Correlation between malondialdehyde level and FOXO3 and CASP3 mRNA expression changed in early-onset preeclampsia placenta by Ni Made Wiasty Sukanty, Febriana Catur Iswanti, Syarifah Dewi, Muhammad Faruqi, Alyssa Shafa Andiana, Ani Retno Prijanti

“…Conclusion: These results indicate that cell integrity is still maintained through the autophagy process and the level of apoptosis in the EOPE placenta is regulated by ROS through FOXO3. …”
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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Furthermore, oral administration of high-dose thiamine also regulated HFFD-induced gut microbiota dysbiosis by reshaping its structure and composition of gut microbiota, such as increasing the relative abundance of Actinobacteria and Bifidobacterium pseudolongum, and reducing the relative abundance of Proteobacteria and Ruminococcus gnavus, accompanied by decreased level of gut-derived endotoxin. …”
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Expression of EZH2 and H3K27me3 predicts tumor biology of urothelial carcinoma by Rasheeda Mohamedali, Suvradeep Mitra, Swarnendu Mandal, Prasant Nayak, Amit K. Adhya, Suvendu Purkait

“…Conclusions: This study establishes an important role of the key epigenetic regulators EZH2 and H3K27me3 in the pathobiology of urothelial carcinomas. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…Genetic models of NAFLD developing on background of obesity and metabolicsyndrome represent the second category (animals, with leptin gene deletion – ob/ob, mice resistant to leptin action, – db/db and transgenic mice with excessive expression of styrene-regulating element of protein-1 isoform. Diet-induced models of NAFLD are engendered by modulation of various alimentary factors. …”
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Final-year students’ perceptions of online integrated primary care learning by Aviva Ruch, Joel Francis, Ann Z. George

“…Methods: This explanatory-sequential mixed-methods study was informed by the technology acceptance model, community of inquiry model and self-regulated learning theory. A cross-sectional online survey was followed by focus group discussions (FGDs) (n = 2 and n = 3, respectively). …”
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IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway. by Ruisong Ma, Xiaochun Hu, Wenwen Fu, Xiaorong Hu

“…Interleukin-34 (IL-34) was recently reported to be a new biomarker for atherosclerosis diseases, such as coronary artery disease and vascular dementia. IL-34 regulates the expression of proinflammatory cytokines (IL-17A, IL-1 and IL-6), which are classical cytokines involved in myocardial ischemia‒reperfusion (MI/R) injury. …”
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Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review by Pietro Cappelletto, Claudia Accolla, Martina Preti, Tiziana Pisano, Carmen Barba, Renzo Guerrini

“…Psychiatric disorders associated with temporal lobe epilepsy are relatively frequent, probably in relation to the critical role that some limbic structures in the temporal lobe, such as the amygdala and hippocampus, play in regulating emotions and behavior.…”
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Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…These substances play important role in lipid metabolism regulating expression of the genes (including PPARα) involved in lipid and glucose metabolism. …”
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Comparative gametogenesis and genomic signatures associated with pollen sterility in the seedless mutant of grapevine by Siddhi Chavan, Satish Phalake, Sujata Tetali, Vitthal T. Barvkar, Ravindra Patil

“…Seedlessness in grapes (Vitis vinifera L.) is triggered by two different mechanisms: stenospermocarpy and parthenocarpy. However, the key regulators of seed development and their targets in grapes are not well characterized. …”
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The Effect of Tumor Angiogenesis Agents on Tumor Growth Dynamics: A Mathematical Model by Ali Mohseni, Mohammad Pooyan, Somayeh Raiesdana, Mohammad Bagher Menhaj

“…Tumor-secreted inhibitor factors are essential to regulating the angiogenesis process. However, increasing inhibitor factors via anti-angiogenic drugs would be a more effective therapeutic approach to eradicate metastasis. …”
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Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study. by Nian Liu, Qian Deng, Zining Peng, Danning Mao, Yuanbo Huang, Fanyu Meng, Xiaoyu Zhang, Jiayan Shen, Zhaofu Li, Weitian Yan, Jiangyun Peng

“…However, to confirm the effectiveness of these genes as therapeutic targets, more in-depth mechanistic studies are needed in the future, particularly to explore the feasibility and specific mechanisms of combating disease progression by regulating the expression of these genes.<h4>Conclusions</h4>This study suggests that AD and OA shares common molecular mechanisms. …”
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Gastronomy vs gastro-anomie? Japan’s foodscape by А. V. Malov, S. V. Chugrov

“…Nowadays, washoku is the institutional foundation for a specialized legislative act regulating the procedure of Re-McDonaldization of the population. …”
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Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease by Sukdev Manna, Sankha Shubhra Chakrabarti, Rohit Singh, Indrajeet Singh Gambhir

“…Hepcidin, a liver-derived peptide, has been identified as the key systemic regulator of iron homeostasis. Our study highlights the potential diagnostic role of serum hepcidin in the evaluation of anemia in elderly. …”
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Smokeless, not harmless: Understanding Naswar's cardiovascular risks in the northwestern Pakistan by Ihsanur Rahman, Fayaz Ahmad, Naveed Sadiq

“…Conclusions: This study adds to the body of literature on significant association between Naswar use and CAD, emphasizing the necessity of regulating SLT products like Naswar to mitigate cardiovascular risks.…”
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Review of Decadal Changes in ASEAN Emissions Based on Regional and Global Emission Inventory Datasets by Shimul Roy, Yun Fat Lam, Shauhrat S. Chopra, Md. Mahbubul Hoque

“…The information from this study will be vital for the ASEAN governments to review and update their approved/planned regulations on emission control with prioritizing the sectors aimed at air quality management and environmental sustainability.…”
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Impact of the grazing ban on the forest soil nutrient dynamics in the Sikkim Himalaya, India by Ghanashyam Sharma, Bharat K. Pradhan, Prakash Chhetri

“…Our results confirm that the management of controlled, regulated, and rotational grazing is beneficial for improving the forest ecosystem health in terms of soil nutrient availability.…”
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Genes of Inflammation and Placental Function GWAS Associated with Idiopathic Recurrent Miscarriage in the Kazakh Population by Alexandra Murtazaliyeva, Gulnara Svyatova, Galina Berezina, Gulfairuz Urazbayeva, Aigerim Sadyrbekova

“…One of the causes of this pathology is the occurrence of mutations both in pleiotropic and pathway-specific regulators and in structural genes. The simplest type of such mutations is single nucleotide polymorphisms. …”
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Physiotherapists’ perspectives on the implementation of direct access to physiotherapy services in Saudi Arabia: a cross-sectional study by Hosam Alzahrani, Razaz Shaheen, Osama Mohammed, Elaf Marouf

“…The primary barriers to DAPT identified were laws and regulations (mean=3.69, SD=1.21), physician support (mean=3.59, SD=0.99), entry-level education (mean=3.45, SD=1.17), patient beliefs (mean=3.38, SD=1.24), self-confidence (mean=3.35, SD=1.15) and professional autonomy (mean=3.34, SD=1.22).Conclusion Physiotherapists in Saudi Arabia demonstrate substantial awareness of direct access. …”
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Expression of MxA in esophageal cancer cell lines can influence sensitivity to chemotherapeutic agents but this does not require apoptosis by R. M. Hayes, T. R. O'Donovan, S. L. McKenna

“…Expression of an anti‐viral protein, myxovirus resistance protein A (MxA) is de‐regulated in many cancers, including esophageal cancer, and its activity has been linked to apoptosis. …”
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Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review by Shangwu Liu, Runhong Zhang, Jamal Hallajzadeh

“…It is hypothesized that exercise-induced changes in ncRNA expression may regulate key processes involved in neuroprotection, including neuroinflammation, oxidative stress, protein aggregation, and synaptic function. …”
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