Nephroprotective effects of Foeniculum vulgare mill (Apiaceae Family) hydromethanol leaf extract against cisplatin-induced nephrotoxicity on Swiss albino mice by Kibur Hunie Tesfa, Chernet Desalegn Gebeyehu, Tiget Ayelgn Mengstie, Hiwot Tezera Endale

“…Results: Mice that received cisplatin alone (group II) exhibited a significant decrease in body weight on day 16, an increase in serum kidney markers, a decrease in serum sodium and chloride, an increase in potassium and calcium, an increase in relative kidney weight, and pathological damage to the kidney as compared to the normal control group. …”
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Efficient adsorption of ofloxacin in a novel nanocomposite formed by nano-hexagonal boron nitride fused with zeolite imidazolite skeleton-8: Experimental and molecular dynamics sim... by Zefang Huang, Yuankai Hong, Yiqun Cui, Huiying Guo, Yan Long, Jinshao Ye

“…Thermodynamic parameters indicated that the adsorption process of ZIF-8@h-BN-X was exothermic and spontaneous when compared to h-BN alone. This study highlights the significant potential of ZIF-8@h-BN-X in treating antibiotic-contaminated wastewater, while providing theoretical and practical insights for developing novel, efficient two-dimensional nanocomposite adsorbents.…”
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The protective effect of coadministration of coenzyme Q10 and vitamin E on myopathy induced by simvastatin in rats by Omar Ammar Hashim, Intesar Tarik Numan, Nadia Hameed Mohammed

“…The combination group showed a superior protective effect than either drug alone. Treatment with vitamin E and CoQ10 showed mild vacuolation and cytoplasm with focal splitting and fragmentation of muscle fibers, scattered central nuclei, and eosinophilic cytoplasm. …”
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Adding A Structured Educational Session to the Rehabilitation Program of Soccer Players Following Anterior Cruciate Ligament Reconstruction: A Feasibility Study by ABDULLAH ALMUHAYA, ALI ALBARRATI, AHMED ALHOWIMEL, FARIS ALODAIBI

“…Participants post ACL reconstruction were randomized to either usual care with a structured educational session (intervention group) or usual care alone (control group). This feasibility study investigated three aspects: recruitment, intervention acceptability and randomization, and retention. …”
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Detection and decontamination of Mycoplasma in cultured cells and viral strains by Glaucia Prado de Andrade, Natália Hettwer Pedroso, Alice Becker, Vinicius Soares dos Santos, Juciane Bonella, José Valter Joaquim Silva Júnior, Rudi Weiblen, Eduardo Furtado Flores

“…The combined P + G treatment was effective in eliminating Mycoplasma spp. from four cultures between days 35 and 42, followed by treatment with Plasmocin ® (3/4) and gentamicin alone (1/4). The CRIB cell line could not be decontaminated. …”
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A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure contr... by Philip Düsing, Stephan H. Schirmer, Sebastian Schäfer, Alexander Krogmann, Jan-Malte Sinning, Nikos Werner, Florian Bönner, Alexander Sedaghat, Cornelius Müller, Irina Eckardt, Georg Nickenig, Andreas Zietzer

“…The control group received standard care alone. From the original cohort, subgroups of patients with systolic BP ≥140 mmHg (n = 44), ≥130 mmHg (n = 89) and diastolic BP ≥90 mmHg (n = 28) were analyzed for BP reduction after 12 weeks.ResultsIn patients with systolic BP ≥140 mmHg, the intervention group showed a reduction in systolic BP by 15.5 mmHg (± 16.7 mmHg, p = 0.0001), which was greater compared to the control group (6.0 ± 13.0 mmHg, p = 0.058). …”
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Polypharmacy and self-medication among older adults in Indian urban communities—a cross-sectional study by Saibal Das, Pavithra Gnanavel, Shalini Smanla, Anku Moni Saikia, Shilpi Mishra, Shweta Khare, S. Arun Murugan, Vadanere Nidhi Prakash, Parimita Roychoudhury, Ishteyaque Ahmad, Vishal Diwan, J. Rajesh, K. Sathish Kumar, Jugal Kishore, Namita Srivastava, Sabrina Yasmin, Mahmuda Nasrin, Rinku Borah, Mandeep Sarma Basistha, Chetanjit Baruah, Manoj Kalita, Shambo Samrat Samajdar, Jerin Jose Cherian, Ashish Pathak, Samiran Panda, Santanu Kumar Tripathi, Cecilia Stålsby Lundborg

“…The prevalence of self-medication was 19.7% (95% CI 16.6–23.1%), associated with factors, such as staying alone [aOR 4.5 (95% CI 2.4–6.6)], multiple comorbidities [aOR 3 (95% CI 1.4–6.7)], and recent hospitalization [aOR 4.8 (95% CI 1.5–8)]. …”
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Capivasertib enhances chimeric antigen receptor T cell activity in preclinical models of B cell lymphoma by Hui-Ju Hsieh, Ryan Urak, Mary C. Clark, Larry W. Kwak, Stephen J. Forman, Xiuli Wang

“…Furthermore, in vivo combination therapy of capivasertib and CD19-specific CAR T cells led to improved early response to and persistence of functional CAR T cells in mice bearing PTEN-deficient lymphoma cells compared to CAR T cells alone. Capivasertib exerts a similar function to AKT Inhibitor VIII in modulating CAR T cells, and combining CAR T cell therapy with capivasertib both ex vivo and in vivo offers the potential to improve patient outcomes. …”
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A single-centre experience of His bundle pacing without electrophysiological mapping system: implant success rate, safety, pacing characteristics and one-year follow up by Swee Leng Kui, Colin Yeo, Lisa Teo, Ai Ling Him, Sherida Binte Syed Hamid, Kelvin Wong, Vern Hsen Tan

“…As a non-university, non-electrophysiology specialised centre in Singapore, we report our experiences in HBP using pacing system analyser alone. Methods: Data of 28 consecutive patients who underwent HBP from August 2018 to February 2019 was retrospectively obtained. …”
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Durable resistance or efficient disease control? Adult Plant Resistance (APR) at the heart of the dilemma by Rimbaud, Loup, Papaïx, Julien, Rey, Jean-François, Moury, Benoît, Barrett, Luke G., Thrall, Peter H.

“…Our numerical experiments explore the deployment of APR in a simulated agricultural landscape, alone or together with a major resistance gene. As a case study, the mathematical model has been parameterised for rust fungi (genus Puccinia) of cereal crops, for which extensive data are available. …”
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Action Plans to Reduce PM2.5 Concentrations in Hotspots of Delhi-NCR Using a One-way Coupled Modeling Approach by Shubham Sharma, Mukesh Khare, Sri Harsha Kota

“…A marginal reduction of 4% estimated for the previously implemented traffic rationing measure, the odd-even rule, indicates that such regulation of vehicles alone might be inefficacious. The results suggest that stakeholders must focus on—(a) source and hotspot-specific interventions alongside city wide interventions to significantly reduce ambient PM2.5 concentrations, (b) local and non-local contributions from regions outside the hotspot grid needs to be carefully considered for estimating efficacy of an action plan.…”
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Soap and water cleaning versus bleach-based cleaners for eliminating SARS-CoV-2 infection by Ekong E. Udoh, Ubong A. Udoh, Abiodun Egwuenu, Ekpereonne B. Esu, Aruk Eteng, Faithman E. Ovat, Uduak Okomo, Olabisi Oduwole, Joseph Okebe, Martin Meremikwu

“…Aim: To compare the effectiveness of soap and water alone to bleach-based cleaners in eliminating SARS-CoV-2 infection in households and community settings. …”
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Contemporary Management of Patients With Chagas Cardiomyopathy in Bolivia by Evan Czulada, BS, Sascha Bercovitch, BA, Yazan Alshawkani, MD, Natalia Noya Weise, MD, Adriana E. Hernani Rodrigo, BS, Ronald Gustavo Durán Saucedo, MD, Marcelo Buhezo Chamón, MD, Robert H. Gilman, MD, David T. Martin, MD

“…Anticoagulation was prescribed if CCM patients had atrial fibrillation (91%) or apical aneurysm with thrombus (86%), yet few cardiologists prescribed anticoagulation in left ventricular systolic dysfunction or CCM diagnosis alone. While pacemaker therapy was generally available to cardiologists (66%), patients received devices only through private insurance or philanthropy, with few physicians (28%) offering implantable cardioverter-defibrillators regularly. …”
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Utilization of Sanitized Human Excreta and Wood Ash for Establishing Multipurpose <i>Ficus Thonningii</i> Blume in a Degraded Tantalum Technosol by D. Neina

“…Five treatments including No amendment; HUF alone (100 mL/pot); HUF+WA (100 mL + 60 g/pot); FM (200 g/pot); and FM+WA (200 g + 60 g/pot) were prepared in ten replicates each. …”
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Microbial diversity, functional attributes, and nutritional proficiency of yogurts produced in Bangladesh by Md. Tanvir Islam, M. Shaminur Rahman, Susmita Roy Chowdhury, Tanay Chakrovarty, S. M. Kador, Md. Mazharul Islam, Khondoker Tanjim Islam, Mohammad Imtiaj Uddin Bhuiyan, Ovinu Kibria Islam

“…Abstract Bangladeshi yogurt is a creamy, tangy dairy product with culinary significance in Bangladesh, often consumed alone or as a complement to spicy dishes. This study investigates the microbial diversity and nutritional composition in 38 samples, spanning commercial and locally produced varieties from eight districts. …”
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Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy by Mengyi Liu, Lue Zhang, Quanming Zhang, Nan Zeng, Shuo Li, Shuyue Guo, Yaqin Zhao, Mingxing Tang, Qiong Yang

“…Objective: This retrospective study aimed at comparing the extent of epithelialization in mastoid obliteration after Canal Wall Down (CWD) mastoidectomy using Hydroxyapatite (HA) alone or using HA in combination with Concentrated Growth Factor (CGF) extracted from autologous blood. …”
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Development of machine learning models for predicting non-remission in early RA highlights the robust predictive importance of the RAID score-evidence from the ARCTIC study by Gaoyang Li, Shrikant S. Kolan, Franco Grimolizzi, Joseph Sexton, Giulia Malachin, Guro Goll, Tore K. Kvien, Tore K. Kvien, Nina Paulshus Sundlisæter, Manuela Zucknick, Siri Lillegraven, Espen A. Haavardsholm, Espen A. Haavardsholm, Bjørn Steen Skålhegg

“…A simplified model using RAID score alone demonstrated comparable performance to the full-feature model.ConclusionThese findings highlight the potential utility of baseline RAID score-based model as an effective tool for early identification of patients at risk of non-remission in clinical practise.…”
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Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD) by John R Hurst, Jennifer K Quint, Hana Müllerova, Liam Smeeth, Harriet Forbes, Susan Eaton, Rachael L DiSantostefano, Kourtney Davis

“…Using a diagnostic code alone, the PPV was 86.5% (77.5–92.3%) while requiring a diagnosis plus spirometry plus specific medication; the PPV was slightly higher at 89.4% (80.7–94.5%) but reduced case numbers by 10%. …”
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Relationship between METS-IR and ABSI index and the prevalence of nocturia: a cross-sectional analysis from the 2005–2020 NHANES data by Fei Xue, Yating Zhou

“…Subgroup analyses showed a stronger association between ABSI and nocturia among individuals living alone and those aged 20–38 years. Nonlinear modeling indicated a threshold effect for ABSI, with nocturia risk significantly increasing when ABSI exceeded 76.2. …”
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Generalizability of machine learning models for diabetes detection a study with nordic islet transplant and PIMA datasets by Dinesh Chellappan, Harikumar Rajaguru

“…On the Nordic islet transplant dataset, the combined ABC-PSO feature extraction with EHO feature selection achieved the highest accuracy of 97.14%, surpassing the 94.28% accuracy obtained with ABC alone and EHO selection. Similarly, on the PIMA Indian diabetes dataset, the ABC-PSO and EHO combination achieved the best accuracy of 98.13%, exceeding the 95.45% accuracy with ABC and DFA selection. …”
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