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  1. 1141
  2. 1142

    Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

    Published 2025-02-01
    “…Conclusion In summary, this study elucidates, for the first time, the potential antiepileptic targets and mechanism of action of caffeic acid using the ABPP strategy. Our study provides evidence supporting the utilization of caffeic acid as a promising therapeutic agent for treating epilepsy and neuroinflammation-related disorders.…”
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    Article
  3. 1143

    Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis by Kai Tang, Kai Tang, Kai Tang, Wei Deng, Wei Deng, Wei Deng, Wei Deng, Zhiying Huang, Zhiying Huang, Zhiying Huang, Simin Chen, Simin Chen, Simin Chen, Zilin Zhu, Zilin Zhu, Shukun Lin, Shukun Lin, Lubin Zhong, Lubin Zhong, Quanxin Zheng, Quanxin Zheng, Wenhua Zhao, Wenhua Zhao, Zhida Zhang, Zhida Zhang, Ling Mo, Ling Mo, Ling Mo

    Published 2025-02-01
    “…Therefore, finding more effective treatments for OP remains an urgent challenge.MethodWe first conducted in vitro experiments to determine whether Neoandrographolide (NEO) exhibits cytotoxic or proliferative effects on bone marrow macrophages (BMMs) and to explore the specific timeframe during which NEO exerts its inhibitory action on osteoclast (OC) differentiation. Through Reverse Transcription Polymerase Chain Reaction (RT-PCR) and Western blot analysis, we examined the relative expression levels of genes and proteins associated with OC differentiation like CTSK,c-Fos,MMP9,NFATc1, and verified the underlying mechanisms. …”
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    Article
  4. 1144
  5. 1145

    Editorial by Ann-Kristin Kölln, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

    Published 2019-07-01
    “…The 16 year-old climate activist, who has also been nominated for a Nobel Peace Prize, started a movement that saw a multitude of student protests and school strikes around the world centred on action against climate change. TIME Magazine quoted her saying, “We can’t save the world by playing by the rules, because the rules have to be changed.” …”
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    Article
  6. 1146

    Study on Innovative Practices to Promote Girls’ Retention and Transition to Secondary and Higher Learning Institutions in Sub-Saharan Africa. by Ayiga, Natal, Adyanga, Francis Akena, Akello, Jacqueline

    Published 2024
    “…This situation calls for actions to promote the reentry of girls who previously dropped out of school and ensure their retention and transition from primary to secondary education. …”
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    Technical Report
  7. 1147

    Specialists Triaging Referrals to eConsult: a feasibility study including acceptability and impact of providing advice on primary health care providers by Ridha Ali, Geetha Mukerji, Susan Humphrey-Murto, Clare Liddy, Heather Lochnan, Erin Keely

    Published 2025-02-01
    “…To assess PCP opinions on safety (advice was clearly identified and actionable) and acceptability (comfort in patient not seeing a specialist, additional time burden and support for expansion) two surveys, one for those referrals triaged to advice only and another for those triaged to advice and appointment, were faxed 14 days after the referral response. …”
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    Article
  8. 1148

    MyPlate for Dysphagia by Jamila R. Lepore, Nancy J. Gal, Wendy J. Dahl

    Published 2013-01-01
    “…Resources and tools at ChooseMyPlate.gov that provide clear, actionable information about how to make better food choices can be easily adapted for persons with swallowing difficulties (dysphagia) that require texture-modified foods. …”
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    Article
  9. 1149

    School Governance and Secondary School Performance in Ndorwa County Kabale District Uganda. by Kyomuhangi, Hope

    Published 2025
    “…The findings aim to provide actionable insights for improving governance practices and educational outcomes in the region.…”
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    Thesis
  10. 1150

    Leveraging LLMs and wearables to provide personalized recommendations for enhancing student well-being and academic performance through a proof of concept by Arfan Ahmed, Sarah Aziz, Alaa Abd-alrazaq, Rawan AlSaad, Javaid Sheikh

    Published 2025-02-01
    “…Validator scoring assessed the clarity, actionability, and alignment of recommendations with student data. …”
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    Article
  11. 1151

    Understanding barriers to veterinary involvement in dairy calf health management by Kristen Y. Edwards, Angel Abuelo, Stephen J. LeBlanc, Trevor J. DeVries, Michael A. Steele, Joao H. C. Costa, David L. Renaud

    Published 2025-02-01
    “…Incomplete records was the most common reason for not reviewing records (60% of respondents) and why actionable recommendations were made less frequently than “most of the time” (67% of respondents). …”
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    Article
  12. 1152

    Integrating ICT in education: A scoping review of pre-service teachers' ICT beliefs. by Honghuan Li

    Published 2025-01-01
    “…This scoping review aims to map the current understanding of pre-service teachers' beliefs about ICT, identify critical research gaps, and provide actionable insights for teacher education policy and practice. …”
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    Article
  13. 1153

    Case report: Low-dose radiation reverses pembrolizumab resistance in melanoma by Ka Hey Agnes Fong, Isaac Ho, Tsz Him So

    Published 2025-02-01
    “…However, upon disease progression on first- and second-line immunotherapy, further systemic treatment options are limited especially for cases without actionable molecular alterations. With emerging evidence suggesting that radiotherapy can enhance the efficacy of immunotherapy via various mechanisms, together with its potential abscopal effect, the possibility of overcoming immunotherapy resistance with radiotherapy is theoretically sound. …”
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    Article
  14. 1154

    Cricketing Insights Unveiled: Python-Based Information Extraction from IPL by Kubra Bashir, Afsheen Maroof, Fatima Maqbool, Kiran Bashir, Syeda Iqra Hassan

    Published 2024-12-01
    “…Utilizing data science and Python programming, this study delves into analyzing raw IPL data to uncover actionable insights. Cricket holds a special place in the hearts of fans worldwide. …”
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    Article
  15. 1155

    Researcher views on returning results from multi-omics data to research participants: insights from The Molecular Transducers of Physical Activity Consortium (MoTrPAC) Study by Kelly E. Ormond, Caroline Stanclift, Chloe M. Reuter, Jennefer N. Carter, Kathleen E. Murphy, Malene E. Lindholm, Matthew T. Wheeler

    Published 2025-02-01
    “…Abstract Background There is growing consensus in favor of returning individual specific research results that are clinically actionable, valid, and reliable. However, deciding what and how research results should be returned remains a challenge. …”
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    Article
  16. 1156

    Major data gaps and recommendations in monitoring regulations of activities in EU marine protected areas by Juliette Aminian-Biquet, Jennifer Sletten, Timothé Vincent, Margherita Pieraccini, Betty Queffelec, Anastasiya Laznya, Natașa Vaidianu, Joachim Claudet, Juliette Young, Barbara Horta e Costa

    Published 2025-02-01
    “…We discuss gaps in MPA regulatory data in light of existing reporting requirements, insufficient connection between various actors and data sources, and challenges in translating legal information into actionable indicators. We provide recommendations for future initiatives to improve the collection and standardization for environmental policies.…”
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    Article
  17. 1157

    Evaluating risk factors in automotive supply chains: A hybrid fuzzy AHP-TOPSIS approach with extended PESTLE framework by Ishansh Gupta, Seyed Taha Raeisi, Sergio Correa, Hendro Wicaksono

    Published 2025-03-01
    “…By extending the traditional PESTLE framework with Transportation and Material dimensions, this study provides actionable strategies to mitigate risks and strengthen supply chain resilience in volatile environments.…”
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    Article
  18. 1158

    NIGERIA TECHNICAL AID CORPS (TAC) AND NATIONAL INTEREST, 1999-2023: AN ASSESSMENT by AGABA HALIDU, EMMANUEL IDEMOR UKHAMI, SOLOMON BABATUNDE KUMAPAYI, AKINOLA JACOB ASHIMOLOWO

    Published 2024-08-01
    “…This assessment not only contributes to the academic discourse on international aid and national interest but also offers actionable insights for policymakers to optimize the impact of TAC in fostering sustainable development and enhancing Nigeria’s global influence. …”
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    Article
  19. 1159

    An automatic pipeline for temporal monitoring of radiotherapy-induced toxicities in head and neck cancer patients by Parsa Bagherzadeh, Khalil Sultanem, Gerald Batist, Shirin Abbasinejad Enger

    Published 2025-02-01
    “…An automatic system enables real-time extraction of toxicities and insights into their temporal patterns, offering actionable data to support dose optimization and minimize toxicities in personalized treatments.…”
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    Article
  20. 1160

    THE MEDIATING ROLE OF ENVIRONMENTAL KNOWLEDGE SHARING ON THE IMPACT OF GREEN LEADERSHIP ON INNOVATION IN VIETNAMESE SMALL AND MEDIUM ENTERPRISES by Thanh Khoa Bui

    Published 2024-06-01
    “…Furthermore, identifying actionable transmission mechanisms informs policy guidelines regarding interventions necessary to nurture sustainable innovation. …”
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    Article