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AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription
Published 2024-12-01“…The transcription factor RBPJ that binds to Notch1 transcriptionally regulated IRS-1, CDH5, TNL1, ASCL2, and LRP6. Experimental validation revealed that Notch1-IC can regulate the expression of IRS-1. …”
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683
2003 Handbook of Employment Regulations Affecting Florida Farm Employers and Workers: Plant Closing Notification / Layoffs (WARN Act) [Federal]
Published 2003-07-01“…This information is included in Circular 1200, Handbook of Employment Regulations Affecting Florida Farm Employers and Workers. …”
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684
Cellular electron tomography of the apical complex in the apicomplexan parasite Eimeria tenella shows a highly organised gateway for regulated secretion.
Published 2022-07-01“…The apical complex of apicomplexan parasites is essential for host cell invasion and intracellular survival and as the site of regulated exocytosis from specialised secretory organelles called rhoptries and micronemes. …”
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685
CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis
Published 2025-02-01“…We also used RNA-seq technology to explore the signal pathways and genes it might regulate. Finally, the luciferase assay and qRT-PCR experiment proved that circWDR78 could sponge miR-653-3p, and confirmed that RGS4 is the downstream target of miR-653-3p. …”
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686
Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway
Published 2025-02-01“…Objective: This study aimed to explore the cumulative effects and expression patterns of electroacupuncture (EA) on irisin secretion, observe the effects of EA on the recovery of neurobehavioral function and vascular remodeling after cerebral ischemia, and elucidate the mechanism by which EA promotes vascular remodeling by regulating irisin expression. Methods: A rat model of left middle cerebral artery occlusion (MCAO) was prepared, and EA was performed. …”
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Monosodium glutamate (MSG) exposure induced oxidative stress and disrupted testicular hormonal regulation, exacerbating reproductive dysfunction in male WISTAR rats
Published 2025-03-01“…Conclusion: Chronic MSG exposure disrupts hormonal regulation and induces oxidative stress in a dose-dependent manner, potentially impairing male reproductive health. …”
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689
Endogenous 17β-estradiol regulates sexually dimorphic anxiety responses in zebrafish via the HPI axis and 5-HT/DA pathways
Published 2025-02-01“…These findings strongly suggest that E2 positively regulates sexually dimorphic anxiety responses possibly by modulating plasma cortisol levels and the synthesis and action of 5-HT/DA in the brain.…”
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Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer
Published 2025-02-01“…These results highlight GRN as a critical regulator of chemo-resistance and a potential biomarker for immunotherapy resistance in SCLC. …”
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693
LAMB1 downregulation suppresses glioma progression by inhibiting aerobic glycolysis through regulation of the NF-κB/HK2 axis
Published 2025-02-01“…Conclusions LAMB1 downregulation exerted antitumor effects on glioma cells by regulating the NF-κB/HK2 axis.…”
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694
Fucoxanthin Inhibits the NMDA and AMPA Receptors Through Regulating the Calcium Response on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice
Published 2025-01-01“…Meanwhile, substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc), a pivotal site in regulating orofacial nociceptive transmission via Aδ and C primary afferent fibers, majorly utilize glutamate as the principal excitatory neurotransmitter. …”
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695
2003 Handbook of Employment Regulations Affecting Florida Farm Employers and Workers: Migrant and Seasonal Agricultural Worker Protection Act (MSPA) [Federal]
Published 2003-07-01“…This information is included in Circular 1200, Handbook of Employment Regulations Affecting Florida Farm Employers and Workers. …”
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696
Stepping into a Critical Crossroads? Analysis of the Current Status and Obstacles of the Introduction of the Deep-Sea Mining Draft Exploitation Regulations, and China's Response
Published 2024-09-01Subjects: “…“deep-sea mining draft exploitation regulations”…”
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2003 Handbook of Employment Regulations Affecting Florida Farm Employers and Workers: Migrant and Seasonal Agricultural Worker Protection Act (MSPA) [Federal]
Published 2003-07-01“…This information is included in Circular 1200, Handbook of Employment Regulations Affecting Florida Farm Employers and Workers. …”
Get full text
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699
Genome-wide identification and characterization of the bZIP family in the Mangrove Plant Kandelia obovata and its role in response to stress
Published 2025-02-01Subjects: Get full text
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700
How speculative culture shapes green innovation performance: A dual regional and institutional lens
Published 2025-01-01Subjects: Get full text
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