Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Sepsis is a life-threatening organ failure resulting from a poorly regulated infection response. Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. …”
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Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma by Wei-Ting Kuo, Yi-Chen Lee, Jia-Bin Liao, Ching-Jiunn Tseng, Yi-Fang Yang

“…Abstract Sulfatases mediate the sulfation level of cell-surface heparan sulfates to regulate signal transduction, thereby promoting cancer progression. …”
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Platycodin D inhibits tumor proliferation by modulating macrophage polarization through promoting JAK2 ubiquitination by Wei Wu, Jie Zhang, Zijiao Wang, Chuan Cheng, Dongdong Yuan, Li Peng, Le Li

“…This study underscores the potential of PD in regulating TAMs, providing new insights into its potential use in cancer therapy.…”
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Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway by Shan-shan Yang, Min LinHu, Xiao-hua Hu, Si-si Jiang, Wen-yue Hu, Xiao-hong Yang

“…Objective: This study aims to explore how Grem1 regulates the differentiation and signaling activity of mandibular bone marrow mesenchymal stem cells (MBMSCs), affecting their osteogenic differentiation capacity and participating in the pathophysiological mechanism of postmenopausal mandibular osteoporosis. …”
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MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 by Yue Zu, Qianyan Gao, Yisheng He, Qiao Deng, Guodong Li, Xiping Li, Tianze Shang, Xinwei Cheng, Chenglong Zhu, Jianqiao Wang, Dong Liu, Chengliang Zhang

“…Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localization of MRP2; however, PDZK1’s role and regulatory machinery in MRP2-mediated estrogen-induced cholestasis (EIC) remain unclear. …”
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Pengaruh Gaya Kepemimpinan Situasional, Motivasi dan Kompensasi Terhadap Produktivitas Kerja Karyawan by Yuni Pratikno, Bambang Nurakhim, Eric Hermawan, Maulana Arief Rachman Hakim

“…Background: The competition in the business world is so tight, but the development of manufacturing companies that are increasingly showing that the positive trend is related to the role of leaders who are figures who regulate the company's operational system. HR work productivity will increase through the implementation of the impact program of leadership style, appropriate compensation. …”
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Pan-genome analysis and expression verification of the maize ARF gene family by Quan-cai Man, Yan-qun Wang, Shun-juan Gao, Zhi-chang Gao, Zheng-ping Peng, Jiang-hui Cui

“…Auxin transcription factors regulate auxin responses and play crucial roles in plant growth, development, and responses to abiotic stress. …”
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Spatial-temporal evolution of habitat quality in tropical monsoon climate region based on “pattern–process–quality” – a case study of Cambodia by Kang Junmei, Yang Fengshuo, Wang Jun, Liu Yang, Fang Dengmao, Jiang Chengcheng

“…The results show that (1) during 2000–2022, forest in Cambodia covered a wide range, showing a landscape pattern mainly distributed in the east and west. (2) The degree of fragmentation of impervious landscape pattern increased gradually from 2000 to 2022, indicating that it was seriously affected by human activities and natural factors, and with the increase in elevation and slope, the area of various types converted to impervious decreased. (3) During 2000–2022, high habitat quality areas were concentrated in Tonle SAP Lake in the east, southwest, and central part of Cambodia, while low habitat quality areas were concentrated in the central part. (4) Natural factors, socio-economic factors, policies, and regulations all have an impact on the change in land use pattern and habitat quality in Cambodia.…”
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The impact of green technology innovation, pro-environmental behavior and eco-design on green new product success: examine the moderating role of green corporate image by Shahid Mahmood, Asifa Iqbal, El-Sayed M El-kenawy, Marwa M Eid, Amel Ali Alhussan, Doaa Sami Khafaga

“…Environmental consciousness has grown, and businesses have been increasingly compelled to adhere to international treaties and regulations. The present study posits that eco-design, green technology and pro-environmental behavior impact the success of new green products by utilizing green process innovation and green product innovation as mediators, with green corporate image serving as a moderator. …”
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Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer by Tanya Tripathi, Apoorva Chaudhary, Divya Janjua, Udit Joshi, Nikita Aggarwal, Chetkar Chandra Keshavam, Alok Chandra Bharti

“…The study will help in designing effective and novel therapeutic interventions for targeting signaling pathways and other regulators involved in mediating CaCx progression, which will eventually help in effective management of CaCx.…”
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Exploring offshore wind’s potential to enhance energy security in nations with limited land and fuel resources by Kenji Shiraishi, Umed Paliwal, Nikit Abhyankar, Daniel M Kammen, Amol Phadke, Won Young Park

“…While it is a highly valuable resource, OSW nonetheless necessitates significant infrastructure development and potentially faces both stricter regulations and local opposition. In recognition of this, the Limited Onshore Resources scenario reduces direct land use by half but finds only a slight increase in overall costs. …”
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Improving photovoltaic water pumping system performance with ANN-based direct torque control using real-time simulation by Ikram Saady, Btissam Majout, Ismail El Kafazi, Mohammed Karim, Badre Bossoufi, Najib El Ouanjli, Said Mahfoud, Ahmed Althobaiti, Thamer A. H. Alghamdi, Mohammed Alenezi

“…The second controller is responsible for regulating the operation of the induction motor through the switching pulses of the Voltage Source Inverter (VSI). …”
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Tire rubber-derived contaminants 6PPD and 6PPD-quinone reduce attachment and outgrowth of trophoblast spheroids onto endometrial epithelial cells by Jong Geol Lee, Seon Min Lee, Moonjung Hyun, Jeong Doo Heo

“…Gene expression profiling of 6PPD- and 6PPDQ-exposed endometrial epithelial cells revealed that both 6PPD and 6PPDQ differentially regulated a panel of transcript markers toward overall downregulation of receptivity and invasion. …”
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Advancing the accuracy of tyrosinase inhibitory peptides prediction via a multiview feature fusion strategy by Watshara Shoombuatong, Nalini Schaduangrat, Nutta Homdee, Saeed Ahmed, Pramote Chumnanpuen

“…Tyrosinase inhibitory peptides (TIPs), mainly designed to regulate the activity of the enzyme tyrosinase, are of interest in various domains, including cosmetics, dermatology, and pharmaceuticals, due to their potential applications in controlling skin pigmentation. …”
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Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis by Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang

“…The results of glutathione-S-transferase (GST) pull-down and proteomics analyses revealed the involvement of HINT2 in regulating mitochondrial oxidative phosphorylation (OXPHOS) in AP mice. …”
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The Commercial Determinants of Nonalcoholic Beer: Redemption, Revenue, or Men’s Harm Reduction? by John L. Oliffe, Nina Gao, Mary T. Kelly, Trevor Goodyear, Murray Drummond, Christine Levesque, Katherine White

“…We conclude with a discussion about the redemption, revenue, and men’s harm reduction potentials, pragmatically arguing the need to both regulate and incentivize NAB. Proposed are promising directions for future research with the goal of reducing men’s alcohol use and associated harms.…”
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Defense Budget Gaps and Legal Implications of Alternative Financing in Indonesia: A Legal Reform Perspective by Aris Marsudiyanto, Athor Subroto, Bambang Permadi Soemantri Brodjonegoro, A. Hanief Saha Ghafur

“…It critically examines the legal challenges posed by these financing mechanisms, particularly in relation to Indonesia’s existing laws, including Law No. 17 of 2003 on State Finances, Law No. 3 of 2002 on National Defense, and various regulations governing defense industry and national security. …”
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Online illegal wildlife trade in Indonesia: strengthening the regulatory framework and law enforcement by Krismanko Padang, Nuruliawati, Zahrah Afifah, Muhammad Irfan Andriansyah, Andina Auria Dwi Putri, Nur Hafizoh, Irma Hermawati, Ade Indah Muktamarianti, Syaras Yulianti, Niken Wuri Handayani, Sofi Mardiah

“…Our analysis of wildlife legislation, focus group discussions and expert interviews showed that the Government of Indonesia Trade Law (2014) and Law on Electronic Information and Transactions (2008) cannot be used to prosecute online illegal wildlife trade cases because these laws do not acknowledge regulations for protected species. Our study emphasizes the urgency of revising the Conservation Act and changing the definition of trade to include advertisements of protected species. …”
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Cross-Regional Capacity Mechanism for Emergency Power Support in Extreme Weather Events by WU Zifeng, YUAN Jiahai, ZHANG Jian, ZHANG Haonan

“…Based on cross-regional supply and demand theory，the architectural design of the cross-regional capacity mechanism is enhanced by incorporating three critical components： mechanism boundaries and regulations，lower and upper bounds of the capacity compensation price，and frameworks for responsibility and penalties. …”
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A novel roseosiphovirus infecting dinoroseobacter shibae DFL12T represents a new genus by Nana Wei, Longfei Lu, Yingying Li, Bo Ding, Lanlan Cai, Yunlan Yang

“…Marine viruses, particularly those targeting Roseobacter, play crucial roles in regulating microbial communities and biogeochemical processes. …”
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