Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…Results indicated that biochar increased soil temperatures by +1 °C during winter, thus favouring an earlier phenology and average biomass (+10 % and +7.2 %) and yield (+13.2 % and +8.5 %) increase in both a[CO2] and e[CO2] treatments compared to the no biochar [B0] treatments. Biochar treatments also increased flag leaf chlorophyll and decreased flavonoids, and enhanced intrinsic water use efficiency due to increases in photosynthesis and decreases in stomatal conductance. …”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…The quantile-based g-computation (QGC), weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were applied to evaluate the overall correlation of BFRs mixtures with NAFLD and identify significant compounds. …”
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Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomize... by Feifei Xu, Tingting Liu, Huiqing Liu, Jiao Deng, Shan He, Zhihong Lu, Haopeng Zhang, Hailong Dong

“…Results In the RIPC group, the incidence of PND (44%) was comparable to that in the control group (44%, P = 0.982). …”
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Effectiveness of flipped classrooms in Chinese students of clinical medicine major undergoing clinical practice: a meta-analysis by Xinrui Sun, Xin Yuan, Linyu Zhang, Yi Zhang, Xue Xiao, Hanmin Liu, Fang Ma

“…Weighted mean differences (WMD) and 95% confidence interval (CI) were used to compare the differences in theoretical and skill scores between the flipped classrooms and traditional lecture groups. …”
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Taung and beyond: The mining history, geology and taphonomy of Australopithecus in South Africa by Rieneke Weij, Stephanie E. Baker, Tara R. Edwards, Job Kibii, Georgina Luti, Robyn Pickering

“…To understand this rich and diverse fossil record, we must understand how the landscape formed (cave formation processes) and changed (mining), when this happened (geochronology), and how the fossils were accumulated and modified (taphonomy). …”
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Cancer Burden Disease Attributable to PM2.5 and Health Risk by PM2.5-bound Toxic Species in Two Urban Chilean Municipalities by Ye Li, Franz Muñoz-lbañéz, Ana Maldonado-Alcaíno, Darby Jack, Beizhan Yan, Li Xu, Marco Acuña, Manuel Leiva-Guzman, Ana Valdés, Dante D. Cáceres

“…Modern carbon in OC and EC analysis showed that the principal source of PM2.5 emission in Coyhaique was firewood burning compared with Independencia. The total PAHs and B[a]P concentrations were 6.3 and 8.9 times higher in Coyhaique than in Independencia. …”
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Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study by Johanna P. van Gemert, Bart Luijk, Merel E. Hellemons, Klara A. Visser, Carina.M.E. Hansen, Renske van der Meer, C. Tji Gan, Hester van der Vaart, Onno W. Akkerman, Willie N. Steenhuis, Marieke Verkleij, Harry G.M. Heijerman, Erik A.M. Verschuuren

“…BMI, HbA1c, SNOT-22 score, GI Symptom Tracker, CF Questionnaire-Revised (CFQ-R), FEV1, creatinine, changes in calcineurin inhibitor (CNI) doses and levels were compared between baseline and 3 months follow-up. Results: Fifty-five PwCF post-LTx were included, of whom 5 were excluded because of ETI discontinuation due to side effects, within 3 month follow-up. …”
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Anti-inflammatory effects of Andrographis paniculata (Fah Talai Jone) via TNFα-JNK pathway and bioactive compound identification by Praphat Manuelo Ruengthanoo, Areeya Changthong, Pranee Sriraj, Jatuporn Prathumtet, Nutchapon Laikaew, Ratchadawan Aukkanimart

“…APE exhibited higher phenolic (8.66 ± 0.37 mg GAE/g) and flavonoid (156.33 ± 4.76 mg QE/g) content compared to APA. Antioxidant assays revealed IC50 values of 11.14 ± 1.07 µg/ml for APA and 2.29 ± 0.13 µg/ml for APE. …”
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Gender differences of health literacy in persons with a migration background: a systematic review and meta-analysis by Elke Kalbe, Nicole Skoetz, Christiane Woopen, Digo Chakraverty, Annika Baumeister, Angela Aldin, Ümran Sema Seven, Ina Monsef

“…Another 27 studies reported data on female participants only and could not be included due to a lack of comparable studies with male participants only. Authors of 56 other eligible studies were asked for data, but without success.Conclusion Men with a migration background—while being much less frequently examined—may have lower health literacy than women. …”
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Evidence Graph Analysis of Postoperative Pain Sensitization Induced by Perioperative Sleep Deprivation by XUE Jianjun, WANG Caihong, GUO Lingling, LI Xiuxia, ZHANG Jie, XU Ziqing, HOU Huaijing, YANG Kehu

“…ObjectiveTo describe and evaluate the clinical studies of postoperative pain sensitization caused by sleep deprivation through the evidence map system, understand the distribution of evidence in this field, and provide reference for subsequent evidence research.MethodsA computer-based search of PubMed, EMBASE, Cochrane library, Web of Science, CNKI, Wanfang Data, VIP and Chinese Biomedical Literature Database from inception to August 2023 was conducted to obtain intervention studies, observational studies and systematic reviews/Meta-analysis of postoperative pain sensitization caused by sleep deprivation. …”
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Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis by Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter S. Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu

“…COX-2, the key enzyme of the AA/eicosanoid pathway, was significantly upregulated in Cr(VI)-exposed lung tissues, as well as in the Cr(VI)-induced transformed (Cr-T) cells compared to parental BEAS-2B (B2B) cells. We then employed multidisciplinary in vitro and in vivo functional assays to characterize the role of COX-2 in Cr(VI)-induced lung cancer. …”
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Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer by Lulu Zhang, Lulu Zhang, Xiyuan Guo, Xiyuan Guo, Xiaoke Sun, Jue Liao, Qin Liu, Yingchun Ye, Zhihui Yang, Ratchada Cressey, Qing He, Qing Yuan, Qing Yuan

“…Finally, we assessed the effects of combined blockade of PD1 and IL-6 on macrophage recruitment in a zebrafish macrophage model and CD8+ T cell function and tumor growth in PBMC humanized mouse model.ResultsThe expression of exhaustion markers on CD8+ T cells was found to be notably higher in both tumor and paraneoplastic tissues compared to peripheral blood. Furthermore, the degree of CD8+ T cell exhaustion exhibited a progressive increase with proximity to the tumor. …”
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Safety and efficacy of switching from adalimumab to sarilumab in patients with rheumatoid arthritis in the ongoing MONARCH open-label extension by Gerd R Burmester, Mark C Genovese, Vibeke Strand, Gregory St John, Andrea Rubbert-Roth, Howard Amital, Tatiana Raskina, Antonio Gómez-Centeno, Claudia Pena-Rossi, Leon Gervitz, Karthinathan Thangavelu, Susan Boklage

“…Improvements postswitch approached continuation-group values, including scores ≥normative values.Conclusions During this OLE, there were no unexpected safety issues in patients switching from adalimumab to sarilumab monotherapy, and disease activity improved in many patients. …”
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Evidence linking phthalate exposure to alterations of hematologic parameters in Chinese children: A cross-sectional study by Mei-Ting Wei, Ying Wen, Zhu-Xia Zhang, Xiu-Ju Liu, Feng-Xiang Wei, Wei-Qiang Liu, Li Zhou, Ding-Yan Chen, Yao Yao

“…To evaluate the connections between mPAEs and hematologic indices, both individually and in combination, several analytical approaches were used, including the generalized linear model (GLM), the Bayesian kernel machine regression (BKMR) model, and the quantile g-computation (QGC) model. The findings of the GLM indicated that the majority of mPAEs were correlated with hematologic parameters. …”
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Variación espacial y estacional de metales y compuestos orgánicos en los sedimentos costeros del Golfo de Arauco by Cristian Chandia, Marco Salamanca, Aldo Hernández, Luis Bermedo, Eduardo Hernández-Miranda, Oscar Inostroza-Michael

“…Se observaron patrones de distribución comparables entre campañas de muestreo, sin evidenciarse diferencias estadísticamente significativas entre ellas. …”
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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

“…RNA sequencing datasets characterizing the model were compared to publicly available RNA/proteomic datasets. …”
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Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…Additionally, AB4′s safety in clinical applications was evaluated.ResultsThe AB4 group demonstrated significantly lower composite clinical scores on Days 7 and 14 compared to the placebo group (p = 0.033 and p = 0.000, respectively). …”
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Synergistic effects of allantoin and Achyranthes japonica-biochar profoundly alleviate lead toxicity during barley growth by Ghulam Murtaza, Najmaldin Ezaldin Hassan, Muhammad Usman, Gang Deng, Zeeshan Ahmed, Javed Iqbal, Mohamed S. Elshikh, Humaira Rizwana, Basharat Ali, Rashid Iqbal, Maximilian Lackner

“…The resistance towards Pb2+ was enhanced by biochar, allantoin, and their combined application, with lower Pb2+ concentrations in shoots (59.9 %, 40.1 %, and 49.8 %), roots (48.2 %, 24.1 %, and 58.3 %), and grains (60.2 %, 29.7 %, and 40.1 %) compared to solely Pb-stress, respectively. In summary, converting the weed Achyranthes japonica into biochar and integrating it with allantoin provides an eco-friendly approach to control its proliferation while efficiently alleviating Pb-induced toxicity in plants.…”
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Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

“…We also observed enhanced infiltration of CD8+ T cells in distant tumors in the AIT with αPD-1 group compared to αPD-1 alone. Hence, mitochondria-targeting represents an effective strategy to potentiate the combination of photothermal, chemodynamic, and immune checkpoint blockade therapies for the treatment of metastatic cancer.…”
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The prevalence of malaria in the five districts of Limpopo Province, South Africa, 2015 - 2017 by M T Lamola, A Musekiwa, A de Voux, C Reddy, M Morifi, P C Mutevedzi

“…In adjusted analyses, ages 15 - 49 years (adjusted odds ratio (aOR) 1.58, 95% confidence interval (CI) 1.48 - 1.68, p<0.001) and <1 year (aOR 1.55, 95% CI 1.37 - 0.74, p<0.001) were at higher odds of having malaria compared with ages ≥65 years. Conclusion. These findings highlight the significant burden of imported malaria in Limpopo Province. …”
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