Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Their application is based on multiple negative feedback mechanisms involved in pancreatic secretion regulation. The high contents of proteases in the drug «Ermital» allows to relieve pain effectively, reduce number of taken capsules per day. …”
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Writers, readers, and erasers of N6-Methyladenosine (m6A) methylomes in oilseed rape: identification, molecular evolution, and expression profiling by Chaofan Shan, Kui Dong, Dongyu Wen, Ziyi Ye, Fei Hu, Meryem Zekraoui, Jun Cao

“…Brassica napus is a major oilseed crop. The dynamic regulation of m6A modifications by writers, erasers, and readers offers potential targets for improving the quality of this crop. …”
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GLP-1 Receptor Agonists’ Impact on Fertility - A Review by Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec, Silvia Ciraolo, Agnieszka Kulczycka-Rowicka

“…Conclusions: We observe, GLP-1 analogs are often used in regulation of type 2 diabetes. They have proven their ability to impact a variety of hormonal as well as metabolic pathways. …”
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Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…A detailed review of the top 30 revealed 9 promising drugs targeting various mechanisms such as genomic instability, p53 regulation, or TMPRSS2-ERG fusion. Conclusion By expanding our negative data labeling approach to all diseases within the ClinicalTrials.gov database, our method could greatly advance supervised drug repositioning, offering a more accurate and data-driven path for discovering new treatments.…”
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Effect of glyphosate on renal function: A study integrating epidemiological and experimental evidence by Lin Hu, Mingcong Chen, Xiaoran Xue, Mingyi Zhao, Qingnan He

“…The damage to the kidneys caused by glyphosate may be mediated through the regulation of metabolic pathways, and the specific mechanisms require further experimental investigation.…”
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Glymphatic system: a self-purification circulation in brain by Siying Chen, Siying Chen, Huijing Wang, Lini Zhang, Yingying Xi, Yiying Lu, Kailin Yu, Yujie Zhu, Izmailova Regina, Yong Bi, Fang Tong, Fang Tong

“…We hypothesize that AQP4 could be a target for the prevention and treatment of certain brain diseases through the regulation on the glymphatic system.…”
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Taurine inhibits acute ammonia-induced oxidative stress, immune response, and apoptosis of large yellow croaker (Larimichthys crocea) during keep-live transport by Xin Zhao, Zhenkun Xu, Jun Mei, Jing Xie

“…The results showed that ammonia stress might also lead to the up-regulation of stress-related parameter (Hsp70) gene and antioxidant enzymes (SOD, CAT and GPx). …”
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Research on the photoelectrical properties of TiO2-doped V2O5/FTO nanocomposite thin films under thermal and electrical excitation by Xue Chang, Li Yi, Zhang Haoting, He Weiye, Peng Weiye, Dai Wenyan, Yuan Zhen, Lin Ke, Wang Wei, Shi Zhangqing, Liu Hongwei

“…The outstanding optical and electrical regulation properties and the favorable cycling stability make the nanocomposite film expected to be applied in the field of optoelectronic devices.…”
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Analysis of long noncoding gene expression and its interactions with protein-coding genes in vascular endothelial cells in keloids by Yunxiang Luo, Zi Ye, Yi Li, Chau Wei Wong, Shuqia Xu, Yu Deng, Zhicheng Su, Xueqing Li, Yingxiong Huang, Bing Han

“…Conclusions Through the in-depth mining of keloid microarray data using bioinformatic methods, we speculated that VECs can affect the development and progression of keloids by epigenomic regulation via lncRNA‒mRNA interactions.…”
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Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures by Clairet, Colin, Lapalu, Nicolas, Simon, Adeline, Soyer, Jessica L., Viaud, Muriel, Zehraoui, Enric, Dalmais, Berengère, Fudal, Isabelle, Ponts, Nadia

“…Understanding genomic organization and its role in expression regulation is the next gear to understand complex cellular mechanisms and their evolution. …”
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The Impact of Physical Activities on Male Fertility: A Systematic Review by Albert Kapla, Alicja Černohorská, Daria Bednarczyk, Julia Białeta, Karolina Siembab, Katarzyna Rowińska, Michalina Jurkiewicz, Wiktor Garbarczyk, Wiktoria Pysiewicz, Agnieszka Napieralska

“…However, moderation in training load is necessary, as excessive training volume can lead to hormonal regulation issues or simply result in injury in the groin area. …”
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The heterogeneity of NOTCH1 to tumor immune infiltration in pan-cancer by XiaoJun Duan, Rihan Wu, Mingyang Zhang, Kexin Li, Lei Yu, Huirong Sun, Xingxia Hao, Changshan Wang

“…NOTCH1 expression was significantly up-regulated in cold tumors but down-regulated in hot tumors. …”
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The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling by Yangyang Fu, Shishun Huang, Rulu Pan, Xingan Chen, Ting Liu, Rongzhe Zhang, Fangsheng Zhu, Qiwei Fang, Liyue Wu, Juji Dai, Ouchen Wang, Liting Lu, Xiduan Wei, Liangxing Wang, Xincheng Lu

“…Abstract Phosphodiesterase 4D interacting protein (PDE4DIP) is a Golgi/centrosome-associated protein that plays critical roles in the regulation of microtubule dynamics and maintenance of the Golgi structure. …”
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VR-Based Workplace Training and Spaces of Learning: A Social Space Study of VR Training for Apprentice Electricians by Katrin Kraus, Martin Berger, Thomas Keller, Elke Brucker-Kley

“…Results: When a VR environment is used for workplace learning, spaces of learning are created from the interplay of four spatial dimensions: The regulation and practices of use of the VR environment, the locality of use, the educational potential of the VR environment, and a mental representation of the real workplace represented in the VR environment. …”
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Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…BCL10 mutants promote a cytokine-reinforced positive feedback loop of lymphomagenesis driving not just NF-kB but multiple additional pathways converging on diffuse activation of oncogenic transcription factors. Up-regulation of anti-apoptotic genes increases mitochondrial membrane potential, underlying multidrug resistance. …”
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Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy by Junrui Luan, Xin Dong, Shuwen Zhou

“…The presence of the material resulted in a 40–50% induction of cell apoptosis, along with down regulation of the anti-apoptotic marker. Finally, the Fe3O4@guar gum/Pd NPs showed suppressive properties on colony formation. …”
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Spatiotemporal Variations of PM2.5 and O3 Relationship during 2014–2021 in Eastern China by Yasong Li, Tijian Wang, Qin’geng Wang, Yawei Qu, Hao Wu, Min Xie, Mengmeng Li, Shu Li, Bingliang Zhuang

“…Conducting a comprehensive spatiotemporal analysis of the relationship between them is crucial to gain insights into their interaction mechanisms and developing regulation measures. We quantified the spatiotemporal variations of them in the Yangtze River Delta (YRD) utilizing long-term integrated data during 2014–2021 and examined the evolution of their relationship at different time scales through statistical analysis. …”
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Smartphone overuse and distraction: which relationship with general well-being across different generations? by Diego Bellini, Maria Lidia Mascia, Rachele Conti, Maria Pietronilla Penna

“…The questionnaire included socio-demographic information, digital tools usage, digital activities, the Mobile Problematic Use Scale (MPPUS) and its subdimensions—withdrawal and social aspects (WITHD) and craving and escape from other problems (CRAV)—the Smartphone Distraction Scale (SDS) and its subdimensions—attention impulsiveness (ATT IMP), online vigilance (ON VIG), emotion regulation (EM REG), and multitasking (MULT)—and the I COPPE well-being scale. …”
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Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers by Hengyan Zhang, Ye Zhou, Heguo Yan, Changxing Huang, Licong Yang, Yangwen Liu

“…Gene set enrichment analysis (GSEA) showed that CXCR4 was closely associated with pathways related to immunology regulation and tissue repair.ConclusionThe findings suggest that CXCR4 and its related pathways play an important role in the pathogenesis of DFUs, providing a new perspective on targeted therapy for wound healing in diabetic patients. …”
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Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves’ Disease and Graves’ Ophthalmopathy by Ke C, Yu Y, Li J, Yu Y, Sun Y, Wang Y, Wang B, Lu Y, Tang M, Wang N, Chen Y

“…The four prioritized protein-coding genes were mainly enriched in the regulation of apoptotic and death processes. In addition, GMPR was associated with both GO and GD in a consistent direction. …”
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