Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study. by Lin Geng, Lilith K Whittles, Borame L Dickens, Martin T W Chio, Yihao Chen, Rayner Kay Jin Tan, Azra Ghani, Jue Tao Lim

“…<h4>Methods and findings</h4>We employed an integrated transmission-dynamic model, calibrated using Bayesian methods to local surveillance data to understand the potential public health impact of 4CMenB in reducing gonorrhea acquisition and transmission in men who have sex with men (MSM) in Singapore. We explored the efficacy of implementing six vaccination programmes: (1) offering vaccination to all male adolescents in schools (vaccination before entry [VbE]), (2) offering vaccination to individuals attending sexual health clinics for testing (vaccination on attendance [VoA]), (3) offering vaccination to individuals attending sexual health clinics and who were diagnosed with gonorrhea (vaccination on diagnosis [VoD]), or (4) vaccination according to risk (VaR), by offering vaccination to patients who were diagnosed with gonorrhea plus individuals who tested negative, but report having more than five sexual partners per year. …”
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Anthropometric measurements as markers of elevated blood pressure among Portuguese children and adolescents by Edmar Mendes, Paulo Farinatti, Alynne Andaki, Susana Vale, Andreia Pizarro, Maria Paula Santos, Clarice Martins, Jorge Mota

“…Elevated BP was defined as systolic and/or diastolic BP > 90th percentile for age and sex. Age-adjusted partial correlations with BP were computed for body mass, body mass index (BMI), waist circumference, and waist-to-height ratio. …”
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Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease by E. A. Kashukh, E. A. Poluektova, A. V. Kudryavtseva, G. S. Krasnov, V. I. Kazey, P. D. Sobolev, P. V. Gremyakova, V. T. Ivashkin

“…Group 4 consisted of healthy individuals, comparable in age and sex with the examined CHD patients. In group 4, blood and stool tests were performed once to provide a comparison with group 1. …”
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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

“…Results-Among 411 patients with MM underwent autologous transplantation of which 249 were male with a sex ratio of 1,53. The overall incidence of thrombosis was estimated at 18,49% (76 patients). …”
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Risk factors associated with degenerative glenohumeral osteoarthritis by Ravi Prakash, Nitin B Jain, Ziyi Chen, Folefac D Atem, Michael S Khazzam, Rashmi Pathak, Daniel Tai, Ursa BezanPetric, Estefanie Garduno Rapp

“…Univariate, least absolute shrinkage and selection operator and multivariate analyses identified risk factors, including age, body mass index (BMI), sex, work-related shoulder problems, shoulder disability, dislocation, previous trauma, surgery, smoking, hypertension, diabetes, depression, heart disease, OA, night pain and overall sleep quality.Results A total of 1827 cases and 1556 controls were identified for GH OA. …”
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Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort by Cyrille Delpierre, Raphaële Castagné, Eloïse Berger, Gianluca Severi, Marie-Christine Boutron-Ruault, Laura Baglietto, Laure Dossus, Amandine Gelot, Richard Dudouet

“…Specific biomarkers associated with the cardiovascular (systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein (HDL)), inflammatory (C reactive protein (CRP)) and hormonal systems (sex hormone-binding globulin (SHBG) and oestradiol) were found socially distributed (OR CRP-high=0.70 (95% CI 0.54; 0.91), OR TG-high=0.79 (95% CI 0.61; 1.04), OR DBP-high=0.69 (95% CI 0.53; 0.90), OR SBP-high=0.57 (95% CI 0.44; 0.74), OR HDL-high=0.79 (95% CI 0.60; 1.03), (OR SHBG-high=0.67 (95% CI 0.52; 0.88), OR oestradiol-high=1.34 (95% CI 1.00; 1.79); model 1). …”
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Investigating mental health disparities in rural sexual and gender minority adults: protocol for the rural exploration and approaches to LGBTQ + Mental Health (REALM) prospective c... by Shoshanna L. Fine, Kalai Willis, Iaah L. Lucas, Kirsten F. Siebach, Jennifer L. Glick, Mariah Valentine-Graves, Savannah Winter, Michael Smith, Thomas Waltz, Gina Bailey Herring, Marissa Hannah, Holly C. Wilcox, Travis Sanchez, Stefan D. Baral, Sarah M. Murray

“…This will include: up to 1,000 cisgender sexual minority persons (up to n = 500 each cisgender women and cisgender men); and up to 1,500 gender minority persons (up to n = 500 persons who were assigned male at birth and identify as a woman, female, and/or transfeminine; up to n = 500 persons who were assigned female at birth and identify as a man, male, and/or transmasculine; and up to n = 500 persons who identify as some other gender, including non-binary, gender non-conforming, and/or agender regardless of sex assigned at birth). All enrolled participants will subsequently be followed over a 12-month period, with repeated surveys at three-month intervals. …”
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Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…Associations for significant psychological symptoms comprised female sex, younger age, a diagnosis of trauma and frightening memories of the ICU admission. …”
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Changes in cancer incidence and stage during the COVID-19 pandemic in 2020–2021 in the Nordic countries by Anna Johansson, Anna Skog, Tom Børge Johannesen, Tor Åge Myklebust, Simon M. Kønig, Charlotte Wessel Skovlund, Lina Steinrud Mørch, Søren Friis, Marnar Fríðheim Kristiansen, David Pettersson, Eva María Gudmundsdóttir, Nanna Margrét Kristinsdóttir, Helgi Birgisson, Sandra Irenaeus, Johan Ahlgren, Mats Lambe, Elli Hirvonen, Janne Pitkäniemi, Giske Ursin

“…Material and methods: Using data from the national cancer registries in Denmark, Finland, Iceland, Norway, and Sweden, we estimated age-, sex-, and period-adjusted incidence rate ratios, expressed as relative percentage change (%) with 95% confidence intervals (CIs), comparing rates in 2020–2021 to those in 2017–2019 (pre-pandemic). …”
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Mental health in public safety personnel with workplace injuries requiring surgery: a longitudinal population-wide administrative data study in Manitoba, Canada by Tracie O Afifi, Jitender Sareen, Dan Chateau, Alyson Mahar, Jordan Nantais, James Bolton, Allen Kraut, Sarvesh Logsetty, Thomas Turgeon, Brenda Comaskey, Justin Gawaziuk, Rae Spiwak, Lauren Burton, Anthony Wightman, Jai Sareen, Natalie Mota

“…The objective of this study was to investigate whether PSP with traumatic physical workplace injuries requiring surgery with anaesthetic have higher post-injury rates of mental disorders compared with the general population with similar non-workplace injuries.Design Retrospective longitudinal cohort study.Setting Population-based study using linked anonymised administrative data for PSP and the general population in Manitoba, Canada.Participants This study compared two groups hospitalised for a traumatic physical injury requiring surgery with anaesthetic between 1 January 2002 and 31 December 2018: (1) PSP (n=293) injured in the workplace and matched 1:5 on sex, age, geographical region and surgical procedure code with (2) individuals in the general population (GenPop) injured outside the workplace (no Workers Compensation Board claim) (n=1198).Primary and secondary outcomes and measures As planned in the study protocol, the prevalence of mental disorders including anxiety, depression and substance use was measured in the cohorts 2 years pre- and post-injury.Results This study found an elevated unadjusted risk of depression in PSP compared with the general population in the 2 years post-injury, adjusting for pre-injury mental health (rate ratio, 1.49; 95% CI, 1.02 to 2.17; p&lt;0.0001). …”
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Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study by Xiaxia Wu, Xiaxia Wu, Jinfang Yang, Jinfang Yang, Xianqun Ji, Yingjian Ye, Ping Song, Lina Song, Peng An, Peng An

“…These were combined with baseline patient data (e.g., age, sex, NIHSS score, medical history) to establish various models for predicting HT-ACI through multivariable logistic regression analysis. …”
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Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise by Huiying Zhu, Huiying Zhu, Jianchao Pan, Jianxuan Wen, Jianxuan Wen, Xiaojing Dang, Xiaojing Dang, Xiankun Chen, Xiankun Chen, Yunxiang Fan, Yunxiang Fan, Weihui Lu, Weihui Lu, Wei Jiang, Wei Jiang

“…After adjusting for age, sex, body mass index (BMI), log N-terminal pro-B type natriuretic peptide (log NT-proBNP), left ventricular ejection fraction (LVEF), hemoglobin, renal function, coronary heart disease and hypertension, the peak VO2 was lower in the T2DM group compared to the non-T2DM group with a mean difference (MD) of −2.0 ml/kg/min [95% confidence interval (CI), −3.18 to −0.82, P &lt; 0.01]. …”
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Reduction of intestinal RIPK1 ameliorates HFD-induced metabolic disorders in female mice by Ye Yuan, Xiaomin Hu, Chunguang Guo, Yihua Xu, Shihan Li, Wei Wen, Xinli Hu, Fanxin Zeng, Weiyi Cui, Wenli Chen, Xueting Sun, Ning Hou, Jue Wang, Rui-Ping Xiao, Xiuqin Zhang

“…These findings demonstrate a new, sex-specific intestinal regulatory mechanism and highlight the critical role of intestinal RIPK1 in regulating HFD-induced metabolic disorders in females.…”
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Multicentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX) by Elisabetta Pupillo, Elisa Bianchi, Ettore Beghi, Francesco Andrea Pedrazzini, Angela Giglio, Edoardo Dalmato Schilke, Marco Percetti, Carlo Morotti Colleoni, Gabriele Mainini, Paolo Calabresi, Guido Primiano, Giovanni Frisullo, Alessandro Padovani, Viviana Cristillo, Andrea Pilotto, Davide Arici, Stefano Gipponi, Gioacchino Tedeschi, Alessandro d’Ambrosio, Rosario Domenico Melisi, Antonio Gallo, Alvino Bisecco, Andrea Salmaggi, Paola Basilico, Chiara Scaccabarozzi, Lorenzo Kiferle, Raffaella Valenti, Gianluca Avino, Annamaria Borghi, Sara Contardi, Andrea Zini, Carlo Ferrarese, Simone Beretta

“…Vaccination exposure was compared between individuals with a first diagnosis of a neurological disorder (cases) and age- and sex-matched controls. A total of 624 participants were enrolled, and after random 1:1 matching 265 cases and 265 matched controls (total 530 participants) were included in the analyses. …”
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Incidence of type 2 diabetes and metabolic syndrome by Occupation – 10-Year follow-up of the Gutenberg Health Study by Juliane Bauer, Janice Hegewald, Karin Rossnagel, Sylvia Jankowiak, Michaela Prigge, Julian Chalabi, Matthias Nübling, Alice Freiberg, Merle Riechmann-Wolf, Pavel Dietz, Philipp S. Wild, Thomas Koeck, Manfred E. Beutel, Norbert Pfeiffer, Karl J. Lackner, Thomas Münzel, Konstantin Strauch, Philipp Lurz, Oliver Tüscher, Julia Weinmann-Menke, Stavros Konstantinides, Andreas Seidler

“…We calculated age- and sex-standardised incidence rates and standardised incidence ratios (SIR) with a 95% confidence interval (CI) for occupations, job complexity levels, and supervisory and managerial positions. 5954 persons at risk for type 2 diabetes and 5103 at risk for metabolic syndrome were observed. …”
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Automatic approach-avoidance tendency toward physical activity, sedentary, and neutral stimuli as a function of age, explicit affective attitude, and intention to be active by Farajzadeh, Ata, Goubran, Miriam, Beehler, Alexa, Cherkaoui, Noura, Morrison, Paula, de Chanaleilles, Margaux, Maltagliati, Silvio, Cheval, Boris, Miller, Matthew W., Sheehy, Lisa, Bilodeau, Martin, Orsholits, Dan, Boisgontier, Matthieu P.

“…Results accounting for age, sex, gender, level of physical activity, body mass index, and chronic health condition confirmed a main tendency to approach physical activity stimuli (i.e., faster reaction to approach vs. avoid; p = .001) and to avoid sedentary stimuli (i.e., faster reaction to avoid vs. approach; p < .001). …”
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Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

“…Kidney function is commonly estimated using inputs of blood proteins alongside demographic inputs of age, sex at birth, and race. Inclusion of race to estimate kidney function has gained increased scrutiny given its problematic nature of being a societal construct rather than an inherent biological trait that affects function of the kidneys. …”
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Risk Factors of Portal Vein Thrombosis in Patients with Different Child-Pugh Classes Liver Cirrhosis by M. Yu. Nadinskaia, Kh. B. Kodzoeva, K. A. Gulyaeva, M.-D. E. Khen, D. I. Koroleva, M. A. Privalov, A. Kh. Tekaeva, V. R. Fedorov, S. G. Prokofev

“…From the database of cirrhotic patients without PVT 60 Controls for class A and 205 for B/C were selected using sratified randomization by sex, age and etiology of cirrhosis. The Mann-Whitney U-test and Pearson's chi-squared test were used to compare the groups. …”
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Relationship between four healthy lifestyle factors and all-cause and cardiovascular disease mortality among residents aged 35 – 75 years in Hebei province by Yuhuan LIU, Lijuan TANG, Xiaoying LU, Jingjing ZHAO, Yajing CAO, Xiaoli LIU, Dongsheng JIANG

“…After adjusting for potential confounders including sex, age, education level, marital status, occupation, annual household income, residence, and social health insurance, multivariable Cox proportional hazards regression analysis showed that adherence to adequate physical activity and a healthy diet was associated with a 26% (HR = 0.74, 95%CI: 0.61 – 0.90) and 24% (HR = 0.76, 95%CI: 0.60 – 0.96) lower risk of all-cause mortality, respectively, compared to non-adherence. …”
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Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis Fro... by Valeria Cento, Sara Carloni, Riccardo Sarti, Linda Bussini, Zian Asif, Paola Morelli, Francesco De Fazio, Federica Maria Tordato, Maddalena Casana, Debora Mondatore, Antonio Desai, Elena Generali, Nicola Pugliese, Elena Costantini, Massimo Vanoni, Maurizio Cecconi, Stefano Aliberti, Giorgio Da Rin, Erminia Casari, Michele Bartoletti, Antonio Voza

“…Clinical features included age, sex, comorbidities (e.g., cancer, diabetes), infection source, presence of central venous catheters (CVC), ongoing therapies, and sepsis severity. …”
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