Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer by Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang

“…Use the HE staining, immunohistochemistry (IHC) and TUNEL staining of tumor issues to verify the anti-neoplasm of each group. We also tested the changes of TME through flow cytometry of spleen of mice in each group, as well as the IHC of cytokines.ResultsThe co-therapy of PO and anti-PD-1 showed admirable anti-tumor effect compared with the control group and the single drug groups. …”
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Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents by Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu

“…Molecular modelling studies suggested the ability of compounds 9m and 9o to establish interactions with three hydrogen bonds to Asp267 and Glu346 of NHE-1, but also the ability with much lower CDOCKER energies than positive control cariporide and buthutin A. …”
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Pregnancy-Associated Plasma Protein-A: Its Significance as a Single Biomarker for Adverse Obstetric Outcomes by Madhusudan Dey, Priyanshi Choudhury, Sunil Chawla, Pranjali Dhume, Suyash Goel, Ankur Shah, Mounica Gowda KN

“…RESULTS: Low pregnancy-associated plasma protein-A levels showed a statistically significant association with gestational hypertension, preeclampsia, abortion, fetal demise, and also for adverse neonatal outcomes like APGAR <5 at 1 min, fetal growth restriction, neonatal intensive care unit admission, and perinatal deaths. …”
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Prediction models for cognitive impairment in middle-aged patients with cerebral small vessel disease by Wei Zheng, Xiaoyan Qin, Ronghua Mu, Peng Yang, Bingqin Huang, Bingqin Huang, Zhixuan Song, Xiqi Zhu, Xiqi Zhu

“…This study also included the extraction of total intracranial volume, gray matter, white matter, cerebrospinal fluid, white matter hypertensit, and hippocampus volume. …”
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Analisis Seleksi Atribut Dalam Memprediksi Kegagalan Skripsi Mahasiswa Menggunakan Algoritme Naïve Bayes pada Jurusan Sistem Informasi Universitas Brawijaya by Satrio Hadi Wijoyo, Satrio Agung Wicaksono, Admaja Dwi Herlambang

“…Abstract   Data mining can be applied to the field of educational institutions or institutions and is often referred to as Educational Data Mining (EDM), which is a method development in exploring unique types of educational data types that aim to study in understanding student performance and environmental settings in which students learn. Data mining can also be used to analyze attribute selection for predicting student learning failure in lectures. …”
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Parchment Glutamine Index (PQI): A novel method to estimate glutamine deamidation levels in parchment collagen obtained from low-quality MALDI-TOF data by Nair, Bharath, Palomo, Ismael Rodríguez, Markussen, Bo, Wiuf, Carsten, Fiddyment, Sarah, Collins, Matthew James

“…MALDIpqi() holds excellent potential for biocodicological and other archaeological studies involving collagen, such as bone, but we also foresee its application in the food and biomedical industry.   …”
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A History of The Six-Year Primary Project in the Use of Yoruba as the Medium of Primary Education by Toyin Falola, Michael Oladejo Afolayan

“…If a young child is forced to speak in English (or the majority language) when they prefer to speak in their mother tongue, they are also forced to operate at a lower intellectual age than they actually are. …”
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Epidemiological and Clinical Aspects of Ulcerative Colitis in Mosul city, Iraq by Muhammed Babakir-Mina

“…The majority of patients was from urban or inside Mosul city center 140 (70%). The study also showed that the more frequency of patients 103 (51.5%) were in severe condition. …”
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Forest restoration efficiency: A comparative analysis of collectively vs. individually managed forests in Nepal by Sony Baral, Saurav Lamichhane, Bir B. Khanal Chhetri, Bikash Adhikari, Kalyan Gauli, Rebecca M Ford

“…These results underscore the benefits of the collectively managed system, but also indicate the need to review the program to ensure better access for dependent households.…”
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Acute toxicological and behavioural effects of perfluorohexanoic acid (PFHxA) in the model nematode, Caenorhabditis elegans by Tanmoy Sana, Manjurul Islam Chowdhury, Panneerselvan Logeshwaran, Mallavarapu Megharaj

“…At 3.14 mg L−1, PFHxA further impaired chemotaxis learning and reduced body-bending frequency. The study also highlights the relationship between PFCA toxicity and chain length, with a toxicity gradient observed (PFOA >> PFHxA> PFBA). …”
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A qualitative exploration of owner experiences following dog adoption by Bethany Joy Moyer, Helen Zulch, Beth Ann Ventura, Oliver Burman

“…Future research should incorporate a longer time-frame to better understand how and when dogs adjust to a home, and as there is variation in dog behaviour during adjustment, it must also account for individual differences. As we develop a better understanding of how to characterise this period, adopters can be better prepared for the initial months of dog ownership, and interventions can be individualised to improve owner experience and dog welfare.…”
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The mediating role of psychological equilibrium in the relationship between dietary variety and self-reported health among older adults in rural China by Zhaoquan Jiang, Zhaoxu Xu, Mingyue Zhou, Huijun Zhang, Shixue Zhou

“…Therefore, this study aimed to analyze this association in a large-scale general population of rural older adults from China. It also investigates the mediating effect of the psychological equilibrium (PE) in the association between dietary variety and SRH in this population. …”
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INTEGRATION OF UKRAINIAN CHILDREN AND YOUTH USING DIGITAL TOOLS IN THE EDUCATIONAL ENVIRONMENT OF SLOVAKIA by Nelly Nychkalo, Nataliia Muranova, Olena Voliarska, Maria Matulcikova

“…It has been established that the integration of Ukrainian school-aged children into the educational environment of Slovakia also requires significant linguistic, educational and socio-psychological support from teachers and pedagogical workers. …”
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Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway by Y. El Yousfi, F. J. Fernández-Farrán, F. J. Oliver, A. López-Rivas, R. Yerbes

“…Although other mechanisms may also be involved in controlling cell death and inflammation in tumor cells facing environmental stress, our results support a model in which regulation of the subcellular localization and activity of the YAP/TAZ transcriptional co-activators could contribute to the microenvironmental control of cell fate decisions in tumor cells undergoing ER stress.…”
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Does sociality affect evolutionary speed? by Socias-Martínez, Lluís, Peckre, Louise Rachel

“…Continuing to refine the theory and evidence on social effects on evolutionary speed might come at a benefit not only for the current issue but also for the domains it integrates. …”
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Mechanical behaviour analysis of cemented tailings rock backfill materials: An insight from mesoscale modelling coupled with damage plasticity model by Chaoyi Yang, Hang Lin, Rugao Gao, Zhengrong Li, Dengjun Gan, Mingwu Liu, Qifan Ren

“…The potential application in real scenarios is also discussed. The key findings include: (1) incorporating waste rock significantly enhances elasticity but slightly reduces strength; (2) a lower cement-to-tailing ratio leads to compressive damage playing a more critical role in failure patterns; and (3) increasing the maximum particle diameter negatively impacts strength. …”
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Regional Arterial Stiffness in Patients with Inflammatory Bowel Disease by V. V. Genkel, R. G. Portnova, T. V. Antipina, I. I. Shaposhnik

“…According to the results of the correlation analysis, the increase in cfPWV was associated with an increase in patient age (r = 0.564; p = 0.01), the duration of IBD history (r = 0.628; p = 0.003), fasting plasma glucose (r = 0.367; p = 0.034) and GFR decrease (r = -0.482; p = 0.031). The crPWV also directly correlated with the IBD duration (r = 0.630; p = 0.003). …”
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Refined Urban Functional Zones Identification via Empirical Bayesian Kriging: A POI-Weighted Scoring Innovation by Xuan Du, Yisha Pan, Xiaoyan Yang, Longgao Chen, Liangchen Liu, Ying Lin

“…Results indicate that: 1) The EBK interpolation method not only accounts for the spatial and directional distance relationships between known and unknown sample points, but also produces more accurate raster images and provides more precise estimates in unmeasured ranges. 2) The method successfully identifies UFZs for 99.5% of the buildings in the central urban area of Xuzhou. …”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Gastric emptying and insulin secretion are also affected by GLP-1 RAs. Clinical trials consistently demonstrate significant weight loss, positive action on cardiovascular risk and better glycemic control. …”
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Huerto urbano Adelfas (Madrid, 24 de enero de 2021) by Claudia Antón Biezma

“…Gardens change the geography of cities and make good use of empty slots, and they are also small green lungs against pollution. …”
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