CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…Dual therapy results in changes in T cell dynamics within tumors, with relatively maintained antigen signaling in Treg compared with conv CD4+. Antigen-engaged CD4 +effectors correlate with tumor growth control, and depletion of Treg by addition of an anti-CD25 ICI, releasing suppression of conventional CD4 +effectors by Treg, enhances survival and activates immune signaling within tumors.…”
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Sero-epidemiological Study of Toxoplasma gondii among Pregnant Women in Akre City by Hogir Mohammed Shukri Saadi, Ahmed Jumaa Ahmed

“…Seropositivity for both IgG (61.90 %) and IgM (9.52%) was higher among pregnant women who had cats compared to those without cat. Seroprevalence of IgM and IgG was 9.67% and 54.83% among population who had undercooked meat, while 1.69% and 59.23% were positive for IgM and IgG respectively, in those well cooked meat meal. …”
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Management of extremity and pelvic fractures in earthquake: our observations and recommendations by Bugra Kundakci, Akif Mirioglu, Bugra Eraslan, Hakki Can Olke, Mustafa Tekin, Melih Bagir, Yusuf Kemal Arslan

“…Women had a significantly higher occurrence of pelvic fractures (33.3%) compared to men (14.5%) (p = 0.003). The frequency of pelvic fractures significantly increased as age decreased (p = 0.007). …”
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China’s CBM exploration and production and associated technological advancements: A review and reflections by Jianping YE

“…Objective and Methods Based on extensive scientific and technical literature and technical data on coalbed methane (CBM) exploration and production projects, this study conducted a comparative analysis of the development process and latest advances in China’s critical technologies for CBM exploration and production and reviewed the CBM exploration and production history of this country over the past three decades. …”
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Efficacy of Group O Washed Red Blood Cell Transfusion on Vital Signs and Hematologic Stability in Trauma Patients With Different Blood Types by Gou XJ, Li LF, He XL, Chen X, Yu AY, Tian WY

“…Changes in blood biochemical indexes and vital signs before and after transfusion were compared, and adverse transfusion reactions were monitored.Results: A total of 65 patients were included in the study, and no adverse transfusion reactions were observed. …”
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Effects of Interplanting Medicinal Herbs on Runoff, Sediment and Nitrogen and Phosphorus Losses in Young Oil Tea Plantation on Red Soil Sloping Field by YAN Shijie, DUAN Jian, SHEN Faxing, XIE Dongjie, ZHENG Haijin

“…[Results] (1) All conservation measures significantly reduced water, soil, and nutrient losses in young oil tea plantations, except for the clean-tillage mode. Compared with CK, the runoff reduction effects of YA, YC and YY amounted to 15.22%, 67.30% and 64.12%, respectively; the sediment reduction effects amounted to 72.63%, 97.19% and 98.19%, respectively; the decrease in total nitrogen (TN) loss was 57.86%, 96.53% and 95.87%, respectively; and the decrease in total phosphorus (TP) loss was 32.18%, 98.62% and 98.86%, respectively. (2) Under moderate rain, heavy rain and rainstorm, YY pattern all showed good soil and water conservation and nutrient interception effects, with runoff reduction effects and sediment reduction effects ranged from 45.11% to 83.25% and 96.08% to 99.02%, respectively. …”
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Anxiety, Depression, and Stress Reaction/Adjustment Disorders and Their Associations with Healthcare Resource Utilization and Costs Among Newly Diagnosed Patients With Breast Cance... by Dingwei Dai, Henriette Coetzer, Sean R. Zion, Michael J. Malecki

“…Patients with anxiety, depression, or stress reaction/adjustment disorder had higher rates of several types of HCRU (_P_ < .0001) and higher total all-cause costs compared with patients without these psychiatric disorders (_P_ < .0001). …”
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Association of dietary niacin intake with all-cause mortality in chronic kidney disease: A retrospective cohort study of NHANES. by Meijuan Xiang, Jianyun Peng, Zhihong Gui, Ju Jin, Jinling Meng

“…During a mean follow-up of 73.92 (1.14) months, 1,325 (28.44%) CKD patients died. Compared to CKD patients with lower niacin intake ≤19mg, those with niacin intake >33 mg were associated with lower all-cause mortality risk (HR = 0.79, 95%CI: 0.64-0.98). …”
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PlaceField2BVec: A bionic geospatial location encoding method for hierarchical temporal memory model by Zugang Chen, Shaohua Wang, Kai Wu, Guoqing Li, Jing Li, Jian Wang

“…At last, our method was compared with existing Space2BVec and Buffer2BVec in terms of location prediction accuracy and to demonstrate the robustness of the binary vector encoding methods, two brain-inspired artificial neural networks— HTM and BinaryLSTM were used. …”
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Using Dose-Effect Relationship for Optimising Systemic Corticosteroid Dosage in Treatment of Inflammatory Bowel Diseases by O. P. Alekseeva, S. V. Krishtopenko, A. A. Alekseeva

“…The repeat CS treatment had the same OCED values of 51.43 ± 1.55 mg/day, but a 42% lower expected effect compared to the first course. The effect did not exceed 40% suggesting its inadequacy in repeat CS treatments in this category of patients.…”
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The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker by Hao-ming He, Ying-ying Xie, Qiang Chen, Yi-ke Li, Xue-xi Li, Sun-jing Fu, Na Li, Yan-ru Han, Yan-xiang Gao, Jin-gang Zheng

“…Receiver operating characteristic (ROC) curve analysis was performed to compare the predictive value. Mediation analysis was used to explore the potential mediator. …”
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Eficacia de insecticidas aplicados al follaje en el control de aphis gossypii glover en algodón by R.E. Beltran, S. Helman, F. Garay, A. Lescano, O. Peterlin

“…En esta etapa se evaluó la eficacia y residualidad de diferentes insecticidas foliares para el control de pulgón Aphis gossypii Glover en el cultivo de algodón durante dos años agrícolas, 2002-03 y 2003-04. …”
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EGCG improve meat quality, restore lipid metabolism disorder and regulate intestinal flora in high-fat fed broilers by Lujia Gao, Chen Liu, Jiaqi Wu, Ying Cui, Man Zhang, Chongpeng Bi, Anshan Shan, Xiujing Dou

“…The results showed that EGCG increased lightness (L*) 24 h (P < 0.05), and decreased drip loss (P < 0.05) of chicken meat; Enhanced the presence of non-essential and flavor amino acids in muscle tissue and greatly enhanced the antioxidant capacity of broilers, leading to a noteworthy upregulation of antioxidant genes at the genetic level (P < 0.05); Reduced in blood lipids, blood glucose, liver and abdominal fat accumulation in high-fat diet-induced obese chickens (P < 0.05), markedly improved serum and liver biochemical parameters, and histological analysis results also demonstrated that EGCG markedly decreased hepatic lipid accumulation caused by HFD feeding. Compared to high-fat diet-induced obese chickens, supplementation of EGCG significantly lowered hepatic fatty acid synthase (FAS) expression and lipid synthesis metabolites, while fatty acid decomposition enzymes showed no significant changes. …”
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Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration by Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

“…MAPT-bvFTD displayed more pronounced differences in transcriptomic signatures compared to the other two genetic forms. The genes that exhibited significantly positive or negative correlations with cortical thickness in MAPT-bvFTD showed opposing directionality in C9orf72-bvFTD and GRN-bvFTD. …”
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Associations between age, red cell distribution width and 180-day and 1-year mortality in giant cell arteritis patients: mediation analyses and machine learning in a cohort study by Si Chen, Rui Nie, Xiaoran Shen, Yan Wang, Haixia Luan, Xiaoli Zeng, Yanhua Chen, Hui Yuan

“…KM survival analysis further showed that GCA patients hospitalized or admitted to the ICU with higher age or elevated RDW levels had significantly lower survival rates compared to younger patients or those with lower RDW levels (P < 0.0001). …”
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Accumulation Characteristics and Hydrological Effects of Litter in Mixed Robinia pseudoacacia Plantations by CAO Zetao, DENG Yangxu, TIAN Jing, WANG Bing, LIU Guobin, YANG Yanfen

“…[Methods] This study focused on five different mixed planting patterns of Robinia pseudoacacia in the loess hilly region, including R. pseudoacacia × Hippophae rhamnoides, R. pseudoacacia × Amorpha fruticosa, R. pseudoacacia × Pinus tabuliformis, R. pseudoacacia × Prunus davidiana, and R. pseudoacacia × Prunus sibirica, with pure R. pseudoacacia plantations serving as a control for comparative analysis. Through field investigations and laboratory experiments, quantitative research was conducted on the accumulation, water-holding capacity, and evaporation characteristics of litter in these mixed plantations. …”
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Exposure to Silica, Arsenic, and Chromium (VI) in Cement Workers: A Probability Health Risk Assessment by Noor Haziqah Kamaludin, Juliana Jalaludin, Shamsul Bahri Mohd Tamrin, Abdah Md Akim, Tri Martiana, Noeroel Widajati

“…Manufacturing workers had a high probability of getting cancer due to Si exposure in cement respirable dust at 29.81 × 10−4 times compared to administrative workers at 4.14 × 10−4 times. …”
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Acetic Acid Chromoendoscopy in the Preliminary Diagnosis of Histological Type of Colon Polyp during Colonoscopy by N. V. Ageykina, E. D. Fedorov, P. G. Malkov, T. V. Nikolaychuk, N. A. Oleynikova

“…On the contrary, the LAW of serrated polyps is delayed compared to the LAW of the surrounding mucosa «acetowhitening positive». …”
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Physicochemical and sensory analysis of fruit juices based on buffalo yogurt whey by Gladis Rébak, Gladys Obregón, Luz Segovia-Espindola, Victoria Cantero, Mariano Pino, Liliana Alegre

“…The results were statistically compared by Tuckey with a significance level of 5%. …”
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Kombinasi K-NN dan Gradient Boosted Trees untuk Klasifikasi Penerima Program Bantuan Sosial by Elly Firasari, Umi Khultsum, Monikka Nur Winnarto, Risnandar Risnandar

“…The test results prove that the combination produced a high percentage value compared to the K-NN or Gradient Boosted Trees method that is 98.17%. …”
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