The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Nonetheless, myrrh’s precise rudimentary mechanisms of action in regulating genes involved in breast cancer evolution and progression remain elusive. …”
Get full text

A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community by Nancy Bonareri Mitaki, Ilemobayo Victor Fasogbon, Onyinye Vivian Ojiakor, Wusa Makena, Emmanuel O. Ikuomola, Reuben Samson Dangana, Ibe Micheal Usman, Ekom Monday Etukudo, Augustine Oviosun, Swase Dominic Terkimbi, Elizabeth Bessy Umoren, Angela Mumbua Musyoka, Solomon A Mbina, Esther Ugo Alum, Ibrahim Babangida Abubakar, Godson Emeka Anyanwu, Patrick Maduabuchi Aja

“…We extracted and analyzed information from the literature and showed that seven medicinal plants reduce blood sugar levels and insulin sensitivity through their mechanism of action. Conclusion: The phytochemical properties of these medicinal plants, mainly containing alkaloids, tannins, and flavonoids, may contribute to their hypoglycemic effects. …”
Get full text

Call for Papers - Advancing Astropharmacy and Sports Pharmacy by Ashley Anderson, Ahmer Raza, Shireen Aziz, Misbah Noreen

“…She is actively working on addressing the challenges of medication stability in space and investigating the physiological effects of the space environment on drug metabolism and action. Misbah is also contributing to the advancement of the emerging field of Astropharmacy, collaborating with global experts to explore innovative pharmaceutical practices and regulatory frameworks for space missions. …”
Get full text

Jianpi Yiqi Busui prescription alleviates myasthenia gravis by regulating Th17 through the TAK1/P38 MAPK/eIF-4E signaling pathway by Zhuming Chen, Jing Lu, Tianying Chang, Dongmei Zhang, Yibin Zhang, Miao Liu, Tong Wu, Peng Xv, Jian Wang

“…However, its mechanisms of action still require further clarification. In this study, an experimental autoimmune myasthenia gravis (EAMG) rat model was established for research. …”
Get full text

Characterization and simulation of AlGaN barrier structure effects in normally-off recessed gate AlGaN/GaN MISHEMTs by An-Chen Liu, Hsin-Chu Chen, Po-Tsung Tu, Yan-Lin Chen, Yan-Chieh Chen, Po-Chun Yeh, Chih-I Wu, Shu-Tong Chang, Tsung-Sheng Kao, Hao-Chung Kuo

“…This is attributed to the hot electrons effect under the action of the high electric field to promote electrons to overcome potential energy barriers that are injected into a buffer, barrier, or insulating layers and trapped there, degrading off-state BV capability.…”
Get full text

Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration by Lei Yu, Wentao Wang, Chang Lv, Qian Chen, Peng Yang, Zhenrong Qi, Haomiao Yu, Ruiqi Cao, Wenhao Li, Yi Qin, Gaoran Ge, Peilai Liu, Lixin Zhu, Houyi Sun, Dechun Geng, Liang Zhang

“…The MBG@D5-Gel complex enables the controlled spatiotemporal release of these agents, markedly enhancing bone regeneration in osteoporotic conditions within ovariectomized rats by inhibiting osteoclastogenesis and bone resorption while promoting osteogenic differentiation and mineralization. This dual-action system synergistically regulates osteoblast and osteoclast activity, optimizing the pathological microenvironment of osteoporosis and facilitating the repair of osteoporotic bone defects. …”
Get full text

Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

“…Background: Chronic low back pain is a costly condition and the leading cause of disability worldwide. A recent call to action identified the overuse of low-value health care as ineffective and potentially harmful in the context of back pain. …”
Get full text

Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects by Mufeng Wu, Xiao Liang, Ying Liu, Chunling Wu, Xingkui An, Zihua Zhao, Guifeng Hao, Ijiti Oluwole Gregory, Zhihong Li, Qing Chen

“…Additionally, the physiological- and biochemical-based mode of action of HCN were seldom determined. To fill those knowledge gaps, the two-spotted spider mite (TSSM), Tetranychus urticae, was used as a model organism to elucidate the toxic mechanism of HCN. …”
Get full text

PENERAPAN PROJECT BASED LEARNING MODEL UNTUK MENINGKATKAN SIKAP ILMIAH MAHASISWA DALAM RANGKA MENGHADAPI ERA MERDEKA BELAJAR by Andik Purwanto, Desy Hanisa Putri, Dedy Hamdani

“…The research was conducted with classroom action research (PTK) which was carried out in several cycles. …”
Get full text

Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…Shaoyao Gancao Decoction (SGD) is a classic Chinese prescription with good neuroprotective activities. However, the action of SGD in PICI remains elusive. Herein, our work was set out to study the potential role and possible mechanism of SGD in PICI through network pharmacology, Mendelian analysis and animal experiments. …”
Get full text

Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway by Teerapap Panklai, Prapapan Temkitthawon, Nungruthai Suphrom, Corine Girard, Perle Totoson, Kowit Hengphasatporn, Yasuteru Shigeta, Krongkarn Chootip, Kornkanok Ingkaninan

“…The mechanism of WLE vascular action involved the endothelial nitric oxide (NO) pathway and stimulation of sGC, while showing no VSMC cytotoxicity.…”
Get full text

UPAYA MENINGKATKAN HASIL BELAJAR DAN KETERAMPILAN PROSES SAINS MELALUI MODEL PEMBELAJARAN BERBASIS MASALAH MENGGUNAKAN VIDEO PEMBELAJARAN PADA MATERI FLUIDA STATIS by Frans Meydy Hutagalung, Nyoman Rohadi, Irwan Koto

“…ABSTRACT   This research was a classroom action research on static fluid material which was carried out in four cycles which aimed to describe the improvement of learning outcomes and science process skills. …”
Get full text

Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…Abstract Antimicrobial resistance (AMR) is a global health challenge requiring cross-sector action, with research largely focused on chickens, leaving ducks underexplored. …”
Get full text

Diabetes distress among immigrants of south Asian descent living in New York City: baseline results from the DREAM randomized control trial by Farhan Mohsin, Laura Wyatt, Hayley Belli, Shahmir Ali, Deborah Onakomaiya, Supriya Misra, Yousra Yusuf, Shinu Mammen, Jennifer Zanowiak, Sarah Hussain, Haroon Zafar, Sahnah Lim, Nadia Islam, Naheed Ahmed

“…Methods Baseline data was collected from the Diabetes Research, Education, and Action for Minorities (DREAM) Initiative, an intervention designed to reduce hemoglobin A1c (HbA1c) among South Asian individuals with uncontrolled T2D at primary care practices in NYC. …”
Get full text

Investigating the Role of Artificial Intelligence Enablers and Companies' Readiness in Adopting an Artificial Intelligence-integrated Customer Relationship Management System by Soheila Mohammadzadeh Vanestan, Rahim Abedi

“…By integrating customer relations with artificial intelligence, businesses can leverage its extensive benefits to take proactive action and derive value. In terms of existing limitations such as time and financial limitations as well as human resources required for quick response and establishing online communication, the use of communication and response programs based on artificial intelligence seems to be an efficient and effective alternative that can improve the financial and non-financial performance of the organization.…”
Get full text

Editorial by Michael Rose, Jonathan M. Hoffmann

“…At the same time, several authors seem to allow for or even emphasise alternative ways of dealing with the C-NIP that uphold the moral relevance of the current generation’s actions with regard to future generations, among them Das, Hoffmann and Rose. …”
Get full text

Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy by Yishen Tian, Jingxuan Li, Na Yang, Yang Zhao, Jiancao Zuo, Hang Xiong, Yiwen Pan, Li Xiao, Min Su, Feng Han, Zhixu He, Rong Hu

“…In the complex immunosuppressive microenvironment, the synergistic action of these components markedly enhanced the clearance efficacy of the immune system. …”
Get full text

Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis by Daciana C. Dumut, Daciana C. Dumut, Marian Hajduch, Marian Hajduch, Amanda M. Zacharias, Qingling Duan, Qingling Duan, Ivo Frydrych, Zuzana Rozankova, Zuzana Rozankova, Miroslav Popper, Miroslav Popper, Dusan Garic, Radu Alexandru Paun, Radu Alexandru Paun, Amanda Centorame, Amanda Centorame, Juhi Shah, Martin Mistrik, Martin Mistrik, Petr Dzubak, Petr Dzubak, Juan B. De Sanctis, Juan B. De Sanctis, Danuta Radzioch, Danuta Radzioch, Danuta Radzioch, Danuta Radzioch

“…This study unveils a novel mechanism of action for CuET: a potent immunomodulator capable of turning cold tumors hot.…”
Get full text

Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Further investigations are warranted to elucidate the underlying mechanisms of action of AgNPs and to assess their safety and efficacy in clinical settings. …”
Get full text

Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis by Shasha Huang, Wanqi Li, Dengke Wang, Huiwen Feng, Bo Wang, Xinyu Dong, Wei Zhao, Dan Liu, Yuan Wang

“…Deltamethrin (DM), a broad-spectrum insecticide, is widely used in the world. It can exert direct action on the central nervous system to produce neurotoxicity. …”
Get full text