Gut Microbiota and Its Impact on Brain Function and Mental Health by Zofia Martyna Wójcik, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Kuba Borys Romańczuk, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

“…Recent research reveals that microbiota not only supports metabolic and immune functions but also influences central nervous system (CNS) regulation via the gut-brain axis, a two-way communication system. …”
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Evaluation of cellular and physiological alterations of cells from Mytilus galloprovincialis exposed to benzisothiazolinone by Federica Impellitteri, Kristian Riolo, Giorgia Zicarelli, Miriam Porretti, Cristiana Roberta Multisanti, Giuseppe Piccione, Alessia Giannetto, Caterina Faggio

“…Two different concentrations (B1: 0.03 µg/L; B2: 0.3 µg/L) were tested at two different times of exposure (T1: 1 h; T2: 3 h) to evaluate the viability of cells, the phagocytic activity (haemocytes), the regulation volume decrease (RVD on DG cells) capability. …”
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LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer by Viola Melone, Domenico Palumbo, Luigi Palo, Noemi Brusco, Annamaria Salvati, Antonietta Tarallo, Giorgio Giurato, Francesca Rizzo, Giovanni Nassa, Alessandro Weisz, Roberta Tarallo

“…A set of lncRNAs was selected among ERα-associated RNAs in BC cell nuclei due to their roles in processes such as transcriptional regulation and epigenetic chromatin modifications. Native immunoprecipitation of nuclear ERα-interacting RNAs coupled to NGS (RIP-Seq) was performed in MCF-7 cells, leading to the identification of essential lncRNAs interacting with the receptor in multi-molecular regulatory complexes. …”
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How spinal GABAergic circuits modulate cerebral processing of postsurgical pain by Bruno Pradier, Daniel Segelcke, Nathalie Just, Mirjam Augustin, Nina Nagelmann, Cornelius Faber, Esther Pogatzki-Zahn

“…Enhancing spinal GABAergic tone increased functional connectivity (FC) in parts of these subnetworks during mechanical stimulation, but not at rest, highlighting spino-cerebral interactions in pain regulation relevant for mechanical hypersensitivity and potentially the transisition to chronic pain after surgery but likely not for pain at rest. …”
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The transcriptional response to yellow and wilt disease, caused by race 6 of Fusarium oxysporum f. sp. Ciceris in two contrasting chickpea cultivars by Aliakbar Faramarzpour, Sara Dezhsetan, Hamid Hassaneian Khoshro, Raheleh Mirdar Mansuri, Hamid Reza Pouralibaba, Zahra-Sadat Shobbar

“…., CaPP7, CaEPS1, CaSTY13, and CaPR-1), transcription regulation (e.g., CaMYBs, CaGLK, CaERFs, CaZAT11-like, and CaNAC6) and cell wall integrity (e.g., CaPGI2-like, CaEXLs, CaCSLD and CaCYP73A100-like). …”
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation by Na Shao, Lei Xi, Yangfan Lv, Muhammad Idris, Lin Zhang, Ya Cao, Jingyi Xiang, Xi Xu, Belinda X. Ong, Qiongyi Zhang, Xu Peng, Xiaoyan Yue, Feng Xu, Chungang Liu

“…This study reveals a ubiquitination-dependent regulation of YTHDF1, proposing USP5 inhibition alongside PD-(L)1 blockade as a promising cancer treatment strategy.…”
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MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…Here, we developed a human Tie2-agonistic antibody (MT-100) that not only resists Ang-2 antagonism and activates Tie2 signaling but also regulates a novel target, sushi repeat-containing protein X-linked 2 (Srpx2). …”
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Wet Feeding Promotes Growth without Affecting Hypothalamic Peptide Gene Expression in Growing Broiler Chicks by Tomoya Matsunami, Yuhui Zhang, Yuji Taniguchi, Sei-ichi Hinomoto, Takaoki Saneyasu, Hiroshi Kamisoyama, Kazuhisa Honda

“…Regulatory mechanisms underlying drinking behavior have not yet been identified in chickens; however, the regulation of osmolality and water intake appears to be closely related. …”
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Barriers and enablers to implementing clinical practice guidelines in primary care: an overview of systematic reviews by Tao Wang, Xian-Liang Liu, Jing-Yu (Benjamin) Tan, Isabella Zhao

“…Six categories of barriers and enablers were identified, which include (1) political, social and culture factors, (2) institutional environment and resources factors, (3) guideline itself related factors, (4) healthcare provider-related factors, (5) patient-related factors and (6) behavioural regulation-related factors. The most commonly reported barriers within the above-mentioned categories were suboptimal healthcare networks and interprofessional communication pathways, time constraints, poor applicability of CPGs in real-world practice, lack of knowledge and skills, poor motivations and adherence, and inadequate reinforcement (eg, remuneration). …”
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Community perspectives regarding brain-computer interfaces: A cross-sectional study of community-dwelling adults in the UK. by Austen El-Osta, Mahmoud Al Ammouri, Shujhat Khan, Sami Altalib, Manisha Karki, Eva Riboli-Sasco, Azeem Majeed

“…The study also explored whether demographic factors were related to beliefs about BCIs increasing inequalities, support for strict regulations, and perceptions of appropriate fields for BCI design, testing and utilization in healthcare.…”
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Protecting the American dream for socially vulnerable families: An evaluation of state-level policies to improve housing security and protect mobile home communities by Morgan Clennin, Denise Hartsock, Olivia Goodman, Stacie Daugherty, Cheryl Kelly

“…State-level policies to enhance the regulation of mobile home parks and expand protections for residents are needed to address these challenges. …”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…This study reveals that plant-metabolite-microbe regulation patterns contribute to the poplar fitness and thoroughly decodes the key regulatory mechanisms of tricin, and provides insights into the interactions of the plant’s key metabolites with its transcriptome and rhizosphere microbes.…”
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Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity by Wassim Daher, Vincent Le Moigne, Yara Tasrini, Shweta Parmar, Danielle L. Sexton, John Jairo Aguilera-Correa, Valentin Berdal, Elitza I. Tocheva, Jean-Louis Herrmann, Laurent Kremer

“…Abstract Type VII secretion systems participate in protein export, virulence, conjugation, and metabolic regulation. Five subtypes (ESX-1 to ESX-5) exist, each with specific roles and well-characterized secretion profiles in various mycobacterial species. …”
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Characterizing PM2.5 Secondary Aerosols via a Fusion Strategy of Two-stage Positive Matrix Factorization and Robust Regression by Chun-Sheng Huang, Ho-Tang Liao, Chia-Yang Chen, Li-Hao Young, Ta-Chih Hsiao, Tsung-I Chou, Jyun-Min Chang, Kuan-Lin Lai, Chang-Fu Wu

“…The results from the fusion model showed that the majority of secondary aerosols (sum of secondary aerosol-related species = 2.67 µg m−3) within three hours were mainly contributed by oil combustion, while the largest contributor of secondary aerosols (1.65 µg m−3) over 24 hours was industry, highlighting the need for regulation of these two sources based on various temporal scales. …”
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Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization by Lu Ding, Bo Chen, Zhou Zhou, Zhaojun Mei, Kan Cao, Xinyu Lu, Wei Chen

“…ER-related signaling pathways and the regulation of DNA damage may play a critical role in the pathogenesis of both diseases.…”
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Efficacy of unified protocol for transdiagnostic treatment of emotional disorders in adolescents (UP-A) in China: protocol for a randomised controlled trial by Xue Gao, Lu Liu, Mei-Rong Pan, Hai-Mei Li, Yu-Feng Wang, Xue-Ying Liu, Zhong-Fang Fu, Qiujin Qian

“…We will evaluate the efficacy of the UP-A, through the following primary and secondary outcomes: emotional disorder severity, emotional symptoms, emotion regulation, cognitive patterns, executive function, resilience, quality of life, social and family functioning. …”
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Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine by Jian Qin, Ziyi Luo, Xu Yang, Yunqing Zhang, Huiying Li, Conghui Wang, Zhiqiang Zou, Yue Ma, Jing Ma, Daoyou Yue, Dipeng Zhao, Sen Qin, Rong Du

“…Additionally, this combined treatment increased the activity of antioxidant enzymes and up-regulated the expression of antioxidant genes in the Nrf2 signaling pathway in stress mice. …”
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The Impact of Family Conflicts on Socio-Economic Prosperity: A Case Study of Muko Sub-County Rubanda District. by Akankwasa, Winfred

“…., the results of the study have revealed that some conciliators do not know the law related to inheritance and succession, that is why we recommend them to learn that law and other rules and regulation in force in the country; the findings of the study have proven that some conciliators are biased, so we recommend them to be impartial in order to mediate parts on family based conflicts fairly and the study concluded that it has been revealed by the findings that family based conflicts have a negative impact on economic prosperity of families where dealing with these conflicts bring about spending and consumes time that could be devoted in generating income activities. …”
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Role of Social Factors in Social Economic Status of Families in Kabale Municipality Kabale District. by Atukunda, Brian

“…., the results of the study have revealed that some conciliators do not know the law related to inheritance and succession, that is why we recommend them to learn that law and other rules and regulation in force in the country; the findings of the study have proven that some conciliators are biased, so we recommend them to be impartial in order to mediate parts on family based conflicts caused by alcohol up take fairly and the study concluded that it has been revealed by the findings that social factors have a negative impact on economic prosperity of families where dealing with these alcoholic beverages bring about spending and consumes time that could be devoted in generating income activities. …”
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Duckweed: a starch-hyperaccumulating plant under cultivation with a combination of nutrient limitation and elevated CO2 by Ling Guo, Ling Guo, Yang Fang, Songhu Wang, Yao Xiao, Yanqiang Ding, Yanling Jin, Xueping Tian, Anping Du, Zhihua Liao, Kaize He, Shuang Chen, Yonggui Zhao, Li Tan, Zhuolin Yi, Yuqing Che, Lanchai Chen, Jinmeng Li, Leyi Zhao, Peng Zhang, Zhengbiao Gu, Fangyuan Zhang, Yan Hong, Qing Zhang, Hai Zhao

“…This phenomenon is associated with the regulation of DNA methylation and transcription factors as well as the significantly upregulated transcription levels and the increased activities of key enzymes involved in starch biosynthesis. …”
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