Editorial by Daniel Halliday

“…The second article in this issue, from Johannes Stößel, Julian Schneidereit and Sonja Stockburger, focuses on intergenerational capital transfers in Germany. Central to the focus in this article is the constitutional provision in Germany for the protection of family-owned businesses. …”
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Exploring patient preferences for intraocular lenses selection in age-related cataract: a discrete choice experiment study by Qiaolin Zhu, Qiaolin Zhu, Qiaolin Zhu, Qianqian Sun, Qianqian Sun, Qianqian Sun, Yujia Huo, Yujia Huo, Yujia Huo, Xiaoling Yang, Xiaoling Yang, Xiaoling Yang, Hehe Huang, Hehe Huang, Hehe Huang, Shanshan Qian, Shanshan Qian, Shanshan Qian, Wenjing Lin, Wentao Yan, Wentao Yan, Wentao Yan

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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

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Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis Fro... by Valeria Cento, Sara Carloni, Riccardo Sarti, Linda Bussini, Zian Asif, Paola Morelli, Francesco De Fazio, Federica Maria Tordato, Maddalena Casana, Debora Mondatore, Antonio Desai, Elena Generali, Nicola Pugliese, Elena Costantini, Massimo Vanoni, Maurizio Cecconi, Stefano Aliberti, Giorgio Da Rin, Erminia Casari, Michele Bartoletti, Antonio Voza

“…., cancer, diabetes), infection source, presence of central venous catheters (CVC), ongoing therapies, and sepsis severity. …”
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Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis by Shasha Huang, Wanqi Li, Dengke Wang, Huiwen Feng, Bo Wang, Xinyu Dong, Wei Zhao, Dan Liu, Yuan Wang

“…It can exert direct action on the central nervous system to produce neurotoxicity. Exposure to DM can lead to iron metabolism disorder, oxidative stress and learning and memory dysfunction. …”
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GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma by Meng Li, Yuan Gao, Wei Zhang, Zhijun Tan, Kuo Zhang, Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang, Kefeng Dou, Ran Zhuang, Boquan Jin, Qiang Hao, Wangqian Zhang, Shuning Wang, Jintao Gu, Lei Shang, Haichuan Su, Yingqi Zhang, Cun Zhang

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Research trends and hotspots in post-stroke speech rehabilitation: A bibliometric analysis by Nan Huang, Kang Zou, Fang Liu, Zhen Su, Long Chen, Yanbiao Zhong, Yun Luo, Maoyuan Wang, Li Xiao

“…Key trends included “communication disorders,” “functional connectivity,” and “melodic intonation therapy,” with “stroke” and “aphasia” emerging as central keywords. Conclusion: Research in post-stroke speech rehabilitation is increasing, with significant contributions from the United States and key institutions. …”
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Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

“…Mass spectrometry revealed a conserved set of proteins including THBS1 (thrombospondin 1), SERPINE1 (serpin family E member 1), ANXA1 (annexin A1), LOX (lysyl oxidase), and ITGB1 (integrin beta-1) which are involved in extracellular matrix (ECM) organization and wound healing, with the PI3K/AKT signaling pathway playing a central role. The PEGDA/SA/Col-I hydrogel demonstrated a unique balance of mechanical and biological properties and an optimal environment for MSC viability and function. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Abstract Parkinson’s disease (PD) is a progressive degenerative disease of the central nervous system associated with neuroinflammation and microglial cell activation. …”
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Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…As such, this description of how this body came to be and an establishment of its workings is of much value. The central involvement of the civil society organisation, Protect the Future, is revealed and specific examples of the Commissioner’s success in exercising his competencies are presented. …”
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Analisis Dampak Kabut Asap dari Kebakaran Hutan dan Lahan dengan Pendekatan Text Mining by Zuliar Efendi, Imas Sukaesih Sitanggang, Lailan Syaufina

“…Data yang digunakan adalah data tweet terkait kabut asap di Provinsi Riau pada jarak 11 – 17 September 2019 dan juga data hotspot atau titik panas serta citra Sentinel2. Data tweet dikelompokkan dengan beberapa percobaan pada jarak antar cluster yaitu single linkage, complete linkage, average linkage, dan ward. …”
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Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis by Roberto Buonaiuto, Aldo Caltavituro, Margherita Tafuro, Alessandra Longobardi, Giuliana Pavone, Pierluigi De Santis, Roberta Caputo, Carmine De Angelis, Lucia Del Mastro, Fabio Puglisi, Mario Giuliano, Grazia Arpino, Martina Pagliuca, Michelino De Laurentiis

“…Methods: We conducted a meta-analysis including the most recent randomized trial data systematically searched from PubMed, Embase, Web of Science, Cochrane CENTRAL (from inception to May 31st, 2024) or presented in abstracts or oral presentations at the ESMO, ASCO, and SABCS international congresses. …”
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Efficacy and safety of the Russian protease inhibitor narlaprevir at treatment-naive and earlier treated noncirrhotic patients with the 1st genotype chronic hepatitis C (PIONEER st... by M. V. Mayevskaya, V. T. Ivashkin, O. O. Znoyko, Ye. A. Klimova, D. T. Abdurakhmanov, I. G. Bakulin, P. O. Bogomolov, E. Z. Burnevich, M. Yu. Galushko, N. I. Geyvandova, K. V. Zhdanov, Ye. V. Esaulenko, S. N. Kizhlo, D. Yu. Konstantinov, N. I. Mironova, V. G. Morozov, Ye. A. Strebkova, I. G. Nikitin, M. F. Osipenko, V. D. Pasechnikov, O. I. Sagalova, I. M. Khayertynova, V. P. Chulanov, A. A. Yakovlev, I. A. Vasyutin, Ye. P. Tarkhova, E. N. Krasavina, M. Yu. Samsonov

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ASKAP Observations of the Radio Shell in the Composite Supernova Remnant G310.6-1.6 by Wenhui Jing, Jennifer L. West, Xiaohui Sun, Wasim Raja, Xianghua Li, Lingxiao Dang, Ping Zhou, Miroslav D. Filipović, Andrew M. Hopkins, Roland Kothes, Sanja Lazarević, Denis Leahy, Emil Lenc, Yik Ki Ma, Cameron L. Van Eck

“…We detect polarized emission from the central pulsar wind nebula (PWN) with rotation measures varying from –696 rad m ^−2 to –601 rad m ^−2 . …”
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Research on Characteristics and Influencing Factors of High Temperature Disaster Risk in Wuhan Based on Local Climate Zone by Shujing GUO, Li ZHANG

“…Finally, geographically weighted regression (GWR) models are used to explore the effect of LCZ landscape patterns on spatial heterogeneity of high temperature disaster risk.ResultsThe characteristics of high temperature disaster risk in each district do not differ much, and the overall spatial presentation of the development center of each district gradually decreases from high to low, with high-risk areas mainly located in the south-central part of Caidian District, the west and north of Jiangxia District, the dense industrial parks in the south of Dongxihu District, the Wuhan Iron and Steel Factory in Qingshan District, and the Tianhe Airport in Huangpi District, and the low-risk areas are mainly in the watershed part. …”
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Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands by Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes

“…The liver plays a central role in fat storage, but little is known about physiological fat accumulation during early development. …”
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Optimizing fodder yield and quality through integrated organic nutrient amendments in multi-crop system by Santosh Onte, Santosh Onte, Vrushabh Vijay Fiskey, Manjunath S. Melavanki, Airadevi P. Angadi, Prasanna S. Pyati, Magan Singh, Dileep Kumar, Sanjivkumar Angadarao Kochewad, Sudhir Kumar, Hari Om, Vijendra Kumar Meena, Kamal Garg, Vetrivel Karunakaran, Manish Kanwat, Babu Lal Meena, Yogananda Shivalli Boregowda, Rahul Bellagi, K. Naveena, Sunil Chandersheker, Elisa Azura Azman, Sanjeev Kumar

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The sport and Lithuanian national identity by Ingvaras Butautas, Rasa Čepaitienė

“…The "sport-loving nation" stereotype was shaped by mass media because even sports contest visiting rates, generally mouthy and inflated in official protocols, prove the slight popularity of sport in Lithuania in comparison with other East-Central European countries. …”
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Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

“…Even where central review is allowed, local review may still be required for vulnerable populations like children. …”
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Deteksi Dan Klasifikasi Hama Potato Beetle Pada Tanaman Kentang Menggunakan YOLOV8 by Daniel Geoffrey Manurung, Mohammad Ryan Pinasthika, Muhammad Azka Obila Vasya, Rania Aprilia Dwi Setya Putri, Agustinus Parasian Tampubolon, Rakan Fadhil Prayata, Septia Khoirin Nisa, Novanto Yudistira

“…Metode yang digunakan untuk mendeteksi dan mengklasifikasikan potato beetle adalah Convolutional Neural Network (CNN) yang merupakan algoritma jaringan syaraf tiruan yang efektif dalam pengolahan citra. Model YOLOv8 (You Only Look Once) diimplementasikan untuk mendeteksi objek pada gambar dengan mengidentifikasi posisi dan kelas dari potato beetle. …”
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