THE DIGITAL FRONTIER: STRATEGIES AND TOOLS FOR CULTIVATING EDUCATIONAL-STRATEGIC COMPETENCE  FOR PRE-SERVICE TEACHERS by Vira Svyrydiuk, Ostap Bodyk, Larysa Kalinina, Nataliya Prokopchuk, Nina Khrystych

“…The intercultural aspect of teaching strategies, which serves as a prominent regulator in the conditions of intercultural communication, is highlighted. …”
Get full text

TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…DNA topoisomerase II-binding protein 1 (TOPBP1) plays a supportive role in regulating the DDR pathway, and its overexpression has been linked to the tumorigenesis of various cancers. …”
Get full text

Amniotic fluid microbiota and metabolism with non-syndromic congenital heart defects: a multi-omics analysis by Wenli Xu, Lu Li, Hong Kang, Meixian Wang, Yanqun Liu, Guicun Wang, Ping Yu, Juan Liang, Zhen Liu

“…Compared to the control group, the case group exhibited 177 metabolites that were significantly increased and 480 metabolites that were down-regulated. The differential metabolites were primarily enriched in the steroid hormone biosynthesis, bile secretion and ovarian steroidogenesis, according to KEGG analysis. …”
Get full text

The COVID-19 pandemic and blood utilisation in South Africa by R Swanevelder, P-L Wessels, V J Louw, A Swarts, M Lennards, K van den Berg

“…Blood utilisation was evaluated against the background of reported COVID‐19 cases and national lockdown regulations. Results. With the onset of the COVID‐19 pandemic, overall RBC utilisation dropped by ~17%. …”
Get full text

Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid–Liquid Phase Separation and Ferroptosis-Related Genes by Wenchao Chen, Ting Zhu, Xiaofan Pu, Linlin Zhao, Senhao Zhou, Xin Zhong, Suihan Wang, Tianyu Lin

“…The interplay between liquid–liquid phase separation (LLPS) and ferroptosis—a regulated form of cell death—has garnered interest in tumorigenesis. …”
Get full text

Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster by Yi Pan, Ke Fan, Linhao Zong, Yantao Luo, Xin Ni, Dong Chen, Jinjun Qian, Fei Ma, Jie Cheng, Miao Guan

“…At the epigenetic level, Cd could perturb fecundity across generations by modulating Dnmt2 expression, a pivotal regulator of methylation processes. Moreover, despite phenotypic recovery in F4, persistent molecular changes indicate enduring toxicity, highlighting the need for vigilance against environmental Cd contamination and its long-term effects. …”
Get full text

An exergy-based analysis for the synthesis of aromatics from biomass by Mohammed Usman, Joseph Akintola, Gabriel Umoh, Joseph Akpan, Ekpotu Wilson, Queen Moses, Philemon Udom, Edose Osagie

“…The chemical process industry has been facing rising energy costs, increasing competition due to rapid globalization, and more stringent government regulations amid growing public concern for the environment, health, and safety. …”
Get full text

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…We further validated PTPRD as a STAT3 phosphatase in the liver, acting as a regulator of peroxisomal fatty acid metabolism. During MASH, low PTPRD led to increased liver steatosis in Ptprd+/− mice and a pronounced unfolded protein response, which impacts insulin signalling. …”
Get full text

Impact of elexacaftor-tezacaftor-ivacaftor in lung transplantation for cystic fibrosis in the United States by Tahuanty A. Pena, MD, MS, Brittany Wright, PharmD, Kalpaj R. Parekh, MBBS, Julia Kleney-Tait, MD, PhD

“…The advent of CF transmembrane conductance regulator (CFTR) modulators, particularly elexacaftor-tezacaftor-ivacaftor (ETI), has significantly improved clinical outcomes for people with CF (pwCF), offering potential alterations in disease progression and transplantation needs. …”
Get full text

Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging by Oliver Lester Saldanha, Jiefu Zhu, Gustav Müller-Franzes, Zunamys I. Carrero, Nicholas R. Payne, Lorena Escudero Sánchez, Paul Christophe Varoutas, Sreenath Kyathanahally, Narmin Ghaffari Laleh, Kevin Pfeiffer, Marta Ligero, Jakob Behner, Kamarul A. Abdullah, Georgios Apostolakos, Chrysafoula Kolofousi, Antri Kleanthous, Michail Kalogeropoulos, Cristina Rossi, Sylwia Nowakowska, Alexandra Athanasiou, Raquel Perez-Lopez, Ritse Mann, Wouter Veldhuis, Julia Camps, Volkmar Schulz, Markus Wenzel, Sergey Morozov, Alexander Ciritsis, Christiane Kuhl, Fiona J. Gilbert, Daniel Truhn, Jakob Nikolas Kather

“…However, the development of AI models is often hindered by manual annotation requirements and strict data-sharing regulations between institutions. Methods In this study, we present an integrated pipeline combining weakly supervised learning—reducing the need for detailed annotations—with local AI model training via swarm learning (SL), which circumvents centralized data sharing. …”
Get full text

tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats by Alireza Majdi, Liyi Chen, Lars E. Larsen, Robrecht Raedt, Myles Mc Laughlin

“…The TN projects to key brainstem nuclei that regulate neurotransmitter release throughout the central nervous system, but the specific pathways involved are not yet well understood. …”
Get full text

Immune-mediated mechanisms in acute osteofascial compartment syndrome: insights from multi-omics analysis by Qinzhen Lu, He Ling, Yonghui Lao, Junjie Liu, Wei Su, Zhao Huang

“…In addition, genes associated with ferroptosis, a form of regulated cell death, are found to be upregulated in the rat model, with non-coding RNAs playing a role in regulatory interactions. …”
Get full text

Disentangling the effects of eutrophication and natural variability on macrobenthic communities across French coastal lagoons by Jones, Auriane G., Schaal, Gauthier, Boyé, Aurélien, Creemers, Marie, Derolez, Valérie, Desroy, Nicolas, Fiandrino, Annie, Mouton, Théophile L., Simier, Monique, Smith, Niamh, Ouisse, Vincent

“…Using correlograms, linear models and variance partitioning, we found that lagoon hydro-morphology (connection to the sea and lagoon surface), which affects the level of environmental variability (salinity and temperature), as well as lagoon-scale benthic habitat diversity (using macrophyte morphotypes) seemed to regulate macrofauna distribution, while eutrophication and associated stressors like low dissolved oxygen, acted upon the existing communities, mainly by reducing species richness and diversity. …”
Get full text

Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2 by Antonietta Coppola, Claudia Cuccurullo, Gianmaria Senerchia, Marica Rubino, Liana Veneziano, Francesco Brancati, Luigi Baratto, Valentina Virginia Iuzzolino, Leonilda Bilo, Pasquale Striano, Raffaele Dubbioso

“…This study suggests that perampanel helps regulate abnormal brain signals and may help managing FAME2 symptoms.…”
Get full text

Newer Generation of Scooters: Polychlorinated Dibenzo-p-dioxin and Dibenzofuran and Polychlorinated Biphenyl Reductions by Hung-Hong Chen, Yun-Hwei Shen, Hsi-Hsien Yang, Jau-Huai Lu, Lin-Chi Wang, Yen-Kung Hsieh, Chia-Fon Lee, Sheng-Lun Lin

“…Consequently, the improvement of electronic fuel injection and onboard diagnostics systems from a carburetor without feedback control not only reduced the regulated pollutants but effectively reduced PCDD/F emissions.…”
Get full text

How can urban expansion and ecological preservation be balanced? A simulation of the spatial dynamics of production-living-ecological spaces in the Huaihe River Eco-Economic Belt by Tonghui Yu, Shanshan Jia, Yu Zhang, Xufeng Cui

“…Overall, considering the vulnerability of production space to further encroachment, future strategies for the Huaihe River Eco-Economic Belt should prioritize protecting high-quality farmland and critical ecological zones, while regulating urban expansion and strengthening land-use planning to ensure PLES sustainability. …”
Get full text

Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Mechanistically, Usp11 sustained the survival of MZ B cells by regulating the ubiquitination of Notch’s ligands, DLL1 and JAG2, thereby promoting immune cell remodeling in the spleen. …”
Get full text

REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy by Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Edward W. Harhaj, Scot R. Kimball, Michael D. Dennis

“…In this investigation, we evaluated the hypothesis that hyperglycemic conditions augment the pro-inflammatory immune response in the kidney by promoting podocyte-specific expression of the stress response protein regulated in development and DNA damage response 1 (REDD1). …”
Get full text

Hubble Space Telescope Observations within the Sphere of Influence of the Powerful Supermassive Black Hole in PKS 0745-191 by Julie Hlavacek-Larrondo, Hyunseop Choi, Minghao Guo, Annabelle Richard-Laferrière, Carter Rhea, Marine Prunier, Helen Russell, Andy Fabian, Jonelle L. Walsh, Marie-Joëlle Gingras, Brian McNamara, Steve Allen, André-Nicolas Chené, Alastair Edge, Marie-Lou Gendron-Marsolais, Michael McDonald, Priyamvada Natarajan, Jeremy Sanders, James F. Steiner, Benjamin Vigneron, Anja von der Linden

“…This process could, in turn, lead to a self-regulating feedback loop. Compared to other BCGs with weaker radio-mode feedback, where rotation is more stable, intense feedback may lead to more chaotic flows, indicating a stronger coupling between jet activity and gas dynamics. …”
Get full text

Validation of SOC Estimation Using OC and EC Concentration in PM2.5 Measured at Seoul by Ha Young Yoo, Ki Ae Kim, Yong Pyo Kim, Chang Hoon Jung, Hye Jung Shin, Kwang Ju Moon, Seung Myung Park, Ji Yi Lee

“…Abstract The organic carbon in the ambient particulate matter (PM) is divided into primary organic carbon (POC) and secondary organic carbon (SOC) by their formation way. To regulate PM effectively, the estimation of the amount of POC and SOC separately is one of the important consideration. …”
Get full text