FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma by Xuejuan Gao, Donglan Huang, Ying Liu, Gui Zhang, Xiaofen Zheng, Baiye Guan, Aiwen Chen, Jiayao Wu, Shi-Ming Luo, Zonghua Liu, Luxuan Chen, Xiaohui Liu, Jingjie Jin, Xingfeng Yin, Zhenghua Sun, Yunfang Zhang, Meizhi Lu, Gong Zhang, Wanting Liu, Langxia Liu

“…Furthermore, TOM70 (Translocase of outer mitochondrial membrane 70, also named as TOMM70) has been identified as a functional interacting partner of FAM210B in its modulation on the expression of IFN-α/β, as well as the proliferative and metastatic phenotypes of LUAD cells. …”
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Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

“…This work, undertaken by the Working Group (WG) on International Collaborations at the European Network of Pediatric Research at the European Medicines Agency (Enpr-EMA) aims to describe the research ethics review requirements including any pediatric specific requirements, as well as current or upcoming changes across six jurisdictions – the European Union (EU), United Kingdom (UK), United States of America (USA), Canada, Japan, and Australia.MethodsAn open questionnaire developed by the WG and directed at both the Competent Authorities (CA) and the national pediatric clinical trial networks arranged by jurisdictions.ResultsA synopsis of the current regulatory requirements covers centralized versus independent review, comparisons between investigator initiated and industry sponsored clinical trials, timelines, review board members requirements and the consenting/assent process for clinical trial (CT) applications, application submission processes and application requirements for each of the six jurisdictions. It also describes changes currently or soon to be implemented in some jurisdictions.ConclusionThis environmental scan highlights the differences in ethics review for CTs in pediatric medicine development across six jurisdictions. …”
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Dynamic Challenges of Active Tuberculosis: Prevalence and Risk Factors of Co-Infection in Clinical and Microbiological Characteristics at King Abdulaziz University Hospital, Jeddah... by Mokhtar JA, Attallah DM, Jiman-Fatani AA, Al-Rabia MW, Alqarni MA, Saleh BH, Amboon MM, Altorki TA, Alkuwaity KK, Abujamel T, Kaki R, Albarakati TN, Daghistani H, Ismail MA, Alharbi O, Abu ITM, Alfadil A, Ibrahem K, Mufrrih M, Sait AM

“…The results were presented using beta coefficients (B) to quantify the relationship between predictors and the outcome, along with the adjusted odds ratio (AOR) to provide an interpretable measure of the strength of these associations.Results: Of the 131 TB patients involved in this paper, a higher incidence of pulmonary TB was observed among men under 30 years old. This group also showed a higher mortality rate due to comorbidities such as renal failure, human immunodeficiency virus (HIV), and autoimmune disease. …”
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Comparison of clinical metagenomics with 16S rDNA Sanger sequencing for the bacteriological diagnosis of culture-negative samples by Camille d’Humières, Skerdi Haviari, Marie Petitjean, Laurène Deconinck, Signara Gueye, Nathan Peiffer-Smadja, Lynda Chalal, Naima Beldjoudi, Geoffrey Rossi, Yann Nguyen, Charles Burdet, Ségolène Perrineau, Diane Le Pluart, Roza Rahli, Michael Thy, Piotr Szychowiak, Xavier Lescure, Véronique Leflon-Guibout, Victoire de Lastours, Etienne Ruppé

“…On the same samples, CMg (Illumina NextSeq) was also performed and compared to 16S rDNA Sanger sequencing. …”
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Adaptive anomaly detection disruption prediction starting from first discharge on tokamak by X.K. Ai, W. Zheng, M. Zhang, Y.H. Ding, D.L. Chen, Z.Y. Chen, B.H. Guo, C.S. Shen, N.C. Wang, Z.J. Yang, Z.P. Chen, Y. Pan, B. Shen, B.J. Xiao, J-TEXT team

“…In this period disruption prediction also aims to support safe exploration of operation range and accumulate necessary data to develop advanced prediction models. …”
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The 0ν2β-decay CROSS experiment: preliminary results and prospects by The CROSS collaboration, I. C. Bandac, A. S. Barabash, L. Bergé, M. Brière, C. Bourgeois, P. Carniti, M. Chapellier, M. de Combarieu, I. Dafinei, F. A. Danevich, N. Dosme, D. Doullet, L. Dumoulin, F. Ferri, A. Giuliani, C. Gotti, P. Gras, E. Guerard, A. Ianni, H. Khalife, S. I. Konovalov, E. Legay, P. Loaiza, P. de Marcillac, S. Marnieros, C. A. Marrache-Kikuchi, C. Nones, V. Novati, E. Olivieri, C. Oriol, G. Pessina, D. V. Poda, T. Redon, V. I. Tretyak, V. I. Umatov, M. M. Zarytsky, A. S. Zolotarova

“…Rejection factors higher than 99.9% of α surface radioactivity have been demonstrated in a series of prototypes based on crystals of Li2MoO4 and TeO2. We have also shown that point-like energy depositions can be identified up to a distance of ∼ 1 mm from the coated surface. …”
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ABO-incompatible liver transplantation – exploring utilitarian solutions to restricted access and organ shortages: A single-centre experience from Johannesburg, South Africa by E U Wessels, J Loveland, H Maher, P Gaylard, B Bobat, A D Mahomed, D Parbhoo, M R Beretta, C Hajinicolaou, P Walabh, S Berkenfeld, D Demopoulos, S Rambarran, B Ströbele, F van der Schyff, J Fabian, L Brannigan

“…There were significantly increased relative risks of relook surgery for the ABOi group compared with the ABOc group, both overall (relative risk (RR) 1.74; 95% CI 1.10 - 2.75) and at 90 days (RR 2.28; 95% CI 1.27 - 4.11); and also, for pre-discharge bloodstream infection (BSI), (RR 1.84; 95% CI 1.11 - 3.06). …”
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Deteksi Persamaan Pola Gerakan pada Koreografi Tari Bali by Ni Made Rai Maryati, Made Windu Antara Kesiman, I Made Gede Sunarya

“…Dances are not only an entertainment but also means of religious ceremonies and tourism assets. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Maria Lenk, Jörg Tremmel, Markus Rutsche

“…Aksel Sundström and Daniel Stockemer, also among the winners of the Intergenerational Justice Prize 2017/18, take a closer look at the age of parliamentarians and investigate which political parties can help to foster the election of young parliamentarians, and to what extent. …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…In a multivariate analysis, only MRD >10–3 was associated with a poorer OS (hazard ratio, 2.6; 95% confidence interval, 1.2-5.5; P = .013). We also observed a trend toward a better median OS in patients who underwent hematopoietic stem cell transplantation with MRD <10–3 (not reached vs 26.0 months; P = .06). …”
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The efficacy of sodium-glucose transporter 2 inhibitors in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis by Hongsheng Li, Yanli Hou, Wenyong Xin, Lina Ding, Ying Yang, Yikun Zhang, Wenqi Wu, Zhibin Wang, Wenyu Ding

“…SGLT-2 inhibitors intervention was also associated with significant reductions in body weight (MD [95 % CI]; −2.72 kg [-3.49, −1.95], p < 0.00001) and BMI (MD [95 % CI]; −1.11 kg/m2 [-1.39, −0.82], p < 0.00001) and improvements in glycaemic indices, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). …”
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Editorial by Pieter Vanhuysse, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…Building on earlier work by Gál et al.,[3] they also show that conclusions on the very direction of intergenerational resource transfers simply reverse when the scope of analysis moves from public policies to the total economy including households. …”
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Adverse events in the nervous system associated with blinatumomab: a real-world study by Wen Gao, Jingwei Yu, Yifei Sun, Zheng Song, Xia Liu, Xue Han, Lanfan Li, Lihua Qiu, Shiyong Zhou, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…The highest fatality rate for neurological events was observed for increased intracranial pressure disorders, which also had the highest co-occurrence rate with cytokine release syndrome (CRS). …”
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Territorios rurales en transformación: desafíos y oportunidades frente al reto de la despoblación by Néstor Vercher

“…Indeed, the crisis in agriculture and livestock farming accelerated the abandonment of farms already during the 60s and 70s of the last century (as can also be seen in the picture), reducing economic opportunities. …”
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Digital mental health treatment implementation playbook: successful practices from implementation experiences in American healthcare organizations by David C. Mohr, David C. Mohr, Alexandra L. Silverman, Alexandra L. Silverman, Soo Jeong Youn, Soo Jeong Youn, Soo Jeong Youn, Patricia Areán, Andrew Bertagnolli, Jenna Carl, Tarolyn Carlton, Neha Chaudhary, David Cooper, Shelly DeVito, Stephanie Eaneff, Megan Flom, Valerie L. Forman-Hoffman, Leanna Fortunato, Karen Franchino, Andrea K. Graham, Heidi Greenberger, Jessica Hauflaire, Benjamin Kaveladze, Rachel Kornfield, Kaylee P. Kruzan, Eric Kuhn, Eric Kuhn, Carolyn MacIver, Frederick Muench, Regina Misch, Adrian Ortega, Lisa Palko, Derek Richards, Derek Richards, Louisa Salhi, Jonathan Schremp, Eva Szigethy, Eva Szigethy, Nathan Tatro, Bethany A. Teachman, Bethany A. Teachman, Trina Histon

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Territorios rurales en transformación: desafíos y oportunidades frente al reto de la despoblación by Néstor Vercher

“…Indeed, the crisis in agriculture and livestock farming accelerated the abandonment of farms already during the 60s and 70s of the last century (as can also be seen in the picture), reducing economic opportunities. …”
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بررسی اثر پوشش گلس بید و صدف بر روی ویژگی های فیزیکی و مکانیکی نانوکامپوزیت های زمینه پلیمری تقویت شده با الیاف شیشه و آرد چوب راش... by سپیده ساسانیان, آرش فرج پور رودسری, اصغر تابعی

“…آزمون‌های برای سنجش خواص فیزیکی و مکانیکی شامل میزان جذب آب و واکشیدگی ضخامت، خمش، کشش، ضربه و سایش بر روی نمونه‌ها براساس درستورالعمل ASTM با سه تکرار انجام شد، درنهایت با وزن مخصوص سنگ نمای ساختمان براساس مقررات ملی ساختمان مقایسه گردید. …”
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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes by Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

“…In response to plitidepsin, cells upregulate EIF2AK3 and proteins that reduce translation, but also proteins that support proteostasis via ribosome synthesis and cap-independent translation by eIF4G2 and IGF2BP2. …”
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Panitumumab versus cetuximab in combination with irinotecan in refractory metastatic colorectal cancer by Maria Ignez Freitas Melro Braghiroli, Daniel Santos Rocha Sobral Filho, Juliana Goes Martins Fagundes, Elizabeth Zambrano Mendoza, Maria Fernanda Batistuzzo Vicentini Neffa, Karla Souza Campos, Leonardo Gomes da Fonseca, Renata Colombo Bonadio, Aley Talans, Oddone Freitas Melro Braghiroli, Maria Cecília Mathias-Machado, Jorge Sabbaga, Camila Motta Venchiarutti Moniz, Paulo Marcelo Gehm Hoff

“…There was no significant difference in median overall survival between treatment groups (9.1 months [I + C] vs 10.1 months [I + P]; p = 0.76). There was also no difference in progression-free survival (3.63 months [I + C] vs 3.73 months [I + P]; p = 0.19) and objective response rate (23.0 % [I + C] vs 22.3 % [I + P]; p = 0.97). …”
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Penerapan Importance Performance Analysis (IPA) pada Evaluasi Keberlanjutan Penggunaan e-filing untuk Pelaporan Pajak Perorangan by Imelda Saluza, Dewi Sartika

“…This is conducted to enhance customer experience. To get the most out of e-filing as a method of uploading individual tax returns (SPT). …”
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