Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

“…Thirty-two patients were enrolled. The median age was 60 years (range: 28–74 years), and 53.1% (17/32) patients were Siewert III type. …”
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Single-center experience and evaluation of rare ıntracranial abscesses in childhood by Nihal Yildiz, Zeynep Gökçe Gayretli Aydin

“…Treatment included ceftriaxone (82.6%), vancomycin (65.2%), meropenem (43.5%), metronidazole (34.8%), and linezolid (17.4%). The median hospitalization duration for patients was 32 days (range: 14–150). …”
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Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study by Che L, Zang H, Bi Y, Wen B, Xu L

“…We conducted the causal estimates using the inverse variance-weighted method (IVW), with sensitivity analyses using MR-Egger, weighted median, weighted mode, and MR pleiotropy residual sum and outlier (MR-PRESSO) analysis. …”
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El asistencialismo en los recursos de ayuda alimentaria by Amaia Inza-Bartolomé, Leire Escajedo San Epifanio

“…Una determinada problematización de dicha inseguridad, ha traído aparejadas ciertas conveniencias de orden secundario, tales como la rentabilidad que logra la industria alimentaria con la remercantilización de alimentos donados o que de otra manera serían despilfarrados, la desresponsabilización de los gobiernos con respecto al derecho a la alimentación, así como la propia entidad benéfica de los propios recursos, que han ayudado a que la opinión pública los vea de manera acrítica. …”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Compared with algorithm testing, upfront comprehensive testing detected a higher number of pathogenic molecular alterations/patient (median: five versus three, P = 0.0005), however no additional actionable alterations. …”
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A Health Economic Analysis Exploring the Cost Consequence of Using a Surgical Site Infection Prevention Bundle for Hip and Knee Arthroplasty in Germany by Rhodri Saunders, Rafael Torrejon Torres, Henning Reuter, Scott Gibson

“…Sensitivity analyses confirmed these findings, indicating a median saving of 2.22% (95% credible interval: 1.00%-3.79%]). …”
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UK multiple sclerosis risk-sharing scheme: a new natural history dataset and an improved Markov model by Jacqueline Palace, Martin Duddy, Thomas Bregenzer, Mike Boggild, Joel Oger, Helen Tremlett, Charles Dobson, Fheng Zhu

“…Transition probabilities were derived and different Markov models (discrete and continuous) with and without baseline covariates were applied.Setting MS clinics in Canada and the UK.Participants From the BCMS database, 898 ‘untreated’ patients with MS considered eligible for drug treatment based on the UK's Association of British Neurologists criteria.Outcome measure The predicted Expanded Disability Status Scale (EDSS) score was collected and assessed for goodness of fit when compared with actual outcome.Results The BCMS untreated cohort contributed 7335 EDSS scores over a median 6.4 years (6357 EDSS ‘transitions’ recorded at consecutive visits) during the period 1980–1995. …”
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Comparative analysis of alectinib and brigatinib in real-world treatment of advanced NSCLC with ALK rearrangements by Kyuhwan Kim, Kyu Yean Kim, Hye Seon Kang, Ah Young Shin, Sung Kyoung Kim, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim, Jeong Uk Lim, Chang Dong Yeo

“…The best ORR was similar between the groups (84.1% for alectinib vs 83.3% for brigatinib, p  = 0.518). The median TTD was 57.8 months (95% confidence interval (CI): 29.0–86.7) for alectinib and 39.6 months (95% CI: 21.7–57.4) for brigatinib ( p  = 0.462). …”
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A vueltas con el derecho a la vivienda y la normativa actual que lo regula by Carolina del Carmen Castillo Martínez

“…Pero la realidad demuestra que intervenir, como se pretende, el mercado inmobiliario no resulta la vía idónea para solucionar el problema y, ante la confrontación argumental con trasfondo ideológico que nos ocupa, la más autorizada doctrina defiende la necesidad de no topar los precios y renunciar a la imposición de normas que tensan el escenario provocando un mercado constreñido, extremadamente regulado y marcadamente punitivo. …”
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Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study by Johanna P. van Gemert, Bart Luijk, Merel E. Hellemons, Klara A. Visser, Carina.M.E. Hansen, Renske van der Meer, C. Tji Gan, Hester van der Vaart, Onno W. Akkerman, Willie N. Steenhuis, Marieke Verkleij, Harry G.M. Heijerman, Erik A.M. Verschuuren

“…Three months results showed a decrease in SNOT-22 score (p< 0.001) and GI symptoms (all 4, p< 0.05), an increase in BMI (p= 0.012) and CFQ-R (6 domains, p< 0.05). Median CNI daily dose had to be reduced from 6 to 4 mg (p< 0.001), to maintain stable CNI trough levels. …”
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Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study by Jasmine De Troy, Sarah-Maria Fendt, Sigrid Hatse, Patrick Neven, Ann Smeets, Annouschka Laenen, Hans Wildiers

“…Results: In total, 1113 patients were included, 10% of them developed distant metastasis over a median follow-up period of 7 years. In multivariable analysis adjusting for age, stage, and subtype, transferrin saturation and serum iron were significantly associated with an increased risk of breast cancer metastasis. …”
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Association between polypharmacy and falls in older adults: a longitudinal study from England by Nafeesa N Dhalwani, Melanie J Davies, Kamlesh Khunti, Harini Sathanapally, Radia Fahami, Sam Seidu

“…Objectives Assess the longitudinal association between polypharmacy and falls and examine the differences in this association by different thresholds for polypharmacy definitions in a nationally representative sample of adults aged over 60 years from England.Design Longitudinal cohort study.Setting The English Longitudinal Study of Ageing waves 6 and 7.Participants 5213 adults aged 60 or older.Main outcome measures Rates, incidence rate ratio (IRR) and 95% CI for falls in people with and without polypharmacy.Results A total of 5213 participants contributed 10 502 person-years of follow-up, with a median follow-up of 2.02 years (IQR 1.9–2.1 years). …”
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Angiotensin-Neprilysin Inhibitor Therapy: A Retrospective Chart Study by Roda Plakogiannis, Abraham Stefanidis, Nubriel Hernandez, Etty Vider

“…Sixty percent of patients experienced an improvement in EF, with a median increase of 10.00% over a 90-day follow-up. …”
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Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study by Chunyan Zhou, Yanyu Zhang, Xiaoyi Liu, Chenyu He, Shiyang Li, Shiyang Li

“…Subgroup analyses and interaction tests were also performed.ResultsDuring a median 109 (108–109) months of follow-up, 745 (10.7%) participants were diagnosed with new-onset CMM. …”
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Assessment of long-term changes in subvalvular aortic stenosis in patients following transcatheter aortic valve implantation by Vladlen V. Bazylev, Andrey B. Voevodin, Alexey S. Masyutin

“…Pre- and postoperative median IVS thicknesses were 17.7±2.2 and 14.4±3.2 mm, respectively. …”
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Prevalence, associated factors, management and outcomes of hypokalaemia in hospitalised patients at a South African tertiary centre by C Burton, M-Y Chothia, A Zemlin, S Lahri

“…The period prevalence of hypokalaemia was 6.8% (3 539/52 243). The median (interquartile range) age was 46 (33 - 63) years, and 60% were female. …”
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Laparoscopic excision of deep rectovaginal endometriosis in BSGE endometriosis centres: a multicentre prospective cohort study by Paul Smith, Lucky Saraswat, Sanjay Vyas, Thomas Ind, Ertan Saridogan, Elizabeth Ball, Edward Morris, James Clark, Tony Chalhoub, David Rowlands, Moiad Alazzam, Dominic Byrne, Tamara Curnow, Alfred Cutner, T Justin Clark, Iris Menninger, Yousri Afifi, Kevin Phillips, Saikat Banerjee, Robert Richardson, Jeremy Hawe, Barry Whitlow, Emmanuel Ofuasia, Ashwini Trehan, Tyrone Carpenter, Christian Becker, Stuart Jack, Kumar Kunde, Chris Barnick, Alan Farthing, Graham Phillips, John Bidmead, Mohamed Abdel-aty, George Botros, Marlin Mubarak, Christian Kremer, Stanley Okolo, Edmond Edi-osagi, Kamel Shehata-iskander, Gaity Ahmad, Jonathan Frappell, Brice Rodriguez, Yemi Coker, Gourab Misra, Adam Moors, Chris Guyer, Caroline Overton, Suku George, Oliver Chappatte, Richard Penketh, Funlayo Odejinmi, Keith Louden, Jon Hughes

“…Global quality of life significantly improved from a median pretreatment score of 55/100 to 80/100 at 6 months. …”
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The Effect of Age on Clinical and Laboratory Parameters in Reproductive Age Women with Endometrial Polyps by Aytekin Tokmak, Ebru Ersoy, Ali Özgür Ersoy, Esra Yaşar Çelik, Ali İrfan Güzel, Mustafa Uğur

“…RESULTS: The mean age of patients in the study and control groups were 45.2±3.5 and 30.6±4.9 years, respectively (p<0.001). The median BMI, gravidity, parity and abortion were significantly higher in study group (p<0.05). …”
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Calm ocean, stormy sea: atmospheric and oceanographic observations of the Atlantic during the Atlantic References and Convection (ARC) ship campaign by L. Köhler, L. Köhler, J. Windmiller, D. Baranowski, M. Brennek, M. Ciuryło, L. Hayo, D. Kȩpski, S. Kinne, B. Latos, B. Lobo, T. Marke, T. Nischik, D. Paul, P. Stammes, A. Szkop, O. Tuinder

“…<p>During the Atlantic References and Convection (ARC) ship campaign with the reference MSM114/2, which took place in early 2023, the German research vessel <i>Maria S. Merian</i> travelled from Mindelo, Cape Verde, to Punta Arenas, Chile. …”
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Potentials of transanal endoscopic surgery at early rectal cancer by Yu. A. Shelygin, S. V. Chernyshov, L. P. Orlova, E. G. Rybakov

“…Preoperative examination included: digital investigation of the rectum, rectoromanoscopy with biopsy, colonoscopy, TRUS, computer tomography and magnetic-resonance tomography of abdominal cavity and small pelvis.Results. The median duration of operation was 39 (25–110) minutes. …”
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