Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats by Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano

“…Given the enzyme's canonical membrane localization, we implemented pharmacological inhibition using a membrane-impermeant sulfonamide inhibitor in neuronal models of brain ischemia. …”
Get full text

Therapeutic resources used by physiotherapists for the relief of labor pain: a cross-sectional study by Alessandra de Campos Gonçalves, Giovana Garçoni Poli, Clara Maria de Araujo Silva, Ana Carolina Sartorato Beleza, Richard Eloin Liebano

Subjects: Get full text

Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…Frontiers in Pharmacology…”
Get full text

Leveraging AI to optimize vaccines supply chain and logistics in Africa: opportunities and challenges by Sulaiman Muhammad Musa, Usman Abubakar Haruna, Lukman Jibril Aliyu, Mubarak Zubairu, Don Eliseo Lucero-Prisno, Don Eliseo Lucero-Prisno, Don Eliseo Lucero-Prisno

“…Frontiers in Pharmacology…”
Get full text

The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…Frontiers in Pharmacology…”
Get full text

Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…Frontiers in Pharmacology…”
Get full text

Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies by Jifeng Gu, Jifeng Gu, Huishan Zhang, Mei Wang, Yuyang Zhou, Yuyang Zhou, Zhipeng Deng, Rong Shi

“…Frontiers in Pharmacology…”
Get full text

Editorial: The mechanistic investigation and emerging therapies for Friedreich’s ataxia by Yina Dong, Yina Dong, Vijayendran Chandran, Elisabetta Soragni, David R. Lynch, David R. Lynch

“…Frontiers in Pharmacology…”
Get full text

Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis by Kai Tang, Kai Tang, Kai Tang, Wei Deng, Wei Deng, Wei Deng, Wei Deng, Zhiying Huang, Zhiying Huang, Zhiying Huang, Simin Chen, Simin Chen, Simin Chen, Zilin Zhu, Zilin Zhu, Shukun Lin, Shukun Lin, Lubin Zhong, Lubin Zhong, Quanxin Zheng, Quanxin Zheng, Wenhua Zhao, Wenhua Zhao, Zhida Zhang, Zhida Zhang, Ling Mo, Ling Mo, Ling Mo

“…Frontiers in Pharmacology…”
Get full text

Extraction, GC-MS analysis, cytotoxic, anti-inflammatory and anticancer potential of Cannabis sativa female flower; in vitro, in vivo and in silico by Waqas Safir, Arif Malik, Arif Malik, Haleema Saadia, Ayesha Zahid, Jinyao Li

“…Frontiers in Pharmacology…”
Get full text

Advances in hydrogel for diagnosis and treatment for Parkinson’s disease by Peining Zhu, Peining Zhu, Peining Zhu, Peining Zhu, Zenghui Zhao, Zenghui Zhao, Zenghui Zhao, Zenghui Zhao, Yufei Gao, Yufei Gao, Yufei Gao, Yufei Gao

“…Frontiers in Pharmacology…”
Get full text

KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning by Huimin Luo, Huimin Luo, Hui Yang, Hui Yang, Ge Zhang, Ge Zhang, Jianlin Wang, Jianlin Wang, Junwei Luo, Chaokun Yan, Chaokun Yan, Chaokun Yan

“…Frontiers in Pharmacology…”
Get full text

Safety profiles of sevoflurane in pediatric patients: a real-world pharmacovigilance assessment based on the FAERS database by Chuang Yang, Bangjian Deng, Qiang Wen, Pei Guo, Xiang Liu, Chen Wang

“…Frontiers in Pharmacology…”
Get full text

Editorial: Ovarian cancer targeted medication: PARP inhibitors, anti-angiogenic drugs, immunotherapy, and more, volume II by Zhi-Bin Wang, Zhi-Bin Wang, Zhi-Bin Wang, De-Hua Liao, Guang Lei, Zhao-Qian Liu, Zhao-Qian Liu, Nayiyuan Wu, Nayiyuan Wu, Jing Wang, Jing Wang

“…Frontiers in Pharmacology…”
Get full text

The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Frontiers in Pharmacology…”
Get full text

MicroRNAs in atrial fibrillation – have we discovered the Holy Grail or opened a Pandora’s box? by Alkora Ioana Balan, Alina Scridon

“…Frontiers in Pharmacology…”
Get full text

Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders by Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang

“…Frontiers in Pharmacology…”
Get full text