Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD by Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

“…Oxysterol induced mTORC1 activation and senescence were regulated by ABCA1 lysosomal trapping. Treatment of APOE4-TR mice with cyclodextrin reduced brain oxysterol levels, ABCA1 lysosome trapping, mTORC1 activation, and attenuated senescence and neuroinflammation markers. …”
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Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei by Maznah Alhesain, Ayman Alzu’bi, Ayman Alzu’bi, Ayman Alzu’bi, Niveditha Sankar, Niveditha Sankar, Charles Smith, Charles Smith, Janet Kerwin, Ross Laws, Susan Lindsay, Gavin J. Clowry

“…It was highly expressed by glutamatergic neurons in many thalamic regions by 14 PCW, sometimes but not always in conjunction with its upstream expression regulator FOXP2.ConclusionIn human discrete thalamic nuclei exhibiting discrete gene expression patterns emerge relatively early from a protomap of gene expression. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…A joint MeRIP-seq and RNA-seq strategy was used to identify the target genes regulated by D-2HG-mediated N6-methyladenosine (m6A) modification. …”
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PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis by JinJing Pan, Ping Wang, Linghong Xiong, Wenqing Yang, Jie Li, Kai Yang, Bingyan Li

“…Considering that epithelial-mesenchymal transition (EMT) is downstream of the SOCS3/STAT3/PI3K pathway, our findings also revealed that 1,25(OH)2D3 markedly regulated the expression of EMT markers. Additionally, the inhibitor of STAT3 exhibited inhibitory effects on EMT progression in breast cancer cells. …”
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Designing an Innovative Human Resources Model Based on Perceived Organizational Support Case Study of Qazvin's Government organizations by Hossein Rasouli, Morteza Mousakhani, Mahdi Alvani, parham azimi

“…This adaptation drew extensively from an in-depth review of pertinent laws, regulations, and foundational documents. Conclusion One of the paramount achievements of this research is the formulation of a multi-level model that proficiently measures the optimal combination of organizational support factors and innovative human resources within Qazvin's government organizations. …”
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Sistem Akuaponik untuk Peternakan Lele dan Tanaman Kangkung Hidroponik Berbasis IoT dan Sistem Inferensi Fuzzy by Fachrul Rozie, Iwan Syarif, Muhammad Udin Harun Al Rasyid, Edi Satriyanto

“…This study aims to develop a smart system in aquaponic cultivation by utilizing Internet of Things technology which is equipped with several types of sensors to monitor and control water quality by applying the Fuzzy Inference System (FIS) algorithm to regulate the speed of pool water circulation in order to save electric power on the pump. …”
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Estimation of blue carbon stock in the Liaohe Estuary wetland based on soil thickness and multi-scenario modeling by Lina Ke, Nan Lei, Shilin Zhang, Changkun Yin, Yao Lu, Lei Wang, Qin Tan, Yu Zhao, Quanming Wang

“…They are crucial in mitigating marine pollution, regulating the climate, and balancing carbon budgets. …”
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Coarse-scale vertical distribution of pelagic amphipods in two contrasting seasons of the southern Gulf of Mexico by Marco Violante-Huerta, Laura Sanvicente-Añorve, Miguel Alatorre-Mendieta, Edlin Guerra-Castro

“…As well, we think that the zooplankton biomass (as a measure of food availability) will play a significant role in regulating the amphipod distribution and abundance. …”
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Analisis dan Perancangan Aplikasi Chatbot Menggunakan Framework Rasa dan Sistem Informasi Pemeliharaan Aplikasi (Studi Kasus: Chatbot Penerimaan Mahasiswa Baru Politeknik Astra) by Laksmi Anindyati

“…Rasa core is a base library to regulate the interaction dialogue between chatbots and users. …”
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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…Additionally, hBMSC-EVs can down-regulate the protein levels associated with UPS and oxidative stress. …”
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Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

“…NichNet analysis revealed that a subpopulation of CXCL11 + APOE + fibroblasts regulated the inflammatory response in the pathogenesis of atrophic gastritis. …”
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Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions by Batyrbek I. Aslanov, Daniil V. Azarov, Maria A. Makarova, Elizaveta G. Marysheva, Lyudmila A. Kraeva, Aleksey S. Mokhov, Ekaterina A. Lebedeva, Nikita E. Goncharov, Natalya V. Lebedeva, Dmitry A. Starikov, Victoria V. Kolodzhieva, Dmitry E. Polev, Artemy E. Goncharov

“…Among the pathogenicity factors identified were haemolysins A, E, F, siderophores, including the yersiniabactin gene cluster, a number of adhesion, colonization and invasion factors, as well as the thermostable enterotoxin EAST-1 and genes that characterize enteroaggregative strains of E. coli (the virulence regulator gene eilA and enteroaggregative protein (air)). …”
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Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Through intersection analysis, we pinpointed 30 potential metabolic target genes regulated by NC through IGF2BP3. Based on the expression of these genes, the metabolic scores for each HCC patient were calculated. …”
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miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

“…Glucocorticoid receptor (GR) plays crucial roles in various processes, including stress response, inflammatory response and toxin response, making it a therapeutic target for numerous diseases. microRNA (miRNA) can target and negatively regulate the expression of GR, thus interfering with its normal function. …”
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Genetic evidence for the causal effects of air pollution on the risk of respiratory diseases by Yanjuan Wu, Yuting Zhang, Jingcun Wang, Qiming Gan, Xiaofen Su, Sun Zhang, Yutong Ding, Xinyan Yang, Nuofu Zhang, Kang Wu

“…Strengthening comprehensive air pollution regulations by relevant authorities could potentially mitigate the risk of these diseases.…”
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An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein... by Chenguang Zhang, Huifeng Liu, Xingwei Jiang, Zhihong Zhang, Xinfeng Hou, Yue Wang, Dangdang Wang, Zongjun Li, Yangchun Cao, Shengru Wu, Sharon A. Huws, Junhu Yao

“…Collectively, these findings offer compelling evidence for the host-microbe interactions, wherein cows actively modulate their rumen microbiota through SNP variants to regulate their own lactation performance. Video Abstract…”
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Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration by Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo

“…Compared with the conventional feeding group, autophagy and apoptosis related proteins B-cell lymphoma-2 (BCL2) and anti-thymocyte globulin (ATG) were significantly down regulated in the 5× FAD group, and the expressions of BCL2 and ATG were increased after treatment with DHA and donepezil. …”
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Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays by Sandra Schwarzlose-Schwarck, Mark Reinwald, Torsten Bauer, Florian Hentschel, Til Kiderlen, Dorinja Zapf, Victor Herbst, Stefan Lüth, David Krieger, Werner Dammermann

“…We tested three novel MT antigens of the dormancy survival regulator (DosR) complex, ACR, Rv1733, Rv2626, for improvement of MT specific interferon gamma release assays (IGRA) for diagnosing TB. …”
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Additifs alimentaires : Inventaire des substances ajoutées aux denrées alimentaires de large consommation dans l’Ouest algérien by Zakaria Lotfi Guaouar, Fatima Zahra Besseguir, Mira Gharbi, Imane Kecir

“…Some additives such as caramel dye or SIN150d are found in 3 local cookie brands and 4 local beverage brands (17.5%); sodium benzoate or SIN211 in 12 beverage brands and 2 jam brands (16.09%); butylhydroxyanisol (BHA) or SIN320 in a brand of chocolate, margarine and chips (1.67%).Overall, the labels of the products comply with the Algerian regulations with the exception of some shortcomings such as the nature of the aroma that was not always specified. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Furthermore, ChIP-seq and DLR demonstrated that DSS-Exo affected STAT3 directly binds to SHANK2 promoter regions, forming hydrogen bonds between 5 key amino acids such as GLN-344, HIS-332 and 6 key bases such as DG-258, DG-261. miRNA profiling identified DSS-Exo increased hsa-miR-27a-5p_R-1 to regulated STAT3-SHANK2 and modulating the EMT. Conclusion This study highlighted the innovative use of Danshensu in enhancing MSC-derived exosome therapy for PF. …”
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