Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. by Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas

“…Here, we delineate pathways of intra- and extracellular siderophore biosynthesis and show that A. fumigatus synthesizes a developmentally regulated fourth siderophore, termed hydroxyferricrocin, employed for conidial iron storage. …”
Get full text

Human Settlements Interactions and Deforestation in Gambari Forest Reserve located in Oluyole Local Government Area (LGA) of Oyo State, Nigeria by E.O. Toyinbo, R.A. Fasasi, C.F. Agbor, C.O. Fakorede

“…It is therefore imperative to regulate the activities of adjoining communities and those within the Gambari forest reserve by appropriate authorities. …”
Get full text

Affordances-in-Practice: How Social Norm Dynamics in Climate Change Publics Are Shaped on Instagram and Twitter by Nathalie Van Raemdonck, Ike Picone, Jo Pierson

“…Social norms are flexible regulating forces of human behavior. They are shaped by humans, whose actions in turn are shaped by their environment, including the online social spaces they venture into. …”
Get full text

Early changes in microRNA expression in Arabidopsis plants infected with the fungal pathogen Fusarium graminearum. by Savio S Ferreira, Suman Pandey, Jesseca Hemminger, Serdar Bozdag, Mauricio S Antunes

“…These short RNA molecules (20-22 nucleotides) have been shown to be important players in the early responses of plants to stresses because they can rapidly regulate the expression levels of a network of downstream genes. …”
Get full text

Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells by HyunJun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben Pathak, William Graff, Alexis LeVee, Jun Wu, Mark A. LaBarge, David Frankhouser, Russell C. Rockne, Patrick Pirrotte, Bin Zhang, Joanne Mortimer, Le Xuan Truong Nguyen, Guido Marcucci

“…Mechanistically, OST-01 induces ferroptosis by downregulating LRP8-regulated selenoproteins, i.e., GPX4. A shift from a basal-mesenchymal to a luminal-epithelial state of breast cancer stem cells (BCSCs) as supported by the downregulation of stemness (e.g., CD44) and mesenchymal (e.g., FN1 and vimentin) markers, along with the upregulation of differentiation markers (e.g., CD24) and luminal-epithelial markers (e.g., CK19), was also observed.…”
Get full text

Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…These drugs reduce inflammation and regulate key biological pathways involved in cancer progression, offering new avenues for prevention and therapy. …”
Get full text

Cyber Security of the Economy and Public Finances: Historiography and Post-War Trajectory of Development by Petrukha Nina M., Petrukha Serhii V., Zhmaiev Anatolii Yu., Synkevych Maksym E.

“…It was found that the emergence and strengthening of the role of artificial intelligence allows for a closer level of correlation between trends in the development of the economy and public finances by adding new data to predictive models, bringing them to the level of big data, identifying threats and risks in them for the development of adaptive anti-crisis-colored regulatory behavioral models for the State regulators, including in terms of creating formal and informal institutional rules for countering cyber threats. …”
Get full text

Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…The ability of SIRT2 to regulate VEGFA expression has been demonstrated. In vivo experiments revealed that SIRT2, VEGFA, and HIF-1α were highly expressed in the kidneys of mice with diabetic nephropathy. …”
Get full text

Disruption of Energy Metabolism and Reactive Oxygen Species Homeostasis in Honglian Type-Cytoplasmic Male Sterility (HL-CMS) Rice Pollen by Wang Mingyue, Zhao Weibo, Feng Xiaoya, Chen Yi, Li Junhao, Fu Jinmei, Yan Yingchun, Chu Zhaohui, Huang Wenchao

“…However, the mechanisms by which sterility genes regulate metabolic alterations and changes in mitochondrial morphology in the pollen of HL-CMS remain unclear. …”
Get full text

Role of microRNA in the risk stratification of ischemic strokes by Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, May Adel Alhamid, Fawaz Al-Mufti

“…It can be used to identify Stroke-Specific microRNA Signatures, identify diagnostic and prognostic values, and regulate Vascular Inflammation, Endothelial Dysfunction, and Thrombus Formation and Resolution. …”
Get full text

Getting the best of carbon bang for mangrove restoration buck by Jingfan Zhang, Zhe Lu, Jinge Zhou, Guoming Qin, Yicheng Bai, Christian J. Sanders, Peter I. Macreadie, Jiacan Yuan, Xingyun Huang, Faming Wang

“…The estimated mangrove ESV in 2019 amounts to $894 billion yr−1, mainly provided by regulating and provisioning services (57.4% and 19.7%). …”
Get full text

Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications by Jialian Wang, Xingyu Tao, Zhengyang Liu, Yuan Yan, Peifeng Cheng, Bin Liu, Huimin Du, Bailin Niu

“…This review focuses on the critical roles of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating “cytokine storms”, oxidative stress, mitochondrial dysfunction, and programmed cell death in SA-ALI, and summarizes the current state and limitations of existing studies on lncRNAs and circRNAs in SA-ALI. …”
Get full text

Psychosocial and mental health in cystic fibrosis in the modern era of care: time to evolve by Beth Smith, Tonia A Douglas, Alexandra L Quittner, Anna M Georgiopoulos, Maggie Harrigan

“…The advent of CF transmembrane conductance regulator modulator therapies is transforming the psychosocial landscape for PWCF with new challenges and evolving psychosocial needs. …”
Get full text

Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco by Abdelmounaim Laabar, Imad Kabach, Sara El Asri, Amr Kchikich, Soufiane Drioua, Ayoub El Hamri, Moulay El Abbes Faouzi

“…They also demonstrated notable α-glucosidase and α-amylase inhibition, suggesting their ability to regulate glucose metabolism. Moreover, their antiglycation effects, marked by the prevention of advanced glycation end products and protein damage, highlight their potential in maintaining cellular integrity.These findings suggest that Sonchus oleraceus and Lobularia maritima extracts possess promising antioxidant, antidiabetic, and anti-inflammatory properties, paving the way for their therapeutic application in managing diabetes, oxidative stress, and related conditions.…”
Get full text

Mélange dehydration and melting beneath South Sandwich Islands arc by Yunchao Shu, Sune G. Nielsen, Veronique Le Roux, Danielle Santiago Ramos, Jerzy Blusztajn, Maureen Auro, Phil T. Leat, Tristan J. Horner

“…Abstract Mechanisms regulating material transfer from subducted slabs to arc magmas remain debated, centered on metasomatized mantle wedge interactions versus mélange mobilization at the slab-mantle interface. …”
Get full text

Effect of Indoleacetic Acid and Zinc Sulphate Application on Growth and Some Physiological Parameters of Cowpea (Vigna sinensis Savi) Plants by Ikbal Muhammed Gharib Tahir, Sargul Ahmad Khudur, Arol Mohsen Anwar

“…This study was conducted in Koya city, Iraq on cowpea (Vigna sinensis Savi) plants California black eye variety by factorial experiment including the effects of foliar spraying of Zinc Sulphate ZnSO4.7H2O (ZS) or the plant growth regulator Indoleacetic Acid C10H9NO2 (IAA). Analysis of data revealed that ZS and IAA application affects significantly on the studied traits. 100 ppm of IAA increased significantly the leaves content of each of chlorophylls a, b, and total, although it decreased the content of total carotenoids. …”
Get full text

SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2 by Katarzyna Blaszczyk, Anna P. Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish, Jolanta Chmielowiec, Omaima M. Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

“…In summary, we identified a molecular mechanism that specifically regulates SC-β-cell proliferation and function, highlighting a unique signaling milieu of SC-β-cells with promise for the robust derivation of fully functional cells for transplantation.…”
Get full text

Stable coding of aversive associations in medial prefrontal populations by Herry, Cyril, Jercog, Daniel

“…Whereas an abundance of evidence suggests a crucial role of the mPFC in regulating fear behaviour, the precise role of the mPFC in this process is not yet entirely clear. …”
Get full text

Computational Study of Trisindoline 5 Against Overexpressed EGFR Protein on Breast Cancer Stem Cell by Nurhayati A.P.D., Fatoni M., Santoso M., Wati F.A.

“…The existing inhibitory drugs used to treat the EGFR that act as the master regulator of the signaling network still have a limited response in breast cancer. …”
Get full text

Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…These drugs reduce inflammation and regulate key biological pathways involved in cancer progression, offering new avenues for prevention and therapy. …”
Get full text