the UF Department of Environmental Horticulture, August 2009. …”
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Antimicrobial Activity of <i>Zingiber Officinale</i> and <i>Allium Sativum</i> on some Drug Resistant Bacterial Isolates by S.E. Emmanuel, E.O. Ehinmitan, R.S. Bodunde, J.C. Joseph

“…Increasing multi-drug resistance of pathogens forces researchers to find alternative compounds for treatment of infectious diseases. …”
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Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis by Mengmeng Li, Jiangyi Wang, Qingfeng Liu, Youqing Liu, Wenyao Mi, Wei Li, Wei Li, Jingyi Li

“…Atopic dermatitis and psoriasis have traditionally been considered distinct inflammatory skin diseases with unique pathogenic mechanisms. However, accumulating evidence suggests significant overlap in their immunological pathways, metabolic features, and microbiome characteristics, challenging this conventional dichotomy. …”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

“…The ArcA transcription factor activates genes related to metabolism, membrane permeability, and virulence, and its presence is required for pathogenicity in Salmonella Typhimurium, which can be phosphorylated independently of its cognate sensor, ArcB. …”
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Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

“…Abstract Background Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenicity and pathophysiology. To address this challenge, we propose a high-throughput screening of cellular functionality through an imaging flow cytometry (IFC)-based platform. …”
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E. coli and Salmonella on animal farms: sources, survival and management by Max Teplitski

“… Significant effort has been made by universities and research agencies to help eliminate Salmonella and pathogenic E. coli from animal and dairy farms. This article highlights findings from these recent studies. …”
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E. coli and Salmonella on animal farms: sources, survival and management by Max Teplitski

“… Significant effort has been made by universities and research agencies to help eliminate Salmonella and pathogenic E. coli from animal and dairy farms. This article highlights findings from these recent studies. …”
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Collection of SARS-CoV-2 Virus from the Air of a Clinic within a University Student Health Care Center and Analyses of the Viral Genomic Sequence by John A. Lednicky, Sripriya N. Shankar, Maha A. Elbadry, Julia C. Gibson, Md. Mahbubul Alam, Caroline J. Stephenson, Arantzazu Eiguren-Fernandez, J. Glenn Morris, Carla N. Mavian, Marco Salemi, James R. Clugston, Chang-Yu Wu

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Bloodstream infections at a tertiary hospital in the Gambia - a one-year retrospective study by Paul Rahden, Ebrima Barrow, Haddy Bah, Sheikh Omar Bittaye, David Nygren, Abdoulie Badjan

“…Blood culture positivity-rates and pathogens were described. Antimicrobial susceptibility testing was performed using disk diffusion following the Clinical & Laboratory Standards Institute guidelines. …”
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Preventing Foodborne Illness: Campylobacteriosis by Keith R. Schneider, Renée M. Goodrich, Melissa A. Kirby

“… This is one in a series of facts sheets discussing common foodborne pathogens of interest to food handlers, processors and retailers. …”
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