Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

“…RNA sequencing datasets characterizing the model were compared to publicly available RNA/proteomic datasets. …”
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Evaluation of Patients’ Received Doses in Chest CT Scan Protocols for COVID-19 Diagnosis by Sadegh Shurche, Tinoosh Almasi, Maryam Tima, Nima Rostampour

“… Purpose: This study aims to investigate and compare the doses received by Corona Virus Disease (Covid-19) patients on Computed Tomography (CT) scans by changing the scan parameters to diagnose the disease and evaluate its course and effects. …”
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Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…Additionally, AB4′s safety in clinical applications was evaluated.ResultsThe AB4 group demonstrated significantly lower composite clinical scores on Days 7 and 14 compared to the placebo group (p = 0.033 and p = 0.000, respectively). …”
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Laparoscopic suture repair for perforated peptic ulcer disease: a meta-review and trial sequential analysis by S. I. Panin, T. V. Nechay, I. V. Sazhin, K. Yu. Melnikov-Makarchuk, A. V. Sazhin, A. V. Puzikova, A. N. Akinchits, A. V. Bykov

“…Their pooled results showed a lower postoperative pain score after laparoscopic repair compared with open closure on postoperative day 1 as the only significant outcome. …”
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The impact of precompetition state on athletic performance among track and field athletes using machine learning by Yuting Zhang, Pengyu Fu, Qi Yu, Qingmei Niu, Dongfeng Nie, Xiangya Dou, Xiaoqin Zhang

“…ObjectiveThis study aims to compare the differences in the precompetition status (nutritional, physiological, biochemical, psychological, and sleep statuses) among college track and field athletes with different competition performances and to screen for key indicators of differences affecting athletic performance.MethodsMultiple indicators, traditional methods, and machine learning methods are used to detect the exercise load, fatigue index, and precompetition state of athletes with different sports performances.Results(1) Two weeks before the competition, the fat mass in the left upper limb in the BP group was significantly higher than that in the BnP group (P < 0.05). …”
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Environmental Surveillance and Transmission Risk Assessments for SARS-CoV-2 in a Fitness Center by Hongwan Li, Sripriya Nannu Shankar, Chiran T. Witanachchi, John A. Lednicky, Julia C. Loeb, Md. Mahbubul Alam, Z. Hugh Fan, Karim Mohamed, Arantzazu Eiguren-Fernandez, Chang-Yu Wu

“…Our model also predicts that a combination of high ventilation, minimal air recirculation, air filtration, and UV sterilization of recirculated air reduced the infection risk up to 94% compared to poorly ventilated facilities. Amongst these measures, high ventilation with outdoor air is most critical in reducing the airborne transmission of SARS-CoV-2. …”
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ASSESSING THE EFFICACY OF CLOUD SERVICES FOR DEVELOPING EDUCATIONAL PRESENTATIONS by Tetiana V. Bondarenko, Nadia M. Stetsenko, Volodymyr P. Stetsenko, Halyna V. Tkachuk

“…Our research conducted a comprehensive comparative analysis of these platforms, utilizing web analytics tools such as Ahrefs, Moz, and Similarweb to establish their respective rankings. …”
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The effect of a community-based health behaviour intervention on healthcare services use among people with type 2 diabetes in Nepal by Grish Paudel, Corneel Vandelanotte, M Mamun Huda, Padam Kanta Dahal, Lal Rawal

“…Results: Intervention participants reported a higher increase in health facility visits, specialist visits, emergency visits and hospital admissions by 7.2 %, 13.5 %, 1.3 % and 0.4 % respectively, compared to control participants. However, these changes were not statistically significant. …”
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Analysis of Vaginal Microbiome in Women with or Without Episodes of Spontaneous Abortion in Eastern Nigeria by Felix Emele Emele, Prisca Onyeulor, Francisca Nwaokorie, Damian Asogwa

“…This study aimed at comparing the vaginal microbiome of women who have had episodes of spontaneous abortion with those who have not experienced any incident - in order to find out any possible role of vaginal microbiota in spontaneous abortion. …”
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Combined effects of topography, soil moisture, and snow cover regimes on growth responses of grasslands in a low- mountain range (Vosges, France) by P.-A. Herrault, A. Ullmann, D. Ertlen

“…We also noted hotspots of browning grasslands (a decrease in annual maximum NDVI), largely overrepresented compared to the greening ones (an increase in annual maximum of NDVI), a pattern which contradicts most productivity signals highlighted in European high-mountain grasslands. …”
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Experimental investigation of the parameters of additively manufactured coaxial swirl injectors by Samir Vekilov, Volodymyr Lipovskyi, Roman Marchan, Artem Lohvynenko

“…The obtained data is analyzed and compared to the calculated values. …”
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Introducing 3D printed models of fractures in osteology learning improves clinical reasoning skills among first-year medical students: a pilot study by Abhishek Agarwal, Anne D Souza, B. Jyostna, Ashwija Shetty, Nandini Bhat

“…At the end of the second session, students were evaluated for their clinical reasoning ability using a case-based MCQ test (maximum score 5). The scores were compared between the two groups using an unpaired t-test. …”
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Synergistic effects of allantoin and Achyranthes japonica-biochar profoundly alleviate lead toxicity during barley growth by Ghulam Murtaza, Najmaldin Ezaldin Hassan, Muhammad Usman, Gang Deng, Zeeshan Ahmed, Javed Iqbal, Mohamed S. Elshikh, Humaira Rizwana, Basharat Ali, Rashid Iqbal, Maximilian Lackner

“…The resistance towards Pb2+ was enhanced by biochar, allantoin, and their combined application, with lower Pb2+ concentrations in shoots (59.9 %, 40.1 %, and 49.8 %), roots (48.2 %, 24.1 %, and 58.3 %), and grains (60.2 %, 29.7 %, and 40.1 %) compared to solely Pb-stress, respectively. In summary, converting the weed Achyranthes japonica into biochar and integrating it with allantoin provides an eco-friendly approach to control its proliferation while efficiently alleviating Pb-induced toxicity in plants.…”
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Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

“…We also observed enhanced infiltration of CD8+ T cells in distant tumors in the AIT with αPD-1 group compared to αPD-1 alone. Hence, mitochondria-targeting represents an effective strategy to potentiate the combination of photothermal, chemodynamic, and immune checkpoint blockade therapies for the treatment of metastatic cancer.…”
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Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study by Xiaofeng Lv, Xinmin Deng, Rui Lai, Shanshan Liu, Zihao Zou, Xuechun Dai, Yalan Luo, Jian Luo, Ying Li

“…Multivariate weighted logistic regression consistently demonstrated that dietary fiber, folic acid, and nicotinic acid intake were negatively associated with the presence of OA, while protein intake exhibited a J-shaped relationship with OA, and carbohydrate or fat intake showed no significant association with OA. Compared with participants in the lowest quartile (Q1), those in the highest quartile (Q4) of dietary fiber, folic acid, and nicotinic acid intake had 27%, 28%, and 33% lower odds of having OA, respectively, after adjusting for potential confounding factors. …”
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The prognostic value of boost dose in residual cervical lymph nodes in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy: a retrospective study by Mengting Xu, Liuling Wang, Jianming Ding, Yiying Xu, Zhaodong Fei

“…Results Patients with positive RCLN findings exhibited considerably lower 3-year relapse-free survival (RRFS), overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) rates compared to those with negative findings (98.0% vs. 92.8%; 93.5% vs. 85.0%; 87.0% vs. 68.4%; 92.8% vs. 81.9%, all P < 0.001). …”
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Efficiency comparison of natural coagulants (Cactus pads and Moringa seeds) for treating textile wastewater (in the case of Kombolcha textile industry) by Getahun Demeke Worku, Shimeles Nigussie Abate

“…The main objective of this study was to evaluate and compare the effectiveness of various powders and Moringa seed cactus pad powders when employed as a natural coagulant to clean up textile effluent. …”
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An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats by Archana K. Thikekar, Asha B. Thomas, Sohan S. Chitlange

“…Notably, the combination treatment (GP+IME-9) significantly decreased FBGL, TC and TG levels compared to individual therapy groups, suggesting synergistic pharmacodynamic effects. …”
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Progress towards 90-90-90 and 95-95-95 strategy implementations and HIV positivity trends in the City of Johannesburg by J C Y Nyasulu, I Maposa

“…HIV access trends were tracked and compared with the set strategy implementation targets. …”
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Beef cattle performance and hair cortisol accumulation in silvopastoral and pastoral systems: a 2-year assessment by A. Ripamonti, G. Foggi, A. Mantino, L. Turini, J. Goracci, A. Silvi, M. Finocchi, M. Mele

“…We conducted a 2-year on-farm experiment to compare growth performance, measuring average daily gain (ADG), hair cortisol accumulation, and blood glucose concentration in Maremmana breed steers and heifers reared in either a silvopastoral (SP) or pastoral (PA) system during spring and summer. …”
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