Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Following a prespecified analysis plan, rwOS by TMB level was assessed using Cox PH models adjusted for Eastern Cooperative Oncology Group performance status, prior treatment, microsatellite instability, sex, age, opioid rx pretherapy, and socioeconomic assessment.Results 8440 patients met inclusion criteria. …”
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Development of Multimorbidity Indexes Based on Common Mental Health Conditions by Junko Kose, Emmanuelle Kesse-Guyot, Pauline Duquenne, Serge Hercberg, Serge Hercberg, Pilar Galan, Mathilde Touvier, Valentina A. Andreeva, Léopold K. Fezeu

“…Performance (C-index) and calibration of the indexes were compared with a simple count.ResultsA general and a sex-specific mental multimorbidity indexes were developed; both were significantly associated with the disability score. …”
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A retrospective analysis of outcomes and complications of living- and deceased-donor split-liver transplantation in Johannesburg, South Africa by R Crawford, J Loveland, P Gaylard, J Fabian, K Kinandu, B Bobat, A Mahomed, D Parbhoo, M Beretta, S Berkenfeld, S Rambarran, F van der Schyff, L Brannigan, B Strobele

“…All comparisons were made unadjusted, and adjusted for recipient age, recipient ethnicity, donor sex, and graft-weight-to-recipient-weight ratio (GWRWR) (for the paediatric cohort); and for donor age and GWRWR (for the adult cohort). …”
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Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis by Aznamariam Ayres, Yawkal Tsega, Abel Endawkie, Shimels Derso Kebede, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Amare Muche, Fekade Demeke Bayou, Mastewal Arefaynie, Asnakew Molla Mekonen, Abiyu Abadi Tareke, Awoke Keleb, Kaleab Mesfin Abera, Natnael Kebede, Endalkachew Mesfin Gebeyehu

“…Wealth index, mother’s education, age of child, type of birth, sex of child and birth interval inequality between rural and urban households explains most of the composite index of anthropometric failure disparity in children under-5 years old. …”
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The diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia by Liping Fan, Jiahao Chen, Chong Chen, Yongwei Zhang, Yeqing Yang, Zhe Chen

“…Additionally, the osteoporosis group presented substantially higher levels of ApoA1, FFAs, and IL-6 than the osteopenia group. (4) IL-6 was positively correlated with FFAs, while a negative correlation was observed with TC, ApoA1, ApoB, HDL-C, and LDL-C. (5) The ROC curve revealed that the areas under the curve (AUCs) of TC, FFAs, IL-6, ApoA1, and the ApoA1/ApoB ratio for predicting osteoporosis or osteopenia were 0.634, 0.713, 0.670, 0.628, and 0.516, respectively, whereas the AUC of the combination of TC, FFAs, IL-6, and ApoA1 was 0.846, and the AUC of the combination of TC, FFAs, IL-6, and the ApoA1/ApoB ratio was 0.842. In the sex stratification analysis, in males, the AUCs of TC, FFAs, IL-6, and the ApoA1/ApoB ratio for the prediction of osteoporosis or osteopenia were 0.596, 0.688, 0.739, and 0.539, respectively. …”
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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

“…Findings: The average age at baseline was 68 years in the discovery cohort of women and 74 years in the mixed-sex replication cohort. During 100,619 person-years of follow-up, 2168 had any fracture, and 538 had a hip fracture. …”
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A prospective cohort study on the impact of healthy lifestyles on all-cause and cardiovascular disease mortality among adult residents in Guizhou province by Jie ZHOU, Ling LI, Ji ZHANG, Lisha YU, Yujin REN, Wei JI, Yingjiao MU, Tao LIU

“…After adjusting for confounding factors such as sex, age, ethnicity, education level, marital status, residence, systolic blood pressure, diastolic blood pressure, fasting blood glucose (FBG), 2-hour postprandial blood glucose (PBG), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), the multivariable Cox proportional hazards regression analysis showed that the risks of all-cause mortality among adult residents in Guizhou province with 4, 5, 6, and ≥ 7 healthy lifestyle factors were 0.732 times (HR = 0.732, 95%CI: 0.542 – 0.990), 0.667 times (HR = 0.667, 95%CI: 0.499 – 0.893), 0.664 times (HR = 0.664, 95%CI: 0.490 – 0.900), and 0.566 times (HR = 0.566, 95%CI: 0.391 – 0.820) that of those with ≤ 3 healthy lifestyle factors, respectively. …”
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International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions by Grant R. Tomkinson, Justin J. Lang, Lukáš Rubín, Ryan McGrath, Bethany Gower, Terry Boyle, Marilyn G. Klug, Alexandra J. Mayhew, Henry T. Blake, Francisco B. Ortega, Cristina Cadenas-Sanchez, Costan G. Magnussen, Brooklyn J. Fraser, Tetsuhiro Kidokoro, Yang Liu, Kaare Christensen, Darryl P. Leong, Mette Aadahl, Edimansyah Abdin, Julian Alcazar, Aqeel Alenazi, Bader Alqahtani, Cledir De A. Amaral, Thatiana L.M. Amaral, Alex Andrade Fernandes, Peter Axelsson, Jennifer N. Baldwin, Karin Bammann, Aline R. Barbosa, Ameline Bardo, Inosha Bimali, Peter Bjerregaard, Martin Bobak, Colin A. Boreham, Klaus Bös, João Carlos Bouzas Marins, Joshua Burns, Nadezda Capkova, Lilia Castillo-Martínez, Liang-Kung Chen, Siu Ming Choi, Rebecca K.J. Choong, Susana C. Confortin, Cyrus Cooper, Jorge E. Correa-Bautista, Amandine Cournil, Grace Cruz, Eling D. de Bruin, José Antonio De Paz, Bruno De Souza Moreira, Luiz Antonio Dos Anjos, María Cristina Enríquez Reyna, Eduardo Ferriolli, Gillian Forrester, Elena Frolova, Abadi K. Gebre, Atef M. Ghaleb, Tiffany K. Gill, Yasuyuki Gondo, M. Cristina Gonzalez, Citlali Gonzalez Alvarez, Mary K. Hannah, Nicholas C. Harvey, Jean-Yves Hogrel, Marie-Theres Huemer, Toshiko Iidaka, Lewis A. Ingram, Dmitri A. Jdanov, Victoria L. Keevil, Wolfgang Kemmler, Rose Anne Kenny, Dae-Yeon Kim, Tracy L. Kivell, Ingirid G.H. Kjær, Alexander Kluttig, Rumi Kozakai, Danit Langer, Lisbeth A. Larsen, Wei-Ju Lee, David A. Leon, Eric Lichtenstein, Bertis B. Little, Roberto Alves Lourenço, Rahul Malhotra, Robert M. Malina, Kiyoaki Matsumoto, Tal Mazor-Karsenty, Marnee J. McKay, Sinéad McLoughlin, Abhishek L. Mensegere, Mostafa Mohammadian, Virgilio Garcia Moreira, Hiroshi Murayama, Anne Murray, Anita Liberalesso Neri, Claudia Niessner, Gabriel Núñez Othón, Gabriel Olveira, Suzanne G. Orchard, Andrezj Pajak, Chan Woong Park, Julie A. Pasco, Maria E. Peña Reyes, Leani Souza Máximo Pereira, Annette Peters, Eric Tsz-Chun Poon, Margareth C. Portela, Jedd Pratt, Robinson Ramírez-Vélez, Wendy Rodríguez-García, Joanne Ryan, Mauricio A. San-Martín, Francisco José Sánchez-Torralvo, Mahnaz Saremi, Arno Schmidt-Trucksäss, Satoshi Seino, Shamsul Azhar Shah, Marc Sim, Bjørn Heine Strand, Mythily Subramaniam, Charlotte Suetta, Sophia X. Sui, Jonas S. Sundarakumar, Koya Suzuki, Abdonas Tamosiunas, Maw Pin Tan, Yu Taniguchi, Barbara Thorand, Anna Turusheva, Anne Therese Tveter, Jonathan Wagner, Dao Wang, Stuart J. Warden, Julia Wearing, Shiou Liang Wee, Leo D. Westbury, Agnieszka Wiśniowska-Szurlej, Alexander Woll, Noriko Yoshimura, Ruby Yu

“…The objective of this study was to generate international sex- and age-specific norms for absolute and body size-normalized HGS across the adult lifespan. …”
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Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study by Pedro Puerta-Alcalde, Jessica O'Keefe, Rachel Woolstencroft, Shipraa Kaul, Néstor López, Katie Cronin, Andrew Lim, Nicole Garcia-Pouton, Míriam Álvarez, Lynette Chee, Mateu Espasa, Ignacio Grafia, Maria Suárez-Lledó, Olivia Smibert, Carolina Garcia-Vidal, Monica A. Slavin, Michelle K. Yong, Alex Soriano, Leon J. Worth

“…Independent risk factors for CDI recurrence were female sex (OR 2.26, 95% CI 1.13-4.52), age >75 years (OR 2.69, 95% CI 1.30-5.59), dialysis (OR 5.15, 95% CI 1.45-18.27), vomiting at presentation (OR 0.06, 95% CI 0.01-0.55), colonic wall thickening in the CT abdomen (OR 2.42, 95% CI 1.06-5.49) and vancomycin therapy (OR 4.60, 95% CI 1.34-15.84). …”
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Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients by Rhian M Touyz, Ninian N Lang, Kevin G Blyth, Naveed Sattar, Patrick B Mark, Stefan Siebert, Colin Berry, Iain McInnes, Giles Roditi, Neil Basu, David Corcoran, Kenneth Mangion, Alex McConnachie, David Carrick, Jaclyn Carberry, Stuart Watkins, Paul Welsh, Sabrina Nordin, Katherine Scott, Christian Delles, Bernard Kelly, Fraser Goldie, John GF Cleland, Sharon Kean, Peter Kellman, David J Lowe, Andrew J Morrow, Antonia Ho, Rosemary Woodward, Tracey Hopkins, Ryan Wereski, Massimo Palmarini, Alasdair McIntosh, Campbell Rogers, Ammani Brown, Catherine Bagot, Kathryn Scott, Robert Sykes, Colin Church, Claire Rooney, Nicola Ryan, Clare Orange, Dirk Husmeier, Xiaoyu Luo, PETER W MACFARLANE, Heerajnarain Bulluck, Iain Findlay, Evonne McLennan, Michael Briscoe, Oliver Peck, Alastair J Rankin, Gruschen Veldtman, Varun Sharma, Kathryn McLaren, Elaine Butler, Sarah Mullen, Andrew Morrow, Patrick Mark, Daniel Doherty, Alexander Payne, Jennifer S Lees, Kaitlin J Mayne, Louise Inglis, Anna Kamdar, Hannah Bayes, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Christopher McGinley, Connor Mckee, Sarah Allwood-Spiers, Sarah Weeden, Laura Knox, Lynn Abel, David Stobo, Andrew Dougherty, Liam Peng, David Barrie Stobo, Sylvia Wright, Stephen Dobbin, Keith Gillis, Sarah A Spiers, Ian Fergus, Kirsty Fallon, Lesley Gilmour, Chloe Cowan, Jurgen Van-Melckebeke, Kim Moran-Jones, Debra Stuart, Maureen Travers, Laura Dymock, Fiona Savage, Nicola Tynan, Sau Lee Chang, Mhairi Dupre, Lindsey Norton, George Bruce, Rosario Gonzalez-Lopez, Rebecca Stace, Dionne Russell, Jean Watt, Shahid Latif, Nick Hill, Amy Collinsworth, Ross McGeoch Vera Lennie, Robin P Weir

“…These features were very infrequent among a group of age-matched, sex-matched and cardiovascular risk factor-matched controls (n=29). …”
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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…These phenotypes did not differ by age, sex, or years of education. The APOE ɛ4 genotype was enriched in the Amnestic Predominant group, who were also rated as least impaired. …”
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Relationship between physical activity level, leisure sedentary time, and frailty among residents aged 30 – 79 years in Wuzhong district, Suzhou city: a baseline surveillance data... by Xikang FAN, Jiang HUA, Jian SU, Hao YU, Yan LU, Yujie HUA, Jianrong JIN, Pei PEI, Dianjianyi SUN, Canqing YU, Jun LYU, Jinyi ZHOU, Ran TAO

“…After adjusting for confounding factors such as sex, age, education level, marital status, annual household income, smoking status, alcohol consumption, frequency of fresh vegetable intake, frequency of fresh fruit intake, and frequency of red meat intake, the results of unordered multinomial logistic regression analysis showed that compared with residents with a physical activity level of < 12.73 MET-h/d, the risk of pre-frailty was 0.76 times lower (OR = 0.76, 95%CI = 0.72 – 0.80), 0.67 times lower (OR = 0.67, 95%CI = 0.63 – 0.71), and 0.66 times lower (OR = 0.66, 95%CI = 0.62 – 0.69) for those with physical activity levels of 12.73 – 23.19 MET-h/d, 23.20 – 37.29 MET-h/d, and ≥ 37.30 MET-h/d, respectively. …”
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Exploring shape diversity and sexual dimorphism in two populations of Nigma conducens through geometric morphometrics by Safa M. El-masry, Tarek G. Ismail, Asmaa N. Mustafa

“…This study employed geometric morphometrics to investigate prosoma shape and size variations between two populations of Nigma conducens spiders and between sexes within each population. Principal Component Analysis (PCA) explored shape variation, while Canonical Variate Analysis (CVA) compared shape differences between populations and sexes. …”
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Etracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats Via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation by Ugochukwu Vincent, Igbokwe, Ejike, Daniel Eze, Moses Dele, Adams, Karimah Mohammed, Rabiu, Iliya, Ezekiel, Prisca Ojochogu, Ajeka, Adam Moyosore, Afodun

“…Thirty rats of both sexes were assigned into 5 categories of six animals apiece. …”
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3D convolutional deep learning for nonlinear estimation of body composition from whole body morphology by Isaac Y. Tian, Jason Liu, Michael C. Wong, Nisa N. Kelly, Yong E. Liu, Andrea K. Garber, Steven B. Heymsfield, Brian Curless, John A. Shepherd

“…Nonlinear GPR produced up to a 20% reduction in prediction error and up to a 30% increase in precision over linear regression for both sexes in 10 tested body composition variables. Deep shape features produced 6–8% reduction in prediction error over linear PCA features for males only, and a 4–14% reduction in precision error for both sexes. …”
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Marriage, sexuality, and holiness: aspects of marital ethics in the Corpus Paulinum by R. Zimmermann

“…In the theologically substantiated union of the sexes one can recognize not only traditional, but especially Judaic forms of speech, created through the close interweaving of relationships between the sexes and the relationship with God. …”
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Assessment of Formalin-Fixed Bovine Larynx Asymmetry Using Geometric Morphometry by Arcesio Salamanca-Carreño, Pere M. Parés-Casanova, Mauricio Vélez-Terranova, Néstor Ismael Monroy-Ochoa

“…Significant differences in the morphometric profile were found between the right and left larynx and between the sexes (p<0.05). Results demonstrate differences between right and left larynx sides as directional asymmetry, at least in fixed structures. …”
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The Epidemiological Characteristics of Coronavirus Disease (COVID-19) in Halabja Province/Kurdistan –Iraq by Osama Hamid Shareef, Othman Abdulrahman Mohammed, Dashty Aziz Ghafor, Ari Shareef Ali, Hardi Rafat Baqi, Ali Aziz Ali, Aryan Mahmood Faraj, Syamand Ahmed Qadir, Ali Muhi Aldeen Omar Aljabary

“…Besides, the confirmed cases for other age groups for both sexes were (50-59) years old was 397, (60-69) years old was 205, (70-79) was 77. …”
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Tick species, tick-borne pathogen distribution and risk factor analysis in border areas of China, Russia and North Korea by Pengfei Min, Jianchen Song, Shaowei Zhao, Zhen Ma, Yinbiao Meng, Zeyu Tang, Zhenyu Wang, Sicheng Lin, Fanglin Zhao, Meng Liu, Longsheng Wang, Lijun Jia, Lijun Jia

“…Four pathogens were detected: Rickettsia, Bartonella, Anaplasma, and Babesia.DiscussionPathogen detection in ticks differed significantly among the environments and between Sexes. There were significant differences in the proportion of ticks infected with Rickettsia, Bartonella, Anaplasma, and Babesia among regions, species, sexes, and environments. …”
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The Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) Performance in Elite Team Handball Players Playing with Shoulder Pain, Previous Pain, or No Pain by Tina Piil Torabi, Jesper Bencke, Roland van den Tillaar

“… # Conclusion A comparison of scores across sexes appears unsuitable, due to the possible positive influence of height on the final score. …”
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