Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis by Hongbin Luo, Qunya Zheng, Youzheng Zhou, Weipeng Lai, Nanwen Zhang, Peng Chen

“…The RA group displayed stronger cell type interactions compared to the OA group with enhanced signaling pathways, such as fibronectin 1-cluster of differentiation 44 (FN1-CD44) and C-X-C motif chemokine ligand 12-C-X-C motif chemokine receptor 4 (CXCL12-CXCR4). …”
Get full text

Effect of 25-hydroxycholecalciferol and high phytase doses on performance, vitamin D status, bone mineralization, and mechanistic target of rapamycin gene expression of broilers by L.S. Bassi, C.C.S. Martins, C.A. Lozano-Poveda, I.C. Dias, S.G. Oliveira, A. Maiorka

“…Phytase did not affect growth performance from 1 to 21 d, but a higher dose (2 000 FYT/kg) reduced feed intake and FCR from 22 to 42 d compared to 600 FYT/kg, also reducing FCR in the total period (P < 0.05). …”
Get full text

Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei by Maznah Alhesain, Ayman Alzu’bi, Ayman Alzu’bi, Ayman Alzu’bi, Niveditha Sankar, Niveditha Sankar, Charles Smith, Charles Smith, Janet Kerwin, Ross Laws, Susan Lindsay, Gavin J. Clowry

“…No GAD67+ neurons were observed in the thalamus at 10 PCW, but by 14 PCW the medial posterior quadrant of the thalamus at various levels was infiltrated by GAD67+/ SOX14+ cells of presumed pretectal/midbrain origin. We compared expression of the neurodevelopmental disease susceptibility gene CNTNAP2 to these patterns. …”
Get full text

Estimating the impact of school closures on the COVID-19 dynamics in 74 countries: A modelling analysis. by Romain Ragonnet, Angus E Hughes, David S Shipman, Michael T Meehan, Alec S Henderson, Guillaume Briffoteaux, Nouredine Melab, Daniel Tuyttens, Emma S McBryde, James M Trauer

“…We then simulated a counterfactual scenario, assuming that schools remained open throughout the study period. We compared the simulated epidemics in terms of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections, deaths, and hospital occupancy pressure. …”
Get full text

Pengukuran Niat Penggunaan Virtual Reality sebagai Alat Simulasi Pelatihan by Riski Arifin, Adithya Sudiarno

“…Abstract Virtual Reality is a technology that describes a virtual environment, the virtual reality continues to show a massive increase of usage over the years ranging from a gaming application to a simulation tool for education and training, which proven to provide better understanding of the learning subject compared to the conventional training. However, given to the current state of the virtual technology, an applicative measurement is needed to increase the use of virtual reality technology from each variable mentioned in this study, therefore this paper use Technology acceptance model to measure the intention of user to use the virtual technology. …”
Get full text

Potential improvement in spatial accessibility of methadone treatment with integration into other outpatient substance use disorder treatment programs, New York City, 2024. by Marcus A Bachhuber, Chinazo O Cunningham, Ashly E Jordan

“…We estimated one-way public transit travel time and compared travel times using population weighted paired t-tests.…”
Get full text

Diversity-Focused Undergraduate Premedical Enrichment Programs: The Impact of Research Experiences by Acevedo A, Babore YB, Greisz J, King S, Clark GS, DeLisser HM

“…The PASS students expressed more confidence in their research skills and felt better able to establish and maintain connections with mentors compared to their non-PASS peers. Both groups of students, however, expressed frustration at the lack of identity-concordant mentors to support their research aspirations and felt the pressure to do research to support their competitiveness for the residency match.Conclusion: The research experiences of diversity-focused enrichment programs may foster the agency and self-efficacy of participants in ways that support their success in medical school.Keywords: medical student diversity, diversity recruitment, pathway programs, health equity, health disparities, medical student admissions…”
Get full text

Evaluación de alternativas al Clorotalonil para el control de viruela del maní by Claudio Oddino, Damian Francisco Giordano, Juan Santiago Mortigliengo, Agustín Bazan

“…La viruela (Passalora arachidicola-Nothopassalora personata) es la enfermedad foliar más importante en todo el mundo. El manejo, se realiza principalmente a través del control químico; siendo clorotalonil el fungicida más utilizado. …”
Get full text

A Clinical Study on Functional Outcome of Percutaneous Transforaminal Endoscopic Discectomy under Local Anesthesia by Suryansh Nema, Varun Kumar Agarwal

“…Transforaminal endoscopic discectomy through a Kambin’s triangle is a minimally invasive procedure which can be done under local anesthesia, without muscle splitting, with short hospital stay and minimal complications compared to other techniques used. Aim: The aim of this study was to evaluate the functional outcomes following percutaneous transforaminal endoscopic discectomy (PTED) under local anesthesia for lumbar disc herniations. …”
Get full text

Bony ankylosis adversely affects postoperative hip function in patients with ankylosing spondylitis undergoing total hip arthroplasty: a retrospective cohort study of 319 consecuti... by Liangliang Li, Jun Fu, Chi Xu, Ming Ni, Wei Chai, Libo Hao, Yonggang Zhou, Jiying Chen

“…The postoperative functional results of the two groups at the most recent follow-up were compared. Results Survivorship was 99.8% with a mean follow-up of 7 years (range, 5–9 years). …”
Get full text

Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…Those affected had a significantly lower mental HRQOL when compared with those who were unaffected. More than half of those affected had co-occurrence of psychological symptoms. …”
Get full text

DEVELOPING INFORMATION AND TECHNOLOGICAL COMPETENCE OF PROSPECTIVE MILITARY SAILORS by Ruslan Shevchenko, Oleh Cherniavskyi, Vasyl Shemchuk, Olena Zlobina, Natalia Benkovska, Nataliia Terentieva, Андрій Гуралюк

“…With the help of a comparative analysis based on the results of two diagnostic sections, the statistical reliability of the differences in the signs of identifying IT competence criteria before and after the training of future officers of the Ukrainian Navy was determined Considering the unique dynamics within a maritime institution of higher education, a systematic blend of lectures, discussions, practical training sessions, situational exercises, utilization of virtual technologies, and the undertaking of group and individual projects significantly elevated the level of information technology competence among future Naval Forces officers. …”
Get full text

Hydrochemical assessment of borehole water in Effurun, Delta state Niger Delta, Nigeria: implications for public health and safety by Odunayo Tope Ojo, Chiaka Joy Ike, Adegoke Ige Aladeboyeje, Olayiwola Grace Olaseeni, Olumuyiwa Femi Adewumi

“…The aim of this study is to assess the quality of borehole water in Effurun by analyzing major ions, trace metals, and other hydrochemical parameters, and to compare the findings with WHO and NSDWQ drinking water standards. …”
Get full text

Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells. by Eiman Abdo, Mohammad A Ismail, Sabal Al Hadidi, Mairvat Al-Mrahleh, Tareq Saleh, Malik Zihlif, Nidaa A Ababneh

“…<h4>Results</h4>Hypoxic PANC-1 cells showed significant resistance to the lytic effect of either CD8+ T-cells co-culture or CD8+ T-cells CM treatment compared to normoxic PANC-1 cells. A significant decrease in TNF-α and IFN-γ levels was also detected. …”
Get full text

Association of workforce participation with depression among US older adults: results from NHANES 2005–2018 by Zhenyu Sun, Yi Wang, Xi Chen, Dongfu Qian

“…Especially, regular daytime working reduced depression risk by 52% compared with those who not working (OR = 0.48; 95%CI: 0.27–0.87). …”
Get full text

Remnant cholesterol and its variability independent of low density lipoprotein cholesterol predict metabolic dysfunction associated steatotic liver disease by Yuting Sun, Xinlei Miao, Manling Hu, Xiaoling Xie, Shuang Liu, Ziping Song, Jiayi Deng, Fei Xu, Meng Li, Yangxuan He, Song Leng

“…During a mean visit-to-visit of 3.19 years (SD 2.06 years), 8374 patients (19.45%) developed MASLD. Compared with Q1, Q4 was associated with a significantly greater risk of MASLD (hazard ratio [HR] 1.309, 95% confidence interval [CI] 1.220–1.403, P < 0.001). …”
Get full text

Exploring the antimicrobial and antioxidative potential of Leucas aspera (Willd.) link: Phytochemical screening, molecular docking, and HR-LC/MS profiling against SARS-CoV-2 protei... by Thavasiaanatham Seenivasan Shalini, Ragothaman Prathiviraj, Poomalai Senthilraja

“…The extract's free radical scavenging capabilities were at 150 µg/ml in DPPH, showing an 87 % effectiveness compared to the standard ascorbic acid 49 % inhibition capacity. …”
Get full text

Chemopreventative potential of Salsola tuberculatiformis Botch and Compound A in the differential regulation of IL-1Ra:IL-1α in UVB exposed skin keratinocytes by T. Magcwebeba, L. McEvoy, S. Hayward, T. Tait, J.L Quanson, L. Kelbe, WCA Gelderblom, M. Lilly, A.C Swart, P. Swart

“…The extract exhibited different anti-inflammatory effects compared to Compound A, as evidenced by the increased intracellular IL-1Ra: IL-1α ratio. …”
Get full text

Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China by Shuang Zhao, Han Yang, Haijuan Zhao, Miao Miao, Qingqing Wang, Yaru Wang, Yuying Yin, Xin Wang

“…Results We observed a dose–response relationship between cognition and mortality. Compared to those with no impairment, elderly with mild (AHR = 1.11, 95% CI 1.05–1.18), moderate (AHR = 1.22, 95% CI 1.13–1.33) and severe (AHR = 1.30, 95% CI 1.19–1.42) cognitive impairment showed increased mortality risk. …”
Get full text

Laminoplasty vs laminectomy in the surgical management of spinal intradural extramedullary tumors by Deepak Kumar Singh, Prevesh Kumar Sharma, Vipin Kumar Chand, Kaif Mohammad, Kuldeep Yadav, Neha Singh

“…In this case series, we aimed to compare the laminectomy and laminoplasty procedure in the surgical management of intradural extramedullary spinal tumors and analyze the advantages and disadvantages of both the procedures. …”
Get full text