SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation by Liangying Zhang, Kun Xiao, Shaoting Zhang, Sien Zhao, Zimei Liu, Ming Wang, Kaiyue Qin, Yuanyuan Yu, Shujing Li, Lijun Ma, Jianmin Sun

“…Abstract The suppressors of cytokine signaling 2 (SOCS2) inhibits growth hormone receptor (GHR) signaling by negative feedback in the regulation of metabolism. In this study, we found that GHR upregulates SOCS2 expression, whereas KIT mutations, the key driver mutations of gastrointestinal stromal tumors (GISTs), inhibits SOCS2 expression in GISTs. …”
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Nitrogen source orchestrates pH modulation and secondary metabolism in Trichoderma harzianum by Stefania Vitale, Felice Salzano, Alessia Staropoli, Roberta Marra, David Turrà, Matteo Lorito, Francesco Vinale

“…Results This study reveals how different nitrogen sources fundamentally regulate the physiology and metabolism of Trichoderma harzianum through pH modulation. …”
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Diagnosis of the vegetation cover in the wetlands of La Caimanera Swamp, Colombia and Casitas Wetland, Mexico by means of Landsat and Sentinel-2A images during last four decades by Gastón Ballut-Dajud, Erick Arturo Betanzo-Torres, Luis Carlos Sandoval Herazo

“…Coastal wetlands have gained significant attention in recent decades for their role in climate regulation, particularly through carbon sequestration. …”
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TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

“…Analyzing of the role of TIM‐4 in the immune regulation of PDAC can offer novel insights for immune therapy. …”
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The Paradox of Indonesia Cyberspace Policy and Cooperation: Neoclassical Realism Perspective by Muhammad Abdurrohim, Indah Kumalasari, Fathur Rosy

“…To manage cyberspace in Indonesia, the government has developed ITE Law to regulate Indonesia’s cyberspace and prevent threats coming from within. …”
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The effect of drought stress on Pinellia ternata in terms of physiology and aquaporin genes after Arbuscular mycorrhizal fungal inoculation by Shuang Li, Yajun Liu, Han He, Yike Xu, Xiaochun Sun, Wenjing Huang

“…AMF can alleviate drought stress-induced damage by regulating photosynthetic capacity, osmosis, antioxidant activities, and aquaporin gene expression. …”
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The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases by Mariana Reste, Kristi Ajazi, Ayca Sayi-Yazgan, Ayca Sayi-Yazgan, Radmila Jankovic, Biljana Bufan, Sven Brandau, Espen S. Bækkevold, Florent Petitprez, Malin Lindstedt, Gosse J. Adema, Catarina R. Almeida

“…Therefore, it is important to analyze the complex functions of DCs within TLS in order to enhance our fundamental understanding of immune regulation but also as a possible route to create innovative clinical interventions designed for the specific needs of patients with diverse pathological diseases.…”
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Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma. by Anton W Roodnat, Chelsey Doyle, Breedge Callaghan, Karen Lester, Megan Henry, Carl Sheridan, Declan J McKenna, Colin E Willoughby, Sarah D Atkinson

“…MicroRNAs (miRNAs) are small non-coding RNA species that are involved in regulation of mRNA expression and translation. To investigate what glaucomatous changes occur in the trabecular meshwork and how these changes may be regulated by miRNAs, we performed a bioinformatics analysis resulting in a miRNA-mRNA interactome. …”
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Exploring chitin metabolite profiles and sensitivity differences in Collembola species exposed to teflubenzuron by Saúl Fernandes, Diana Ilyaskina, Matty P. Berg, Marja H. Lamoree, Pim E.G. Leonards, Cornelis A.M. van Gestel

“…This study emphasizes the importance of incorporating metabolomics to understand the differential responses of non-target organisms to pesticides and advocates for species-specific risk assessments in pesticide regulation. The distinct metabolic responses among Collembola species to chitin synthesis inhibitors provide critical insights into their ecological resilience or vulnerability, enhancing our understanding of ecosystem dynamics and the potential ramifications of chemical exposure.…”
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Principles of Rational Nutrition for Managing Constipation by Yu. O. Shulpekova, D. A. Sheptulin, N. V. Shulpekova

“…Flavonoids also play an important role in the regulation of intestinal peristalsis and secretion. …”
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Experimental study of the effects of siestas on the nocturnal sleep quality and thermal comfort levels under thermoneutral environment in summer by Huili Yu, Xue Zhao, Liping Chen, Xiaohui Tian, Shimin Liang, Songtao Hu

“…Furthermore, dopamine (DA) levels, which played important roles in emotional regulation, were measured after the nocturnal sleep. …”
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Impact of sleep chronotype on blood pressure and metabolic markers by Weiwei Huang, Qinglu Wang, Yuan Gao, Jiefeng Wang, Feihao Wang, Jiyou Tang

“…These variations may be linked to the effects of different sleep chronotype on blood pressure regulation or the blood pressure’s autonomous rhythm.…”
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On the specifics of valuing effort: a developmental and a formalized perspective on preferences for cognitive and physical effort by Wolff, Wanja, Stähler, Johanna, Schüler, Julia, Bieleke, Maik

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The Role of Phosphatidylethanolamine-N-methyltransferase (PEMT) Gene rs12449964 Polymorphism in the Development of Acute Pancreatitis and its Complications by T. A. Samgina, Yu. E. Azarova, Yu. V. Kanishchev, V. A. Lazarenko, P. M. Nazarenko, A. V. Polonikov

“…The phosphatidylethanolamine-N-methyltransferase enzyme plays a significant role in the regulation of lipid metabolism by catalyzing the process of methylation of phosphatidylethanolamine to phosphatidylcholine. …”
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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity by Yu-Chieh Chen, Li-Tung Huang, Hong-Ren Yu, Jiunn-Ming Sheen

“…Significance: IP MTX can induce significant cognitive impairment, which is related to the disruption of BBB integrity. miR-155 plays a vital role in the regulation of MTX-induced cognitive impairment, mainly through the maintenance of BBB integrity.…”
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Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment by Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa

“…This was accompanied by down regulation of ferritinophagy inducers and enhancing ferritinophagy inhibitors. …”
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Whole Genome Sequencing Reveals Substantial Genetic Structure and Evidence of Local Adaptation in Alaskan Red King Crab by Carl A. St. John, Laura E. Timm, Kristen M. Gruenthal, Wesley A. Larson

“…Managers have identified stock structure and local adaptation as crucial information to help understand biomass declines and how to potentially reverse them, with regulation and possible stock enhancement. We generated low‐coverage whole genome sequencing (lcWGS) data on red king crabs from five regions: The Aleutian Islands, eastern Bering Sea, northern Bering Sea, Gulf of Alaska, and Southeast Alaska. …”
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Nanobody-thioesterase chimeras to specifically target protein palmitoylation by Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller

“…The temporal and spatial control of these PTMs is central to organism physiology, and mis-regulation of PTMs is a hallmark of many diseases. Here we present an approach to manipulate PTMs on target proteins using nanobodies fused to enzymes that control these PTMs. …”
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Experimental and Computational Analysis of Surgical Mask Effectiveness Against COVID-19 in Indoor Environment by Chin Yan Suen, Helen Hoi Ling Kwok, Yuk Hang Tsui, Ka Hei Lui, Hong Hang Leung, Ka Wo Lam, Karen Pik Shuen Hung, Joseph Kai Cho Kwan, Kin Fai Ho

“…The findings suggest a need to revise the existing regulation of the control policy.…”
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Impacts of Strategic Mobility Restrictions Policies during 2020 COVID-19 Outbreak on Brazil’s Regional Air Quality by Anderson P. Rudke, Daniela S. de Almeida, Ronaldo A. Alves, Alexandra Beal, Leila D. Martins, Jorge A. Martins, Ricardo Hallak, Taciana T. de Almeida Albuquerque

“…Although there was no national regulation regarding mobility restrictions, the results show that the reduction in urban mobility was similar for all the analyzed states. …”
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