Panitumumab versus cetuximab in combination with irinotecan in refractory metastatic colorectal cancer by Maria Ignez Freitas Melro Braghiroli, Daniel Santos Rocha Sobral Filho, Juliana Goes Martins Fagundes, Elizabeth Zambrano Mendoza, Maria Fernanda Batistuzzo Vicentini Neffa, Karla Souza Campos, Leonardo Gomes da Fonseca, Renata Colombo Bonadio, Aley Talans, Oddone Freitas Melro Braghiroli, Maria Cecília Mathias-Machado, Jorge Sabbaga, Camila Motta Venchiarutti Moniz, Paulo Marcelo Gehm Hoff

“…There was no significant difference in median overall survival between treatment groups (9.1 months [I + C] vs 10.1 months [I + P]; p = 0.76). …”
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Comparing The Viral Load of Severe Acute Respiratory Syndrome Coronavirus 2 in Different Human Specimens by Ali Hattem Hussain

“…The mean of viral load cycle threshold value is 17.8 (±11.7), with a median of 15.95 with minimum value of 0.2 and a maximum value of 36.5. …”
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Progression of Heart Failure in People with Type 2 Diabetes in Germany: An Analysis Using German Health Insurance Claims Data by Keni Cheng-Siang Lee, Tobias Wagner, Adee Kennedy, Michael Wilke

“…**Results:** Among the 173 195 individuals with T2D identified in 2013, 6725 (median age, 74 years) developed HF in 2014 or 2015. 34.4% of individuals had MACEs, and 42.9% died over 5 years. …”
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The concentration of selected organophosphorus pesticides associated with PM10 in agricultural ambient air in Iran: Health risk assessment using Monte Carlo simulation by Asma Tabanasl, Amin Mohammadpour, Aboozar Soltani, Mohammad Hoseini, Mohammadali Baghapour

“…For adults, the corresponding values were 0.0016, 0.0050, and 0.0101, respectively. The median carcinogenic risk (CR) values were estimated at 1.40E-9 for children and 2.49E-9 for adults. …”
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Modeled Respiratory Tract Deposition of Smoke Aerosol from Conventional Cigarettes, Electronic Cigarettes and Heat-not-burn Products by Yawen Li, Huapeng Cui, Li Chen, Meijuan Fan, Junlan Cai, Junwei Guo, Caner U. Yurteri, Xiaoxi Si, Shaofeng Liu, Fuwei Xie, Jianping Xie

“…The DMS results showed that the particle size distribution of aerosol from the three products differed considerably, with a count median diameter of 14.2–25.4 nm, 50.6–55.3 nm and 172–179 nm for the e-cigarette, heat-not-burn product and conventional cigarette, respectively. …”
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Pregnancy-Associated Plasma Protein-A: Its Significance as a Single Biomarker for Adverse Obstetric Outcomes by Madhusudan Dey, Priyanshi Choudhury, Sunil Chawla, Pranjali Dhume, Suyash Goel, Ankur Shah, Mounica Gowda KN

“…Maternal serum pregnancy-associated plasma protein-A levels were assessed at 11 to 13+6 weeks of gestation, converted in multiples of the median and patients were followed till delivery. Maternal outcomes were recorded in terms of abortions, development of gestational hypertension, gestational diabetes, preeclampsia, placental abruption, fetal growth restriction, fetal demise, neonatal intensive care unit admission, etc., and analyzed to find an association with levels first trimester of pregnancy-associated plasma protein-A. …”
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Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B by S. N. Batskikh, E. V. Vinnitskaya, E. S. Sbikina, Zh. V. Borunova, A. S. Dorofeev, Yu. G. Sandler

“…A single-centre cross-sectional trial included 110 HBsAg- and anti-HCV-negative patients with confirmed NAFLD (median (IQR) age 60 (53-66) years). Obesity, type 2 diabetes and dyslipidemia were in 78 (70.9%), 64 (58.2%) and 77 (70%) individuals, respectively. …”
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The utilization of the multimodal immunotherapy for the opsoclonus–myoclonus syndrome can reduce relapses and permanent neurological sequelae by Fang He, Miriam Kessi, Ciliu Zhang, Jing Peng, Fei Yin, Lifen Yang

“…Results Of the six recruited patients, three were (50.00%) males. The median age of onset was 15.50 months. Preceding manifestation was present in one patient and two cases had neuroblastoma. …”
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Biliary Atresia Treatment: Can Shear Wave Elastography Predict Kasai Procedure Outcomes? by Sekarsari Damayanti, Gema Ramadhan Muhammad, Rinaldhy Kshetra, Prihartono Joedo

“…Results Twenty-one subjects, with 8 males and 13 females (median age: 82 days), were evaluated. Of the 21 subjects, 9 (42.9%) had successful Kasai outcomes, while 12 (57.1%) were unsuccessful. …”
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A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits. by Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas

“…We used correlation coefficients and median absolute error to assess fit between predicted and observed measures, as well as agreement between duplicates. …”
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Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Additionally, we identified a prognostic gene set (RPS10, MIF, MT-ATP6, CSTB, IFI30, NPC2, BTG1, CTSD, FCGR2A, SEC61G, IER3, HSPB1, HMOX1, and ZFP36L1) and differentiated high-risk from low-risk PDAC patients based on median risk score threshold. Based on these findings, we developed a novel prognostic model that identifies poorer prognosis in high-risk groups. …”
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Relationship between caries indexes and obesity in a sample of Puerto Rican adolescents by Lydia M. Lopez del Valle, Mariely Nieves-Plaza, Sona Rivas-Tumanyan, Rosana Hanke-Herrero

“…No significant differences were found between caries indexes and obesity status (P > 0.05). The median (p25, p75) SiC index among overweight/obese adolescents was 9.5 (7, 12), whereas for healthy weight/underweight participants was 7 (5, 8) (p < 0.005).ConclusionsBased on the limited number of participants, no association was found between dental caries (D3-6MFS and D3-6MFT) and obesity (BMI) among adolescents.…”
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A comparison of development methods used to define portion sizes in food-based dietary guidelines around the world by Fanny Salesse, Fanny Salesse, Alison L. Eldridge, Tsz Ning Mak, Eileen R. Gibney, Eileen R. Gibney

“…Of the countries providing portion size information, only one did not report its methodological approach. Comparisons of median portions sizes of food groups across methodologies showed no significant differences. …”
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Pre-existing atrial fibrillation and risk of arterial thromboembolism and death following pneumonia: a population-based cohort study by Reimar Wernich Thomsen, Christian Fynbo Christiansen, Bodil Steen Rasmussen, Lars Hvilsted Rasmussen, Jacob Gamst

“…Objectives To examine the effect of pre-existing atrial fibrillation (AF) and associated therapy on the risk of arterial thromboembolism (ATE) and death following pneumonia.Design, setting and participants Population-based cohort study (1997–2012) of 88 315 patients with first-time hospitalisation with pneumonia in Northern Denmark.Results Of the included patients (median age 73.4 years), 8880 (10.1%) had pre-existing AF. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…We assessed the predictive performance of our model for distinguishing the enrichment of exceptional longevity among long-lived individuals in two replication cohorts (the Scripps Wellderly cohort and the Medical Genome Reference Bank (MRGB)) and showed that the median lifespan in the highest decile of our composite prognostic index is up to 4.8 years longer. …”
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The relationship between the atherogenic index of plasma and postoperative myocardial injury following non-cardiac surgery under general anaesthesia: a retrospective cohort study by Yuanjun Zhou, Liping Zhong, Yilin Liao, Yuting Zhong

“…Results The cohort consisted of 1,160 adult patients, with a median preoperative AIP of -0.05. The incidence of MINS was 7.9%. …”
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Characteristics of pediatric patients with febrile convulsions admitted to a tertiary care hospital in Riyadh, Saudi Arabia by Alanoud A. Abuhaimed, Nawaf A. Alghamdi, Ghadah I. Alhussin, Ghadah S. Alduhaimi, Fatmah Othman, Duaa M. Baarmah, Hamad A. Alkhalaf

“…Most of the patients (77%) convulsions were triggered by upper respiratory tract infections and median duration of the convulsion episode was 4 min; 55% of the patients had a simple FC, and 40% had recurrence of FCs. …”
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Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest by Magnus Gylling, Johanna Krøll, Peder Emil Warming, Carolina Malta Hansen, Fredrik Folke, Steen M. Hansen, Lars Køber, Christian Torp-Pedersen, Rodrigue Garcia, Jacob Tfelt-Hansen, Peter E. Weeke

“…Results: Of 45,293 patients with OHCA 4,994, were eligible for inclusion (median age 50 years at OHCA, 76% male). Of these 47.7% had a family history of CVD (vs. 42.1% of controls), 68.2% of all-cause death (vs. 60.9%), 23% of premature death (vs. 15.8%) and 33.3% of cardiovascular death (vs. 27%) (p < 0.001 for all). …”
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Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies by Jingjing Qu, Zhen Chen, Yanping Zhu, JinYan Huang, Qian Shen

“…Results The cohort included three females and two males, with a median age of 44 years. Clinical features commonly involved centrally located masses with mediastinal invasion. …”
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The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in colorectal cancer and colorectal anastomotic leakage patients: a retrospe... by Nuo Xu, Jian-Xin Zhang, Jia-Jie Zhang, Zhuo Huang, Lian-Chun Mao, Zhi-Yong Zhang, Wei-Dong Jin

“…Results A total of 890 patients with colorectal cancer, 102 patients with CAL, and 788 patients with non- anastomotic leakage (AL) colorectal cancer were enrolled for a median follow-up of 96 months (quartile range 33–133). …”
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