Sustainable Distance E-Learning for Enhanced Students Retention and Support: Faculty of Law National Open University of Nigeria in Focus by Erimma Gloria Orie

“…The institution has 455,837 students as at April 2016 enrolled and has graduated 12000 students since re-launched in 2002 and in 2017 alone graduated 12000 students, the highest in any year since its relaunch in 2002. …”
Get full text

Assessing the role of genotype by environment interaction of winter wheat cultivars using envirotyping techniques in North China by Haiwang Yue, Yanbing Wang, Zhaoyang Chen, Jiashuai Zhu, Partha Pratim Behera, Pengcheng Liu, Haoxiang Yang, Jianwei Wei, Junzhou Bu, Xuwen Jiang, Xuwen Jiang, Wujun Ma

“…Furthermore, the joint analysis showed that GEI variance exceeded the variance attributed to genotypic effects alone. The Additive Main Effects and Multiplicative Interaction (AMMI) model indicates that the first three interaction principal component axes (IPCAs) account for over 70% of the GEI variance, thereby demonstrating the relevance of this model to the current study. …”
Get full text

TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Bintrafusp alfa (BA) is a bifunctional fusion protein that simultaneously blocks nonredundant immunosuppressive TGF-β and PD-(L)1 pathways.Methods This first-in-human, dose-escalation study in patients with advanced solid tumors (N=58; aged ≥18 years, ECOG PS≤1) evaluated M6223 alone (Part 1A, n=40; M6223 10–2400 mg every 2 weeks, n=32; M6223 2400 mg every 3 weeks, n=8) or with BA (Part 1B, n=18; M6223 300–1600 mg with BA 1200 mg; both every 2 weeks, intravenous). …”
Get full text

Clinical, genomic, and histopathologic diversity in cerebral cavernous malformations by Jian Ren, Daochao Wang, Leiming Wang, Chendan Jiang, An Tian, Ziwei Cui, Yeqing Ren, Lisong Bian, Gao Zeng, Guolu Meng, Yongzhi Shan, Jiantao Liang, Xinru Xiao, Jie Tang, Yukui Wei, Chuan He, Liyong Sun, Yongjie Ma, Jiaxing Yu, Guilin Li, Ming Ye, Peng Hu, Jingwei Li, Ye Li, Lijian Niu, Qianwen Li, Feng Ling, Jan-Karl Burkhardt, Hongqi Zhang, Tao Hong

“…For non-hemorrhagic epilepsy, patients with single MAP3K3 mutations or combined MAP3K3 & PIK3CA mutations were at greater risk than those with PIK3CA mutations alone. Histopathologically, lesions with PIK3CA mutations displayed cyst walls, pS6-positive dilated capillaries, and fresh blood cells, while MAP3K3 and double mutation lesions exhibited classic CCM pathology with SMA-positive and KLF4-positive vessels, collagen, and calcification. …”
Get full text

Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species by Zhang J, Li G, Hu J, Tan J, Zhang H, Zhou Y

“…The antifungal efficacy of PP, either alone or in combination with azoles, was tested according to the reference method. …”
Get full text

The Cost-effectiveness of Celecoxib versus Non-steroidal Anti-inflammatory Drugs plus Proton-pump Inhibitors for Treating Osteoarthritis in Algeria by Nadir Hammoumraoui, Sid Ahmed Kherraf, Joaquin Mould-Quevedo, Tarek A. Ismail

“…Treatment with celecoxib alone showed an ICER of US$1,530.56 versus diclofenac+PPI. …”
Get full text

How does dispersal shape the genetic patterns of animal populations in European cities? A simulation approach by Savary, Paul, Tannier, Cécile, Foltête, Jean-Christophe, Bourgeois, Marc, Vuidel, Gilles, Khimoun, Aurélie, Moal, Hervé, Garnier, Stéphane

“…Considering this, we tested whether variations in dispersal constraints alone could explain the variability of neutral genetic patterns commonly observed in urban areas. …”
Get full text

Spatial analysis of measles cases and vaccination coverage in the Somali region, eastern Ethiopia by Abdilahi Ibrahim Muse, Abdilahi Ibrahim Muse, Mahdi Yonis Kayat, Mohamed Harir Aden, Jemal Beksisa Shuramu, Shikur Mohammed, Musse Ahmed Ibrahim, Musse Ahmed Ibrahim, Binyam Mohammedbirhan Berhe, Ahmed Abdi Kalinle, Sahardiid Ali Abdilahi

“…It can be prevented by two doses of the measles vaccine, either alone or in combination with measles-rubella (MR), which is a low-cost strategy for lowering morbidity and mortality among children.ObjectivesTo conduct spatial analysis of measles cases and vaccination coverage in the Somali region, Eastern Ethiopia.MethodsThis retrospective study was done by using public health emergency directorate measles data from 2022 to 2023 and four years (July 2019–July 2023) of vaccination data from district health information system version 2.36. …”
Get full text

Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice by Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu

“…In addition, hepatocytic necrosis and lipid deposition were significantly improved under SEN pretreatment conditions compared to the HIRI group alone. Meanwhile, HIRI can significantly increase the expression of genes related to liver injury and inflammation, while SEN pretreatment can lead to a concentration-dependent decrease in these genes. …”
Get full text

Altered functional brain connectivity in Dyt1 knock-in mouse models by R. Z. Adury, B. J. Wilkes, P. Girdhar, Y. Li, D. E. Vaillancourt, D. E. Vaillancourt, D. E. Vaillancourt

“…We also hypothesized that EMX mice would exhibit altered functional connectivity and activation patterns, supporting the idea that TorsinA dysfunction in the sensorimotor cortex alone can induce network abnormalities. In dGAG animals, we observed significantly lower functional connectivity between key sensorimotor nodes, such as the globus pallidus, somatosensory cortex, thalamus, and cerebellum. …”
Get full text

Molecular characterization and potential therapeutic roles of miR125a in HER-2 positive gastric cancer by Afraa Mamoori, Zena Hasan Sahib, Haider Alkafaji

“…The effects of miR-125a-3p alone and in combination with 5-FU (fluorouracil) on the growth of HER2 positive (NUGC4) and HER2 negative (ECC10) gastric carcinoma cells were also analyzed by in vitro studies. …”
Get full text

Smart Pharmaceutical Monitoring System With Personalized Medication Schedules and Self-Management Programs for Patients With Diabetes: Development and Evaluation Study by Jian Xiao, Mengyao Li, Ruwen Cai, Hangxing Huang, Huimin Yu, Ling Huang, Jingyang Li, Ting Yu, Jiani Zhang, Shuqiao Cheng

“…ObjectiveThis study aims to develop and establish a stand-alone diabetes management service system designed to enhance self-management support for patients, as well as to assess its performance with experienced health care professionals. …”
Get full text

Metode Deteksi Intrusi Menggunakan Algoritme Extreme Learning Machine dengan Correlation-based Feature Selection by Sulandri Sulandri, Achmad Basuki, Fitra Abdurrachman Bachtiar

“…However, using the ELM method alone is not able to produce good accuracy, so the ELM method needs to be added to the Correlation-Based Feature Selection (CFS) feature selection method to improve the accuracy and computational time. …”
Get full text

Idénymunka és idénymunkások a gyümölcstermesztésben. Hazai munkaerőpiaci folyamatok és közelképek európai összevetésben by Katalin Kovács, Eszter Hamza, Katalin Rácz, Nigel John Swain, Monika Mária Váradi

“…A tanulmány két eltérő természeti, klimatikus adottságú és gazdasági helyzetű térségben, a Nagykőrösi és a Bonyhádi járás területén végzett empirikus kutatás eredményei alapján részletesen bemutatja, hogy a gyümölcságazat gazdálkodói miként érzékelik, és milyen okokkal magyarázzák a munkaerőhiányt, valamint elemzi azokat a stratégiákat, gyakorlatokat, amelyek e kihíváshoz való alkalmazkodást szolgálják. A vállalkozók egyfelől igyekeznek megtartani alkalmas, megbízható embereiket minél hosszabbra nyúló foglalkoztatással (ezt segíti a gyümölcsfajták diverzifikációja) és a munkafeltételek javításával, másfelől mérsékelni kívánják munkaerőigényüket a tevékenységek, illetve a termékszerkezet diverzifikációja, valamint egyes termesztési fázisok gépesítése révén. …”
Get full text

Real-World Treatment Patterns in Men with Castration- Resistant Prostate Cancer Receiving Docetaxel by Keith L. Davis, Benjamin Gutierrez, Teresa Zyczynski, James A. Kaye

“…Most (78.9%) patients initiated docetaxel with prednisone, while 18.5% initiated docetaxel alone and 2.6% initiated with other medications. …”
Get full text

Interventions for SARS-CoV-2 prevention among Jailed adults: A network-based modeling analysis by Isaac Schneider, Karina Wallrafen-Sam, Shanika Kennedy, Matthew J. Akiyama, Anne C. Spaulding, Samuel M. Jenness

“…Results: Cell-level contact tracing alone was an ineffective intervention (3.2% PIA), but its impact increased in combination with other interventions (i.e., vaccination or increased jail release rate). …”
Get full text

Effect of a tailor-made hydrotherapy on physical functions in patients after unilateral unicompartmental knee arthroplasty—A feasibility study by Wai-Wang Chau, Mei-Yan Lau, Tsz-Lung Choi, Gloria Yan-Ting Lam, Michael Tim-Yun Ong, Kevin Ki-Wai Ho

“…Combination of hydrotherapy with conventional postoperative physiotherapy rehabilitation yielded even better outcomes than conventional physiotherapy alone. Further research with advanced study design, larger sample size and longer follow-up periods for patients who underwent UKA is recommended. …”
Get full text

Surgical Treatment Patterns, Healthcare Resource Utilization, and Economic Burden in Patients with Tenosynovial Giant Cell Tumor Who Underwent Joint Surgery in the United States by Feng Lin, Winghan J. Kwong, Sherry Shi, Irina Pivneva, Eric Q. Wu, John A. Abraham

“…**Conclusions:** Surgical resection alone might be inadequate to control TGCT. New treatment options may complement surgery and alleviate the clinical and economic burden experienced by patients with TGCT who had received prior surgery.…”
Get full text

PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis by JinJing Pan, Ping Wang, Linghong Xiong, Wenqing Yang, Jie Li, Kai Yang, Bingyan Li

“…In this study, our findings not only demonstrated the effective encapsulation of 1,25(OH)2D3 in PLGA (PLGA-1,25(OH)2D3, PD) but also indicated that the PD has a more potent inhibitory effect on the proliferation and migration of breast cancer cells compared with 1,25(OH)2D3 alone. Consistently, PD exhibits superior efficacy in suppressing subcutaneous neoplasia and lung metastasis of breast cancer cells compared to 1,25(OH)2D3. …”
Get full text

Optimization of Harvesting Fish Return From Norongoza Pond in Mwanjari Ward Southern Division Kabale Municipality. by Nuwaha, Louis

“…The study revealed that the most realistic model is one where h,(t,x) depends on the fishing effort size of the tilapia population while h,(t, y) was assumed to depend on the effort and the size of Nile perch alone that is h,(t,x) = o,h,(x) and h,(t,y) = o, ha(). …”
Get full text