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    SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation by Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson

    Published 2025-02-01
    “…Confirmation of this synthetic lethal interaction is performed in isogenic clear cell renal cell carcinoma and immortalized renal epithelial cell lines, in mouse and human backgrounds. Depletion of NSD1 using a CRISPRi targeting approach promotes the loss of SETD2-mutant cells coincident with elevated levels of DNA damage and apoptosis. …”
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    Understanding cannabis use in Singapore: profile of users and drug progression by Doris Xin Yi Chia, Charis Wei Ling Ng, Pezhummoottil Vasudevan Nair Asharani, Sabina Au Yong, Jun Wen Tan, Noor Azizah Bte Zainuldin, Samuel Kee Guan Chua, Lambert Tchern Kuang Low, Christopher Cheng Soon Cheok, Gomathinayagam Kandasami

    Published 2023-06-01
    “…Methods: A total of 450 participants who had used cannabis at least once in their lifetime were recruited from the National Addictions Management Service, prisons, the Community Rehabilitation Centre and halfway houses from August 2017 to May 2018. A face-to-face questionnaire was administered and descriptive analyses were conducted. …”
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