Frailty in older adults admitted to hospital: outcomes from the Western Sydney Clinical Frailty Registry by Julee McDonagh, Richard I Lindley, Karen Byth, Reejamol John, Caleb Ferguson

“…Increased cumulative incidence of first rehospitalisation and/or death during the first 12 months post-discharge was significantly associated with higher modified Charlson comorbidity (p < 0.001) and Clinical Frailty Scale (CFS) scores (p < 0.001). Compared to the ‘non-frail’ group (CFS 1–4), those who were severely frail (CFS 7–9) had an 85% increased risk of rehospitalisation and/or death (95% CI 1.36–2.52), and those who were mild-moderately frail (CFS 5–6) had a 52% increased risk after adjusting for effects of the other variables (95% CI 1.18–1.94). …”
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Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study by Vin-Cent Wu, Ting-Ya Yang, Min-Hsiang Chuang, Hong-Min Lin, Heng-Chih Pan, Yun Chou, Jui-Yi Chen

“…After matching, the ICPi-AKI group exhibited a higher risk of all-cause mortality (HR=1.27; 95% CI 1.02 to 1.61), MAKE (HR=3.83; 95% CI 1.72 to 8.40), MACE (HR=1.35; 95% CI 1.03 to 1.75)) compared with the non-ICPi-AKI group. Subgroup analyses confirmed these findings across various patient’s characteristics.Conclusion Individuals with ICPi-AKI are associated with an increased risk of all-cause mortality, MAKE and MACE. …”
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Estimation of median LC50 and toxicity of environmentally relevant concentrations of thiram in Labeo rohita by Sana Alam, Gulnaz Afzal, Riaz Hussain, Hafiz Muhammad Ali, Amtul Sami, Rabbiah Manzoor Malik, Raheela Jabeen, Farid Shokry Ataya, Kun Li

“…Oxidative stress parameters; ROS and TBARS were increased significantly (p < 0.05) while antioxidant enzymes (CAT, SOD, POD, GSH) showed a significant (p < 0.05) decrease in the treated groups compared to the control. Moreover, comet assay revealed significant (p < 0.05) DNA damage in the isolated cells of kidneys, heart and brain at higher doses (80 μg/L and 120 μg/L) of thiram that was further confirmed by histo-pathological alterations in these tissues. …”
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Racial and ethnic disparities in longitudinal trajectories of cardiovascular risk factors in U.S. middle-aged and older adults. by Matthew E Dupre, Radha Dhingra, Hanzhang Xu, Scott M Lynch, Qing Yang, Cassie Ford, Michael D Green, Ying Xian, Ann Marie Navar, Eric D Peterson

“…<h4>Results</h4>Among 10,292 participants (median age: 61), approximately 32% had an overall favorable profile of CVD risk factors. Compared with non-Hispanic White adults, non-Hispanic Black adults were more likely to exhibit elevated systolic BP with high risks of DM (relative risk ratio [RRR] = 3.36; 95% CI, 2.69-4.21; P < .001) and with low risks of DM (RRR = 3.23; 95% CI, 2.38-4.38; P < .001). …”
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Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients by Rhian M Touyz, Ninian N Lang, Kevin G Blyth, Naveed Sattar, Patrick B Mark, Stefan Siebert, Colin Berry, Iain McInnes, Giles Roditi, Neil Basu, David Corcoran, Kenneth Mangion, Alex McConnachie, David Carrick, Jaclyn Carberry, Stuart Watkins, Paul Welsh, Sabrina Nordin, Katherine Scott, Christian Delles, Bernard Kelly, Fraser Goldie, John GF Cleland, Sharon Kean, Peter Kellman, David J Lowe, Andrew J Morrow, Antonia Ho, Rosemary Woodward, Tracey Hopkins, Ryan Wereski, Massimo Palmarini, Alasdair McIntosh, Campbell Rogers, Ammani Brown, Catherine Bagot, Kathryn Scott, Robert Sykes, Colin Church, Claire Rooney, Nicola Ryan, Clare Orange, Dirk Husmeier, Xiaoyu Luo, PETER W MACFARLANE, Heerajnarain Bulluck, Iain Findlay, Evonne McLennan, Michael Briscoe, Oliver Peck, Alastair J Rankin, Gruschen Veldtman, Varun Sharma, Kathryn McLaren, Elaine Butler, Sarah Mullen, Andrew Morrow, Patrick Mark, Daniel Doherty, Alexander Payne, Jennifer S Lees, Kaitlin J Mayne, Louise Inglis, Anna Kamdar, Hannah Bayes, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Christopher McGinley, Connor Mckee, Sarah Allwood-Spiers, Sarah Weeden, Laura Knox, Lynn Abel, David Stobo, Andrew Dougherty, Liam Peng, David Barrie Stobo, Sylvia Wright, Stephen Dobbin, Keith Gillis, Sarah A Spiers, Ian Fergus, Kirsty Fallon, Lesley Gilmour, Chloe Cowan, Jurgen Van-Melckebeke, Kim Moran-Jones, Debra Stuart, Maureen Travers, Laura Dymock, Fiona Savage, Nicola Tynan, Sau Lee Chang, Mhairi Dupre, Lindsey Norton, George Bruce, Rosario Gonzalez-Lopez, Rebecca Stace, Dionne Russell, Jean Watt, Shahid Latif, Nick Hill, Amy Collinsworth, Ross McGeoch Vera Lennie, Robin P Weir

“…The majority of COVID-19 cohort (68%) had less than 20% persisting radiological abnormalities, with 67% demonstrating overall improvement compared with admission imaging. Older age, premorbid performance status, typical acute COVID-19 radiological features, markers of severe acute COVID-19, convalescent ICAM-1 and P-selectin were associated with persisting lung abnormalities (all p&lt;0.05). …”
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Clinical and angiographic profile of left main coronary artery disease in patients with chronic coronary syndrome: a retrospective study by Abdulsalam Mahmoud Algamal, Mahmoud Abdelbadie Salem, Ahmed Ibrahim Bedier, Mohammed Salah A. Hussein, Mona Malek Abdelrahim, Shady Hussein Elhusseiny

“…About 9.8% of LMD patients were < 50 years. Compared to males, females with LMD had significantly older age and increasing prevalence with age from 9.7% in patients < 50 years to 27.4% in patients > 70 years. …”
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The change rule of smoke dispersion and temperature evolution in fires within lithium iron phosphate energy storage prefabricated cabin by ZHANG Yin, QIN Chaoqun, TIAN Shuangshuang, GE Zhichao, DONG Jun, ZHANG Xiaoxing

“…Based on direct numerical simulation and vortex simulation, a numerical model of lithium iron phosphate energy storage prefabricated cabin based on the size of the actual energy storage prefabricated cabin is studied, and the t2 model which is more in line with the development of the fire situation compared with the stable fire model, and investigated the change rule of the smoke dispersion and temperature inside the prefabricated cabin by simulating the fire situation with different thermal runaway positions. …”
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Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Results: The top 5 features of pathologic stromal remodeling most associated with adverse allograft outcomes were also strongly associated with histories of both overt and indolent inflammatory events. Compared to controls, a history of high-grade or treated rejection was significantly associated with progressive pathologic remodeling and future adverse outcomes (32.9% vs 5.1%, p < 0.001). …”
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Chemical Fingerprints for PM2.5 in the Ambient Air near a Raw Material Storage Site for Iron Ore, Coal, Limestone, and Sinter by Kavita Justus Mutuku, Yen-Yi Lee, Guo-Ping Chang-Chien, Sheng-Lun Lin, Wei-Hsin Chen, Wen-Che Hou

“…Abstract To understand the contributions of a raw material storage site for iron ore, coal, limestone, and sinter to ambient air fine particulate matter (PM2.5), the concentrations and chemical fingerprints for resuspended and ambient air PM2.5 were compared. Investigations were done for 15 piles of raw materials, including 5 iron piles, 5 coal piles, 3 stone piles, and a single pile each for coke and sinter. …”
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Empirical analysis of control models for different converter topologies from a statistical perspective by Hole Shreyas Rajendra

“…It was observed that bioinspired models and incremental learning techniques assists in improving control performance for efficiency-aware use cases. This text also compares the evaluated models in terms of their conversion efficiency, cost of deployment, delay needed for control, scalability and computational complexity under different scenarios. …”
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Clinical manifestations, para-clinical features and outcome of Iranian adults with respiratory syncytial virus (RSV) infection: a report from hospitalized patients by Maryam Shafaati, Abbas Shakoori Farahani, Mohammadreza Salehi, Mohammad Arabzadeh, Helya Bolouki Azari, Arman Soleimany, Maryam Edalatifard, Vahid Salimi, Alireza Abdollahi

“…The mean age of the hospitalized patients was 53.28 ± 20.37 years (range: 15–83), with a slightly higher proportion of females (52.80%) compared to males (47.20%). Dyspnea, productive cough, and fever were the most common symptoms, with a mean symptom duration of 10.50 days. …”
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Impact of parathyroidectomy on inflammatory and cardiovascular risk parameters in primary hyperparathyroidism: a retrospective analysis by Nese Bulbul, Suat Sen, Fettah Acibucu

“…Patient demographics, hemogram data, calcium, parathormone (PTH), vitamin D, high-density lipoprotein (HDL), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-HDL ratio (MHR) were recorded and compared pre- and postoperatively. Results The analysis revealed significant postoperative increases in platelet, MPV, HDL, PLR, and vitamin D levels (p = 0.001, p = 0.001, p = 0.001, p = 0.024, p = 0.001, respectively). …”
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Shear bond strength of three different fixed retainers: Stainless steel wires versus fiber reinforced composite (An in Vitro study) by Anees Mahmood Mudhir

“…This in vitro study is conducted to evaluate and compare the bond strength (shear bond strength) of three different fixed lingual retainers using a specific retainer composite and fracture modes of different retainer’s wire/adhesive combination. …”
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The Effect of Concussion History on Lower Extremity Injury Risk in College Athletes: A Systematic Review and Meta-Analysis by Vanessa Ramirez, Ryan McCann, Eric Schussler, Jessica Martinez

“… # Conclusions Lower extremity injury risk is potentially increased in college athletes following a concussion compared to those without a history of a concussion. …”
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An Interval Throwing Program for Baseball Pitchers Based upon Workload Data by Michael M. Reinold, Brittany Dowling, Glenn S. Fleisig, Leonard C. Macrina, Kevin E. Wilk, John T. Streepy, James R. Andrews

“… # Hypothesis/Purpose To 1) develop a updated ITP for rehabilitation of modern baseball pitchers based upon biomechanical and throwing workload data, and 2) compare the updated program with a past program to determine differences in chronic workload and acute:chronic workload ratios (ACWR)…”
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Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition. by Tiffany M Halvorsen, Kaitlin A Schroeder, Allison M Jones, Disa Hammarlöf, David A Low, Sanna Koskiniemi, Christopher S Hayes

“…The CDI ionophores deployed by E. coli isolates partition into six major groups based on their entry domain structures. Comparative sequence analyses led to the identification of receptor proteins for ionophore toxins from groups 1 & 3 (AcrB), group 2 (SecY) and groups 4 (YciB). …”
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A qualitative investigation of the influences of gender among low-socioeconomic status students’ motivations to study biology by Svetlana Masjutina, Elizabeth Stearns

“…Results Using interview data from LSES students who were participants in an externally funded scholarship program, we found that personal interests, positive learning experiences, and particularly medical career opportunities were highly influential for shaping major-related choices for LSES students, comparable to the motivations seen among biology students from all demographic groups. …”
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Comparison of robotic-assisted and laparoscopic partial nephrectomy based on the PADUA score and the predictive value of the PADUA score and the Mayo Adhesive Probability score for... by Shuo Liu, Bowen Zhang, Bowen Weng, Xiangqiang Liu, Sichuan Hou

“…Abstract Purpose This study compared perioperative outcomes of robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN) through the PADUA score as well as assessed the predictive value of the PADUA score and the Mayo Adhesive Probability (MAP) score for postoperative complications. …”
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The good, the bad, and the ugly: Compliance of e-pharmacies serving India and Kenya with regulatory requirements and best practices. by Gautam Satheesh, Sammy Masibo, Sasi Kumar Tiruttani, Irene Khayoni, Benjamin Palafox, Devaki Nambiar, Jaison Joseph, Emmanuel Kweyu, Abdul Salam, Francis Wafula, Catherine Goodman

“…In both countries, high-traffic websites and e-pharmacies located within the study country had higher mean compliance to regulation and best practices compared to the others. These findings can be leveraged to strengthen enforcement in Kenya and inform the development of a comprehensive regulatory framework in India. …”
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Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis by Aditi Apte, Ashwini Parge, Radhika Nimkar, Anju Sinha

“…However, there is low certainty of evidence that the intervention led to improvement in fractional absorption of iron as compared to placebo or iron [8 studies, n = 335, mean increase 0.74%, 95%CI-0.11–1.38, p = 0.02]. …”
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